Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 |
| Enrichment Score (ES) | 0.49693322 |
| Normalized Enrichment Score (NES) | 1.6202439 |
| Nominal p-value | 0.0077279755 |
| FDR q-value | 0.045264468 |
| FWER p-Value | 0.538 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CYP1B1 | NA | CYP1B1 Entrez, Source | cytochrome P450, family 1, subfamily B, polypeptide 1 | 26 | 4.879 | 0.0664 | Yes |
| 2 | ALDH3A1 | NA | ALDH3A1 Entrez, Source | aldehyde dehydrogenase 3 family, memberA1 | 31 | 4.860 | 0.1338 | Yes |
| 3 | AKR1C1 | NA | AKR1C1 Entrez, Source | aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) | 72 | 4.603 | 0.1956 | Yes |
| 4 | CYP1A1 | NA | CYP1A1 Entrez, Source | cytochrome P450, family 1, subfamily A, polypeptide 1 | 75 | 4.587 | 0.2592 | Yes |
| 5 | AKR1C3 | NA | AKR1C3 Entrez, Source | aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) | 83 | 4.572 | 0.3224 | Yes |
| 6 | AKR1C2 | NA | AKR1C2 Entrez, Source | aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) | 295 | 3.746 | 0.3627 | Yes |
| 7 | EPHX1 | NA | EPHX1 Entrez, Source | epoxide hydrolase 1, microsomal (xenobiotic) | 429 | 3.367 | 0.4021 | Yes |
| 8 | ADH1C | NA | ADH1C Entrez, Source | alcohol dehydrogenase 1C (class I), gamma polypeptide | 628 | 2.899 | 0.4314 | Yes |
| 9 | GSTM2 | NA | GSTM2 Entrez, Source | glutathione S-transferase M2 (muscle) | 912 | 2.406 | 0.4491 | Yes |
| 10 | CYP2S1 | NA | CYP2S1 Entrez, Source | cytochrome P450, family 2, subfamily S, polypeptide 1 | 1366 | 1.872 | 0.4498 | Yes |
| 11 | MGST1 | NA | MGST1 Entrez, Source | microsomal glutathione S-transferase 1 | 1401 | 1.843 | 0.4735 | Yes |
| 12 | CYP2E1 | NA | CYP2E1 Entrez, Source | cytochrome P450, family 2, subfamily E, polypeptide 1 | 1641 | 1.652 | 0.4832 | Yes |
| 13 | MGST3 | NA | MGST3 Entrez, Source | microsomal glutathione S-transferase 3 | 1938 | 1.452 | 0.4869 | Yes |
| 14 | ALDH3B1 | NA | ALDH3B1 Entrez, Source | aldehyde dehydrogenase 3 family, member B1 | 2098 | 1.362 | 0.4969 | Yes |
| 15 | UGT2B15 | NA | UGT2B15 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide B15 | 2569 | 1.150 | 0.4867 | No |
| 16 | ADH5 | NA | ADH5 Entrez, Source | alcohol dehydrogenase 5 (class III), chi polypeptide | 2762 | 1.074 | 0.4909 | No |
| 17 | CYP1A2 | NA | CYP1A2 Entrez, Source | cytochrome P450, family 1, subfamily A, polypeptide 2 | 3060 | 0.973 | 0.4879 | No |
| 18 | UGT1A6 | NA | UGT1A6 Entrez, Source | UDP glucuronosyltransferase 1 family, polypeptide A6 | 3691 | 0.833 | 0.4643 | No |
| 19 | CYP2C9 | NA | CYP2C9 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 9 | 3806 | 0.809 | 0.4692 | No |
| 20 | ADH6 | NA | ADH6 Entrez, Source | alcohol dehydrogenase 6 (class V) | 4357 | 0.688 | 0.4480 | No |
| 21 | ADH1B | NA | ADH1B Entrez, Source | alcohol dehydrogenase IB (class I), beta polypeptide | 5041 | 0.547 | 0.4175 | No |
| 22 | UGT2B10 | NA | UGT2B10 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide B10 | 5982 | 0.418 | 0.3709 | No |
| 23 | UGT1A7 | NA | UGT1A7 Entrez, Source | UDP glucuronosyltransferase 1 family, polypeptide A7 | 6196 | 0.415 | 0.3647 | No |
| 24 | GSTM3 | NA | GSTM3 Entrez, Source | glutathione S-transferase M3 (brain) | 6384 | 0.384 | 0.3596 | No |
| 25 | CYP2F1 | NA | CYP2F1 Entrez, Source | cytochrome P450, family 2, subfamily F, polypeptide 1 | 6838 | 0.316 | 0.3387 | No |
| 26 | GSTA4 | NA | GSTA4 Entrez, Source | glutathione S-transferase A4 | 7108 | 0.273 | 0.3275 | No |
| 27 | ALDH3B2 | NA | ALDH3B2 Entrez, Source | aldehyde dehydrogenase 3 family, member B2 | 7850 | 0.166 | 0.2885 | No |
| 28 | CYP3A43 | NA | CYP3A43 Entrez, Source | cytochrome P450, family 3, subfamily A, polypeptide 43 | 7950 | 0.151 | 0.2850 | No |
| 29 | UGT2B7 | NA | UGT2B7 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide B7 | 7958 | 0.151 | 0.2868 | No |
| 30 | GSTK1 | NA | GSTK1 Entrez, Source | glutathione S-transferase kappa 1 | 8082 | 0.134 | 0.2818 | No |
| 31 | ADH1A | NA | ADH1A Entrez, Source | alcohol dehydrogenase 1A (class I), alpha polypeptide | 8128 | 0.129 | 0.2810 | No |
| 32 | DHDH | NA | DHDH Entrez, Source | dihydrodiol dehydrogenase (dimeric) | 8349 | 0.102 | 0.2702 | No |
| 33 | CYP2C19 | NA | CYP2C19 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 19 | 8501 | 0.079 | 0.2629 | No |
| 34 | CYP2B6 | NA | CYP2B6 Entrez, Source | cytochrome P450, family 2, subfamily B, polypeptide 6 | 8549 | 0.074 | 0.2613 | No |
| 35 | GSTT2 | NA | GSTT2 Entrez, Source | glutathione S-transferase theta 2 | 9186 | 0.000 | 0.2258 | No |
| 36 | UGT2B4 | NA | UGT2B4 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide B4 | 9383 | 0.000 | 0.2148 | No |
| 37 | UGT1A1 | NA | UGT1A1 Entrez, Source | UDP glucuronosyltransferase 1 family, polypeptide A1 | 9387 | 0.000 | 0.2147 | No |
| 38 | UGT1A10 | NA | UGT1A10 Entrez, Source | UDP glucuronosyltransferase 1 family, polypeptide A10 | 10099 | -0.078 | 0.1760 | No |
| 39 | ADH7 | NA | ADH7 Entrez, Source | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide | 10170 | -0.086 | 0.1733 | No |
| 40 | CYP3A4 | NA | CYP3A4 Entrez, Source | cytochrome P450, family 3, subfamily A, polypeptide 4 | 10323 | -0.099 | 0.1662 | No |
| 41 | ADH4 | NA | ADH4 Entrez, Source | alcohol dehydrogenase 4 (class II), pi polypeptide | 10677 | -0.151 | 0.1486 | No |
| 42 | CYP3A7 | NA | CYP3A7 Entrez, Source | cytochrome P450, family 3, subfamily A, polypeptide 7 | 11245 | -0.232 | 0.1202 | No |
| 43 | UGT2A3 | NA | UGT2A3 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide A3 | 11814 | -0.314 | 0.0929 | No |
| 44 | MGST2 | NA | MGST2 Entrez, Source | microsomal glutathione S-transferase 2 | 12590 | -0.414 | 0.0554 | No |
| 45 | UGT2B11 | NA | UGT2B11 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide B11 | 12780 | -0.445 | 0.0510 | No |
| 46 | UGT2A1 | NA | UGT2A1 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide A1 | 12964 | -0.451 | 0.0471 | No |
| 47 | UGT1A9 | NA | UGT1A9 Entrez, Source | UDP glucuronosyltransferase 1 family, polypeptide A9 | 12966 | -0.451 | 0.0533 | No |
| 48 | GSTA2 | NA | GSTA2 Entrez, Source | glutathione S-transferase A2 | 13089 | -0.470 | 0.0530 | No |
| 49 | CYP2C18 | NA | CYP2C18 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 18 | 13300 | -0.503 | 0.0483 | No |
| 50 | GSTM5 | NA | GSTM5 Entrez, Source | glutathione S-transferase M5 | 13633 | -0.565 | 0.0376 | No |
| 51 | AKR1C4 | NA | AKR1C4 Entrez, Source | aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) | 15071 | -0.886 | -0.0303 | No |
| 52 | GSTA5 | NA | GSTA5 Entrez, Source | glutathione S-transferase A5 | 15116 | -0.895 | -0.0203 | No |
| 53 | GSTM1 | NA | GSTM1 Entrez, Source | glutathione S-transferase M1 | 15434 | -0.977 | -0.0244 | No |
| 54 | GSTO1 | NA | GSTO1 Entrez, Source | glutathione S-transferase omega 1 | 15522 | -1.003 | -0.0153 | No |
| 55 | GSTP1 | NA | GSTP1 Entrez, Source | glutathione S-transferase pi | 16021 | -1.182 | -0.0267 | No |
| 56 | CYP2C8 | NA | CYP2C8 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 8 | 16034 | -1.190 | -0.0108 | No |
| 57 | GSTM4 | NA | GSTM4 Entrez, Source | glutathione S-transferase M4 | 17120 | -1.897 | -0.0450 | No |
| 58 | CYP3A5 | NA | CYP3A5 Entrez, Source | cytochrome P450, family 3, subfamily A, polypeptide 5 | 17254 | -2.091 | -0.0233 | No |
| 59 | GSTO2 | NA | GSTO2 Entrez, Source | glutathione S-transferase omega 2 | 17274 | -2.118 | 0.0051 | No |
| 60 | ALDH1A3 | NA | ALDH1A3 Entrez, Source | aldehyde dehydrogenase 1 family, member A3 | 17470 | -2.441 | 0.0281 | No |
