Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_MELANOMA |
| Enrichment Score (ES) | -0.32210228 |
| Normalized Enrichment Score (NES) | -1.2094818 |
| Nominal p-value | 0.12738854 |
| FDR q-value | 0.45962104 |
| FWER p-Value | 1.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | EGF | NA | EGF Entrez, Source | epidermal growth factor (beta-urogastrone) | 664 | 2.799 | 0.0028 | No |
| 2 | FGFR1 | NA | FGFR1 Entrez, Source | fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) | 688 | 2.742 | 0.0406 | No |
| 3 | PIK3CA | NA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 693 | 2.734 | 0.0794 | No |
| 4 | MITF | NA | MITF Entrez, Source | microphthalmia-associated transcription factor | 842 | 2.485 | 0.1066 | No |
| 5 | MET | NA | MET Entrez, Source | met proto-oncogene (hepatocyte growth factor receptor) | 871 | 2.445 | 0.1398 | No |
| 6 | CDKN1A | NA | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 888 | 2.413 | 0.1733 | No |
| 7 | FGF14 | NA | FGF14 Entrez, Source | fibroblast growth factor 14 | 956 | 2.335 | 0.2029 | No |
| 8 | PIK3R1 | NA | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 1994 | 1.422 | 0.1652 | No |
| 9 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 2109 | 1.354 | 0.1782 | No |
| 10 | MDM2 | NA | MDM2 Entrez, Source | Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) | 2914 | 1.022 | 0.1479 | No |
| 11 | EGFR | NA | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 4260 | 0.710 | 0.0829 | No |
| 12 | PIK3CB | NA | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 4450 | 0.668 | 0.0818 | No |
| 13 | E2F3 | NA | E2F3 Entrez, Source | E2F transcription factor 3 | 4563 | 0.644 | 0.0848 | No |
| 14 | CDH1 | NA | CDH1 Entrez, Source | cadherin 1, type 1, E-cadherin (epithelial) | 4645 | 0.630 | 0.0892 | No |
| 15 | PDGFRB | NA | PDGFRB Entrez, Source | platelet-derived growth factor receptor, beta polypeptide | 4739 | 0.609 | 0.0927 | No |
| 16 | FGF1 | NA | FGF1 Entrez, Source | fibroblast growth factor 1 (acidic) | 4850 | 0.584 | 0.0949 | No |
| 17 | CCND1 | NA | CCND1 Entrez, Source | cyclin D1 | 4946 | 0.569 | 0.0977 | No |
| 18 | ARAF | NA | ARAF Entrez, Source | v-raf murine sarcoma 3611 viral oncogene homolog | 5103 | 0.534 | 0.0966 | No |
| 19 | PDGFD | NA | PDGFD Entrez, Source | platelet derived growth factor D | 5112 | 0.533 | 0.1038 | No |
| 20 | MAP2K2 | NA | MAP2K2 Entrez, Source | mitogen-activated protein kinase kinase 2 | 5201 | 0.518 | 0.1062 | No |
| 21 | FGF8 | NA | FGF8 Entrez, Source | fibroblast growth factor 8 (androgen-induced) | 5613 | 0.459 | 0.0898 | No |
| 22 | FGF6 | NA | FGF6 Entrez, Source | fibroblast growth factor 6 | 6045 | 0.418 | 0.0717 | No |
| 23 | FGF9 | NA | FGF9 Entrez, Source | fibroblast growth factor 9 (glia-activating factor) | 6301 | 0.398 | 0.0632 | No |
| 24 | FGF18 | NA | FGF18 Entrez, Source | fibroblast growth factor 18 | 6363 | 0.387 | 0.0653 | No |
| 25 | FGF2 | NA | FGF2 Entrez, Source | fibroblast growth factor 2 (basic) | 6401 | 0.381 | 0.0686 | No |
| 26 | BAD | NA | BAD Entrez, Source | BCL2-antagonist of cell death | 6874 | 0.310 | 0.0467 | No |
| 27 | FGF20 | NA | FGF20 Entrez, Source | fibroblast growth factor 20 | 6968 | 0.295 | 0.0457 | No |
| 28 | HRAS | NA | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 8120 | 0.131 | -0.0167 | No |
| 29 | AKT2 | NA | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 8193 | 0.120 | -0.0190 | No |
| 30 | PTEN | NA | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 8711 | 0.051 | -0.0472 | No |
| 31 | FGF21 | NA | FGF21 Entrez, Source | fibroblast growth factor 21 | 9297 | 0.000 | -0.0798 | No |
| 32 | FGF16 | NA | FGF16 Entrez, Source | fibroblast growth factor 16 | 9298 | 0.000 | -0.0798 | No |
| 33 | CDKN2A | NA | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 9300 | 0.000 | -0.0799 | No |
| 34 | FGF4 | NA | FGF4 Entrez, Source | fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene) | 9353 | 0.000 | -0.0828 | No |
| 35 | KRAS | NA | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 9550 | -0.022 | -0.0934 | No |
| 36 | IGF1 | NA | IGF1 Entrez, Source | insulin-like growth factor 1 (somatomedin C) | 9670 | -0.039 | -0.0995 | No |
| 37 | FGF17 | NA | FGF17 Entrez, Source | fibroblast growth factor 17 | 10008 | -0.070 | -0.1173 | No |
| 38 | FGF5 | NA | FGF5 Entrez, Source | fibroblast growth factor 5 | 10772 | -0.164 | -0.1576 | No |
| 39 | FGF19 | NA | FGF19 Entrez, Source | fibroblast growth factor 19 | 10829 | -0.174 | -0.1583 | No |
| 40 | PIK3R5 | NA | PIK3R5 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 5, p101 | 11218 | -0.228 | -0.1767 | No |
| 41 | PDGFRA | NA | PDGFRA Entrez, Source | platelet-derived growth factor receptor, alpha polypeptide | 11364 | -0.248 | -0.1812 | No |
| 42 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 11524 | -0.274 | -0.1862 | No |
| 43 | BRAF | NA | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 11539 | -0.277 | -0.1830 | No |
| 44 | CDK6 | NA | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 11618 | -0.286 | -0.1833 | No |
| 45 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 11952 | -0.332 | -0.1972 | No |
| 46 | FGF10 | NA | FGF10 Entrez, Source | fibroblast growth factor 10 | 12515 | -0.411 | -0.2227 | No |
| 47 | RAF1 | NA | RAF1 Entrez, Source | v-raf-1 murine leukemia viral oncogene homolog 1 | 12700 | -0.434 | -0.2268 | No |
| 48 | FGF12 | NA | FGF12 Entrez, Source | fibroblast growth factor 12 | 13191 | -0.487 | -0.2472 | No |
| 49 | E2F2 | NA | E2F2 Entrez, Source | E2F transcription factor 2 | 13257 | -0.498 | -0.2437 | No |
| 50 | E2F1 | NA | E2F1 Entrez, Source | E2F transcription factor 1 | 13748 | -0.585 | -0.2628 | No |
| 51 | AKT1 | NA | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 13847 | -0.604 | -0.2596 | No |
| 52 | NRAS | NA | NRAS Entrez, Source | neuroblastoma RAS viral (v-ras) oncogene homolog | 13927 | -0.620 | -0.2552 | No |
| 53 | CDK4 | NA | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 13941 | -0.622 | -0.2470 | No |
| 54 | AKT3 | NA | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 14156 | -0.671 | -0.2494 | No |
| 55 | FGF7 | NA | FGF7 Entrez, Source | fibroblast growth factor 7 (keratinocyte growth factor) | 14818 | -0.831 | -0.2745 | No |
| 56 | PIK3R2 | NA | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 14983 | -0.863 | -0.2714 | No |
| 57 | HGF | NA | HGF Entrez, Source | hepatocyte growth factor (hepapoietin A; scatter factor) | 15015 | -0.871 | -0.2607 | No |
| 58 | PDGFC | NA | PDGFC Entrez, Source | platelet derived growth factor C | 16116 | -1.222 | -0.3047 | Yes |
| 59 | RB1 | NA | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 16178 | -1.250 | -0.2903 | Yes |
| 60 | MAPK3 | NA | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 16746 | -1.562 | -0.2997 | Yes |
| 61 | IGF1R | NA | IGF1R Entrez, Source | insulin-like growth factor 1 receptor | 16802 | -1.603 | -0.2799 | Yes |
| 62 | MAP2K1 | NA | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 16861 | -1.650 | -0.2596 | Yes |
| 63 | TP53 | NA | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 17294 | -2.152 | -0.2530 | Yes |
| 64 | PDGFA | NA | PDGFA Entrez, Source | platelet-derived growth factor alpha polypeptide | 17541 | -2.598 | -0.2297 | Yes |
| 65 | FGF23 | NA | FGF23 Entrez, Source | fibroblast growth factor 23 | 17551 | -2.601 | -0.1932 | Yes |
| 66 | FGF11 | NA | FGF11 Entrez, Source | fibroblast growth factor 11 | 17677 | -3.020 | -0.1571 | Yes |
| 67 | PDGFB | NA | PDGFB Entrez, Source | platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) | 17712 | -3.137 | -0.1143 | Yes |
| 68 | PIK3CG | NA | PIK3CG Entrez, Source | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 17882 | -4.130 | -0.0648 | Yes |
| 69 | FGF13 | NA | FGF13 Entrez, Source | fibroblast growth factor 13 | 17958 | -4.904 | 0.0009 | Yes |
