Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_LEISHMANIA_INFECTION |
| Enrichment Score (ES) | 0.5409899 |
| Normalized Enrichment Score (NES) | 1.8549318 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0029778774 |
| FWER p-Value | 0.027 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | HLA-DRB1 | NA | HLA-DRB1 Entrez, Source | major histocompatibility complex, class II, DR beta 1 | 8 | 4.960 | 0.0478 | Yes |
| 2 | HLA-DRA | NA | HLA-DRA Entrez, Source | major histocompatibility complex, class II, DR alpha | 27 | 4.871 | 0.0941 | Yes |
| 3 | TLR2 | NA | TLR2 Entrez, Source | toll-like receptor 2 | 71 | 4.610 | 0.1365 | Yes |
| 4 | HLA-DPA1 | NA | HLA-DPA1 Entrez, Source | major histocompatibility complex, class II, DP alpha 1 | 107 | 4.489 | 0.1782 | Yes |
| 5 | HLA-DRB5 | NA | HLA-DRB5 Entrez, Source | major histocompatibility complex, class II, DR beta 5 | 137 | 4.339 | 0.2187 | Yes |
| 6 | HLA-DMB | NA | HLA-DMB Entrez, Source | major histocompatibility complex, class II, DM beta | 164 | 4.259 | 0.2587 | Yes |
| 7 | HLA-DRB3 | NA | HLA-DRB3 Entrez, Source | major histocompatibility complex, class II, DR beta 3 | 226 | 4.018 | 0.2943 | Yes |
| 8 | HLA-DRB4 | NA | HLA-DRB4 Entrez, Source | major histocompatibility complex, class II, DR beta 4 | 242 | 3.963 | 0.3320 | Yes |
| 9 | HLA-DMA | NA | HLA-DMA Entrez, Source | major histocompatibility complex, class II, DM alpha | 294 | 3.747 | 0.3656 | Yes |
| 10 | PTPN6 | NA | PTPN6 Entrez, Source | protein tyrosine phosphatase, non-receptor type 6 | 407 | 3.417 | 0.3925 | Yes |
| 11 | HLA-DQB1 | NA | HLA-DQB1 Entrez, Source | major histocompatibility complex, class II, DQ beta 1 | 438 | 3.353 | 0.4235 | Yes |
| 12 | NCF2 | NA | NCF2 Entrez, Source | neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2) | 651 | 2.846 | 0.4393 | Yes |
| 13 | FCGR3B | NA | FCGR3B Entrez, Source | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | 901 | 2.407 | 0.4488 | Yes |
| 14 | MARCKSL1 | NA | MARCKSL1 Entrez, Source | MARCKS-like 1 | 981 | 2.310 | 0.4668 | Yes |
| 15 | PTGS2 | NA | PTGS2 Entrez, Source | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 1085 | 2.190 | 0.4823 | Yes |
| 16 | HLA-DPB1 | NA | HLA-DPB1 Entrez, Source | major histocompatibility complex, class II, DP beta 1 | 1127 | 2.142 | 0.5009 | Yes |
| 17 | TGFB3 | NA | TGFB3 Entrez, Source | transforming growth factor, beta 3 | 1345 | 1.887 | 0.5071 | Yes |
| 18 | IL12A | NA | IL12A Entrez, Source | interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) | 1403 | 1.842 | 0.5218 | Yes |
| 19 | HLA-DOB | NA | HLA-DOB Entrez, Source | major histocompatibility complex, class II, DO beta | 1460 | 1.797 | 0.5362 | Yes |
| 20 | HLA-DOA | NA | HLA-DOA Entrez, Source | major histocompatibility complex, class II, DO alpha | 1660 | 1.640 | 0.5410 | Yes |
| 21 | CR1 | NA | CR1 Entrez, Source | complement component (3b/4b) receptor 1 (Knops blood group) | 2414 | 1.210 | 0.5107 | No |
| 22 | TGFB2 | NA | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 3389 | 0.883 | 0.4649 | No |
| 23 | STAT1 | NA | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 3769 | 0.817 | 0.4517 | No |
| 24 | FCGR2A | NA | FCGR2A Entrez, Source | Fc fragment of IgG, low affinity IIa, receptor (CD32) | 3899 | 0.785 | 0.4521 | No |
| 25 | FCGR3A | NA | FCGR3A Entrez, Source | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) | 4045 | 0.751 | 0.4513 | No |
| 26 | JAK2 | NA | JAK2 Entrez, Source | Janus kinase 2 (a protein tyrosine kinase) | 4325 | 0.696 | 0.4425 | No |
| 27 | NFKBIA | NA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 4475 | 0.662 | 0.4406 | No |
| 28 | MAPK14 | NA | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 4664 | 0.626 | 0.4362 | No |
| 29 | IL4 | NA | IL4 Entrez, Source | interleukin 4 | 5828 | 0.428 | 0.3754 | No |
| 30 | ELK1 | NA | ELK1 Entrez, Source | ELK1, member of ETS oncogene family | 5949 | 0.421 | 0.3728 | No |
| 31 | HLA-DQA1 | NA | HLA-DQA1 Entrez, Source | major histocompatibility complex, class II, DQ alpha 1 | 6116 | 0.415 | 0.3675 | No |
| 32 | IRAK1 | NA | IRAK1 Entrez, Source | interleukin-1 receptor-associated kinase 1 | 6339 | 0.392 | 0.3589 | No |
| 33 | IFNGR1 | NA | IFNGR1 Entrez, Source | interferon gamma receptor 1 | 6371 | 0.386 | 0.3609 | No |
| 34 | IRAK4 | NA | IRAK4 Entrez, Source | interleukin-1 receptor-associated kinase 4 | 6921 | 0.302 | 0.3332 | No |
| 35 | NCF1 | NA | NCF1 Entrez, Source | neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1) | 6959 | 0.296 | 0.3340 | No |
| 36 | PRKCB | NA | 7147 | 0.267 | 0.3262 | No | ||
| 37 | JUN | NA | JUN Entrez, Source | jun oncogene | 7197 | 0.258 | 0.3259 | No |
| 38 | FOS | NA | FOS Entrez, Source | v-fos FBJ murine osteosarcoma viral oncogene homolog | 7265 | 0.247 | 0.3246 | No |
| 39 | ITGA4 | NA | ITGA4 Entrez, Source | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | 7633 | 0.196 | 0.3060 | No |
| 40 | TGFB1 | NA | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 8450 | 0.087 | 0.2613 | No |
| 41 | IL10 | NA | IL10 Entrez, Source | interleukin 10 | 8629 | 0.062 | 0.2519 | No |
| 42 | RELA | NA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 9422 | -0.003 | 0.2077 | No |
| 43 | IFNGR2 | NA | IFNGR2 Entrez, Source | interferon gamma receptor 2 (interferon gamma transducer 1) | 9453 | -0.007 | 0.2061 | No |
| 44 | ITGB1 | NA | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 9602 | -0.030 | 0.1982 | No |
| 45 | FCGR1A | NA | FCGR1A Entrez, Source | Fc fragment of IgG, high affinity Ia, receptor (CD64) | 9795 | -0.051 | 0.1879 | No |
| 46 | TNF | NA | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 9956 | -0.066 | 0.1796 | No |
| 47 | TAB2 | NA | 10260 | -0.093 | 0.1636 | No | ||
| 48 | NCF4 | NA | NCF4 Entrez, Source | neutrophil cytosolic factor 4, 40kDa | 10312 | -0.097 | 0.1617 | No |
| 49 | TAB1 | NA | 10961 | -0.192 | 0.1274 | No | ||
| 50 | IL12B | NA | IL12B Entrez, Source | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 11133 | -0.216 | 0.1199 | No |
| 51 | HLA-DQA2 | NA | HLA-DQA2 Entrez, Source | major histocompatibility complex, class II, DQ alpha 2 | 11354 | -0.247 | 0.1101 | No |
| 52 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 11524 | -0.274 | 0.1033 | No |
| 53 | MAPK13 | NA | MAPK13 Entrez, Source | mitogen-activated protein kinase 13 | 11527 | -0.275 | 0.1058 | No |
| 54 | IFNG | NA | IFNG Entrez, Source | interferon, gamma | 12804 | -0.445 | 0.0389 | No |
| 55 | MYD88 | NA | MYD88 Entrez, Source | myeloid differentiation primary response gene (88) | 13793 | -0.593 | -0.0105 | No |
| 56 | MAP3K7 | NA | MAP3K7 Entrez, Source | mitogen-activated protein kinase kinase kinase 7 | 13854 | -0.605 | -0.0080 | No |
| 57 | NOS2 | NA | 13878 | -0.610 | -0.0033 | No | ||
| 58 | TLR4 | NA | TLR4 Entrez, Source | toll-like receptor 4 | 14463 | -0.745 | -0.0287 | No |
| 59 | NFKB1 | NA | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 14554 | -0.768 | -0.0263 | No |
| 60 | ITGB2 | NA | ITGB2 Entrez, Source | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 14916 | -0.848 | -0.0382 | No |
| 61 | TRAF6 | NA | TRAF6 Entrez, Source | TNF receptor-associated factor 6 | 15267 | -0.932 | -0.0487 | No |
| 62 | JAK1 | NA | JAK1 Entrez, Source | Janus kinase 1 (a protein tyrosine kinase) | 15684 | -1.057 | -0.0616 | No |
| 63 | MAPK3 | NA | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 16746 | -1.562 | -0.1057 | No |
| 64 | MAPK12 | NA | MAPK12 Entrez, Source | mitogen-activated protein kinase 12 | 16881 | -1.669 | -0.0970 | No |
| 65 | ITGAM | NA | ITGAM Entrez, Source | integrin, alpha M (complement component 3 receptor 3 subunit) | 17198 | -2.003 | -0.0952 | No |
| 66 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 17373 | -2.282 | -0.0827 | No |
| 67 | MAPK11 | NA | MAPK11 Entrez, Source | mitogen-activated protein kinase 11 | 17451 | -2.412 | -0.0635 | No |
| 68 | CYBA | NA | CYBA Entrez, Source | cytochrome b-245, alpha polypeptide | 17624 | -2.790 | -0.0460 | No |
| 69 | C3 | NA | C3 Entrez, Source | complement component 3 | 17698 | -3.089 | -0.0201 | No |
| 70 | IL1A | NA | IL1A Entrez, Source | interleukin 1, alpha | 17815 | -3.646 | 0.0089 | No |
