Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION |
| Enrichment Score (ES) | 0.6961352 |
| Normalized Enrichment Score (NES) | 2.2016141 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | HLA-DRB1 | NA | HLA-DRB1 Entrez, Source | major histocompatibility complex, class II, DR beta 1 | 8 | 4.960 | 0.0630 | Yes |
| 2 | HLA-DRA | NA | HLA-DRA Entrez, Source | major histocompatibility complex, class II, DR alpha | 27 | 4.871 | 0.1243 | Yes |
| 3 | ICOSLG | NA | ICOSLG Entrez, Source | inducible T-cell co-stimulator ligand | 88 | 4.556 | 0.1792 | Yes |
| 4 | CXCR4 | NA | CXCR4 Entrez, Source | chemokine (C-X-C motif) receptor 4 | 90 | 4.546 | 0.2373 | Yes |
| 5 | HLA-DPA1 | NA | HLA-DPA1 Entrez, Source | major histocompatibility complex, class II, DP alpha 1 | 107 | 4.489 | 0.2938 | Yes |
| 6 | HLA-DRB5 | NA | HLA-DRB5 Entrez, Source | major histocompatibility complex, class II, DR beta 5 | 137 | 4.339 | 0.3477 | Yes |
| 7 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 148 | 4.301 | 0.4022 | Yes |
| 8 | HLA-DMB | NA | HLA-DMB Entrez, Source | major histocompatibility complex, class II, DM beta | 164 | 4.259 | 0.4558 | Yes |
| 9 | HLA-DRB3 | NA | HLA-DRB3 Entrez, Source | major histocompatibility complex, class II, DR beta 3 | 226 | 4.018 | 0.5038 | Yes |
| 10 | HLA-DRB4 | NA | HLA-DRB4 Entrez, Source | major histocompatibility complex, class II, DR beta 4 | 242 | 3.963 | 0.5537 | Yes |
| 11 | HLA-DMA | NA | HLA-DMA Entrez, Source | major histocompatibility complex, class II, DM alpha | 294 | 3.747 | 0.5988 | Yes |
| 12 | HLA-DQB1 | NA | HLA-DQB1 Entrez, Source | major histocompatibility complex, class II, DQ beta 1 | 438 | 3.353 | 0.6337 | Yes |
| 13 | CCL28 | NA | CCL28 Entrez, Source | chemokine (C-C motif) ligand 28 | 782 | 2.574 | 0.6475 | Yes |
| 14 | HLA-DPB1 | NA | HLA-DPB1 Entrez, Source | major histocompatibility complex, class II, DP beta 1 | 1127 | 2.142 | 0.6557 | Yes |
| 15 | TNFSF13B | NA | TNFSF13B Entrez, Source | tumor necrosis factor (ligand) superfamily, member 13b | 1203 | 2.037 | 0.6775 | Yes |
| 16 | HLA-DOB | NA | HLA-DOB Entrez, Source | major histocompatibility complex, class II, DO beta | 1460 | 1.797 | 0.6863 | Yes |
| 17 | HLA-DOA | NA | HLA-DOA Entrez, Source | major histocompatibility complex, class II, DO alpha | 1660 | 1.640 | 0.6961 | Yes |
| 18 | MAP3K14 | NA | MAP3K14 Entrez, Source | mitogen-activated protein kinase kinase kinase 14 | 2127 | 1.344 | 0.6873 | No |
| 19 | LTBR | NA | LTBR Entrez, Source | lymphotoxin beta receptor (TNFR superfamily, member 3) | 3145 | 0.950 | 0.6428 | No |
| 20 | TNFRSF17 | NA | TNFRSF17 Entrez, Source | tumor necrosis factor receptor superfamily, member 17 | 3383 | 0.885 | 0.6409 | No |
| 21 | IL15RA | NA | IL15RA Entrez, Source | interleukin 15 receptor, alpha | 3917 | 0.782 | 0.6211 | No |
| 22 | PIGR | NA | PIGR Entrez, Source | polymeric immunoglobulin receptor | 3956 | 0.771 | 0.6289 | No |
| 23 | CXCL12 | NA | CXCL12 Entrez, Source | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | 5453 | 0.483 | 0.5516 | No |
| 24 | IL4 | NA | IL4 Entrez, Source | interleukin 4 | 5828 | 0.428 | 0.5362 | No |
| 25 | HLA-DQA1 | NA | HLA-DQA1 Entrez, Source | major histocompatibility complex, class II, DQ alpha 1 | 6116 | 0.415 | 0.5255 | No |
| 26 | TNFRSF13B | NA | TNFRSF13B Entrez, Source | tumor necrosis factor receptor superfamily, member 13B | 6813 | 0.320 | 0.4908 | No |
| 27 | ITGA4 | NA | ITGA4 Entrez, Source | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | 7633 | 0.196 | 0.4476 | No |
| 28 | TNFSF13 | NA | TNFSF13 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 13 | 7762 | 0.176 | 0.4427 | No |
| 29 | CCR9 | NA | CCR9 Entrez, Source | chemokine (C-C motif) receptor 9 | 7820 | 0.169 | 0.4417 | No |
| 30 | TGFB1 | NA | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 8450 | 0.087 | 0.4077 | No |
| 31 | IL10 | NA | IL10 Entrez, Source | interleukin 10 | 8629 | 0.062 | 0.3986 | No |
| 32 | IL2 | NA | IL2 Entrez, Source | interleukin 2 | 9229 | 0.000 | 0.3652 | No |
| 33 | ICOS | NA | ICOS Entrez, Source | inducible T-cell co-stimulator | 9264 | 0.000 | 0.3633 | No |
| 34 | ITGB7 | NA | ITGB7 Entrez, Source | integrin, beta 7 | 9842 | -0.057 | 0.3318 | No |
| 35 | CD80 | NA | CD80 Entrez, Source | CD80 molecule | 10403 | -0.111 | 0.3020 | No |
| 36 | CD86 | NA | CD86 Entrez, Source | CD86 molecule | 10856 | -0.177 | 0.2790 | No |
| 37 | MADCAM1 | NA | MADCAM1 Entrez, Source | mucosal vascular addressin cell adhesion molecule 1 | 11084 | -0.209 | 0.2691 | No |
| 38 | HLA-DQA2 | NA | HLA-DQA2 Entrez, Source | major histocompatibility complex, class II, DQ alpha 2 | 11354 | -0.247 | 0.2572 | No |
| 39 | AICDA | NA | AICDA Entrez, Source | activation-induced cytidine deaminase | 11367 | -0.248 | 0.2597 | No |
| 40 | CCL25 | NA | CCL25 Entrez, Source | chemokine (C-C motif) ligand 25 | 11922 | -0.329 | 0.2330 | No |
| 41 | CD40LG | NA | CD40LG Entrez, Source | CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome) | 12489 | -0.411 | 0.2067 | No |
| 42 | IL15 | NA | IL15 Entrez, Source | interleukin 15 | 12600 | -0.416 | 0.2059 | No |
| 43 | CCL27 | NA | CCL27 Entrez, Source | chemokine (C-C motif) ligand 27 | 12928 | -0.451 | 0.1934 | No |
| 44 | CCR10 | NA | CCR10 Entrez, Source | chemokine (C-C motif) receptor 10 | 15968 | -1.159 | 0.0387 | No |
| 45 | TNFRSF13C | NA | TNFRSF13C Entrez, Source | tumor necrosis factor receptor superfamily, member 13C | 16633 | -1.489 | 0.0208 | No |
| 46 | CD28 | NA | CD28 Entrez, Source | CD28 molecule | 17036 | -1.802 | 0.0214 | No |
| 47 | CD40 | NA | CD40 Entrez, Source | CD40 molecule, TNF receptor superfamily member 5 | 17453 | -2.414 | 0.0291 | No |
