Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_HOMOLOGOUS_RECOMBINATION |
| Enrichment Score (ES) | -0.43965328 |
| Normalized Enrichment Score (NES) | -1.3274361 |
| Nominal p-value | 0.10928962 |
| FDR q-value | 0.324366 |
| FWER p-Value | 0.992 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | XRCC2 | NA | XRCC2 Entrez, Source | X-ray repair complementing defective repair in Chinese hamster cells 2 | 2267 | 1.272 | -0.0540 | No |
| 2 | XRCC3 | NA | XRCC3 Entrez, Source | X-ray repair complementing defective repair in Chinese hamster cells 3 | 3208 | 0.938 | -0.0531 | No |
| 3 | RPA4 | NA | RPA4 Entrez, Source | replication protein A4, 34kDa | 4013 | 0.759 | -0.0547 | No |
| 4 | EME1 | NA | EME1 Entrez, Source | essential meiotic endonuclease 1 homolog 1 (S. pombe) | 5541 | 0.470 | -0.1131 | No |
| 5 | RAD54L | NA | RAD54L Entrez, Source | RAD54-like (S. cerevisiae) | 6482 | 0.370 | -0.1444 | No |
| 6 | MUS81 | NA | MUS81 Entrez, Source | MUS81 endonuclease homolog (S. cerevisiae) | 6904 | 0.306 | -0.1505 | No |
| 7 | RAD50 | NA | RAD50 Entrez, Source | RAD50 homolog (S. cerevisiae) | 7667 | 0.190 | -0.1822 | No |
| 8 | RAD51D | NA | 8189 | 0.121 | -0.2043 | No | ||
| 9 | RPA2 | NA | RPA2 Entrez, Source | replication protein A2, 32kDa | 10881 | -0.181 | -0.3440 | No |
| 10 | RPA1 | NA | RPA1 Entrez, Source | replication protein A1, 70kDa | 11194 | -0.226 | -0.3485 | No |
| 11 | TOP3B | NA | TOP3B Entrez, Source | topoisomerase (DNA) III beta | 11234 | -0.231 | -0.3376 | No |
| 12 | RAD51C | NA | RAD51C Entrez, Source | RAD51 homolog C (S. cerevisiae) | 11241 | -0.232 | -0.3248 | No |
| 13 | TOP3A | NA | TOP3A Entrez, Source | topoisomerase (DNA) III alpha | 12331 | -0.388 | -0.3634 | No |
| 14 | RAD52 | NA | RAD52 Entrez, Source | RAD52 homolog (S. cerevisiae) | 13701 | -0.576 | -0.4069 | Yes |
| 15 | SSBP1 | NA | SSBP1 Entrez, Source | single-stranded DNA binding protein 1 | 13780 | -0.591 | -0.3777 | Yes |
| 16 | RAD51 | NA | RAD51 Entrez, Source | RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) | 13792 | -0.593 | -0.3446 | Yes |
| 17 | POLD1 | NA | POLD1 Entrez, Source | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 13802 | -0.595 | -0.3113 | Yes |
| 18 | POLD4 | NA | POLD4 Entrez, Source | polymerase (DNA-directed), delta 4 | 13855 | -0.605 | -0.2798 | Yes |
| 19 | RAD51B | NA | 14238 | -0.689 | -0.2619 | Yes | ||
| 20 | RPA3 | NA | RPA3 Entrez, Source | replication protein A3, 14kDa | 14239 | -0.689 | -0.2228 | Yes |
| 21 | POLD3 | NA | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 14617 | -0.783 | -0.1993 | Yes |
| 22 | POLD2 | NA | POLD2 Entrez, Source | polymerase (DNA directed), delta 2, regulatory subunit 50kDa | 15203 | -0.914 | -0.1799 | Yes |
| 23 | NBN | NA | NBN Entrez, Source | nibrin | 15782 | -1.087 | -0.1503 | Yes |
| 24 | BLM | NA | BLM Entrez, Source | Bloom syndrome | 17305 | -2.178 | -0.1113 | Yes |
| 25 | BRCA2 | NA | BRCA2 Entrez, Source | breast cancer 2, early onset | 17561 | -2.614 | 0.0230 | Yes |
