Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_HEMATOPOIETIC_CELL_LINEAGE |
| Enrichment Score (ES) | 0.48550072 |
| Normalized Enrichment Score (NES) | 1.6992719 |
| Nominal p-value | 0.0014858841 |
| FDR q-value | 0.02137375 |
| FWER p-Value | 0.264 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | HLA-DRB1 | NA | HLA-DRB1 Entrez, Source | major histocompatibility complex, class II, DR beta 1 | 8 | 4.960 | 0.0419 | Yes |
| 2 | HLA-DRA | NA | HLA-DRA Entrez, Source | major histocompatibility complex, class II, DR alpha | 27 | 4.871 | 0.0825 | Yes |
| 3 | CSF1 | NA | CSF1 Entrez, Source | colony stimulating factor 1 (macrophage) | 109 | 4.487 | 0.1163 | Yes |
| 4 | IL1R1 | NA | IL1R1 Entrez, Source | interleukin 1 receptor, type I | 124 | 4.410 | 0.1532 | Yes |
| 5 | CSF2RA | NA | CSF2RA Entrez, Source | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | 133 | 4.359 | 0.1899 | Yes |
| 6 | HLA-DRB5 | NA | HLA-DRB5 Entrez, Source | major histocompatibility complex, class II, DR beta 5 | 137 | 4.339 | 0.2268 | Yes |
| 7 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 148 | 4.301 | 0.2630 | Yes |
| 8 | HLA-DRB3 | NA | HLA-DRB3 Entrez, Source | major histocompatibility complex, class II, DR beta 3 | 226 | 4.018 | 0.2930 | Yes |
| 9 | HLA-DRB4 | NA | HLA-DRB4 Entrez, Source | major histocompatibility complex, class II, DR beta 4 | 242 | 3.963 | 0.3260 | Yes |
| 10 | CD55 | NA | CD55 Entrez, Source | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 431 | 3.362 | 0.3442 | Yes |
| 11 | ITGA2 | NA | ITGA2 Entrez, Source | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 483 | 3.253 | 0.3691 | Yes |
| 12 | CR2 | NA | CR2 Entrez, Source | complement component (3d/Epstein Barr virus) receptor 2 | 510 | 3.161 | 0.3947 | Yes |
| 13 | CD38 | NA | CD38 Entrez, Source | CD38 molecule | 533 | 3.109 | 0.4200 | Yes |
| 14 | CD14 | NA | CD14 Entrez, Source | CD14 molecule | 571 | 2.998 | 0.4435 | Yes |
| 15 | ITGA3 | NA | ITGA3 Entrez, Source | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 978 | 2.317 | 0.4406 | Yes |
| 16 | KITLG | NA | KITLG Entrez, Source | KIT ligand | 1071 | 2.198 | 0.4542 | Yes |
| 17 | CD22 | NA | CD22 Entrez, Source | CD22 molecule | 1074 | 2.196 | 0.4729 | Yes |
| 18 | IL1R2 | NA | IL1R2 Entrez, Source | interleukin 1 receptor, type II | 1207 | 2.032 | 0.4828 | Yes |
| 19 | CD9 | NA | CD9 Entrez, Source | CD9 molecule | 1847 | 1.500 | 0.4599 | Yes |
| 20 | IL7R | NA | IL7R Entrez, Source | interleukin 7 receptor | 1939 | 1.452 | 0.4673 | Yes |
| 21 | CD34 | NA | CD34 Entrez, Source | CD34 molecule | 2241 | 1.284 | 0.4614 | Yes |
| 22 | ITGA5 | NA | ITGA5 Entrez, Source | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 2293 | 1.258 | 0.4693 | Yes |
| 23 | CR1 | NA | CR1 Entrez, Source | complement component (3b/4b) receptor 1 (Knops blood group) | 2414 | 1.210 | 0.4729 | Yes |
| 24 | CD3E | NA | CD3E Entrez, Source | CD3e molecule, epsilon (CD3-TCR complex) | 2451 | 1.194 | 0.4811 | Yes |
| 25 | ITGA2B | NA | ITGA2B Entrez, Source | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | 2705 | 1.096 | 0.4763 | Yes |
| 26 | CSF2 | NA | CSF2 Entrez, Source | colony stimulating factor 2 (granulocyte-macrophage) | 2709 | 1.095 | 0.4855 | Yes |
| 27 | IL7 | NA | IL7 Entrez, Source | interleukin 7 | 3059 | 0.973 | 0.4743 | No |
| 28 | ITGA1 | NA | ITGA1 Entrez, Source | integrin, alpha 1 | 3645 | 0.836 | 0.4487 | No |
| 29 | CD3G | NA | CD3G Entrez, Source | CD3g molecule, gamma (CD3-TCR complex) | 4391 | 0.680 | 0.4129 | No |
| 30 | CD37 | NA | CD37 Entrez, Source | CD37 molecule | 4466 | 0.664 | 0.4145 | No |
| 31 | CD1D | NA | CD1D Entrez, Source | CD1d molecule | 4484 | 0.659 | 0.4191 | No |
| 32 | CSF1R | NA | CSF1R Entrez, Source | colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog | 4500 | 0.657 | 0.4239 | No |
| 33 | ITGA6 | NA | ITGA6 Entrez, Source | integrin, alpha 6 | 4506 | 0.656 | 0.4292 | No |
| 34 | IL3RA | NA | IL3RA Entrez, Source | interleukin 3 receptor, alpha (low affinity) | 4543 | 0.647 | 0.4327 | No |
| 35 | CD5 | NA | CD5 Entrez, Source | CD5 molecule | 5226 | 0.512 | 0.3990 | No |
| 36 | TFRC | NA | TFRC Entrez, Source | transferrin receptor (p90, CD71) | 5482 | 0.481 | 0.3889 | No |
| 37 | GP1BA | NA | GP1BA Entrez, Source | glycoprotein Ib (platelet), alpha polypeptide | 5717 | 0.441 | 0.3795 | No |
| 38 | IL4 | NA | IL4 Entrez, Source | interleukin 4 | 5828 | 0.428 | 0.3770 | No |
| 39 | MME | NA | MME Entrez, Source | membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase) | 5941 | 0.423 | 0.3744 | No |
| 40 | CD7 | NA | CD7 Entrez, Source | CD7 molecule | 5960 | 0.418 | 0.3770 | No |
| 41 | CD1B | NA | CD1B Entrez, Source | CD1b molecule | 6059 | 0.418 | 0.3751 | No |
| 42 | CD19 | NA | CD19 Entrez, Source | CD19 molecule | 6060 | 0.418 | 0.3786 | No |
| 43 | CD2 | NA | CD2 Entrez, Source | CD2 molecule | 6092 | 0.415 | 0.3804 | No |
| 44 | GP9 | NA | GP9 Entrez, Source | glycoprotein IX (platelet) | 6609 | 0.349 | 0.3546 | No |
| 45 | CD1E | NA | CD1E Entrez, Source | CD1e molecule | 6711 | 0.333 | 0.3518 | No |
| 46 | KIT | NA | KIT Entrez, Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 7055 | 0.281 | 0.3350 | No |
| 47 | GP5 | NA | GP5 Entrez, Source | glycoprotein V (platelet) | 7137 | 0.267 | 0.3328 | No |
| 48 | CD8A | NA | CD8A Entrez, Source | CD8a molecule | 7312 | 0.240 | 0.3251 | No |
| 49 | ITGA4 | NA | ITGA4 Entrez, Source | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | 7633 | 0.196 | 0.3089 | No |
| 50 | FLT3 | NA | FLT3 Entrez, Source | fms-related tyrosine kinase 3 | 8267 | 0.111 | 0.2744 | No |
| 51 | IL5RA | NA | IL5RA Entrez, Source | interleukin 5 receptor, alpha | 8310 | 0.106 | 0.2730 | No |
| 52 | IL2RA | NA | IL2RA Entrez, Source | interleukin 2 receptor, alpha | 8687 | 0.055 | 0.2524 | No |
| 53 | CD1C | NA | CD1C Entrez, Source | CD1c molecule | 8745 | 0.045 | 0.2496 | No |
| 54 | CD36 | NA | CD36 Entrez, Source | CD36 molecule (thrombospondin receptor) | 9407 | -0.000 | 0.2127 | No |
| 55 | CD59 | NA | CD59 Entrez, Source | CD59 molecule, complement regulatory protein | 9435 | -0.005 | 0.2112 | No |
| 56 | FCGR1A | NA | FCGR1A Entrez, Source | Fc fragment of IgG, high affinity Ia, receptor (CD64) | 9795 | -0.051 | 0.1916 | No |
| 57 | TNF | NA | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 9956 | -0.066 | 0.1832 | No |
| 58 | CD4 | NA | CD4 Entrez, Source | CD4 molecule | 9976 | -0.068 | 0.1827 | No |
| 59 | MS4A1 | NA | MS4A1 Entrez, Source | membrane-spanning 4-domains, subfamily A, member 1 | 10281 | -0.096 | 0.1666 | No |
| 60 | EPOR | NA | EPOR Entrez, Source | erythropoietin receptor | 10656 | -0.148 | 0.1469 | No |
| 61 | CD44 | NA | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 10782 | -0.166 | 0.1414 | No |
| 62 | CD1A | NA | CD1A Entrez, Source | CD1a molecule | 11053 | -0.206 | 0.1280 | No |
| 63 | DNTT | NA | DNTT Entrez, Source | deoxynucleotidyltransferase, terminal | 11643 | -0.288 | 0.0976 | No |
| 64 | IL3 | NA | IL3 Entrez, Source | interleukin 3 (colony-stimulating factor, multiple) | 11751 | -0.305 | 0.0942 | No |
| 65 | THPO | NA | THPO Entrez, Source | thrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor) | 11898 | -0.327 | 0.0888 | No |
| 66 | CSF3R | NA | CSF3R Entrez, Source | colony stimulating factor 3 receptor (granulocyte) | 12554 | -0.411 | 0.0557 | No |
| 67 | TPO | NA | TPO Entrez, Source | thyroid peroxidase | 12936 | -0.451 | 0.0383 | No |
| 68 | IL4R | NA | IL4R Entrez, Source | interleukin 4 receptor | 13336 | -0.508 | 0.0203 | No |
| 69 | CD3D | NA | CD3D Entrez, Source | CD3d molecule, delta (CD3-TCR complex) | 13345 | -0.509 | 0.0242 | No |
| 70 | ITGB3 | NA | ITGB3 Entrez, Source | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 13638 | -0.565 | 0.0127 | No |
| 71 | GYPA | NA | GYPA Entrez, Source | glycophorin A (MNS blood group) | 13643 | -0.566 | 0.0174 | No |
| 72 | GP1BB | NA | GP1BB Entrez, Source | glycoprotein Ib (platelet), beta polypeptide | 13654 | -0.569 | 0.0216 | No |
| 73 | EPO | NA | EPO Entrez, Source | erythropoietin | 15664 | -1.052 | -0.0817 | No |
| 74 | IL6R | NA | IL6R Entrez, Source | interleukin 6 receptor | 15858 | -1.120 | -0.0829 | No |
| 75 | FLT3LG | NA | FLT3LG Entrez, Source | fms-related tyrosine kinase 3 ligand | 16656 | -1.504 | -0.1146 | No |
| 76 | IL11 | NA | IL11 Entrez, Source | interleukin 11 | 17089 | -1.857 | -0.1229 | No |
| 77 | IL9R | NA | IL9R Entrez, Source | interleukin 9 receptor | 17185 | -1.986 | -0.1112 | No |
| 78 | ITGAM | NA | ITGAM Entrez, Source | integrin, alpha M (complement component 3 receptor 3 subunit) | 17198 | -2.003 | -0.0948 | No |
| 79 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 17373 | -2.282 | -0.0850 | No |
| 80 | ANPEP | NA | ANPEP Entrez, Source | alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150) | 17395 | -2.321 | -0.0664 | No |
| 81 | CD33 | NA | CD33 Entrez, Source | CD33 molecule | 17765 | -3.428 | -0.0577 | No |
| 82 | IL1A | NA | IL1A Entrez, Source | interleukin 1, alpha | 17815 | -3.646 | -0.0293 | No |
| 83 | CSF3 | NA | CSF3 Entrez, Source | colony stimulating factor 3 (granulocyte) | 17920 | -4.470 | 0.0030 | No |
