Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_GRAFT_VERSUS_HOST_DISEASE |
| Enrichment Score (ES) | 0.68451494 |
| Normalized Enrichment Score (NES) | 2.0496776 |
| Nominal p-value | 0.0 |
| FDR q-value | 1.6525423E-4 |
| FWER p-Value | 0.001 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | HLA-DRB1 | NA | HLA-DRB1 Entrez, Source | major histocompatibility complex, class II, DR beta 1 | 8 | 4.960 | 0.0751 | Yes |
| 2 | HLA-DRA | NA | HLA-DRA Entrez, Source | major histocompatibility complex, class II, DR alpha | 27 | 4.871 | 0.1482 | Yes |
| 3 | HLA-DPA1 | NA | HLA-DPA1 Entrez, Source | major histocompatibility complex, class II, DP alpha 1 | 107 | 4.489 | 0.2121 | Yes |
| 4 | HLA-DRB5 | NA | HLA-DRB5 Entrez, Source | major histocompatibility complex, class II, DR beta 5 | 137 | 4.339 | 0.2765 | Yes |
| 5 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 148 | 4.301 | 0.3414 | Yes |
| 6 | HLA-DMB | NA | HLA-DMB Entrez, Source | major histocompatibility complex, class II, DM beta | 164 | 4.259 | 0.4054 | Yes |
| 7 | HLA-DRB3 | NA | HLA-DRB3 Entrez, Source | major histocompatibility complex, class II, DR beta 3 | 226 | 4.018 | 0.4632 | Yes |
| 8 | HLA-DRB4 | NA | HLA-DRB4 Entrez, Source | major histocompatibility complex, class II, DR beta 4 | 242 | 3.963 | 0.5227 | Yes |
| 9 | HLA-DMA | NA | HLA-DMA Entrez, Source | major histocompatibility complex, class II, DM alpha | 294 | 3.747 | 0.5768 | Yes |
| 10 | HLA-DQB1 | NA | HLA-DQB1 Entrez, Source | major histocompatibility complex, class II, DQ beta 1 | 438 | 3.353 | 0.6199 | Yes |
| 11 | HLA-DPB1 | NA | HLA-DPB1 Entrez, Source | major histocompatibility complex, class II, DP beta 1 | 1127 | 2.142 | 0.6142 | Yes |
| 12 | HLA-DOB | NA | HLA-DOB Entrez, Source | major histocompatibility complex, class II, DO beta | 1460 | 1.797 | 0.6230 | Yes |
| 13 | HLA-E | NA | HLA-E Entrez, Source | major histocompatibility complex, class I, E | 1528 | 1.738 | 0.6457 | Yes |
| 14 | HLA-DOA | NA | HLA-DOA Entrez, Source | major histocompatibility complex, class II, DO alpha | 1660 | 1.640 | 0.6634 | Yes |
| 15 | FAS | NA | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 1716 | 1.589 | 0.6845 | Yes |
| 16 | KLRC1 | NA | KLRC1 Entrez, Source | killer cell lectin-like receptor subfamily C, member 1 | 2407 | 1.212 | 0.6645 | No |
| 17 | HLA-C | NA | HLA-C Entrez, Source | major histocompatibility complex, class I, C | 4338 | 0.693 | 0.5675 | No |
| 18 | HLA-G | NA | HLA-G Entrez, Source | HLA-G histocompatibility antigen, class I, G | 4577 | 0.642 | 0.5640 | No |
| 19 | HLA-A | NA | HLA-A Entrez, Source | major histocompatibility complex, class I, A | 4720 | 0.613 | 0.5654 | No |
| 20 | HLA-F | NA | HLA-F Entrez, Source | major histocompatibility complex, class I, F | 4736 | 0.609 | 0.5738 | No |
| 21 | PRF1 | NA | PRF1 Entrez, Source | perforin 1 (pore forming protein) | 5383 | 0.490 | 0.5452 | No |
| 22 | HLA-DQA1 | NA | HLA-DQA1 Entrez, Source | major histocompatibility complex, class II, DQ alpha 1 | 6116 | 0.415 | 0.5108 | No |
| 23 | KLRD1 | NA | KLRD1 Entrez, Source | killer cell lectin-like receptor subfamily D, member 1 | 6669 | 0.339 | 0.4851 | No |
| 24 | FASLG | NA | FASLG Entrez, Source | Fas ligand (TNF superfamily, member 6) | 7435 | 0.220 | 0.4459 | No |
| 25 | HLA-B | NA | HLA-B Entrez, Source | major histocompatibility complex, class I, B | 8759 | 0.043 | 0.3728 | No |
| 26 | IL2 | NA | IL2 Entrez, Source | interleukin 2 | 9229 | 0.000 | 0.3466 | No |
| 27 | TNF | NA | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 9956 | -0.066 | 0.3072 | No |
| 28 | CD80 | NA | CD80 Entrez, Source | CD80 molecule | 10403 | -0.111 | 0.2840 | No |
| 29 | CD86 | NA | CD86 Entrez, Source | CD86 molecule | 10856 | -0.177 | 0.2615 | No |
| 30 | HLA-DQA2 | NA | HLA-DQA2 Entrez, Source | major histocompatibility complex, class II, DQ alpha 2 | 11354 | -0.247 | 0.2375 | No |
| 31 | IFNG | NA | IFNG Entrez, Source | interferon, gamma | 12804 | -0.445 | 0.1635 | No |
| 32 | KIR3DL1 | NA | KIR3DL1 Entrez, Source | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 | 12835 | -0.445 | 0.1686 | No |
| 33 | CD28 | NA | CD28 Entrez, Source | CD28 molecule | 17036 | -1.802 | -0.0380 | No |
| 34 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 17373 | -2.282 | -0.0220 | No |
| 35 | IL1A | NA | IL1A Entrez, Source | interleukin 1, alpha | 17815 | -3.646 | 0.0089 | No |
