Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_ERBB_SIGNALING_PATHWAY |
| Enrichment Score (ES) | 0.4699609 |
| Normalized Enrichment Score (NES) | 1.6324326 |
| Nominal p-value | 0.001459854 |
| FDR q-value | 0.04304662 |
| FWER p-Value | 0.497 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | EREG | NA | EREG Entrez, Source | epiregulin | 97 | 4.528 | 0.0425 | Yes |
| 2 | TGFA | NA | TGFA Entrez, Source | transforming growth factor, alpha | 131 | 4.365 | 0.0869 | Yes |
| 3 | AREG | NA | AREG Entrez, Source | amphiregulin (schwannoma-derived growth factor) | 232 | 4.000 | 0.1237 | Yes |
| 4 | NRG1 | NA | NRG1 Entrez, Source | neuregulin 1 | 275 | 3.822 | 0.1619 | Yes |
| 5 | BTC | NA | BTC Entrez, Source | betacellulin | 276 | 3.820 | 0.2023 | Yes |
| 6 | ERBB3 | NA | ERBB3 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 343 | 3.623 | 0.2370 | Yes |
| 7 | EGF | NA | EGF Entrez, Source | epidermal growth factor (beta-urogastrone) | 664 | 2.799 | 0.2488 | Yes |
| 8 | PIK3CA | NA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 693 | 2.734 | 0.2762 | Yes |
| 9 | SHC3 | NA | SHC3 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 3 | 824 | 2.512 | 0.2956 | Yes |
| 10 | CDKN1A | NA | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 888 | 2.413 | 0.3176 | Yes |
| 11 | CAMK2B | NA | CAMK2B Entrez, Source | calcium/calmodulin-dependent protein kinase (CaM kinase) II beta | 1046 | 2.232 | 0.3325 | Yes |
| 12 | CAMK2D | NA | CAMK2D Entrez, Source | calcium/calmodulin-dependent protein kinase (CaM kinase) II delta | 1138 | 2.128 | 0.3499 | Yes |
| 13 | CBLC | NA | CBLC Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence c | 1217 | 2.026 | 0.3670 | Yes |
| 14 | MTOR | NA | 1269 | 1.965 | 0.3850 | Yes | ||
| 15 | CAMK2A | NA | CAMK2A Entrez, Source | calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha | 1367 | 1.869 | 0.3994 | Yes |
| 16 | PRKCA | NA | PRKCA Entrez, Source | protein kinase C, alpha | 1594 | 1.691 | 0.4047 | Yes |
| 17 | PRKCG | NA | PRKCG Entrez, Source | protein kinase C, gamma | 1726 | 1.583 | 0.4141 | Yes |
| 18 | PIK3R1 | NA | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 1994 | 1.422 | 0.4143 | Yes |
| 19 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 2109 | 1.354 | 0.4222 | Yes |
| 20 | SHC2 | NA | SHC2 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 2 | 2171 | 1.322 | 0.4328 | Yes |
| 21 | EIF4EBP1 | NA | EIF4EBP1 Entrez, Source | eukaryotic translation initiation factor 4E binding protein 1 | 2606 | 1.133 | 0.4206 | Yes |
| 22 | ERBB2 | NA | ERBB2 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 2625 | 1.122 | 0.4315 | Yes |
| 23 | CBL | NA | CBL Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 2658 | 1.111 | 0.4414 | Yes |
| 24 | CBLB | NA | CBLB Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence b | 2690 | 1.101 | 0.4514 | Yes |
| 25 | PAK6 | NA | PAK6 Entrez, Source | p21(CDKN1A)-activated kinase 6 | 2890 | 1.033 | 0.4512 | Yes |
| 26 | PAK2 | NA | PAK2 Entrez, Source | p21 (CDKN1A)-activated kinase 2 | 2899 | 1.029 | 0.4616 | Yes |
| 27 | CDKN1B | NA | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 2942 | 1.008 | 0.4700 | Yes |
| 28 | SOS2 | NA | SOS2 Entrez, Source | son of sevenless homolog 2 (Drosophila) | 3376 | 0.887 | 0.4552 | No |
| 29 | HBEGF | NA | HBEGF Entrez, Source | heparin-binding EGF-like growth factor | 3451 | 0.870 | 0.4602 | No |
| 30 | ERBB4 | NA | ERBB4 Entrez, Source | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) | 3581 | 0.845 | 0.4620 | No |
| 31 | PAK3 | NA | PAK3 Entrez, Source | p21 (CDKN1A)-activated kinase 3 | 3677 | 0.833 | 0.4655 | No |
| 32 | EGFR | NA | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 4260 | 0.710 | 0.4405 | No |
| 33 | PIK3CB | NA | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 4450 | 0.668 | 0.4370 | No |
| 34 | ABL2 | NA | ABL2 Entrez, Source | v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) | 4501 | 0.657 | 0.4412 | No |
| 35 | SOS1 | NA | SOS1 Entrez, Source | son of sevenless homolog 1 (Drosophila) | 4768 | 0.603 | 0.4327 | No |
| 36 | ARAF | NA | ARAF Entrez, Source | v-raf murine sarcoma 3611 viral oncogene homolog | 5103 | 0.534 | 0.4197 | No |
| 37 | PLCG2 | NA | PLCG2 Entrez, Source | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 5184 | 0.521 | 0.4207 | No |
| 38 | MAP2K2 | NA | MAP2K2 Entrez, Source | mitogen-activated protein kinase kinase 2 | 5201 | 0.518 | 0.4253 | No |
| 39 | SHC4 | NA | SHC4 Entrez, Source | SHC (Src homology 2 domain containing) family, member 4 | 5408 | 0.486 | 0.4189 | No |
| 40 | NCK2 | NA | NCK2 Entrez, Source | NCK adaptor protein 2 | 5645 | 0.453 | 0.4105 | No |
| 41 | ELK1 | NA | ELK1 Entrez, Source | ELK1, member of ETS oncogene family | 5949 | 0.421 | 0.3981 | No |
| 42 | BAD | NA | BAD Entrez, Source | BCL2-antagonist of cell death | 6874 | 0.310 | 0.3497 | No |
| 43 | PRKCB | NA | 7147 | 0.267 | 0.3373 | No | ||
| 44 | JUN | NA | JUN Entrez, Source | jun oncogene | 7197 | 0.258 | 0.3373 | No |
| 45 | GAB1 | NA | GAB1 Entrez, Source | GRB2-associated binding protein 1 | 7617 | 0.196 | 0.3160 | No |
| 46 | NCK1 | NA | NCK1 Entrez, Source | NCK adaptor protein 1 | 8112 | 0.132 | 0.2897 | No |
| 47 | HRAS | NA | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 8120 | 0.131 | 0.2907 | No |
| 48 | AKT2 | NA | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 8193 | 0.120 | 0.2880 | No |
| 49 | RPS6KB1 | NA | RPS6KB1 Entrez, Source | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 8490 | 0.080 | 0.2723 | No |
| 50 | MAPK9 | NA | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 8847 | 0.036 | 0.2528 | No |
| 51 | KRAS | NA | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 9550 | -0.022 | 0.2138 | No |
| 52 | NRG2 | NA | NRG2 Entrez, Source | neuregulin 2 | 9704 | -0.044 | 0.2057 | No |
| 53 | CRKL | NA | CRKL Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 9970 | -0.068 | 0.1916 | No |
| 54 | CRK | NA | CRK Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian) | 9987 | -0.069 | 0.1914 | No |
| 55 | MAPK10 | NA | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 10350 | -0.102 | 0.1723 | No |
| 56 | MAPK8 | NA | MAPK8 Entrez, Source | mitogen-activated protein kinase 8 | 10418 | -0.113 | 0.1697 | No |
| 57 | SRC | NA | SRC Entrez, Source | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 10694 | -0.154 | 0.1560 | No |
| 58 | PAK4 | NA | PAK4 Entrez, Source | p21(CDKN1A)-activated kinase 4 | 10917 | -0.186 | 0.1455 | No |
| 59 | PIK3R5 | NA | PIK3R5 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 5, p101 | 11218 | -0.228 | 0.1312 | No |
| 60 | MAP2K7 | NA | MAP2K7 Entrez, Source | mitogen-activated protein kinase kinase 7 | 11308 | -0.241 | 0.1288 | No |
| 61 | ABL1 | NA | ABL1 Entrez, Source | v-abl Abelson murine leukemia viral oncogene homolog 1 | 11310 | -0.241 | 0.1313 | No |
| 62 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 11524 | -0.274 | 0.1223 | No |
| 63 | BRAF | NA | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 11539 | -0.277 | 0.1244 | No |
| 64 | STAT5B | NA | STAT5B Entrez, Source | signal transducer and activator of transcription 5B | 11802 | -0.312 | 0.1131 | No |
| 65 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 11952 | -0.332 | 0.1083 | No |
| 66 | GRB2 | NA | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 12041 | -0.344 | 0.1070 | No |
| 67 | STAT5A | NA | STAT5A Entrez, Source | signal transducer and activator of transcription 5A | 12573 | -0.412 | 0.0817 | No |
| 68 | PLCG1 | NA | PLCG1 Entrez, Source | phospholipase C, gamma 1 | 12635 | -0.421 | 0.0827 | No |
| 69 | RAF1 | NA | RAF1 Entrez, Source | v-raf-1 murine leukemia viral oncogene homolog 1 | 12700 | -0.434 | 0.0837 | No |
| 70 | PTK2 | NA | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 12873 | -0.447 | 0.0789 | No |
| 71 | CAMK2G | NA | CAMK2G Entrez, Source | calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma | 13634 | -0.565 | 0.0424 | No |
| 72 | MAP2K4 | NA | MAP2K4 Entrez, Source | mitogen-activated protein kinase kinase 4 | 13697 | -0.575 | 0.0450 | No |
| 73 | AKT1 | NA | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 13847 | -0.604 | 0.0431 | No |
| 74 | NRAS | NA | NRAS Entrez, Source | neuroblastoma RAS viral (v-ras) oncogene homolog | 13927 | -0.620 | 0.0452 | No |
| 75 | AKT3 | NA | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 14156 | -0.671 | 0.0396 | No |
| 76 | RPS6KB2 | NA | RPS6KB2 Entrez, Source | ribosomal protein S6 kinase, 70kDa, polypeptide 2 | 14640 | -0.786 | 0.0209 | No |
| 77 | PIK3R2 | NA | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 14983 | -0.863 | 0.0109 | No |
| 78 | MYC | NA | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 15055 | -0.881 | 0.0163 | No |
| 79 | NRG3 | NA | NRG3 Entrez, Source | neuregulin 3 | 15848 | -1.116 | -0.0162 | No |
| 80 | GSK3B | NA | GSK3B Entrez, Source | glycogen synthase kinase 3 beta | 16081 | -1.206 | -0.0164 | No |
| 81 | PAK1 | NA | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 16221 | -1.270 | -0.0107 | No |
| 82 | NRG4 | NA | NRG4 Entrez, Source | neuregulin 4 | 16417 | -1.372 | -0.0070 | No |
| 83 | SHC1 | NA | SHC1 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 1 | 16678 | -1.516 | -0.0055 | No |
| 84 | MAPK3 | NA | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 16746 | -1.562 | 0.0073 | No |
| 85 | MAP2K1 | NA | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 16861 | -1.650 | 0.0184 | No |
| 86 | PIK3CG | NA | PIK3CG Entrez, Source | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 17882 | -4.130 | 0.0051 | No |
