Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_ECM_RECEPTOR_INTERACTION |
| Enrichment Score (ES) | 0.4919213 |
| Normalized Enrichment Score (NES) | 1.7157769 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.018350894 |
| FWER p-Value | 0.212 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | THBS2 | NA | THBS2 Entrez, Source | thrombospondin 2 | 64 | 4.649 | 0.0426 | Yes |
| 2 | RELN | NA | RELN Entrez, Source | reelin | 87 | 4.558 | 0.0867 | Yes |
| 3 | ITGB4 | NA | ITGB4 Entrez, Source | integrin, beta 4 | 126 | 4.390 | 0.1282 | Yes |
| 4 | COL4A4 | NA | COL4A4 Entrez, Source | collagen, type IV, alpha 4 | 296 | 3.745 | 0.1559 | Yes |
| 5 | LAMA4 | NA | LAMA4 Entrez, Source | laminin, alpha 4 | 352 | 3.578 | 0.1884 | Yes |
| 6 | LAMA1 | NA | LAMA1 Entrez, Source | laminin, alpha 1 | 373 | 3.508 | 0.2221 | Yes |
| 7 | LAMA3 | NA | LAMA3 Entrez, Source | laminin, alpha 3 | 378 | 3.490 | 0.2566 | Yes |
| 8 | LAMA2 | NA | LAMA2 Entrez, Source | laminin, alpha 2 (merosin, congenital muscular dystrophy) | 424 | 3.370 | 0.2876 | Yes |
| 9 | ITGA2 | NA | ITGA2 Entrez, Source | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 483 | 3.253 | 0.3167 | Yes |
| 10 | HSPG2 | NA | HSPG2 Entrez, Source | heparan sulfate proteoglycan 2 (perlecan) | 507 | 3.169 | 0.3469 | Yes |
| 11 | COL1A2 | NA | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 538 | 3.100 | 0.3760 | Yes |
| 12 | LAMB1 | NA | LAMB1 Entrez, Source | laminin, beta 1 | 627 | 2.902 | 0.3999 | Yes |
| 13 | COL6A3 | NA | COL6A3 Entrez, Source | collagen, type VI, alpha 3 | 756 | 2.624 | 0.4188 | Yes |
| 14 | ITGA3 | NA | ITGA3 Entrez, Source | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 978 | 2.317 | 0.4295 | Yes |
| 15 | ITGB5 | NA | ITGB5 Entrez, Source | integrin, beta 5 | 1125 | 2.144 | 0.4426 | Yes |
| 16 | LAMA5 | NA | LAMA5 Entrez, Source | laminin, alpha 5 | 1343 | 1.888 | 0.4493 | Yes |
| 17 | COL4A6 | NA | COL4A6 Entrez, Source | collagen, type IV, alpha 6 | 1688 | 1.614 | 0.4461 | Yes |
| 18 | LAMC1 | NA | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 1929 | 1.455 | 0.4471 | Yes |
| 19 | COL11A2 | NA | COL11A2 Entrez, Source | collagen, type XI, alpha 2 | 2087 | 1.368 | 0.4519 | Yes |
| 20 | ITGA5 | NA | ITGA5 Entrez, Source | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 2293 | 1.258 | 0.4530 | Yes |
| 21 | SPP1 | NA | SPP1 Entrez, Source | secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) | 2399 | 1.215 | 0.4592 | Yes |
| 22 | COL5A1 | NA | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 2511 | 1.174 | 0.4646 | Yes |
| 23 | DAG1 | NA | DAG1 Entrez, Source | dystroglycan 1 (dystrophin-associated glycoprotein 1) | 2575 | 1.146 | 0.4725 | Yes |
| 24 | THBS1 | NA | THBS1 Entrez, Source | thrombospondin 1 | 2604 | 1.136 | 0.4822 | Yes |
| 25 | ITGA2B | NA | ITGA2B Entrez, Source | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | 2705 | 1.096 | 0.4875 | Yes |
| 26 | SDC2 | NA | SDC2 Entrez, Source | syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan) | 2815 | 1.055 | 0.4919 | Yes |
| 27 | GP6 | NA | GP6 Entrez, Source | glycoprotein VI (platelet) | 3362 | 0.893 | 0.4703 | No |
| 28 | ITGA1 | NA | ITGA1 Entrez, Source | integrin, alpha 1 | 3645 | 0.836 | 0.4628 | No |
| 29 | TNR | NA | TNR Entrez, Source | tenascin R (restrictin, janusin) | 3740 | 0.823 | 0.4658 | No |
| 30 | COL6A6 | NA | 3799 | 0.810 | 0.4706 | No | ||
| 31 | ITGAV | NA | ITGAV Entrez, Source | integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) | 3832 | 0.802 | 0.4767 | No |
| 32 | CD47 | NA | CD47 Entrez, Source | CD47 molecule | 4270 | 0.708 | 0.4593 | No |
| 33 | AGRN | NA | 4498 | 0.657 | 0.4532 | No | ||
| 34 | ITGA6 | NA | ITGA6 Entrez, Source | integrin, alpha 6 | 4506 | 0.656 | 0.4593 | No |
| 35 | COL2A1 | NA | COL2A1 Entrez, Source | collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) | 4659 | 0.627 | 0.4571 | No |
| 36 | ITGB6 | NA | ITGB6 Entrez, Source | integrin, beta 6 | 4683 | 0.621 | 0.4619 | No |
| 37 | VTN | NA | VTN Entrez, Source | vitronectin | 5658 | 0.451 | 0.4120 | No |
| 38 | GP1BA | NA | GP1BA Entrez, Source | glycoprotein Ib (platelet), alpha polypeptide | 5717 | 0.441 | 0.4131 | No |
| 39 | COL1A1 | NA | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 6216 | 0.412 | 0.3894 | No |
| 40 | GP9 | NA | GP9 Entrez, Source | glycoprotein IX (platelet) | 6609 | 0.349 | 0.3709 | No |
| 41 | LAMC3 | NA | LAMC3 Entrez, Source | laminin, gamma 3 | 6612 | 0.348 | 0.3743 | No |
| 42 | ITGA10 | NA | ITGA10 Entrez, Source | integrin, alpha 10 | 6630 | 0.344 | 0.3768 | No |
| 43 | LAMB4 | NA | LAMB4 Entrez, Source | laminin, beta 4 | 6911 | 0.304 | 0.3641 | No |
| 44 | COL3A1 | NA | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 6922 | 0.302 | 0.3666 | No |
| 45 | LAMC2 | NA | LAMC2 Entrez, Source | laminin, gamma 2 | 7079 | 0.277 | 0.3606 | No |
| 46 | ITGA7 | NA | ITGA7 Entrez, Source | integrin, alpha 7 | 7113 | 0.272 | 0.3615 | No |
| 47 | GP5 | NA | GP5 Entrez, Source | glycoprotein V (platelet) | 7137 | 0.267 | 0.3628 | No |
| 48 | COL5A3 | NA | COL5A3 Entrez, Source | collagen, type V, alpha 3 | 7590 | 0.200 | 0.3396 | No |
| 49 | ITGA4 | NA | ITGA4 Entrez, Source | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | 7633 | 0.196 | 0.3392 | No |
| 50 | SDC3 | NA | SDC3 Entrez, Source | syndecan 3 (N-syndecan) | 8638 | 0.061 | 0.2836 | No |
| 51 | COL6A1 | NA | COL6A1 Entrez, Source | collagen, type VI, alpha 1 | 8911 | 0.027 | 0.2687 | No |
| 52 | CD36 | NA | CD36 Entrez, Source | CD36 molecule (thrombospondin receptor) | 9407 | -0.000 | 0.2410 | No |
| 53 | ITGB1 | NA | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 9602 | -0.030 | 0.2305 | No |
| 54 | ITGB7 | NA | ITGB7 Entrez, Source | integrin, beta 7 | 9842 | -0.057 | 0.2177 | No |
| 55 | IBSP | NA | IBSP Entrez, Source | integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II) | 9875 | -0.062 | 0.2165 | No |
| 56 | SV2B | NA | SV2B Entrez, Source | synaptic vesicle glycoprotein 2B | 9965 | -0.067 | 0.2122 | No |
| 57 | ITGA11 | NA | ITGA11 Entrez, Source | integrin, alpha 11 | 9992 | -0.070 | 0.2115 | No |
| 58 | ITGA8 | NA | ITGA8 Entrez, Source | integrin, alpha 8 | 10364 | -0.104 | 0.1918 | No |
| 59 | SV2A | NA | SV2A Entrez, Source | synaptic vesicle glycoprotein 2A | 10511 | -0.127 | 0.1849 | No |
| 60 | CHAD | NA | CHAD Entrez, Source | chondroadherin | 10664 | -0.149 | 0.1778 | No |
| 61 | CD44 | NA | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 10782 | -0.166 | 0.1730 | No |
| 62 | TNC | NA | TNC Entrez, Source | tenascin C (hexabrachion) | 11058 | -0.207 | 0.1596 | No |
| 63 | ITGB8 | NA | ITGB8 Entrez, Source | integrin, beta 8 | 11443 | -0.261 | 0.1408 | No |
| 64 | TNN | NA | TNN Entrez, Source | tenascin N | 11813 | -0.314 | 0.1233 | No |
| 65 | SDC4 | NA | SDC4 Entrez, Source | syndecan 4 (amphiglycan, ryudocan) | 11969 | -0.335 | 0.1179 | No |
| 66 | TNXB | NA | TNXB Entrez, Source | tenascin XB | 12687 | -0.432 | 0.0821 | No |
| 67 | FN1 | NA | FN1 Entrez, Source | fibronectin 1 | 12699 | -0.434 | 0.0858 | No |
| 68 | SV2C | NA | SV2C Entrez, Source | synaptic vesicle glycoprotein 2C | 12860 | -0.445 | 0.0813 | No |
| 69 | LAMB2 | NA | LAMB2 Entrez, Source | laminin, beta 2 (laminin S) | 13227 | -0.493 | 0.0658 | No |
| 70 | ITGB3 | NA | ITGB3 Entrez, Source | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 13638 | -0.565 | 0.0485 | No |
| 71 | GP1BB | NA | GP1BB Entrez, Source | glycoprotein Ib (platelet), beta polypeptide | 13654 | -0.569 | 0.0533 | No |
| 72 | VWF | NA | VWF Entrez, Source | von Willebrand factor | 13772 | -0.589 | 0.0526 | No |
| 73 | LAMB3 | NA | LAMB3 Entrez, Source | laminin, beta 3 | 14379 | -0.719 | 0.0259 | No |
| 74 | COL11A1 | NA | COL11A1 Entrez, Source | collagen, type XI, alpha 1 | 14477 | -0.750 | 0.0279 | No |
| 75 | SDC1 | NA | SDC1 Entrez, Source | syndecan 1 | 14863 | -0.838 | 0.0147 | No |
| 76 | THBS4 | NA | THBS4 Entrez, Source | thrombospondin 4 | 15147 | -0.902 | 0.0078 | No |
| 77 | COL5A2 | NA | COL5A2 Entrez, Source | collagen, type V, alpha 2 | 15860 | -1.120 | -0.0208 | No |
| 78 | THBS3 | NA | THBS3 Entrez, Source | thrombospondin 3 | 16331 | -1.324 | -0.0339 | No |
| 79 | COMP | NA | COMP Entrez, Source | cartilage oligomeric matrix protein | 16501 | -1.414 | -0.0293 | No |
| 80 | COL4A2 | NA | COL4A2 Entrez, Source | collagen, type IV, alpha 2 | 16767 | -1.575 | -0.0285 | No |
| 81 | COL4A1 | NA | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 17070 | -1.831 | -0.0272 | No |
| 82 | HMMR | NA | HMMR Entrez, Source | hyaluronan-mediated motility receptor (RHAMM) | 17255 | -2.092 | -0.0167 | No |
| 83 | ITGA9 | NA | ITGA9 Entrez, Source | integrin, alpha 9 | 17315 | -2.199 | 0.0019 | No |
| 84 | COL6A2 | NA | COL6A2 Entrez, Source | collagen, type VI, alpha 2 | 17784 | -3.514 | 0.0106 | No |
