Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_DNA_REPLICATION |
| Enrichment Score (ES) | -0.507331 |
| Normalized Enrichment Score (NES) | -1.6709462 |
| Nominal p-value | 0.005263158 |
| FDR q-value | 0.0446867 |
| FWER p-Value | 0.289 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | RFC4 | NA | RFC4 Entrez, Source | replication factor C (activator 1) 4, 37kDa | 751 | 2.636 | 0.0518 | No |
| 2 | RPA4 | NA | RPA4 Entrez, Source | replication protein A4, 34kDa | 4013 | 0.759 | -0.1030 | No |
| 3 | RNASEH2C | NA | RNASEH2C Entrez, Source | ribonuclease H2, subunit C | 4621 | 0.634 | -0.1143 | No |
| 4 | PRIM2 | NA | 4710 | 0.615 | -0.0973 | No | ||
| 5 | RFC1 | NA | RFC1 Entrez, Source | replication factor C (activator 1) 1, 145kDa | 6374 | 0.385 | -0.1764 | No |
| 6 | RFC2 | NA | RFC2 Entrez, Source | replication factor C (activator 1) 2, 40kDa | 9589 | -0.028 | -0.3545 | No |
| 7 | POLE | NA | POLE Entrez, Source | polymerase (DNA directed), epsilon | 10020 | -0.071 | -0.3760 | No |
| 8 | MCM3 | NA | MCM3 Entrez, Source | MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) | 10258 | -0.093 | -0.3859 | No |
| 9 | RNASEH1 | NA | RNASEH1 Entrez, Source | ribonuclease H1 | 10669 | -0.150 | -0.4034 | No |
| 10 | RPA2 | NA | RPA2 Entrez, Source | replication protein A2, 32kDa | 10881 | -0.181 | -0.4087 | No |
| 11 | POLE2 | NA | POLE2 Entrez, Source | polymerase (DNA directed), epsilon 2 (p59 subunit) | 11124 | -0.215 | -0.4146 | No |
| 12 | RPA1 | NA | RPA1 Entrez, Source | replication protein A1, 70kDa | 11194 | -0.226 | -0.4104 | No |
| 13 | RNASEH2A | NA | RNASEH2A Entrez, Source | ribonuclease H2, subunit A | 12295 | -0.384 | -0.4581 | No |
| 14 | MCM6 | NA | MCM6 Entrez, Source | MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) | 12750 | -0.444 | -0.4676 | No |
| 15 | PCNA | NA | PCNA Entrez, Source | proliferating cell nuclear antigen | 13241 | -0.495 | -0.4773 | No |
| 16 | SSBP1 | NA | SSBP1 Entrez, Source | single-stranded DNA binding protein 1 | 13780 | -0.591 | -0.4863 | Yes |
| 17 | POLD1 | NA | POLD1 Entrez, Source | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 13802 | -0.595 | -0.4664 | Yes |
| 18 | POLD4 | NA | POLD4 Entrez, Source | polymerase (DNA-directed), delta 4 | 13855 | -0.605 | -0.4477 | Yes |
| 19 | POLA2 | NA | POLA2 Entrez, Source | polymerase (DNA directed), alpha 2 (70kD subunit) | 13950 | -0.623 | -0.4308 | Yes |
| 20 | MCM7 | NA | MCM7 Entrez, Source | MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) | 13965 | -0.626 | -0.4093 | Yes |
| 21 | RFC5 | NA | RFC5 Entrez, Source | replication factor C (activator 1) 5, 36.5kDa | 14006 | -0.636 | -0.3890 | Yes |
| 22 | POLE3 | NA | POLE3 Entrez, Source | polymerase (DNA directed), epsilon 3 (p17 subunit) | 14225 | -0.686 | -0.3767 | Yes |
| 23 | RPA3 | NA | RPA3 Entrez, Source | replication protein A3, 14kDa | 14239 | -0.689 | -0.3529 | Yes |
| 24 | PRIM1 | NA | PRIM1 Entrez, Source | primase, polypeptide 1, 49kDa | 14500 | -0.753 | -0.3407 | Yes |
| 25 | POLD3 | NA | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 14617 | -0.783 | -0.3193 | Yes |
| 26 | MCM4 | NA | MCM4 Entrez, Source | MCM4 minichromosome maintenance deficient 4 (S. cerevisiae) | 14975 | -0.861 | -0.3086 | Yes |
| 27 | DNA2 | NA | 15082 | -0.888 | -0.2829 | Yes | ||
| 28 | POLD2 | NA | POLD2 Entrez, Source | polymerase (DNA directed), delta 2, regulatory subunit 50kDa | 15203 | -0.914 | -0.2571 | Yes |
| 29 | MCM5 | NA | MCM5 Entrez, Source | MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) | 15464 | -0.988 | -0.2365 | Yes |
| 30 | MCM2 | NA | MCM2 Entrez, Source | MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) | 15624 | -1.036 | -0.2085 | Yes |
| 31 | FEN1 | NA | FEN1 Entrez, Source | flap structure-specific endonuclease 1 | 15662 | -1.051 | -0.1732 | Yes |
| 32 | POLA1 | NA | POLA1 Entrez, Source | polymerase (DNA directed), alpha 1 | 15670 | -1.054 | -0.1362 | Yes |
| 33 | LIG1 | NA | LIG1 Entrez, Source | ligase I, DNA, ATP-dependent | 16383 | -1.354 | -0.1277 | Yes |
| 34 | RFC3 | NA | RFC3 Entrez, Source | replication factor C (activator 1) 3, 38kDa | 17031 | -1.799 | -0.0999 | Yes |
| 35 | POLE4 | NA | POLE4 Entrez, Source | polymerase (DNA-directed), epsilon 4 (p12 subunit) | 17248 | -2.078 | -0.0380 | Yes |
| 36 | RNASEH2B | NA | RNASEH2B Entrez, Source | ribonuclease H2, subunit B | 17319 | -2.207 | 0.0365 | Yes |
