Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY |
| Enrichment Score (ES) | 0.5037029 |
| Normalized Enrichment Score (NES) | 1.570331 |
| Nominal p-value | 0.016949153 |
| FDR q-value | 0.07115492 |
| FWER p-Value | 0.725 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | PYCARD | NA | PYCARD Entrez, Source | PYD and CARD domain containing | 111 | 4.484 | 0.0823 | Yes |
| 2 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 148 | 4.301 | 0.1651 | Yes |
| 3 | AIM2 | NA | AIM2 Entrez, Source | absent in melanoma 2 | 277 | 3.809 | 0.2331 | Yes |
| 4 | CASP1 | NA | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 302 | 3.732 | 0.3054 | Yes |
| 5 | IL18 | NA | IL18 Entrez, Source | interleukin 18 (interferon-gamma-inducing factor) | 564 | 3.030 | 0.3506 | Yes |
| 6 | IRF7 | NA | IRF7 Entrez, Source | interferon regulatory factor 7 | 1058 | 2.215 | 0.3668 | Yes |
| 7 | RIPK3 | NA | RIPK3 Entrez, Source | receptor-interacting serine-threonine kinase 3 | 1115 | 2.155 | 0.4062 | Yes |
| 8 | IKBKB | NA | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 1509 | 1.757 | 0.4189 | Yes |
| 9 | CXCL10 | NA | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 1672 | 1.634 | 0.4421 | Yes |
| 10 | DDX58 | NA | DDX58 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 1683 | 1.616 | 0.4735 | Yes |
| 11 | POLR3D | NA | POLR3D Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide D, 44kDa | 1706 | 1.596 | 0.5037 | Yes |
| 12 | MAVS | NA | 3161 | 0.945 | 0.4413 | No | ||
| 13 | IL33 | NA | 3778 | 0.814 | 0.4230 | No | ||
| 14 | POLR1C | NA | POLR1C Entrez, Source | polymerase (RNA) I polypeptide C, 30kDa | 4276 | 0.707 | 0.4092 | No |
| 15 | NFKBIA | NA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 4475 | 0.662 | 0.4112 | No |
| 16 | CCL5 | NA | CCL5 Entrez, Source | chemokine (C-C motif) ligand 5 | 4674 | 0.624 | 0.4125 | No |
| 17 | IKBKG | NA | IKBKG Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 4773 | 0.600 | 0.4188 | No |
| 18 | IRF3 | NA | IRF3 Entrez, Source | interferon regulatory factor 3 | 5514 | 0.475 | 0.3869 | No |
| 19 | IFNB1 | NA | IFNB1 Entrez, Source | interferon, beta 1, fibroblast | 5849 | 0.428 | 0.3767 | No |
| 20 | CCL4L2 | NA | CCL4L2 Entrez, Source | chemokine (C-C motif) ligand 4-like 2 | 6152 | 0.415 | 0.3681 | No |
| 21 | TMEM173 | NA | TMEM173 Entrez, Source | transmembrane protein 173 | 6699 | 0.334 | 0.3442 | No |
| 22 | POLR3G | NA | POLR3G Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide G (32kD) | 7386 | 0.228 | 0.3105 | No |
| 23 | ZBP1 | NA | ZBP1 Entrez, Source | Z-DNA binding protein 1 | 7573 | 0.202 | 0.3041 | No |
| 24 | POLR3F | NA | POLR3F Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa | 8478 | 0.082 | 0.2553 | No |
| 25 | CCL4 | NA | CCL4 Entrez, Source | chemokine (C-C motif) ligand 4 | 9393 | 0.000 | 0.2043 | No |
| 26 | RELA | NA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 9422 | -0.003 | 0.2028 | No |
| 27 | IFNA21 | NA | IFNA21 Entrez, Source | interferon, alpha 21 | 9732 | -0.046 | 0.1865 | No |
| 28 | ADAR | NA | ADAR Entrez, Source | adenosine deaminase, RNA-specific | 10155 | -0.083 | 0.1646 | No |
| 29 | POLR3B | NA | POLR3B Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide B | 10437 | -0.115 | 0.1512 | No |
| 30 | POLR3GL | NA | POLR3GL Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide G (32kD) like | 11684 | -0.292 | 0.0875 | No |
| 31 | TBK1 | NA | TBK1 Entrez, Source | TANK-binding kinase 1 | 11760 | -0.306 | 0.0893 | No |
| 32 | POLR3A | NA | POLR3A Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide A, 155kDa | 12039 | -0.344 | 0.0806 | No |
| 33 | POLR3C | NA | POLR3C Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide C (62kD) | 12056 | -0.347 | 0.0865 | No |
| 34 | POLR3H | NA | POLR3H Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) | 12166 | -0.364 | 0.0876 | No |
| 35 | RIPK1 | NA | RIPK1 Entrez, Source | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 12607 | -0.417 | 0.0713 | No |
| 36 | CHUK | NA | CHUK Entrez, Source | conserved helix-loop-helix ubiquitous kinase | 14002 | -0.635 | 0.0061 | No |
| 37 | NFKB1 | NA | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 14554 | -0.768 | -0.0095 | No |
| 38 | IFNA8 | NA | IFNA8 Entrez, Source | interferon, alpha 8 | 14874 | -0.839 | -0.0107 | No |
| 39 | TREX1 | NA | TREX1 Entrez, Source | three prime repair exonuclease 1 | 15337 | -0.951 | -0.0177 | No |
| 40 | POLR1D | NA | POLR1D Entrez, Source | polymerase (RNA) I polypeptide D, 16kDa | 17148 | -1.928 | -0.0806 | No |
| 41 | POLR3K | NA | POLR3K Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa | 17204 | -2.011 | -0.0440 | No |
| 42 | IKBKE | NA | IKBKE Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 17276 | -2.121 | -0.0061 | No |
| 43 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 17373 | -2.282 | 0.0335 | No |
