Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_COMPLEMENT_AND_COAGULATION_CASCADES |
| Enrichment Score (ES) | 0.5417648 |
| Normalized Enrichment Score (NES) | 1.8299532 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.003442718 |
| FWER p-Value | 0.038 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | C4BPB | NA | C4BPB Entrez, Source | complement component 4 binding protein, beta | 11 | 4.950 | 0.0543 | Yes |
| 2 | MASP2 | NA | MASP2 Entrez, Source | mannan-binding lectin serine peptidase 2 | 214 | 4.081 | 0.0883 | Yes |
| 3 | C2 | NA | C2 Entrez, Source | complement component 2 | 271 | 3.833 | 0.1278 | Yes |
| 4 | THBD | NA | THBD Entrez, Source | thrombomodulin | 371 | 3.510 | 0.1612 | Yes |
| 5 | CD55 | NA | CD55 Entrez, Source | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 431 | 3.362 | 0.1952 | Yes |
| 6 | CR2 | NA | CR2 Entrez, Source | complement component (3d/Epstein Barr virus) receptor 2 | 510 | 3.161 | 0.2259 | Yes |
| 7 | PLAT | NA | PLAT Entrez, Source | plasminogen activator, tissue | 516 | 3.147 | 0.2606 | Yes |
| 8 | F2R | NA | F2R Entrez, Source | coagulation factor II (thrombin) receptor | 561 | 3.041 | 0.2919 | Yes |
| 9 | CFH | NA | CFH Entrez, Source | complement factor H | 581 | 2.980 | 0.3239 | Yes |
| 10 | PLAU | NA | PLAU Entrez, Source | plasminogen activator, urokinase | 600 | 2.949 | 0.3556 | Yes |
| 11 | SERPINE1 | NA | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 620 | 2.910 | 0.3868 | Yes |
| 12 | C1R | NA | C1R Entrez, Source | complement component 1, r subcomponent | 694 | 2.734 | 0.4131 | Yes |
| 13 | CFI | NA | CFI Entrez, Source | complement factor I | 821 | 2.513 | 0.4340 | Yes |
| 14 | F3 | NA | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 876 | 2.438 | 0.4580 | Yes |
| 15 | CFD | NA | CFD Entrez, Source | complement factor D (adipsin) | 942 | 2.357 | 0.4806 | Yes |
| 16 | SERPING1 | NA | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 993 | 2.294 | 0.5032 | Yes |
| 17 | SERPIND1 | NA | SERPIND1 Entrez, Source | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 | 1051 | 2.227 | 0.5248 | Yes |
| 18 | CFB | NA | CFB Entrez, Source | complement factor B | 1197 | 2.041 | 0.5393 | Yes |
| 19 | PLG | NA | PLG Entrez, Source | plasminogen | 1857 | 1.494 | 0.5191 | Yes |
| 20 | BDKRB1 | NA | BDKRB1 Entrez, Source | bradykinin receptor B1 | 2028 | 1.409 | 0.5253 | Yes |
| 21 | C4B | NA | C4B Entrez, Source | complement component 4B (Childo blood group) | 2383 | 1.222 | 0.5191 | Yes |
| 22 | CR1 | NA | CR1 Entrez, Source | complement component (3b/4b) receptor 1 (Knops blood group) | 2414 | 1.210 | 0.5308 | Yes |
| 23 | C4A | NA | C4A Entrez, Source | complement component 4A (Rodgers blood group) | 2600 | 1.137 | 0.5331 | Yes |
| 24 | FGB | NA | FGB Entrez, Source | fibrinogen beta chain | 2666 | 1.107 | 0.5418 | Yes |
| 25 | C5AR1 | NA | C5AR1 Entrez, Source | complement component 5a receptor 1 | 3184 | 0.943 | 0.5234 | No |
| 26 | F13B | NA | F13B Entrez, Source | coagulation factor XIII, B polypeptide | 3390 | 0.883 | 0.5217 | No |
| 27 | FGA | NA | FGA Entrez, Source | fibrinogen alpha chain | 3609 | 0.840 | 0.5189 | No |
| 28 | C1S | NA | C1S Entrez, Source | complement component 1, s subcomponent | 3847 | 0.800 | 0.5145 | No |
| 29 | TFPI | NA | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 5087 | 0.539 | 0.4513 | No |
| 30 | F5 | NA | F5 Entrez, Source | coagulation factor V (proaccelerin, labile factor) | 5126 | 0.531 | 0.4551 | No |
| 31 | F11 | NA | F11 Entrez, Source | coagulation factor XI (plasma thromboplastin antecedent) | 5236 | 0.512 | 0.4547 | No |
| 32 | CD46 | NA | CD46 Entrez, Source | CD46 molecule, complement regulatory protein | 5468 | 0.483 | 0.4471 | No |
| 33 | SERPINF2 | NA | SERPINF2 Entrez, Source | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 | 6403 | 0.381 | 0.3992 | No |
| 34 | C6 | NA | C6 Entrez, Source | complement component 6 | 7318 | 0.239 | 0.3508 | No |
| 35 | PLAUR | NA | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 7676 | 0.188 | 0.3330 | No |
| 36 | F9 | NA | F9 Entrez, Source | coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B) | 7774 | 0.175 | 0.3295 | No |
| 37 | KNG1 | NA | KNG1 Entrez, Source | kininogen 1 | 8074 | 0.135 | 0.3143 | No |
| 38 | C9 | NA | C9 Entrez, Source | complement component 9 | 8168 | 0.125 | 0.3105 | No |
| 39 | MASP1 | NA | MASP1 Entrez, Source | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | 8586 | 0.068 | 0.2880 | No |
| 40 | C4BPA | NA | C4BPA Entrez, Source | complement component 4 binding protein, alpha | 8974 | 0.018 | 0.2666 | No |
| 41 | CD59 | NA | CD59 Entrez, Source | CD59 molecule, complement regulatory protein | 9435 | -0.005 | 0.2409 | No |
| 42 | F10 | NA | F10 Entrez, Source | coagulation factor X | 9456 | -0.007 | 0.2399 | No |
| 43 | C8A | NA | C8A Entrez, Source | complement component 8, alpha polypeptide | 9500 | -0.014 | 0.2376 | No |
| 44 | C7 | NA | C7 Entrez, Source | complement component 7 | 9558 | -0.024 | 0.2347 | No |
| 45 | F7 | NA | F7 Entrez, Source | coagulation factor VII (serum prothrombin conversion accelerator) | 10325 | -0.099 | 0.1931 | No |
| 46 | KLKB1 | NA | KLKB1 Entrez, Source | kallikrein B, plasma (Fletcher factor) 1 | 11119 | -0.214 | 0.1512 | No |
| 47 | BDKRB2 | NA | BDKRB2 Entrez, Source | bradykinin receptor B2 | 11387 | -0.252 | 0.1390 | No |
| 48 | CPB2 | NA | CPB2 Entrez, Source | carboxypeptidase B2 (plasma, carboxypeptidase U) | 11569 | -0.281 | 0.1321 | No |
| 49 | C8G | NA | C8G Entrez, Source | complement component 8, gamma polypeptide | 11727 | -0.300 | 0.1266 | No |
| 50 | PROC | NA | PROC Entrez, Source | protein C (inactivator of coagulation factors Va and VIIIa) | 11893 | -0.327 | 0.1210 | No |
| 51 | FGG | NA | FGG Entrez, Source | fibrinogen gamma chain | 12431 | -0.407 | 0.0956 | No |
| 52 | PROS1 | NA | PROS1 Entrez, Source | protein S (alpha) | 13016 | -0.458 | 0.0680 | No |
| 53 | F8 | NA | F8 Entrez, Source | coagulation factor VIII, procoagulant component (hemophilia A) | 13126 | -0.477 | 0.0672 | No |
| 54 | MBL2 | NA | MBL2 Entrez, Source | mannose-binding lectin (protein C) 2, soluble (opsonic defect) | 13245 | -0.495 | 0.0661 | No |
| 55 | C8B | NA | C8B Entrez, Source | complement component 8, beta polypeptide | 13690 | -0.574 | 0.0477 | No |
| 56 | SERPINC1 | NA | SERPINC1 Entrez, Source | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 13702 | -0.576 | 0.0535 | No |
| 57 | VWF | NA | VWF Entrez, Source | von Willebrand factor | 13772 | -0.589 | 0.0562 | No |
| 58 | F13A1 | NA | F13A1 Entrez, Source | coagulation factor XIII, A1 polypeptide | 14763 | -0.816 | 0.0100 | No |
| 59 | A2M | NA | A2M Entrez, Source | alpha-2-macroglobulin | 15303 | -0.943 | -0.0097 | No |
| 60 | C3AR1 | NA | C3AR1 Entrez, Source | complement component 3a receptor 1 | 16041 | -1.192 | -0.0376 | No |
| 61 | C5 | NA | C5 Entrez, Source | complement component 5 | 16535 | -1.431 | -0.0492 | No |
| 62 | SERPINA1 | NA | SERPINA1 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 16974 | -1.746 | -0.0543 | No |
| 63 | F2 | NA | F2 Entrez, Source | coagulation factor II (thrombin) | 17157 | -1.953 | -0.0428 | No |
| 64 | F12 | NA | F12 Entrez, Source | coagulation factor XII (Hageman factor) | 17344 | -2.238 | -0.0283 | No |
| 65 | SERPINA5 | NA | SERPINA5 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | 17565 | -2.622 | -0.0115 | No |
| 66 | C3 | NA | C3 Entrez, Source | complement component 3 | 17698 | -3.089 | 0.0154 | No |
