Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_COLORECTAL_CANCER |
| Enrichment Score (ES) | -0.35202393 |
| Normalized Enrichment Score (NES) | -1.3041768 |
| Nominal p-value | 0.07012195 |
| FDR q-value | 0.3266914 |
| FWER p-Value | 0.996 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | TCF7 | NA | TCF7 Entrez, Source | transcription factor 7 (T-cell specific, HMG-box) | 238 | 3.984 | 0.0567 | No |
| 2 | PIK3CA | NA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 693 | 2.734 | 0.0794 | No |
| 3 | CASP9 | NA | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 1081 | 2.192 | 0.0963 | No |
| 4 | TGFB3 | NA | TGFB3 Entrez, Source | transforming growth factor, beta 3 | 1345 | 1.887 | 0.1148 | No |
| 5 | PIK3R1 | NA | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 1994 | 1.422 | 0.1036 | No |
| 6 | TGFBR1 | NA | TGFBR1 Entrez, Source | transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) | 2106 | 1.356 | 0.1213 | No |
| 7 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 2109 | 1.354 | 0.1450 | No |
| 8 | TGFB2 | NA | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 3389 | 0.883 | 0.0891 | No |
| 9 | BCL2 | NA | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 3409 | 0.880 | 0.1035 | No |
| 10 | AXIN2 | NA | AXIN2 Entrez, Source | axin 2 (conductin, axil) | 3442 | 0.873 | 0.1170 | No |
| 11 | PIK3CB | NA | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 4450 | 0.668 | 0.0726 | No |
| 12 | CCND1 | NA | CCND1 Entrez, Source | cyclin D1 | 4946 | 0.569 | 0.0549 | No |
| 13 | ARAF | NA | ARAF Entrez, Source | v-raf murine sarcoma 3611 viral oncogene homolog | 5103 | 0.534 | 0.0556 | No |
| 14 | BAD | NA | BAD Entrez, Source | BCL2-antagonist of cell death | 6874 | 0.310 | -0.0378 | No |
| 15 | JUN | NA | JUN Entrez, Source | jun oncogene | 7197 | 0.258 | -0.0512 | No |
| 16 | FOS | NA | FOS Entrez, Source | v-fos FBJ murine osteosarcoma viral oncogene homolog | 7265 | 0.247 | -0.0506 | No |
| 17 | SMAD2 | NA | SMAD2 Entrez, Source | SMAD, mothers against DPP homolog 2 (Drosophila) | 7392 | 0.227 | -0.0536 | No |
| 18 | AKT2 | NA | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 8193 | 0.120 | -0.0962 | No |
| 19 | TGFB1 | NA | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 8450 | 0.087 | -0.1090 | No |
| 20 | APC | NA | APC Entrez, Source | adenomatosis polyposis coli | 8696 | 0.054 | -0.1217 | No |
| 21 | APC2 | NA | APC2 Entrez, Source | adenomatosis polyposis coli 2 | 8718 | 0.049 | -0.1220 | No |
| 22 | MAPK9 | NA | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 8847 | 0.036 | -0.1285 | No |
| 23 | KRAS | NA | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 9550 | -0.022 | -0.1673 | No |
| 24 | BAX | NA | BAX Entrez, Source | BCL2-associated X protein | 9792 | -0.051 | -0.1799 | No |
| 25 | MSH2 | NA | MSH2 Entrez, Source | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | 10163 | -0.085 | -0.1990 | No |
| 26 | MAPK10 | NA | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 10350 | -0.102 | -0.2076 | No |
| 27 | MAPK8 | NA | MAPK8 Entrez, Source | mitogen-activated protein kinase 8 | 10418 | -0.113 | -0.2094 | No |
| 28 | RAC1 | NA | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 10982 | -0.195 | -0.2374 | No |
| 29 | PIK3R5 | NA | PIK3R5 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 5, p101 | 11218 | -0.228 | -0.2465 | No |
| 30 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 11524 | -0.274 | -0.2587 | No |
| 31 | BRAF | NA | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 11539 | -0.277 | -0.2546 | No |
| 32 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 11952 | -0.332 | -0.2718 | No |
| 33 | RAF1 | NA | RAF1 Entrez, Source | v-raf-1 murine leukemia viral oncogene homolog 1 | 12700 | -0.434 | -0.3059 | No |
| 34 | BIRC5 | NA | BIRC5 Entrez, Source | baculoviral IAP repeat-containing 5 (survivin) | 13169 | -0.482 | -0.3235 | No |
| 35 | MSH6 | NA | MSH6 Entrez, Source | mutS homolog 6 (E. coli) | 13437 | -0.525 | -0.3292 | No |
| 36 | AKT1 | NA | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 13847 | -0.604 | -0.3414 | Yes |
| 37 | TCF7L2 | NA | TCF7L2 Entrez, Source | transcription factor 7-like 2 (T-cell specific, HMG-box) | 13906 | -0.615 | -0.3338 | Yes |
| 38 | CYCS | NA | CYCS Entrez, Source | cytochrome c, somatic | 13931 | -0.620 | -0.3243 | Yes |
| 39 | SMAD3 | NA | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 14025 | -0.642 | -0.3182 | Yes |
| 40 | RAC2 | NA | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 14098 | -0.658 | -0.3107 | Yes |
| 41 | AKT3 | NA | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 14156 | -0.671 | -0.3021 | Yes |
| 42 | SMAD4 | NA | SMAD4 Entrez, Source | SMAD, mothers against DPP homolog 4 (Drosophila) | 14181 | -0.678 | -0.2915 | Yes |
| 43 | CTNNB1 | NA | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 14196 | -0.681 | -0.2803 | Yes |
| 44 | RHOA | NA | RHOA Entrez, Source | ras homolog gene family, member A | 14227 | -0.687 | -0.2699 | Yes |
| 45 | AXIN1 | NA | AXIN1 Entrez, Source | axin 1 | 14551 | -0.767 | -0.2745 | Yes |
| 46 | PIK3R2 | NA | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 14983 | -0.863 | -0.2834 | Yes |
| 47 | MYC | NA | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 15055 | -0.881 | -0.2718 | Yes |
| 48 | MLH1 | NA | MLH1 Entrez, Source | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | 15889 | -1.132 | -0.2984 | Yes |
| 49 | GSK3B | NA | GSK3B Entrez, Source | glycogen synthase kinase 3 beta | 16081 | -1.206 | -0.2879 | Yes |
| 50 | RAC3 | NA | RAC3 Entrez, Source | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) | 16175 | -1.249 | -0.2712 | Yes |
| 51 | MSH3 | NA | MSH3 Entrez, Source | mutS homolog 3 (E. coli) | 16195 | -1.255 | -0.2502 | Yes |
| 52 | LEF1 | NA | LEF1 Entrez, Source | lymphoid enhancer-binding factor 1 | 16302 | -1.306 | -0.2332 | Yes |
| 53 | TGFBR2 | NA | TGFBR2 Entrez, Source | transforming growth factor, beta receptor II (70/80kDa) | 16329 | -1.323 | -0.2113 | Yes |
| 54 | APPL1 | NA | 16341 | -1.328 | -0.1886 | Yes | ||
| 55 | DCC | NA | DCC Entrez, Source | deleted in colorectal carcinoma | 16599 | -1.469 | -0.1772 | Yes |
| 56 | TCF7L1 | NA | TCF7L1 Entrez, Source | transcription factor 7-like 1 (T-cell specific, HMG-box) | 16609 | -1.475 | -0.1517 | Yes |
| 57 | RALGDS | NA | RALGDS Entrez, Source | ral guanine nucleotide dissociation stimulator | 16615 | -1.481 | -0.1260 | Yes |
| 58 | MAPK3 | NA | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 16746 | -1.562 | -0.1058 | Yes |
| 59 | MAP2K1 | NA | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 16861 | -1.650 | -0.0832 | Yes |
| 60 | CASP3 | NA | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 17177 | -1.978 | -0.0660 | Yes |
| 61 | TP53 | NA | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 17294 | -2.152 | -0.0347 | Yes |
| 62 | PIK3CG | NA | PIK3CG Entrez, Source | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 17882 | -4.130 | 0.0051 | Yes |
