Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_CITRATE_CYCLE_TCA_CYCLE |
| Enrichment Score (ES) | -0.4630432 |
| Normalized Enrichment Score (NES) | -1.4328891 |
| Nominal p-value | 0.04071247 |
| FDR q-value | 0.18441449 |
| FWER p-Value | 0.9 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | IDH1 | NA | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 1999 | 1.421 | -0.0572 | No |
| 2 | IDH3G | NA | IDH3G Entrez, Source | isocitrate dehydrogenase 3 (NAD+) gamma | 2303 | 1.252 | -0.0264 | No |
| 3 | OGDHL | NA | OGDHL Entrez, Source | oxoglutarate dehydrogenase-like | 2757 | 1.076 | -0.0106 | No |
| 4 | OGDH | NA | OGDH Entrez, Source | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 2818 | 1.054 | 0.0262 | No |
| 5 | SDHB | NA | SDHB Entrez, Source | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | 5299 | 0.500 | -0.0929 | No |
| 6 | PC | NA | PC Entrez, Source | pyruvate carboxylase | 5473 | 0.482 | -0.0842 | No |
| 7 | PCK1 | NA | PCK1 Entrez, Source | phosphoenolpyruvate carboxykinase 1 (soluble) | 5535 | 0.472 | -0.0696 | No |
| 8 | MDH2 | NA | MDH2 Entrez, Source | malate dehydrogenase 2, NAD (mitochondrial) | 6688 | 0.336 | -0.1210 | No |
| 9 | CS | NA | CS Entrez, Source | citrate synthase | 6914 | 0.304 | -0.1219 | No |
| 10 | DLST | NA | DLST Entrez, Source | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) | 8019 | 0.143 | -0.1780 | No |
| 11 | ACO2 | NA | ACO2 Entrez, Source | aconitase 2, mitochondrial | 8290 | 0.109 | -0.1889 | No |
| 12 | SDHA | NA | SDHA Entrez, Source | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | 10024 | -0.071 | -0.2827 | No |
| 13 | PDHA1 | NA | PDHA1 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 1 | 11566 | -0.281 | -0.3579 | No |
| 14 | PDHB | NA | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 13068 | -0.466 | -0.4238 | No |
| 15 | SDHC | NA | SDHC Entrez, Source | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa | 13774 | -0.589 | -0.4406 | Yes |
| 16 | DLD | NA | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 13981 | -0.630 | -0.4281 | Yes |
| 17 | SDHD | NA | SDHD Entrez, Source | succinate dehydrogenase complex, subunit D, integral membrane protein | 14135 | -0.666 | -0.4112 | Yes |
| 18 | DLAT | NA | DLAT Entrez, Source | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | 14426 | -0.732 | -0.3994 | Yes |
| 19 | FH | NA | FH Entrez, Source | fumarate hydratase | 14758 | -0.815 | -0.3868 | Yes |
| 20 | ACO1 | NA | ACO1 Entrez, Source | aconitase 1, soluble | 15335 | -0.951 | -0.3827 | Yes |
| 21 | PCK2 | NA | PCK2 Entrez, Source | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 15512 | -1.001 | -0.3543 | Yes |
| 22 | IDH3A | NA | IDH3A Entrez, Source | isocitrate dehydrogenase 3 (NAD+) alpha | 15719 | -1.066 | -0.3252 | Yes |
| 23 | ACLY | NA | ACLY Entrez, Source | ATP citrate lyase | 16197 | -1.256 | -0.3039 | Yes |
| 24 | SUCLG2 | NA | SUCLG2 Entrez, Source | succinate-CoA ligase, GDP-forming, beta subunit | 16477 | -1.402 | -0.2659 | Yes |
| 25 | SUCLA2 | NA | SUCLA2 Entrez, Source | succinate-CoA ligase, ADP-forming, beta subunit | 16541 | -1.434 | -0.2148 | Yes |
| 26 | MDH1 | NA | MDH1 Entrez, Source | malate dehydrogenase 1, NAD (soluble) | 17141 | -1.921 | -0.1750 | Yes |
| 27 | IDH2 | NA | IDH2 Entrez, Source | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 17605 | -2.752 | -0.0958 | Yes |
| 28 | SUCLG1 | NA | SUCLG1 Entrez, Source | succinate-CoA ligase, GDP-forming, alpha subunit | 17688 | -3.052 | 0.0159 | Yes |
