Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_CELL_CYCLE |
| Enrichment Score (ES) | -0.35260943 |
| Normalized Enrichment Score (NES) | -1.447154 |
| Nominal p-value | 0.010830325 |
| FDR q-value | 0.18159004 |
| FWER p-Value | 0.872 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CDKN1A | NA | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 888 | 2.413 | -0.0230 | No |
| 2 | ZBTB17 | NA | ZBTB17 Entrez, Source | zinc finger and BTB domain containing 17 | 913 | 2.404 | 0.0023 | No |
| 3 | CCND3 | NA | CCND3 Entrez, Source | cyclin D3 | 1309 | 1.922 | 0.0014 | No |
| 4 | TGFB3 | NA | TGFB3 Entrez, Source | transforming growth factor, beta 3 | 1345 | 1.887 | 0.0204 | No |
| 5 | MAD2L2 | NA | MAD2L2 Entrez, Source | MAD2 mitotic arrest deficient-like 2 (yeast) | 1814 | 1.523 | 0.0110 | No |
| 6 | CDC25B | NA | CDC25B Entrez, Source | cell division cycle 25B | 2781 | 1.067 | -0.0313 | No |
| 7 | CDC14B | NA | CDC14B Entrez, Source | CDC14 cell division cycle 14 homolog B (S. cerevisiae) | 2854 | 1.043 | -0.0238 | No |
| 8 | MDM2 | NA | MDM2 Entrez, Source | Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) | 2914 | 1.022 | -0.0158 | No |
| 9 | CDKN1B | NA | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 2942 | 1.008 | -0.0061 | No |
| 10 | SKP1 | NA | 3071 | 0.970 | -0.0025 | No | ||
| 11 | CCNH | NA | CCNH Entrez, Source | cyclin H | 3227 | 0.933 | -0.0009 | No |
| 12 | TGFB2 | NA | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 3389 | 0.883 | -0.0001 | No |
| 13 | BUB1 | NA | BUB1 Entrez, Source | BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) | 3781 | 0.813 | -0.0130 | No |
| 14 | GADD45G | NA | GADD45G Entrez, Source | growth arrest and DNA-damage-inducible, gamma | 3866 | 0.795 | -0.0089 | No |
| 15 | HDAC1 | NA | HDAC1 Entrez, Source | histone deacetylase 1 | 4094 | 0.741 | -0.0134 | No |
| 16 | CDC6 | NA | CDC6 Entrez, Source | CDC6 cell division cycle 6 homolog (S. cerevisiae) | 4305 | 0.700 | -0.0174 | No |
| 17 | SMC1B | NA | SMC1B Entrez, Source | structural maintenance of chromosomes 1B | 4403 | 0.677 | -0.0154 | No |
| 18 | E2F3 | NA | E2F3 Entrez, Source | E2F transcription factor 3 | 4563 | 0.644 | -0.0171 | No |
| 19 | ORC4 | NA | 4673 | 0.624 | -0.0163 | No | ||
| 20 | PTTG1 | NA | PTTG1 Entrez, Source | pituitary tumor-transforming 1 | 4819 | 0.590 | -0.0179 | No |
| 21 | EP300 | NA | EP300 Entrez, Source | E1A binding protein p300 | 4832 | 0.587 | -0.0121 | No |
| 22 | CCND1 | NA | CCND1 Entrez, Source | cyclin D1 | 4946 | 0.569 | -0.0121 | No |
| 23 | SMC1A | NA | SMC1A Entrez, Source | structural maintenance of chromosomes 1A | 5005 | 0.557 | -0.0092 | No |
| 24 | TFDP2 | NA | TFDP2 Entrez, Source | transcription factor Dp-2 (E2F dimerization partner 2) | 5308 | 0.499 | -0.0206 | No |
| 25 | E2F5 | NA | E2F5 Entrez, Source | E2F transcription factor 5, p130-binding | 5620 | 0.457 | -0.0330 | No |
| 26 | CUL1 | NA | CUL1 Entrez, Source | cullin 1 | 5700 | 0.445 | -0.0324 | No |
| 27 | CDC23 | NA | CDC23 Entrez, Source | CDC23 (cell division cycle 23, yeast, homolog) | 5767 | 0.435 | -0.0313 | No |
| 28 | ANAPC4 | NA | ANAPC4 Entrez, Source | anaphase promoting complex subunit 4 | 6387 | 0.383 | -0.0618 | No |
| 29 | CDC25C | NA | CDC25C Entrez, Source | cell division cycle 25C | 6556 | 0.357 | -0.0672 | No |
| 30 | DBF4 | NA | DBF4 Entrez, Source | DBF4 homolog (S. cerevisiae) | 7217 | 0.255 | -0.1014 | No |
| 31 | CCNE1 | NA | CCNE1 Entrez, Source | cyclin E1 | 7352 | 0.234 | -0.1063 | No |
| 32 | SMAD2 | NA | SMAD2 Entrez, Source | SMAD, mothers against DPP homolog 2 (Drosophila) | 7392 | 0.227 | -0.1059 | No |
| 33 | ORC2 | NA | 7701 | 0.184 | -0.1212 | No | ||
| 34 | CDC14A | NA | CDC14A Entrez, Source | CDC14 cell division cycle 14 homolog A (S. cerevisiae) | 8044 | 0.140 | -0.1388 | No |
| 35 | CREBBP | NA | CREBBP Entrez, Source | CREB binding protein (Rubinstein-Taybi syndrome) | 8158 | 0.126 | -0.1437 | No |
| 36 | CCNA1 | NA | CCNA1 Entrez, Source | cyclin A1 | 8359 | 0.100 | -0.1538 | No |
| 37 | TGFB1 | NA | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 8450 | 0.087 | -0.1579 | No |
| 38 | WEE2 | NA | WEE2 Entrez, Source | WEE1 homolog 2 (S. pombe) | 8658 | 0.058 | -0.1688 | No |
| 39 | CDKN2D | NA | CDKN2D Entrez, Source | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 8702 | 0.052 | -0.1707 | No |
| 40 | YWHAG | NA | YWHAG Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | 8729 | 0.048 | -0.1716 | No |
| 41 | CDKN2A | NA | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 9300 | 0.000 | -0.2035 | No |
| 42 | PTTG2 | NA | PTTG2 Entrez, Source | pituitary tumor-transforming 2 | 9317 | 0.000 | -0.2044 | No |
| 43 | CDC27 | NA | CDC27 Entrez, Source | cell division cycle 27 | 9473 | -0.010 | -0.2130 | No |
| 44 | YWHAQ | NA | YWHAQ Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | 9488 | -0.013 | -0.2136 | No |
| 45 | ORC5 | NA | 9523 | -0.019 | -0.2153 | No | ||
| 46 | MCM3 | NA | MCM3 Entrez, Source | MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) | 10258 | -0.093 | -0.2554 | No |
| 47 | ANAPC2 | NA | ANAPC2 Entrez, Source | anaphase promoting complex subunit 2 | 10537 | -0.129 | -0.2696 | No |
| 48 | CDC20 | NA | CDC20 Entrez, Source | CDC20 cell division cycle 20 homolog (S. cerevisiae) | 11005 | -0.198 | -0.2935 | No |
| 49 | CDK7 | NA | CDK7 Entrez, Source | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 11014 | -0.200 | -0.2918 | No |
| 50 | ANAPC7 | NA | ANAPC7 Entrez, Source | anaphase promoting complex subunit 7 | 11082 | -0.209 | -0.2932 | No |
| 51 | ABL1 | NA | ABL1 Entrez, Source | v-abl Abelson murine leukemia viral oncogene homolog 1 | 11310 | -0.241 | -0.3032 | No |
| 52 | ANAPC11 | NA | ANAPC11 Entrez, Source | APC11 anaphase promoting complex subunit 11 homolog (yeast) | 11365 | -0.248 | -0.3035 | No |
| 53 | CDKN2B | NA | CDKN2B Entrez, Source | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | 11530 | -0.275 | -0.3097 | No |
| 54 | RBX1 | NA | RBX1 Entrez, Source | ring-box 1 | 11557 | -0.279 | -0.3080 | No |
| 55 | PRKDC | NA | PRKDC Entrez, Source | protein kinase, DNA-activated, catalytic polypeptide | 11616 | -0.286 | -0.3081 | No |
| 56 | CDK6 | NA | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 11618 | -0.286 | -0.3050 | No |
| 57 | CHEK1 | NA | CHEK1 Entrez, Source | CHK1 checkpoint homolog (S. pombe) | 11651 | -0.289 | -0.3036 | No |
| 58 | ANAPC13 | NA | ANAPC13 Entrez, Source | anaphase promoting complex subunit 13 | 12330 | -0.388 | -0.3373 | No |
| 59 | ATM | NA | ATM Entrez, Source | ataxia telangiectasia mutated (includes complementation groups A, C and D) | 12356 | -0.392 | -0.3343 | No |
| 60 | CCNB3 | NA | CCNB3 Entrez, Source | cyclin B3 | 12387 | -0.398 | -0.3316 | No |
| 61 | PKMYT1 | NA | PKMYT1 Entrez, Source | protein kinase, membrane associated tyrosine/threonine 1 | 12442 | -0.408 | -0.3301 | No |
| 62 | YWHAH | NA | YWHAH Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 12614 | -0.418 | -0.3351 | No |
| 63 | CDKN1C | NA | CDKN1C Entrez, Source | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 12628 | -0.419 | -0.3311 | No |
| 64 | MCM6 | NA | MCM6 Entrez, Source | MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) | 12750 | -0.444 | -0.3330 | No |
| 65 | MAD1L1 | NA | MAD1L1 Entrez, Source | MAD1 mitotic arrest deficient-like 1 (yeast) | 13030 | -0.460 | -0.3435 | No |
| 66 | CCNE2 | NA | CCNE2 Entrez, Source | cyclin E2 | 13105 | -0.473 | -0.3424 | No |
| 67 | PCNA | NA | PCNA Entrez, Source | proliferating cell nuclear antigen | 13241 | -0.495 | -0.3445 | No |
| 68 | E2F2 | NA | E2F2 Entrez, Source | E2F transcription factor 2 | 13257 | -0.498 | -0.3398 | No |
| 69 | ANAPC10 | NA | ANAPC10 Entrez, Source | anaphase promoting complex subunit 10 | 13453 | -0.527 | -0.3449 | No |
| 70 | YWHAE | NA | YWHAE Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 13591 | -0.556 | -0.3465 | Yes |
| 71 | CCNB1 | NA | CCNB1 Entrez, Source | cyclin B1 | 13592 | -0.556 | -0.3403 | Yes |
| 72 | ANAPC1 | NA | ANAPC1 Entrez, Source | anaphase promoting complex subunit 1 | 13600 | -0.558 | -0.3345 | Yes |
| 73 | FZR1 | NA | FZR1 Entrez, Source | fizzy/cell division cycle 20 related 1 (Drosophila) | 13710 | -0.579 | -0.3342 | Yes |
| 74 | E2F1 | NA | E2F1 Entrez, Source | E2F transcription factor 1 | 13748 | -0.585 | -0.3298 | Yes |
| 75 | RBL1 | NA | RBL1 Entrez, Source | retinoblastoma-like 1 (p107) | 13911 | -0.617 | -0.3320 | Yes |
| 76 | GADD45B | NA | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 13919 | -0.618 | -0.3256 | Yes |
| 77 | CDK4 | NA | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 13941 | -0.622 | -0.3199 | Yes |
| 78 | STAG2 | NA | STAG2 Entrez, Source | stromal antigen 2 | 13963 | -0.626 | -0.3141 | Yes |
| 79 | MCM7 | NA | MCM7 Entrez, Source | MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) | 13965 | -0.626 | -0.3072 | Yes |
| 80 | SMAD3 | NA | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 14025 | -0.642 | -0.3034 | Yes |
| 81 | PLK1 | NA | PLK1 Entrez, Source | polo-like kinase 1 (Drosophila) | 14126 | -0.664 | -0.3017 | Yes |
| 82 | SMAD4 | NA | SMAD4 Entrez, Source | SMAD, mothers against DPP homolog 4 (Drosophila) | 14181 | -0.678 | -0.2972 | Yes |
| 83 | CDC7 | NA | CDC7 Entrez, Source | CDC7 cell division cycle 7 (S. cerevisiae) | 14187 | -0.679 | -0.2899 | Yes |
| 84 | CCNA2 | NA | CCNA2 Entrez, Source | cyclin A2 | 14235 | -0.689 | -0.2849 | Yes |
| 85 | ORC3 | NA | 14391 | -0.722 | -0.2856 | Yes | ||
| 86 | YWHAZ | NA | YWHAZ Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 14444 | -0.739 | -0.2804 | Yes |
| 87 | CDC26 | NA | CDC26 Entrez, Source | cell division cycle 26 | 14457 | -0.743 | -0.2728 | Yes |
| 88 | ESPL1 | NA | ESPL1 Entrez, Source | extra spindle poles like 1 (S. cerevisiae) | 14462 | -0.745 | -0.2648 | Yes |
| 89 | CDC45 | NA | 14502 | -0.753 | -0.2586 | Yes | ||
| 90 | ATR | NA | ATR Entrez, Source | ataxia telangiectasia and Rad3 related | 14531 | -0.762 | -0.2518 | Yes |
| 91 | YWHAB | NA | YWHAB Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 14532 | -0.762 | -0.2433 | Yes |
| 92 | RAD21 | NA | RAD21 Entrez, Source | RAD21 homolog (S. pombe) | 14590 | -0.774 | -0.2379 | Yes |
| 93 | CDC16 | NA | CDC16 Entrez, Source | CDC16 cell division cycle 16 homolog (S. cerevisiae) | 14599 | -0.776 | -0.2298 | Yes |
| 94 | ORC1 | NA | 14680 | -0.795 | -0.2255 | Yes | ||
| 95 | CDK2 | NA | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 14755 | -0.815 | -0.2206 | Yes |
| 96 | MCM4 | NA | MCM4 Entrez, Source | MCM4 minichromosome maintenance deficient 4 (S. cerevisiae) | 14975 | -0.861 | -0.2233 | Yes |
| 97 | MYC | NA | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 15055 | -0.881 | -0.2180 | Yes |
| 98 | BUB1B | NA | BUB1B Entrez, Source | BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 15148 | -0.902 | -0.2131 | Yes |
| 99 | CDC25A | NA | CDC25A Entrez, Source | cell division cycle 25A | 15209 | -0.915 | -0.2064 | Yes |
| 100 | MAD2L1 | NA | MAD2L1 Entrez, Source | MAD2 mitotic arrest deficient-like 1 (yeast) | 15344 | -0.954 | -0.2033 | Yes |
| 101 | HDAC2 | NA | HDAC2 Entrez, Source | histone deacetylase 2 | 15421 | -0.974 | -0.1968 | Yes |
| 102 | MCM5 | NA | MCM5 Entrez, Source | MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) | 15464 | -0.988 | -0.1882 | Yes |
| 103 | CDKN2C | NA | CDKN2C Entrez, Source | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 15593 | -1.025 | -0.1840 | Yes |
| 104 | MCM2 | NA | MCM2 Entrez, Source | MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) | 15624 | -1.036 | -0.1742 | Yes |
| 105 | GADD45A | NA | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 15708 | -1.064 | -0.1671 | Yes |
| 106 | E2F4 | NA | E2F4 Entrez, Source | E2F transcription factor 4, p107/p130-binding | 15750 | -1.078 | -0.1574 | Yes |
| 107 | ORC6 | NA | 15806 | -1.098 | -0.1483 | Yes | ||
| 108 | BUB3 | NA | BUB3 Entrez, Source | BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) | 15915 | -1.142 | -0.1417 | Yes |
| 109 | CHEK2 | NA | CHEK2 Entrez, Source | CHK2 checkpoint homolog (S. pombe) | 16039 | -1.190 | -0.1355 | Yes |
| 110 | CCND2 | NA | CCND2 Entrez, Source | cyclin D2 | 16061 | -1.200 | -0.1233 | Yes |
| 111 | GSK3B | NA | GSK3B Entrez, Source | glycogen synthase kinase 3 beta | 16081 | -1.206 | -0.1110 | Yes |
| 112 | STAG1 | NA | STAG1 Entrez, Source | stromal antigen 1 | 16118 | -1.222 | -0.0995 | Yes |
| 113 | RB1 | NA | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 16178 | -1.250 | -0.0890 | Yes |
| 114 | RBL2 | NA | RBL2 Entrez, Source | retinoblastoma-like 2 (p130) | 16301 | -1.306 | -0.0814 | Yes |
| 115 | SFN | NA | SFN Entrez, Source | stratifin | 16410 | -1.369 | -0.0723 | Yes |
| 116 | WEE1 | NA | WEE1 Entrez, Source | WEE1 homolog (S. pombe) | 16440 | -1.384 | -0.0586 | Yes |
| 117 | SMC3 | NA | SMC3 Entrez, Source | structural maintenance of chromosomes 3 | 16499 | -1.412 | -0.0462 | Yes |
| 118 | TFDP1 | NA | TFDP1 Entrez, Source | transcription factor Dp-1 | 16542 | -1.434 | -0.0326 | Yes |
| 119 | ANAPC5 | NA | ANAPC5 Entrez, Source | anaphase promoting complex subunit 5 | 16597 | -1.464 | -0.0194 | Yes |
| 120 | CDK1 | NA | 16637 | -1.491 | -0.0051 | Yes | ||
| 121 | CCNB2 | NA | CCNB2 Entrez, Source | cyclin B2 | 16828 | -1.630 | 0.0023 | Yes |
| 122 | TTK | NA | TTK Entrez, Source | TTK protein kinase | 16883 | -1.669 | 0.0178 | Yes |
| 123 | SKP2 | NA | SKP2 Entrez, Source | S-phase kinase-associated protein 2 (p45) | 16979 | -1.751 | 0.0318 | Yes |
| 124 | TP53 | NA | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 17294 | -2.152 | 0.0381 | Yes |
