Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_BASE_EXCISION_REPAIR |
| Enrichment Score (ES) | -0.5298579 |
| Normalized Enrichment Score (NES) | -1.7487925 |
| Nominal p-value | 0.005449591 |
| FDR q-value | 0.042360194 |
| FWER p-Value | 0.15 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | POLB | NA | POLB Entrez, Source | polymerase (DNA directed), beta | 841 | 2.488 | 0.0290 | No |
| 2 | APEX2 | NA | APEX2 Entrez, Source | APEX nuclease (apurinic/apyrimidinic endonuclease) 2 | 1877 | 1.486 | 0.0166 | No |
| 3 | NEIL2 | NA | NEIL2 Entrez, Source | nei like 2 (E. coli) | 3026 | 0.983 | -0.0174 | No |
| 4 | LIG3 | NA | LIG3 Entrez, Source | ligase III, DNA, ATP-dependent | 3711 | 0.828 | -0.0302 | No |
| 5 | NEIL3 | NA | NEIL3 Entrez, Source | nei endonuclease VIII-like 3 (E. coli) | 7486 | 0.213 | -0.2341 | No |
| 6 | POLL | NA | POLL Entrez, Source | polymerase (DNA directed), lambda | 8239 | 0.115 | -0.2725 | No |
| 7 | SMUG1 | NA | SMUG1 Entrez, Source | single-strand-selective monofunctional uracil-DNA glycosylase 1 | 8288 | 0.109 | -0.2718 | No |
| 8 | POLE | NA | POLE Entrez, Source | polymerase (DNA directed), epsilon | 10020 | -0.071 | -0.3662 | No |
| 9 | TDG | NA | TDG Entrez, Source | thymine-DNA glycosylase | 10456 | -0.117 | -0.3868 | No |
| 10 | MBD4 | NA | MBD4 Entrez, Source | methyl-CpG binding domain protein 4 | 10596 | -0.140 | -0.3903 | No |
| 11 | POLE2 | NA | POLE2 Entrez, Source | polymerase (DNA directed), epsilon 2 (p59 subunit) | 11124 | -0.215 | -0.4131 | No |
| 12 | OGG1 | NA | OGG1 Entrez, Source | 8-oxoguanine DNA glycosylase | 11423 | -0.258 | -0.4219 | No |
| 13 | UNG | NA | UNG Entrez, Source | uracil-DNA glycosylase | 11768 | -0.307 | -0.4317 | No |
| 14 | PCNA | NA | PCNA Entrez, Source | proliferating cell nuclear antigen | 13241 | -0.495 | -0.4986 | No |
| 15 | POLD1 | NA | POLD1 Entrez, Source | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 13802 | -0.595 | -0.5117 | Yes |
| 16 | POLD4 | NA | POLD4 Entrez, Source | polymerase (DNA-directed), delta 4 | 13855 | -0.605 | -0.4961 | Yes |
| 17 | POLE3 | NA | POLE3 Entrez, Source | polymerase (DNA directed), epsilon 3 (p17 subunit) | 14225 | -0.686 | -0.4958 | Yes |
| 18 | POLD3 | NA | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 14617 | -0.783 | -0.4937 | Yes |
| 19 | XRCC1 | NA | XRCC1 Entrez, Source | X-ray repair complementing defective repair in Chinese hamster cells 1 | 15076 | -0.887 | -0.4922 | Yes |
| 20 | POLD2 | NA | POLD2 Entrez, Source | polymerase (DNA directed), delta 2, regulatory subunit 50kDa | 15203 | -0.914 | -0.4713 | Yes |
| 21 | NTHL1 | NA | NTHL1 Entrez, Source | nth endonuclease III-like 1 (E. coli) | 15286 | -0.937 | -0.4473 | Yes |
| 22 | FEN1 | NA | FEN1 Entrez, Source | flap structure-specific endonuclease 1 | 15662 | -1.051 | -0.4362 | Yes |
| 23 | APEX1 | NA | APEX1 Entrez, Source | APEX nuclease (multifunctional DNA repair enzyme) 1 | 16264 | -1.287 | -0.4304 | Yes |
| 24 | LIG1 | NA | LIG1 Entrez, Source | ligase I, DNA, ATP-dependent | 16383 | -1.354 | -0.3957 | Yes |
| 25 | PARP4 | NA | PARP4 Entrez, Source | poly (ADP-ribose) polymerase family, member 4 | 16584 | -1.453 | -0.3625 | Yes |
| 26 | MPG | NA | MPG Entrez, Source | N-methylpurine-DNA glycosylase | 16606 | -1.472 | -0.3188 | Yes |
| 27 | PARP1 | NA | PARP1 Entrez, Source | poly (ADP-ribose) polymerase family, member 1 | 16705 | -1.536 | -0.2774 | Yes |
| 28 | NEIL1 | NA | NEIL1 Entrez, Source | nei endonuclease VIII-like 1 (E. coli) | 16713 | -1.540 | -0.2308 | Yes |
| 29 | PARP2 | NA | PARP2 Entrez, Source | poly (ADP-ribose) polymerase family, member 2 | 16739 | -1.557 | -0.1847 | Yes |
| 30 | MUTYH | NA | MUTYH Entrez, Source | mutY homolog (E. coli) | 17034 | -1.800 | -0.1462 | Yes |
| 31 | PARP3 | NA | PARP3 Entrez, Source | poly (ADP-ribose) polymerase family, member 3 | 17184 | -1.984 | -0.0940 | Yes |
| 32 | POLE4 | NA | POLE4 Entrez, Source | polymerase (DNA-directed), epsilon 4 (p12 subunit) | 17248 | -2.078 | -0.0341 | Yes |
| 33 | HMGB1 | NA | HMGB1 Entrez, Source | high-mobility group box 1 | 17472 | -2.444 | 0.0280 | Yes |
