Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_AXON_GUIDANCE |
| Enrichment Score (ES) | 0.44915587 |
| Normalized Enrichment Score (NES) | 1.6670005 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.031235758 |
| FWER p-Value | 0.375 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | NTN4 | NA | NTN4 Entrez, Source | netrin 4 | 62 | 4.671 | 0.0262 | Yes |
| 2 | CXCR4 | NA | CXCR4 Entrez, Source | chemokine (C-X-C motif) receptor 4 | 90 | 4.546 | 0.0536 | Yes |
| 3 | NGEF | NA | NGEF Entrez, Source | neuronal guanine nucleotide exchange factor | 162 | 4.261 | 0.0768 | Yes |
| 4 | EPHA4 | NA | EPHA4 Entrez, Source | EPH receptor A4 | 182 | 4.185 | 0.1023 | Yes |
| 5 | NFATC2 | NA | NFATC2 Entrez, Source | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 297 | 3.741 | 0.1197 | Yes |
| 6 | SEMA3B | NA | SEMA3B Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 360 | 3.556 | 0.1389 | Yes |
| 7 | DPYSL2 | NA | DPYSL2 Entrez, Source | dihydropyrimidinase-like 2 | 365 | 3.537 | 0.1611 | Yes |
| 8 | SEMA6A | NA | SEMA6A Entrez, Source | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | 417 | 3.394 | 0.1799 | Yes |
| 9 | SEMA3C | NA | SEMA3C Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 556 | 3.054 | 0.1915 | Yes |
| 10 | PLXNA3 | NA | PLXNA3 Entrez, Source | plexin A3 | 635 | 2.888 | 0.2055 | Yes |
| 11 | EPHA2 | NA | EPHA2 Entrez, Source | EPH receptor A2 | 650 | 2.849 | 0.2229 | Yes |
| 12 | SLIT2 | NA | SLIT2 Entrez, Source | slit homolog 2 (Drosophila) | 698 | 2.728 | 0.2376 | Yes |
| 13 | SEMA3D | NA | SEMA3D Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | 703 | 2.723 | 0.2547 | Yes |
| 14 | SEMA3F | NA | SEMA3F Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F | 711 | 2.701 | 0.2715 | Yes |
| 15 | UNC5C | NA | UNC5C Entrez, Source | unc-5 homolog C (C. elegans) | 752 | 2.635 | 0.2860 | Yes |
| 16 | EPHB2 | NA | EPHB2 Entrez, Source | EPH receptor B2 | 784 | 2.574 | 0.3006 | Yes |
| 17 | MET | NA | MET Entrez, Source | met proto-oncogene (hepatocyte growth factor receptor) | 871 | 2.445 | 0.3114 | Yes |
| 18 | EPHB1 | NA | EPHB1 Entrez, Source | EPH receptor B1 | 948 | 2.343 | 0.3220 | Yes |
| 19 | PLXNA1 | NA | PLXNA1 Entrez, Source | plexin A1 | 1054 | 2.222 | 0.3303 | Yes |
| 20 | RHOD | NA | RHOD Entrez, Source | ras homolog gene family, member D | 1055 | 2.220 | 0.3444 | Yes |
| 21 | EPHA7 | NA | EPHA7 Entrez, Source | EPH receptor A7 | 1272 | 1.962 | 0.3447 | Yes |
| 22 | EPHA5 | NA | EPHA5 Entrez, Source | EPH receptor A5 | 1348 | 1.887 | 0.3525 | Yes |
| 23 | EFNB2 | NA | EFNB2 Entrez, Source | ephrin-B2 | 1408 | 1.837 | 0.3609 | Yes |
| 24 | PPP3CC | NA | PPP3CC Entrez, Source | protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma) | 1484 | 1.773 | 0.3680 | Yes |
| 25 | SEMA6D | NA | SEMA6D Entrez, Source | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D | 1486 | 1.771 | 0.3792 | Yes |
| 26 | EPHB3 | NA | EPHB3 Entrez, Source | EPH receptor B3 | 1499 | 1.766 | 0.3898 | Yes |
| 27 | LIMK1 | NA | LIMK1 Entrez, Source | LIM domain kinase 1 | 1770 | 1.544 | 0.3845 | Yes |
| 28 | ROBO2 | NA | ROBO2 Entrez, Source | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 1837 | 1.507 | 0.3903 | Yes |
| 29 | PLXNA2 | NA | PLXNA2 Entrez, Source | plexin A2 | 1893 | 1.475 | 0.3966 | Yes |
| 30 | SRGAP1 | NA | SRGAP1 Entrez, Source | SLIT-ROBO Rho GTPase activating protein 1 | 1932 | 1.454 | 0.4038 | Yes |
| 31 | ABLIM2 | NA | ABLIM2 Entrez, Source | actin binding LIM protein family, member 2 | 2044 | 1.397 | 0.4064 | Yes |
| 32 | EFNA5 | NA | EFNA5 Entrez, Source | ephrin-A5 | 2119 | 1.348 | 0.4109 | Yes |
| 33 | NRP1 | NA | NRP1 Entrez, Source | neuropilin 1 | 2191 | 1.309 | 0.4152 | Yes |
| 34 | CFL2 | NA | CFL2 Entrez, Source | cofilin 2 (muscle) | 2222 | 1.294 | 0.4218 | Yes |
| 35 | GNAI1 | NA | GNAI1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 2274 | 1.270 | 0.4270 | Yes |
| 36 | SEMA4D | NA | SEMA4D Entrez, Source | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | 2277 | 1.266 | 0.4349 | Yes |
| 37 | DPYSL5 | NA | DPYSL5 Entrez, Source | dihydropyrimidinase-like 5 | 2386 | 1.221 | 0.4366 | Yes |
| 38 | EFNB1 | NA | EFNB1 Entrez, Source | ephrin-B1 | 2479 | 1.186 | 0.4390 | Yes |
| 39 | NFAT5 | NA | NFAT5 Entrez, Source | nuclear factor of activated T-cells 5, tonicity-responsive | 2671 | 1.106 | 0.4353 | Yes |
| 40 | SLIT1 | NA | SLIT1 Entrez, Source | slit homolog 1 (Drosophila) | 2839 | 1.047 | 0.4326 | Yes |
| 41 | EPHA6 | NA | EPHA6 Entrez, Source | EPH receptor A6 | 2881 | 1.036 | 0.4369 | Yes |
| 42 | PAK6 | NA | PAK6 Entrez, Source | p21(CDKN1A)-activated kinase 6 | 2890 | 1.033 | 0.4431 | Yes |
| 43 | PAK2 | NA | PAK2 Entrez, Source | p21 (CDKN1A)-activated kinase 2 | 2899 | 1.029 | 0.4492 | Yes |
| 44 | EPHA3 | NA | EPHA3 Entrez, Source | EPH receptor A3 | 3187 | 0.942 | 0.4391 | No |
| 45 | UNC5D | NA | UNC5D Entrez, Source | unc-5 homolog D (C. elegans) | 3289 | 0.916 | 0.4392 | No |
| 46 | PLXNC1 | NA | PLXNC1 Entrez, Source | plexin C1 | 3291 | 0.915 | 0.4450 | No |
| 47 | EPHA8 | NA | EPHA8 Entrez, Source | EPH receptor A8 | 3673 | 0.833 | 0.4289 | No |
| 48 | PAK3 | NA | PAK3 Entrez, Source | p21 (CDKN1A)-activated kinase 3 | 3677 | 0.833 | 0.4341 | No |
| 49 | RND1 | NA | RND1 Entrez, Source | Rho family GTPase 1 | 4188 | 0.722 | 0.4101 | No |
| 50 | ABLIM3 | NA | ABLIM3 Entrez, Source | actin binding LIM protein family, member 3 | 4519 | 0.653 | 0.3958 | No |
| 51 | RASA1 | NA | RASA1 Entrez, Source | RAS p21 protein activator (GTPase activating protein) 1 | 5001 | 0.558 | 0.3724 | No |
| 52 | EPHB6 | NA | EPHB6 Entrez, Source | EPH receptor B6 | 5074 | 0.542 | 0.3718 | No |
| 53 | EPHB4 | NA | EPHB4 Entrez, Source | EPH receptor B4 | 5153 | 0.527 | 0.3707 | No |
| 54 | CXCL12 | NA | CXCL12 Entrez, Source | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | 5453 | 0.483 | 0.3571 | No |
| 55 | ARHGEF12 | NA | ARHGEF12 Entrez, Source | Rho guanine nucleotide exchange factor (GEF) 12 | 5631 | 0.455 | 0.3500 | No |
| 56 | NCK2 | NA | NCK2 Entrez, Source | NCK adaptor protein 2 | 5645 | 0.453 | 0.3522 | No |
| 57 | ROCK2 | NA | ROCK2 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 2 | 5670 | 0.449 | 0.3537 | No |
| 58 | ABLIM1 | NA | ABLIM1 Entrez, Source | actin binding LIM protein 1 | 5712 | 0.441 | 0.3542 | No |
| 59 | CDC42 | NA | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 6248 | 0.408 | 0.3268 | No |
| 60 | FYN | NA | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 6328 | 0.393 | 0.3249 | No |
| 61 | PLXNB2 | NA | PLXNB2 Entrez, Source | plexin B2 | 6655 | 0.342 | 0.3088 | No |
| 62 | SEMA4A | NA | SEMA4A Entrez, Source | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 7032 | 0.284 | 0.2896 | No |
| 63 | ROCK1 | NA | ROCK1 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 1 | 7149 | 0.266 | 0.2848 | No |
| 64 | SEMA3E | NA | SEMA3E Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | 7203 | 0.257 | 0.2834 | No |
| 65 | PPP3CA | NA | PPP3CA Entrez, Source | protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha) | 7218 | 0.255 | 0.2842 | No |
| 66 | SEMA6C | NA | SEMA6C Entrez, Source | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C | 7528 | 0.207 | 0.2683 | No |
| 67 | SEMA4B | NA | SEMA4B Entrez, Source | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 7940 | 0.152 | 0.2462 | No |
| 68 | CDK5 | NA | CDK5 Entrez, Source | cyclin-dependent kinase 5 | 8004 | 0.145 | 0.2436 | No |
| 69 | NCK1 | NA | NCK1 Entrez, Source | NCK adaptor protein 1 | 8112 | 0.132 | 0.2384 | No |
| 70 | HRAS | NA | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 8120 | 0.131 | 0.2389 | No |
| 71 | CHP2 | NA | 8226 | 0.117 | 0.2337 | No | ||
| 72 | PPP3R2 | NA | PPP3R2 Entrez, Source | protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, beta isoform (calcineurin B, type II) | 8295 | 0.108 | 0.2306 | No |
| 73 | SRGAP2 | NA | SRGAP2 Entrez, Source | SLIT-ROBO Rho GTPase activating protein 2 | 8807 | 0.040 | 0.2022 | No |
| 74 | SRGAP3 | NA | SRGAP3 Entrez, Source | SLIT-ROBO Rho GTPase activating protein 3 | 9078 | 0.010 | 0.1872 | No |
| 75 | EFNA2 | NA | EFNA2 Entrez, Source | ephrin-A2 | 9107 | 0.009 | 0.1857 | No |
| 76 | KRAS | NA | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 9550 | -0.022 | 0.1610 | No |
| 77 | ITGB1 | NA | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 9602 | -0.030 | 0.1584 | No |
| 78 | EFNA4 | NA | EFNA4 Entrez, Source | ephrin-A4 | 10507 | -0.126 | 0.1085 | No |
| 79 | SLIT3 | NA | SLIT3 Entrez, Source | slit homolog 3 (Drosophila) | 10605 | -0.141 | 0.1040 | No |
| 80 | NFATC3 | NA | NFATC3 Entrez, Source | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 10798 | -0.169 | 0.0943 | No |
| 81 | GNAI3 | NA | GNAI3 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 10843 | -0.176 | 0.0929 | No |
| 82 | NTN1 | NA | NTN1 Entrez, Source | netrin 1 | 10872 | -0.179 | 0.0925 | No |
| 83 | PPP3CB | NA | PPP3CB Entrez, Source | protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta) | 10888 | -0.182 | 0.0928 | No |
| 84 | EFNB3 | NA | EFNB3 Entrez, Source | ephrin-B3 | 10909 | -0.185 | 0.0929 | No |
| 85 | PAK4 | NA | PAK4 Entrez, Source | p21(CDKN1A)-activated kinase 4 | 10917 | -0.186 | 0.0937 | No |
| 86 | SEMA5B | NA | SEMA5B Entrez, Source | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B | 10953 | -0.191 | 0.0929 | No |
| 87 | NTN3 | NA | 10976 | -0.194 | 0.0929 | No | ||
| 88 | RAC1 | NA | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 10982 | -0.195 | 0.0939 | No |
| 89 | ABL1 | NA | ABL1 Entrez, Source | v-abl Abelson murine leukemia viral oncogene homolog 1 | 11310 | -0.241 | 0.0771 | No |
| 90 | SEMA4G | NA | SEMA4G Entrez, Source | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G | 11406 | -0.255 | 0.0734 | No |
| 91 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 11524 | -0.274 | 0.0686 | No |
| 92 | UNC5B | NA | UNC5B Entrez, Source | unc-5 homolog B (C. elegans) | 11796 | -0.311 | 0.0554 | No |
| 93 | PLXNB3 | NA | PLXNB3 Entrez, Source | plexin B3 | 11870 | -0.324 | 0.0534 | No |
| 94 | SEMA3A | NA | SEMA3A Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 11909 | -0.328 | 0.0533 | No |
| 95 | SEMA7A | NA | SEMA7A Entrez, Source | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | 11945 | -0.331 | 0.0535 | No |
| 96 | EFNA1 | NA | EFNA1 Entrez, Source | ephrin-A1 | 12204 | -0.369 | 0.0414 | No |
| 97 | PTK2 | NA | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 12873 | -0.447 | 0.0068 | No |
| 98 | LRRC4C | NA | LRRC4C Entrez, Source | leucine rich repeat containing 4C | 12899 | -0.451 | 0.0082 | No |
| 99 | SEMA3G | NA | SEMA3G Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G | 13071 | -0.467 | 0.0016 | No |
| 100 | CFL1 | NA | CFL1 Entrez, Source | cofilin 1 (non-muscle) | 13088 | -0.470 | 0.0037 | No |
| 101 | RGS3 | NA | RGS3 Entrez, Source | regulator of G-protein signalling 3 | 13423 | -0.521 | -0.0117 | No |
| 102 | NRAS | NA | NRAS Entrez, Source | neuroblastoma RAS viral (v-ras) oncogene homolog | 13927 | -0.620 | -0.0359 | No |
| 103 | RAC2 | NA | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 14098 | -0.658 | -0.0413 | No |
| 104 | RHOA | NA | RHOA Entrez, Source | ras homolog gene family, member A | 14227 | -0.687 | -0.0441 | No |
| 105 | GNAI2 | NA | GNAI2 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 14733 | -0.810 | -0.0672 | No |
| 106 | ROBO1 | NA | ROBO1 Entrez, Source | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 15299 | -0.942 | -0.0929 | No |
| 107 | EPHA1 | NA | EPHA1 Entrez, Source | EPH receptor A1 | 15377 | -0.963 | -0.0911 | No |
| 108 | SEMA4C | NA | SEMA4C Entrez, Source | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C | 15838 | -1.110 | -0.1098 | No |
| 109 | GSK3B | NA | GSK3B Entrez, Source | glycogen synthase kinase 3 beta | 16081 | -1.206 | -0.1157 | No |
| 110 | ROBO3 | NA | ROBO3 Entrez, Source | roundabout, axon guidance receptor, homolog 3 (Drosophila) | 16150 | -1.238 | -0.1116 | No |
| 111 | RAC3 | NA | RAC3 Entrez, Source | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) | 16175 | -1.249 | -0.1050 | No |
| 112 | PAK1 | NA | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 16221 | -1.270 | -0.0995 | No |
| 113 | DCC | NA | DCC Entrez, Source | deleted in colorectal carcinoma | 16599 | -1.469 | -0.1112 | No |
| 114 | SEMA5A | NA | SEMA5A Entrez, Source | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 16626 | -1.485 | -0.1032 | No |
| 115 | MAPK3 | NA | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 16746 | -1.562 | -0.1000 | No |
| 116 | PPP3R1 | NA | PPP3R1 Entrez, Source | protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) | 16772 | -1.581 | -0.0913 | No |
| 117 | SEMA6B | NA | SEMA6B Entrez, Source | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | 16826 | -1.627 | -0.0839 | No |
| 118 | FES | NA | FES Entrez, Source | feline sarcoma oncogene | 16858 | -1.649 | -0.0752 | No |
| 119 | NTNG1 | NA | NTNG1 Entrez, Source | netrin G1 | 16952 | -1.727 | -0.0694 | No |
| 120 | NFATC1 | NA | NFATC1 Entrez, Source | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 | 17003 | -1.773 | -0.0609 | No |
| 121 | LIMK2 | NA | LIMK2 Entrez, Source | LIM domain kinase 2 | 17016 | -1.783 | -0.0503 | No |
| 122 | SEMA4F | NA | SEMA4F Entrez, Source | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F | 17162 | -1.957 | -0.0460 | No |
| 123 | L1CAM | NA | L1CAM Entrez, Source | L1 cell adhesion molecule | 17216 | -2.028 | -0.0360 | No |
| 124 | PLXNB1 | NA | PLXNB1 Entrez, Source | plexin B1 | 17559 | -2.605 | -0.0386 | No |
| 125 | NFATC4 | NA | NFATC4 Entrez, Source | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 17584 | -2.702 | -0.0228 | No |
| 126 | EFNA3 | NA | EFNA3 Entrez, Source | ephrin-A3 | 17599 | -2.743 | -0.0061 | No |
| 127 | UNC5A | NA | UNC5A Entrez, Source | unc-5 homolog A (C. elegans) | 17896 | -4.257 | 0.0044 | No |
