Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_AUTOIMMUNE_THYROID_DISEASE |
| Enrichment Score (ES) | 0.69687235 |
| Normalized Enrichment Score (NES) | 2.1078565 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | HLA-DRB1 | NA | HLA-DRB1 Entrez, Source | major histocompatibility complex, class II, DR beta 1 | 8 | 4.960 | 0.0833 | Yes |
| 2 | HLA-DRA | NA | HLA-DRA Entrez, Source | major histocompatibility complex, class II, DR alpha | 27 | 4.871 | 0.1645 | Yes |
| 3 | HLA-DPA1 | NA | HLA-DPA1 Entrez, Source | major histocompatibility complex, class II, DP alpha 1 | 107 | 4.489 | 0.2359 | Yes |
| 4 | HLA-DRB5 | NA | HLA-DRB5 Entrez, Source | major histocompatibility complex, class II, DR beta 5 | 137 | 4.339 | 0.3075 | Yes |
| 5 | HLA-DMB | NA | HLA-DMB Entrez, Source | major histocompatibility complex, class II, DM beta | 164 | 4.259 | 0.3780 | Yes |
| 6 | HLA-DRB3 | NA | HLA-DRB3 Entrez, Source | major histocompatibility complex, class II, DR beta 3 | 226 | 4.018 | 0.4424 | Yes |
| 7 | HLA-DRB4 | NA | HLA-DRB4 Entrez, Source | major histocompatibility complex, class II, DR beta 4 | 242 | 3.963 | 0.5084 | Yes |
| 8 | HLA-DMA | NA | HLA-DMA Entrez, Source | major histocompatibility complex, class II, DM alpha | 294 | 3.747 | 0.5689 | Yes |
| 9 | HLA-DQB1 | NA | HLA-DQB1 Entrez, Source | major histocompatibility complex, class II, DQ beta 1 | 438 | 3.353 | 0.6175 | Yes |
| 10 | HLA-DPB1 | NA | HLA-DPB1 Entrez, Source | major histocompatibility complex, class II, DP beta 1 | 1127 | 2.142 | 0.6153 | Yes |
| 11 | HLA-DOB | NA | HLA-DOB Entrez, Source | major histocompatibility complex, class II, DO beta | 1460 | 1.797 | 0.6271 | Yes |
| 12 | HLA-E | NA | HLA-E Entrez, Source | major histocompatibility complex, class I, E | 1528 | 1.738 | 0.6527 | Yes |
| 13 | HLA-DOA | NA | HLA-DOA Entrez, Source | major histocompatibility complex, class II, DO alpha | 1660 | 1.640 | 0.6731 | Yes |
| 14 | FAS | NA | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 1716 | 1.589 | 0.6969 | Yes |
| 15 | CTLA4 | NA | CTLA4 Entrez, Source | cytotoxic T-lymphocyte-associated protein 4 | 3119 | 0.957 | 0.6349 | No |
| 16 | HLA-C | NA | HLA-C Entrez, Source | major histocompatibility complex, class I, C | 4338 | 0.693 | 0.5786 | No |
| 17 | HLA-G | NA | HLA-G Entrez, Source | HLA-G histocompatibility antigen, class I, G | 4577 | 0.642 | 0.5762 | No |
| 18 | HLA-A | NA | HLA-A Entrez, Source | major histocompatibility complex, class I, A | 4720 | 0.613 | 0.5786 | No |
| 19 | HLA-F | NA | HLA-F Entrez, Source | major histocompatibility complex, class I, F | 4736 | 0.609 | 0.5881 | No |
| 20 | PRF1 | NA | PRF1 Entrez, Source | perforin 1 (pore forming protein) | 5383 | 0.490 | 0.5603 | No |
| 21 | IL4 | NA | IL4 Entrez, Source | interleukin 4 | 5828 | 0.428 | 0.5428 | No |
| 22 | HLA-DQA1 | NA | HLA-DQA1 Entrez, Source | major histocompatibility complex, class II, DQ alpha 1 | 6116 | 0.415 | 0.5338 | No |
| 23 | FASLG | NA | FASLG Entrez, Source | Fas ligand (TNF superfamily, member 6) | 7435 | 0.220 | 0.4640 | No |
| 24 | TSHR | NA | TSHR Entrez, Source | thyroid stimulating hormone receptor | 7895 | 0.159 | 0.4411 | No |
| 25 | IL10 | NA | IL10 Entrez, Source | interleukin 10 | 8629 | 0.062 | 0.4013 | No |
| 26 | HLA-B | NA | HLA-B Entrez, Source | major histocompatibility complex, class I, B | 8759 | 0.043 | 0.3948 | No |
| 27 | IL2 | NA | IL2 Entrez, Source | interleukin 2 | 9229 | 0.000 | 0.3687 | No |
| 28 | TG | NA | TG Entrez, Source | thyroglobulin | 9588 | -0.028 | 0.3492 | No |
| 29 | IFNA21 | NA | IFNA21 Entrez, Source | interferon, alpha 21 | 9732 | -0.046 | 0.3420 | No |
| 30 | CGA | NA | CGA Entrez, Source | glycoprotein hormones, alpha polypeptide | 9949 | -0.066 | 0.3311 | No |
| 31 | CD80 | NA | CD80 Entrez, Source | CD80 molecule | 10403 | -0.111 | 0.3077 | No |
| 32 | CD86 | NA | CD86 Entrez, Source | CD86 molecule | 10856 | -0.177 | 0.2855 | No |
| 33 | HLA-DQA2 | NA | HLA-DQA2 Entrez, Source | major histocompatibility complex, class II, DQ alpha 2 | 11354 | -0.247 | 0.2619 | No |
| 34 | CD40LG | NA | CD40LG Entrez, Source | CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome) | 12489 | -0.411 | 0.2056 | No |
| 35 | TSHB | NA | TSHB Entrez, Source | thyroid stimulating hormone, beta | 12558 | -0.411 | 0.2088 | No |
| 36 | TPO | NA | TPO Entrez, Source | thyroid peroxidase | 12936 | -0.451 | 0.1954 | No |
| 37 | IFNA8 | NA | IFNA8 Entrez, Source | interferon, alpha 8 | 14874 | -0.839 | 0.1015 | No |
| 38 | CD28 | NA | CD28 Entrez, Source | CD28 molecule | 17036 | -1.802 | 0.0115 | No |
| 39 | CD40 | NA | CD40 Entrez, Source | CD40 molecule, TNF receptor superfamily member 5 | 17453 | -2.414 | 0.0290 | No |
