Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_ARACHIDONIC_ACID_METABOLISM |
| Enrichment Score (ES) | 0.546031 |
| Normalized Enrichment Score (NES) | 1.7854849 |
| Nominal p-value | 0.0014662757 |
| FDR q-value | 0.0071072415 |
| FWER p-Value | 0.083 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | GPX3 | NA | GPX3 Entrez, Source | glutathione peroxidase 3 (plasma) | 13 | 4.944 | 0.0795 | Yes |
| 2 | GGT5 | NA | 16 | 4.936 | 0.1595 | Yes | ||
| 3 | AKR1C3 | NA | AKR1C3 Entrez, Source | aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) | 83 | 4.572 | 0.2301 | Yes |
| 4 | CYP2J2 | NA | CYP2J2 Entrez, Source | cytochrome P450, family 2, subfamily J, polypeptide 2 | 210 | 4.092 | 0.2895 | Yes |
| 5 | TBXAS1 | NA | TBXAS1 Entrez, Source | thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) | 260 | 3.873 | 0.3496 | Yes |
| 6 | PTGS1 | NA | PTGS1 Entrez, Source | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | 348 | 3.594 | 0.4031 | Yes |
| 7 | CYP4F3 | NA | CYP4F3 Entrez, Source | cytochrome P450, family 4, subfamily F, polypeptide 3 | 989 | 2.299 | 0.4047 | Yes |
| 8 | PTGS2 | NA | PTGS2 Entrez, Source | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 1085 | 2.190 | 0.4350 | Yes |
| 9 | PLA2G12A | NA | PLA2G12A Entrez, Source | phospholipase A2, group XIIA | 1253 | 1.985 | 0.4579 | Yes |
| 10 | CYP2U1 | NA | CYP2U1 Entrez, Source | cytochrome P450, family 2, subfamily U, polypeptide 1 | 1369 | 1.868 | 0.4818 | Yes |
| 11 | EPHX2 | NA | EPHX2 Entrez, Source | epoxide hydrolase 2, cytoplasmic | 1564 | 1.713 | 0.4988 | Yes |
| 12 | CYP2E1 | NA | CYP2E1 Entrez, Source | cytochrome P450, family 2, subfamily E, polypeptide 1 | 1641 | 1.652 | 0.5213 | Yes |
| 13 | PTGES | NA | PTGES Entrez, Source | prostaglandin E synthase | 1674 | 1.631 | 0.5460 | Yes |
| 14 | ALOX5 | NA | ALOX5 Entrez, Source | arachidonate 5-lipoxygenase | 2954 | 1.004 | 0.4910 | No |
| 15 | PLA2G4E | NA | PLA2G4E Entrez, Source | phospholipase A2, group IVE | 3370 | 0.891 | 0.4823 | No |
| 16 | CBR1 | NA | CBR1 Entrez, Source | carbonyl reductase 1 | 3602 | 0.841 | 0.4830 | No |
| 17 | PLA2G2F | NA | PLA2G2F Entrez, Source | phospholipase A2, group IIF | 3735 | 0.823 | 0.4890 | No |
| 18 | CYP2C9 | NA | CYP2C9 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 9 | 3806 | 0.809 | 0.4982 | No |
| 19 | PLA2G4B | NA | PLA2G4B Entrez, Source | phospholipase A2, group IVB (cytosolic) | 3971 | 0.767 | 0.5015 | No |
| 20 | ALOX15B | NA | ALOX15B Entrez, Source | arachidonate 15-lipoxygenase, type B | 4158 | 0.727 | 0.5030 | No |
| 21 | PTGIS | NA | PTGIS Entrez, Source | prostaglandin I2 (prostacyclin) synthase | 4161 | 0.726 | 0.5147 | No |
| 22 | GPX4 | NA | GPX4 Entrez, Source | glutathione peroxidase 4 (phospholipid hydroperoxidase) | 4809 | 0.592 | 0.4882 | No |
| 23 | CBR3 | NA | CBR3 Entrez, Source | carbonyl reductase 3 | 5222 | 0.513 | 0.4735 | No |
| 24 | CYP4F2 | NA | CYP4F2 Entrez, Source | cytochrome P450, family 4, subfamily F, polypeptide 2 | 5314 | 0.499 | 0.4765 | No |
| 25 | HPGDS | NA | 5927 | 0.424 | 0.4493 | No | ||
| 26 | PLA2G5 | NA | PLA2G5 Entrez, Source | phospholipase A2, group V | 6189 | 0.415 | 0.4414 | No |
| 27 | JMJD7-PLA2G4B | NA | 6190 | 0.415 | 0.4482 | No | ||
| 28 | GPX5 | NA | GPX5 Entrez, Source | glutathione peroxidase 5 (epididymal androgen-related protein) | 6712 | 0.333 | 0.4245 | No |
| 29 | GPX1 | NA | GPX1 Entrez, Source | glutathione peroxidase 1 | 7208 | 0.256 | 0.4010 | No |
| 30 | GGT6 | NA | GGT6 Entrez, Source | gamma-glutamyltransferase 6 homolog (rat) | 7268 | 0.247 | 0.4017 | No |
| 31 | PLA2G2A | NA | PLA2G2A Entrez, Source | phospholipase A2, group IIA (platelets, synovial fluid) | 7620 | 0.196 | 0.3853 | No |
| 32 | PTGES2 | NA | PTGES2 Entrez, Source | prostaglandin E synthase 2 | 8231 | 0.116 | 0.3532 | No |
| 33 | ALOX15 | NA | ALOX15 Entrez, Source | arachidonate 15-lipoxygenase | 8346 | 0.102 | 0.3485 | No |
| 34 | CYP2C19 | NA | CYP2C19 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 19 | 8501 | 0.079 | 0.3412 | No |
| 35 | CYP2B6 | NA | CYP2B6 Entrez, Source | cytochrome P450, family 2, subfamily B, polypeptide 6 | 8549 | 0.074 | 0.3397 | No |
| 36 | PLA2G2D | NA | PLA2G2D Entrez, Source | phospholipase A2, group IID | 9058 | 0.012 | 0.3116 | No |
| 37 | PLA2G12B | NA | PLA2G12B Entrez, Source | phospholipase A2, group XIIB | 9094 | 0.009 | 0.3098 | No |
| 38 | CYP4A11 | NA | CYP4A11 Entrez, Source | cytochrome P450, family 4, subfamily A, polypeptide 11 | 9173 | 0.002 | 0.3055 | No |
| 39 | PTGDS | NA | PTGDS Entrez, Source | prostaglandin D2 synthase 21kDa (brain) | 9231 | 0.000 | 0.3023 | No |
| 40 | ALOX12 | NA | ALOX12 Entrez, Source | arachidonate 12-lipoxygenase | 9668 | -0.039 | 0.2786 | No |
| 41 | GPX2 | NA | GPX2 Entrez, Source | glutathione peroxidase 2 (gastrointestinal) | 10544 | -0.130 | 0.2319 | No |
| 42 | PLA2G10 | NA | PLA2G10 Entrez, Source | phospholipase A2, group X | 10621 | -0.143 | 0.2300 | No |
| 43 | LTA4H | NA | LTA4H Entrez, Source | leukotriene A4 hydrolase | 10705 | -0.155 | 0.2278 | No |
| 44 | PLA2G3 | NA | PLA2G3 Entrez, Source | phospholipase A2, group III | 11904 | -0.327 | 0.1663 | No |
| 45 | PLA2G6 | NA | PLA2G6 Entrez, Source | phospholipase A2, group VI (cytosolic, calcium-independent) | 12145 | -0.361 | 0.1588 | No |
| 46 | LTC4S | NA | LTC4S Entrez, Source | leukotriene C4 synthase | 12498 | -0.411 | 0.1458 | No |
| 47 | CYP2C18 | NA | CYP2C18 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 18 | 13300 | -0.503 | 0.1093 | No |
| 48 | PLA2G1B | NA | PLA2G1B Entrez, Source | phospholipase A2, group IB (pancreas) | 14535 | -0.763 | 0.0528 | No |
| 49 | PLA2G4A | NA | PLA2G4A Entrez, Source | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 14893 | -0.842 | 0.0466 | No |
| 50 | ALOX12B | NA | ALOX12B Entrez, Source | arachidonate 12-lipoxygenase, 12R type | 15180 | -0.910 | 0.0454 | No |
| 51 | CYP2C8 | NA | CYP2C8 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 8 | 16034 | -1.190 | 0.0171 | No |
| 52 | GGT7 | NA | 17530 | -2.557 | -0.0248 | No | ||
| 53 | GPX7 | NA | GPX7 Entrez, Source | glutathione peroxidase 7 | 17687 | -3.052 | 0.0160 | No |
