Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION |
| Enrichment Score (ES) | 0.6094107 |
| Normalized Enrichment Score (NES) | 2.0220425 |
| Nominal p-value | 0.0 |
| FDR q-value | 2.5001826E-4 |
| FWER p-Value | 0.002 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CD74 | NA | CD74 Entrez, Source | CD74 molecule, major histocompatibility complex, class II invariant chain | 5 | 4.973 | 0.0552 | Yes |
| 2 | HLA-DRB1 | NA | HLA-DRB1 Entrez, Source | major histocompatibility complex, class II, DR beta 1 | 8 | 4.960 | 0.1105 | Yes |
| 3 | HLA-DRA | NA | HLA-DRA Entrez, Source | major histocompatibility complex, class II, DR alpha | 27 | 4.871 | 0.1639 | Yes |
| 4 | HLA-DPA1 | NA | HLA-DPA1 Entrez, Source | major histocompatibility complex, class II, DP alpha 1 | 107 | 4.489 | 0.2096 | Yes |
| 5 | HLA-DRB5 | NA | HLA-DRB5 Entrez, Source | major histocompatibility complex, class II, DR beta 5 | 137 | 4.339 | 0.2564 | Yes |
| 6 | HLA-DMB | NA | HLA-DMB Entrez, Source | major histocompatibility complex, class II, DM beta | 164 | 4.259 | 0.3025 | Yes |
| 7 | CIITA | NA | CIITA Entrez, Source | class II, major histocompatibility complex, transactivator | 168 | 4.245 | 0.3497 | Yes |
| 8 | HLA-DRB3 | NA | HLA-DRB3 Entrez, Source | major histocompatibility complex, class II, DR beta 3 | 226 | 4.018 | 0.3914 | Yes |
| 9 | HLA-DRB4 | NA | HLA-DRB4 Entrez, Source | major histocompatibility complex, class II, DR beta 4 | 242 | 3.963 | 0.4348 | Yes |
| 10 | HLA-DMA | NA | HLA-DMA Entrez, Source | major histocompatibility complex, class II, DM alpha | 294 | 3.747 | 0.4738 | Yes |
| 11 | HLA-DQB1 | NA | HLA-DQB1 Entrez, Source | major histocompatibility complex, class II, DQ beta 1 | 438 | 3.353 | 0.5033 | Yes |
| 12 | CTSB | NA | CTSB Entrez, Source | cathepsin B | 739 | 2.651 | 0.5161 | Yes |
| 13 | KLRC2 | NA | KLRC2 Entrez, Source | killer cell lectin-like receptor subfamily C, member 2 | 1078 | 2.195 | 0.5217 | Yes |
| 14 | HLA-DPB1 | NA | HLA-DPB1 Entrez, Source | major histocompatibility complex, class II, DP beta 1 | 1127 | 2.142 | 0.5430 | Yes |
| 15 | HLA-DOB | NA | HLA-DOB Entrez, Source | major histocompatibility complex, class II, DO beta | 1460 | 1.797 | 0.5445 | Yes |
| 16 | TAPBP | NA | TAPBP Entrez, Source | TAP binding protein (tapasin) | 1526 | 1.739 | 0.5603 | Yes |
| 17 | HLA-E | NA | HLA-E Entrez, Source | major histocompatibility complex, class I, E | 1528 | 1.738 | 0.5797 | Yes |
| 18 | HSPA1A | NA | HSPA1A Entrez, Source | heat shock 70kDa protein 1A | 1614 | 1.675 | 0.5936 | Yes |
| 19 | HLA-DOA | NA | HLA-DOA Entrez, Source | major histocompatibility complex, class II, DO alpha | 1660 | 1.640 | 0.6094 | Yes |
| 20 | HSPA1B | NA | HSPA1B Entrez, Source | heat shock 70kDa protein 1B | 2020 | 1.411 | 0.6051 | No |
| 21 | KLRC1 | NA | KLRC1 Entrez, Source | killer cell lectin-like receptor subfamily C, member 1 | 2407 | 1.212 | 0.5971 | No |
| 22 | HSPA5 | NA | HSPA5 Entrez, Source | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 2543 | 1.161 | 0.6025 | No |
| 23 | PSME1 | NA | PSME1 Entrez, Source | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | 2743 | 1.082 | 0.6035 | No |
| 24 | LGMN | NA | LGMN Entrez, Source | legumain | 2948 | 1.006 | 0.6033 | No |
| 25 | KLRC3 | NA | KLRC3 Entrez, Source | killer cell lectin-like receptor subfamily C, member 3 | 3052 | 0.974 | 0.6085 | No |
| 26 | HSPA1L | NA | HSPA1L Entrez, Source | heat shock 70kDa protein 1-like | 3713 | 0.828 | 0.5808 | No |
| 27 | HSPA4 | NA | HSPA4 Entrez, Source | heat shock 70kDa protein 4 | 4049 | 0.751 | 0.5705 | No |
| 28 | PSME2 | NA | PSME2 Entrez, Source | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | 4095 | 0.741 | 0.5763 | No |
| 29 | CREB1 | NA | CREB1 Entrez, Source | cAMP responsive element binding protein 1 | 4273 | 0.707 | 0.5743 | No |
| 30 | HLA-C | NA | HLA-C Entrez, Source | major histocompatibility complex, class I, C | 4338 | 0.693 | 0.5785 | No |
| 31 | HLA-G | NA | HLA-G Entrez, Source | HLA-G histocompatibility antigen, class I, G | 4577 | 0.642 | 0.5723 | No |
| 32 | HLA-A | NA | HLA-A Entrez, Source | major histocompatibility complex, class I, A | 4720 | 0.613 | 0.5712 | No |
| 33 | HLA-F | NA | HLA-F Entrez, Source | major histocompatibility complex, class I, F | 4736 | 0.609 | 0.5772 | No |
| 34 | HSPA8 | NA | HSPA8 Entrez, Source | heat shock 70kDa protein 8 | 4884 | 0.579 | 0.5755 | No |
| 35 | TAP1 | NA | TAP1 Entrez, Source | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 4961 | 0.566 | 0.5775 | No |
| 36 | HLA-DQA1 | NA | HLA-DQA1 Entrez, Source | major histocompatibility complex, class II, DQ alpha 1 | 6116 | 0.415 | 0.5177 | No |
| 37 | KLRC4 | NA | KLRC4 Entrez, Source | killer cell lectin-like receptor subfamily C, member 4 | 6129 | 0.415 | 0.5217 | No |
| 38 | LTA | NA | LTA Entrez, Source | lymphotoxin alpha (TNF superfamily, member 1) | 6479 | 0.370 | 0.5064 | No |
| 39 | KLRD1 | NA | KLRD1 Entrez, Source | killer cell lectin-like receptor subfamily D, member 1 | 6669 | 0.339 | 0.4996 | No |
| 40 | NFYA | NA | NFYA Entrez, Source | nuclear transcription factor Y, alpha | 6933 | 0.300 | 0.4883 | No |
| 41 | CD8A | NA | CD8A Entrez, Source | CD8a molecule | 7312 | 0.240 | 0.4698 | No |
| 42 | HSPA6 | NA | HSPA6 Entrez, Source | heat shock 70kDa protein 6 (HSP70B') | 7340 | 0.236 | 0.4710 | No |
| 43 | CALR | NA | CALR Entrez, Source | calreticulin | 7754 | 0.177 | 0.4499 | No |
| 44 | HSP90AB1 | NA | HSP90AB1 Entrez, Source | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 8137 | 0.128 | 0.4300 | No |
| 45 | IFI30 | NA | IFI30 Entrez, Source | interferon, gamma-inducible protein 30 | 8240 | 0.115 | 0.4256 | No |
| 46 | HLA-B | NA | HLA-B Entrez, Source | major histocompatibility complex, class I, B | 8759 | 0.043 | 0.3971 | No |
| 47 | TAP2 | NA | TAP2 Entrez, Source | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | 8872 | 0.033 | 0.3912 | No |
| 48 | IFNA21 | NA | IFNA21 Entrez, Source | interferon, alpha 21 | 9732 | -0.046 | 0.3438 | No |
| 49 | HSP90AA1 | NA | HSP90AA1 Entrez, Source | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 9814 | -0.054 | 0.3399 | No |
| 50 | CD4 | NA | CD4 Entrez, Source | CD4 molecule | 9976 | -0.068 | 0.3316 | No |
| 51 | CANX | NA | CANX Entrez, Source | calnexin | 10236 | -0.091 | 0.3182 | No |
| 52 | RFXANK | NA | RFXANK Entrez, Source | regulatory factor X-associated ankyrin-containing protein | 11045 | -0.205 | 0.2754 | No |
| 53 | B2M | NA | B2M Entrez, Source | beta-2-microglobulin | 11181 | -0.224 | 0.2703 | No |
| 54 | HLA-DQA2 | NA | HLA-DQA2 Entrez, Source | major histocompatibility complex, class II, DQ alpha 2 | 11354 | -0.247 | 0.2635 | No |
| 55 | NFYC | NA | NFYC Entrez, Source | nuclear transcription factor Y, gamma | 11692 | -0.294 | 0.2480 | No |
| 56 | RFX5 | NA | RFX5 Entrez, Source | regulatory factor X, 5 (influences HLA class II expression) | 12429 | -0.406 | 0.2114 | No |
| 57 | KIR3DL1 | NA | KIR3DL1 Entrez, Source | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 | 12835 | -0.445 | 0.1938 | No |
| 58 | RFXAP | NA | RFXAP Entrez, Source | regulatory factor X-associated protein | 13280 | -0.502 | 0.1746 | No |
| 59 | PDIA3 | NA | PDIA3 Entrez, Source | protein disulfide isomerase family A, member 3 | 13281 | -0.502 | 0.1802 | No |
| 60 | IFNA8 | NA | IFNA8 Entrez, Source | interferon, alpha 8 | 14874 | -0.839 | 0.1007 | No |
| 61 | PSME3 | NA | PSME3 Entrez, Source | proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) | 14970 | -0.860 | 0.1050 | No |
| 62 | HSPA2 | NA | HSPA2 Entrez, Source | heat shock 70kDa protein 2 | 15081 | -0.888 | 0.1087 | No |
| 63 | NFYB | NA | NFYB Entrez, Source | nuclear transcription factor Y, beta | 16182 | -1.250 | 0.0613 | No |
| 64 | CTSS | NA | CTSS Entrez, Source | cathepsin S | 17772 | -3.468 | 0.0113 | No |
