Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_WNT_BETA_CATENIN_SIGNALING |
| Enrichment Score (ES) | -0.26525554 |
| Normalized Enrichment Score (NES) | -0.9010129 |
| Nominal p-value | 0.6260388 |
| FDR q-value | 0.78471476 |
| FWER p-Value | 1.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | TCF7 | NA | TCF7 Entrez, Source | transcription factor 7 (T-cell specific, HMG-box) | 238 | 3.984 | 0.0570 | Yes |
| 2 | JAG2 | NA | JAG2 Entrez, Source | jagged 2 | 400 | 3.433 | 0.1087 | Yes |
| 3 | JAG1 | NA | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 495 | 3.207 | 0.1600 | Yes |
| 4 | FZD1 | NA | FZD1 Entrez, Source | frizzled homolog 1 (Drosophila) | 517 | 3.142 | 0.2143 | Yes |
| 5 | DKK1 | NA | DKK1 Entrez, Source | dickkopf homolog 1 (Xenopus laevis) | 893 | 2.408 | 0.2359 | Yes |
| 6 | WNT5B | NA | WNT5B Entrez, Source | wingless-type MMTV integration site family, member 5B | 2250 | 1.279 | 0.1829 | Yes |
| 7 | GNAI1 | NA | GNAI1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 2274 | 1.270 | 0.2040 | Yes |
| 8 | ADAM17 | NA | ADAM17 Entrez, Source | ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) | 2533 | 1.165 | 0.2102 | Yes |
| 9 | HEY2 | NA | HEY2 Entrez, Source | hairy/enhancer-of-split related with YRPW motif 2 | 2997 | 0.992 | 0.2019 | Yes |
| 10 | PPARD | NA | PPARD Entrez, Source | peroxisome proliferative activated receptor, delta | 3037 | 0.978 | 0.2169 | Yes |
| 11 | PSEN2 | NA | PSEN2 Entrez, Source | presenilin 2 (Alzheimer disease 4) | 3201 | 0.940 | 0.2244 | Yes |
| 12 | NCSTN | NA | NCSTN Entrez, Source | nicastrin | 3215 | 0.936 | 0.2402 | Yes |
| 13 | AXIN2 | NA | AXIN2 Entrez, Source | axin 2 (conductin, axil) | 3442 | 0.873 | 0.2430 | Yes |
| 14 | NOTCH1 | NA | NOTCH1 Entrez, Source | Notch homolog 1, translocation-associated (Drosophila) | 3601 | 0.841 | 0.2491 | Yes |
| 15 | RBPJ | NA | 3900 | 0.785 | 0.2463 | No | ||
| 16 | WNT1 | NA | WNT1 Entrez, Source | wingless-type MMTV integration site family, member 1 | 5363 | 0.491 | 0.1735 | No |
| 17 | CUL1 | NA | CUL1 Entrez, Source | cullin 1 | 5700 | 0.445 | 0.1626 | No |
| 18 | DKK4 | NA | DKK4 Entrez, Source | dickkopf homolog 4 (Xenopus laevis) | 5818 | 0.428 | 0.1636 | No |
| 19 | MAML1 | NA | MAML1 Entrez, Source | mastermind-like 1 (Drosophila) | 7841 | 0.167 | 0.0538 | No |
| 20 | NUMB | NA | NUMB Entrez, Source | numb homolog (Drosophila) | 8463 | 0.086 | 0.0207 | No |
| 21 | KAT2A | NA | 11132 | -0.216 | -0.1243 | No | ||
| 22 | WNT6 | NA | WNT6 Entrez, Source | wingless-type MMTV integration site family, member 6 | 12926 | -0.451 | -0.2163 | No |
| 23 | FZD8 | NA | FZD8 Entrez, Source | frizzled homolog 8 (Drosophila) | 13513 | -0.539 | -0.2395 | No |
| 24 | DVL2 | NA | DVL2 Entrez, Source | dishevelled, dsh homolog 2 (Drosophila) | 13570 | -0.551 | -0.2329 | No |
| 25 | CSNK1E | NA | CSNK1E Entrez, Source | casein kinase 1, epsilon | 13604 | -0.559 | -0.2248 | No |
| 26 | CTNNB1 | NA | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 14196 | -0.681 | -0.2458 | No |
| 27 | PTCH1 | NA | PTCH1 Entrez, Source | patched homolog 1 (Drosophila) | 14377 | -0.719 | -0.2431 | No |
| 28 | HEY1 | NA | HEY1 Entrez, Source | hairy/enhancer-of-split related with YRPW motif 1 | 14406 | -0.727 | -0.2318 | No |
| 29 | AXIN1 | NA | AXIN1 Entrez, Source | axin 1 | 14551 | -0.767 | -0.2263 | No |
| 30 | MYC | NA | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 15055 | -0.881 | -0.2388 | No |
| 31 | HDAC2 | NA | HDAC2 Entrez, Source | histone deacetylase 2 | 15421 | -0.974 | -0.2420 | No |
| 32 | NCOR2 | NA | NCOR2 Entrez, Source | nuclear receptor co-repressor 2 | 15839 | -1.111 | -0.2457 | No |
| 33 | CCND2 | NA | CCND2 Entrez, Source | cyclin D2 | 16061 | -1.200 | -0.2368 | No |
| 34 | LEF1 | NA | LEF1 Entrez, Source | lymphoid enhancer-binding factor 1 | 16302 | -1.306 | -0.2271 | No |
| 35 | HDAC11 | NA | HDAC11 Entrez, Source | histone deacetylase 11 | 16391 | -1.359 | -0.2080 | No |
| 36 | SKP2 | NA | SKP2 Entrez, Source | S-phase kinase-associated protein 2 (p45) | 16979 | -1.751 | -0.2099 | No |
| 37 | HDAC5 | NA | HDAC5 Entrez, Source | histone deacetylase 5 | 17215 | -2.025 | -0.1872 | No |
| 38 | DLL1 | NA | DLL1 Entrez, Source | delta-like 1 (Drosophila) | 17249 | -2.078 | -0.1524 | No |
| 39 | TP53 | NA | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 17294 | -2.152 | -0.1169 | No |
| 40 | NKD1 | NA | NKD1 Entrez, Source | naked cuticle homolog 1 (Drosophila) | 17397 | -2.327 | -0.0815 | No |
| 41 | FRAT1 | NA | FRAT1 Entrez, Source | frequently rearranged in advanced T-cell lymphomas | 17442 | -2.399 | -0.0416 | No |
| 42 | NOTCH4 | NA | NOTCH4 Entrez, Source | Notch homolog 4 (Drosophila) | 17862 | -4.034 | 0.0062 | No |
