Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | HALLMARK_UV_RESPONSE_DN |
| Enrichment Score (ES) | 0.3875799 |
| Normalized Enrichment Score (NES) | 1.4487784 |
| Nominal p-value | 0.0065789474 |
| FDR q-value | 0.028798802 |
| FWER p-Value | 0.397 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | ID1 | NA | ID1 Entrez, Source | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 66 | 4.635 | 0.0239 | Yes |
| 2 | LPAR1 | NA | 135 | 4.340 | 0.0460 | Yes | ||
| 3 | GJA1 | NA | GJA1 Entrez, Source | gap junction protein, alpha 1, 43kDa (connexin 43) | 347 | 3.607 | 0.0557 | Yes |
| 4 | PLCB4 | NA | PLCB4 Entrez, Source | phospholipase C, beta 4 | 374 | 3.504 | 0.0751 | Yes |
| 5 | COL1A2 | NA | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 538 | 3.100 | 0.0845 | Yes |
| 6 | BDNF | NA | BDNF Entrez, Source | brain-derived neurotrophic factor | 616 | 2.917 | 0.0975 | Yes |
| 7 | SERPINE1 | NA | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 620 | 2.910 | 0.1147 | Yes |
| 8 | CELF2 | NA | 708 | 2.708 | 0.1260 | Yes | ||
| 9 | LTBP1 | NA | LTBP1 Entrez, Source | latent transforming growth factor beta binding protein 1 | 773 | 2.600 | 0.1379 | Yes |
| 10 | TGFBR3 | NA | TGFBR3 Entrez, Source | transforming growth factor, beta receptor III (betaglycan, 300kDa) | 791 | 2.563 | 0.1522 | Yes |
| 11 | VLDLR | NA | VLDLR Entrez, Source | very low density lipoprotein receptor | 798 | 2.550 | 0.1671 | Yes |
| 12 | FHL2 | NA | FHL2 Entrez, Source | four and a half LIM domains 2 | 830 | 2.504 | 0.1803 | Yes |
| 13 | SYNE1 | NA | SYNE1 Entrez, Source | spectrin repeat containing, nuclear envelope 1 | 864 | 2.456 | 0.1931 | Yes |
| 14 | MET | NA | MET Entrez, Source | met proto-oncogene (hepatocyte growth factor receptor) | 871 | 2.445 | 0.2073 | Yes |
| 15 | F3 | NA | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 876 | 2.438 | 0.2216 | Yes |
| 16 | IRS1 | NA | IRS1 Entrez, Source | insulin receptor substrate 1 | 1017 | 2.274 | 0.2273 | Yes |
| 17 | MAGI2 | NA | MAGI2 Entrez, Source | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 1282 | 1.949 | 0.2242 | Yes |
| 18 | PEX14 | NA | PEX14 Entrez, Source | peroxisomal biogenesis factor 14 | 1295 | 1.937 | 0.2350 | Yes |
| 19 | NFIB | NA | NFIB Entrez, Source | nuclear factor I/B | 1317 | 1.911 | 0.2453 | Yes |
| 20 | RBPMS | NA | RBPMS Entrez, Source | RNA binding protein with multiple splicing | 1338 | 1.895 | 0.2554 | Yes |
| 21 | RND3 | NA | RND3 Entrez, Source | Rho family GTPase 3 | 1392 | 1.851 | 0.2635 | Yes |
| 22 | EFEMP1 | NA | EFEMP1 Entrez, Source | EGF-containing fibulin-like extracellular matrix protein 1 | 1439 | 1.812 | 0.2717 | Yes |
| 23 | PDLIM5 | NA | PDLIM5 Entrez, Source | PDZ and LIM domain 5 | 1472 | 1.784 | 0.2806 | Yes |
| 24 | DLC1 | NA | DLC1 Entrez, Source | deleted in liver cancer 1 | 1483 | 1.773 | 0.2906 | Yes |
| 25 | PRKCA | NA | PRKCA Entrez, Source | protein kinase C, alpha | 1594 | 1.691 | 0.2945 | Yes |
| 26 | GCNT1 | NA | GCNT1 Entrez, Source | glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase) | 1629 | 1.661 | 0.3025 | Yes |
| 27 | ADORA2B | NA | ADORA2B Entrez, Source | adenosine A2b receptor | 1685 | 1.615 | 0.3091 | Yes |
| 28 | PRDM2 | NA | PRDM2 Entrez, Source | PR domain containing 2, with ZNF domain | 1707 | 1.595 | 0.3174 | Yes |
| 29 | ATXN1 | NA | ATXN1 Entrez, Source | ataxin 1 | 1754 | 1.560 | 0.3241 | Yes |
| 30 | ACVR2A | NA | ACVR2A Entrez, Source | activin A receptor, type IIA | 1834 | 1.508 | 0.3287 | Yes |
| 31 | MT1E | NA | MT1E Entrez, Source | metallothionein 1E (functional) | 1842 | 1.505 | 0.3373 | Yes |
| 32 | CDON | NA | CDON Entrez, Source | Cdon homolog (mouse) | 1862 | 1.493 | 0.3451 | Yes |
| 33 | LAMC1 | NA | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 1929 | 1.455 | 0.3501 | Yes |
| 34 | NR3C1 | NA | NR3C1 Entrez, Source | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 2017 | 1.411 | 0.3536 | Yes |
| 35 | ATP2B1 | NA | ATP2B1 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 1 | 2021 | 1.411 | 0.3618 | Yes |
| 36 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 2109 | 1.354 | 0.3650 | Yes |
| 37 | NRP1 | NA | NRP1 Entrez, Source | neuropilin 1 | 2191 | 1.309 | 0.3683 | Yes |
| 38 | ABCC1 | NA | ABCC1 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 2339 | 1.239 | 0.3675 | Yes |
| 39 | DUSP1 | NA | DUSP1 Entrez, Source | dual specificity phosphatase 1 | 2409 | 1.211 | 0.3708 | Yes |
| 40 | CITED2 | NA | CITED2 Entrez, Source | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 2609 | 1.132 | 0.3664 | Yes |
| 41 | ERBB2 | NA | ERBB2 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 2625 | 1.122 | 0.3723 | Yes |
| 42 | CYR61 | NA | CYR61 Entrez, Source | cysteine-rich, angiogenic inducer, 61 | 2682 | 1.103 | 0.3757 | Yes |
| 43 | RXRA | NA | RXRA Entrez, Source | retinoid X receptor, alpha | 2739 | 1.085 | 0.3790 | Yes |
| 44 | MAP1B | NA | MAP1B Entrez, Source | microtubule-associated protein 1B | 2756 | 1.076 | 0.3845 | Yes |
| 45 | SDC2 | NA | SDC2 Entrez, Source | syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan) | 2815 | 1.055 | 0.3876 | Yes |
| 46 | CDKN1B | NA | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 2942 | 1.008 | 0.3865 | No |
| 47 | SMAD7 | NA | SMAD7 Entrez, Source | SMAD, mothers against DPP homolog 7 (Drosophila) | 3103 | 0.961 | 0.3833 | No |
| 48 | NOTCH2 | NA | NOTCH2 Entrez, Source | Notch homolog 2 (Drosophila) | 3224 | 0.934 | 0.3821 | No |
| 49 | FBLN5 | NA | FBLN5 Entrez, Source | fibulin 5 | 3310 | 0.910 | 0.3828 | No |
| 50 | ATRN | NA | ATRN Entrez, Source | attractin | 3457 | 0.869 | 0.3798 | No |
| 51 | SYNJ2 | NA | SYNJ2 Entrez, Source | synaptojanin 2 | 3587 | 0.844 | 0.3776 | No |
| 52 | DLG1 | NA | DLG1 Entrez, Source | discs, large homolog 1 (Drosophila) | 3999 | 0.762 | 0.3591 | No |
| 53 | PIAS3 | NA | PIAS3 Entrez, Source | protein inhibitor of activated STAT, 3 | 4207 | 0.718 | 0.3518 | No |
| 54 | APBB2 | NA | APBB2 Entrez, Source | amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like) | 4278 | 0.706 | 0.3520 | No |
| 55 | PTPN21 | NA | PTPN21 Entrez, Source | protein tyrosine phosphatase, non-receptor type 21 | 4392 | 0.680 | 0.3498 | No |
| 56 | CDC42BPA | NA | CDC42BPA Entrez, Source | CDC42 binding protein kinase alpha (DMPK-like) | 4422 | 0.674 | 0.3522 | No |
| 57 | PTPRM | NA | PTPRM Entrez, Source | protein tyrosine phosphatase, receptor type, M | 4432 | 0.672 | 0.3557 | No |
| 58 | MAPK14 | NA | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 4664 | 0.626 | 0.3464 | No |
| 59 | PDGFRB | NA | PDGFRB Entrez, Source | platelet-derived growth factor receptor, beta polypeptide | 4739 | 0.609 | 0.3459 | No |
| 60 | TFPI | NA | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 5087 | 0.539 | 0.3297 | No |
| 61 | MMP16 | NA | MMP16 Entrez, Source | matrix metallopeptidase 16 (membrane-inserted) | 5181 | 0.522 | 0.3276 | No |
| 62 | ATP2B4 | NA | ATP2B4 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 4 | 5220 | 0.514 | 0.3285 | No |
| 63 | CAP2 | NA | CAP2 Entrez, Source | CAP, adenylate cyclase-associated protein, 2 (yeast) | 5244 | 0.510 | 0.3303 | No |
| 64 | NEK7 | NA | NEK7 Entrez, Source | NIMA (never in mitosis gene a)-related kinase 7 | 6085 | 0.416 | 0.2857 | No |
| 65 | COL1A1 | NA | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 6216 | 0.412 | 0.2808 | No |
| 66 | FYN | NA | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 6328 | 0.393 | 0.2769 | No |
| 67 | IGFBP5 | NA | IGFBP5 Entrez, Source | insulin-like growth factor binding protein 5 | 6443 | 0.375 | 0.2728 | No |
| 68 | PMP22 | NA | PMP22 Entrez, Source | peripheral myelin protein 22 | 6664 | 0.340 | 0.2625 | No |
| 69 | PHF3 | NA | PHF3 Entrez, Source | PHD finger protein 3 | 6849 | 0.315 | 0.2541 | No |
| 70 | COL3A1 | NA | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 6922 | 0.302 | 0.2518 | No |
| 71 | DYRK1A | NA | DYRK1A Entrez, Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 7034 | 0.284 | 0.2473 | No |
| 72 | KIT | NA | KIT Entrez, Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 7055 | 0.281 | 0.2478 | No |
| 73 | NR1D2 | NA | NR1D2 Entrez, Source | nuclear receptor subfamily 1, group D, member 2 | 7151 | 0.266 | 0.2441 | No |
| 74 | BMPR1A | NA | BMPR1A Entrez, Source | bone morphogenetic protein receptor, type IA | 8024 | 0.143 | 0.1961 | No |
| 75 | ARHGEF9 | NA | ARHGEF9 Entrez, Source | Cdc42 guanine nucleotide exchange factor (GEF) 9 | 8195 | 0.120 | 0.1872 | No |
| 76 | VAV2 | NA | VAV2 Entrez, Source | vav 2 oncogene | 8212 | 0.118 | 0.1871 | No |
| 77 | MTA1 | NA | MTA1 Entrez, Source | metastasis associated 1 | 8227 | 0.117 | 0.1870 | No |
| 78 | ATP2C1 | NA | ATP2C1 Entrez, Source | ATPase, Ca++ transporting, type 2C, member 1 | 8399 | 0.094 | 0.1779 | No |
| 79 | CAV1 | NA | CAV1 Entrez, Source | caveolin 1, caveolae protein, 22kDa | 8434 | 0.089 | 0.1766 | No |
| 80 | PTEN | NA | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 8711 | 0.051 | 0.1614 | No |
| 81 | YTHDC1 | NA | YTHDC1 Entrez, Source | YTH domain containing 1 | 8878 | 0.032 | 0.1523 | No |
| 82 | ZMIZ1 | NA | 10049 | -0.073 | 0.0871 | No | ||
| 83 | SPOP | NA | SPOP Entrez, Source | speckle-type POZ protein | 10225 | -0.089 | 0.0778 | No |
| 84 | AMPH | NA | AMPH Entrez, Source | amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen) | 10516 | -0.127 | 0.0623 | No |
| 85 | CDK13 | NA | 10589 | -0.138 | 0.0591 | No | ||
| 86 | PAPD7 | NA | 10712 | -0.156 | 0.0532 | No | ||
| 87 | INPP4B | NA | INPP4B Entrez, Source | inositol polyphosphate-4-phosphatase, type II, 105kDa | 10736 | -0.159 | 0.0529 | No |
| 88 | NIPBL | NA | NIPBL Entrez, Source | Nipped-B homolog (Drosophila) | 10919 | -0.187 | 0.0438 | No |
| 89 | SRI | NA | SRI Entrez, Source | sorcin | 11416 | -0.257 | 0.0175 | No |
| 90 | ADD3 | NA | ADD3 Entrez, Source | adducin 3 (gamma) | 11657 | -0.290 | 0.0058 | No |
| 91 | ATP5S | NA | ATP5S Entrez, Source | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B) | 11705 | -0.297 | 0.0049 | No |
| 92 | TJP1 | NA | TJP1 Entrez, Source | tight junction protein 1 (zona occludens 1) | 11834 | -0.319 | -0.0004 | No |
| 93 | WDR37 | NA | WDR37 Entrez, Source | WD repeat domain 37 | 11887 | -0.327 | -0.0013 | No |
| 94 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 11952 | -0.332 | -0.0029 | No |
| 95 | FZD2 | NA | FZD2 Entrez, Source | frizzled homolog 2 (Drosophila) | 12101 | -0.354 | -0.0091 | No |
| 96 | LDLR | NA | LDLR Entrez, Source | low density lipoprotein receptor (familial hypercholesterolemia) | 12407 | -0.400 | -0.0238 | No |
| 97 | SIPA1L1 | NA | SIPA1L1 Entrez, Source | signal-induced proliferation-associated 1 like 1 | 12410 | -0.401 | -0.0216 | No |
| 98 | MIOS | NA | 12729 | -0.440 | -0.0368 | No | ||
| 99 | DBP | NA | DBP Entrez, Source | D site of albumin promoter (albumin D-box) binding protein | 13013 | -0.457 | -0.0499 | No |
| 100 | MAP2K5 | NA | MAP2K5 Entrez, Source | mitogen-activated protein kinase kinase 5 | 13363 | -0.512 | -0.0664 | No |
| 101 | ITGB3 | NA | ITGB3 Entrez, Source | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 13638 | -0.565 | -0.0784 | No |
| 102 | AGGF1 | NA | AGGF1 Entrez, Source | angiogenic factor with G patch and FHA domains 1 | 13671 | -0.571 | -0.0768 | No |
| 103 | DDAH1 | NA | DDAH1 Entrez, Source | dimethylarginine dimethylaminohydrolase 1 | 13686 | -0.573 | -0.0742 | No |
| 104 | PPARG | NA | PPARG Entrez, Source | peroxisome proliferative activated receptor, gamma | 14022 | -0.640 | -0.0891 | No |
| 105 | SMAD3 | NA | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 14025 | -0.642 | -0.0854 | No |
| 106 | AKT3 | NA | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 14156 | -0.671 | -0.0887 | No |
| 107 | COL11A1 | NA | COL11A1 Entrez, Source | collagen, type XI, alpha 1 | 14477 | -0.750 | -0.1022 | No |
| 108 | NFKB1 | NA | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 14554 | -0.768 | -0.1019 | No |
| 109 | PRKCE | NA | PRKCE Entrez, Source | protein kinase C, epsilon | 14753 | -0.814 | -0.1081 | No |
| 110 | BCKDHB | NA | BCKDHB Entrez, Source | branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) | 14814 | -0.829 | -0.1065 | No |
| 111 | RGS4 | NA | RGS4 Entrez, Source | regulator of G-protein signalling 4 | 14891 | -0.841 | -0.1058 | No |
| 112 | MYC | NA | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 15055 | -0.881 | -0.1097 | No |
| 113 | SCAF8 | NA | 15073 | -0.887 | -0.1053 | No | ||
| 114 | ATRX | NA | ATRX Entrez, Source | alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) | 15438 | -0.979 | -0.1199 | No |
| 115 | RUNX1 | NA | RUNX1 Entrez, Source | runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) | 15607 | -1.030 | -0.1232 | No |
| 116 | ICA1 | NA | ICA1 Entrez, Source | islet cell autoantigen 1, 69kDa | 15635 | -1.039 | -0.1185 | No |
| 117 | DAB2 | NA | DAB2 Entrez, Source | disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) | 15808 | -1.099 | -0.1216 | No |
| 118 | COL5A2 | NA | COL5A2 Entrez, Source | collagen, type V, alpha 2 | 15860 | -1.120 | -0.1178 | No |
| 119 | SLC22A18 | NA | SLC22A18 Entrez, Source | solute carrier family 22 (organic cation transporter), member 18 | 15927 | -1.147 | -0.1146 | No |
| 120 | RASA2 | NA | RASA2 Entrez, Source | RAS p21 protein activator 2 | 15930 | -1.147 | -0.1079 | No |
| 121 | CACNA1A | NA | CACNA1A Entrez, Source | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 16046 | -1.195 | -0.1072 | No |
| 122 | TGFBR2 | NA | TGFBR2 Entrez, Source | transforming growth factor, beta receptor II (70/80kDa) | 16329 | -1.323 | -0.1151 | No |
| 123 | PTGFR | NA | PTGFR Entrez, Source | prostaglandin F receptor (FP) | 16348 | -1.333 | -0.1082 | No |
| 124 | PRKAR2B | NA | PRKAR2B Entrez, Source | protein kinase, cAMP-dependent, regulatory, type II, beta | 16642 | -1.496 | -0.1157 | No |
| 125 | ANXA2 | NA | ANXA2 Entrez, Source | annexin A2 | 16698 | -1.528 | -0.1097 | No |
| 126 | MRPS31 | NA | MRPS31 Entrez, Source | mitochondrial ribosomal protein S31 | 16708 | -1.537 | -0.1010 | No |
| 127 | ANXA4 | NA | ANXA4 Entrez, Source | annexin A4 | 16776 | -1.584 | -0.0953 | No |
| 128 | IGF1R | NA | IGF1R Entrez, Source | insulin-like growth factor 1 receptor | 16802 | -1.603 | -0.0872 | No |
| 129 | MGLL | NA | MGLL Entrez, Source | monoglyceride lipase | 16963 | -1.735 | -0.0858 | No |
| 130 | SLC7A1 | NA | SLC7A1 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 16964 | -1.737 | -0.0754 | No |
| 131 | GRK5 | NA | GRK5 Entrez, Source | G protein-coupled receptor kinase 5 | 17196 | -2.001 | -0.0765 | No |
| 132 | INSIG1 | NA | INSIG1 Entrez, Source | insulin induced gene 1 | 17202 | -2.009 | -0.0648 | No |
| 133 | KCNMA1 | NA | KCNMA1 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | 17244 | -2.075 | -0.0547 | No |
| 134 | BHLHE40 | NA | 17439 | -2.394 | -0.0513 | No | ||
| 135 | SNAI2 | NA | SNAI2 Entrez, Source | snail homolog 2 (Drosophila) | 17636 | -2.825 | -0.0454 | No |
| 136 | HAS2 | NA | HAS2 Entrez, Source | hyaluronan synthase 2 | 17666 | -2.972 | -0.0294 | No |
| 137 | SCN8A | NA | SCN8A Entrez, Source | sodium channel, voltage gated, type VIII, alpha | 17821 | -3.701 | -0.0159 | No |
| 138 | KALRN | NA | KALRN Entrez, Source | kalirin, RhoGEF kinase | 17875 | -4.099 | 0.0056 | No |
