Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_SPERMATOGENESIS |
| Enrichment Score (ES) | -0.34037262 |
| Normalized Enrichment Score (NES) | -1.4440677 |
| Nominal p-value | 0.0066006603 |
| FDR q-value | 0.032999404 |
| FWER p-Value | 0.15 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CFTR | NA | CFTR Entrez, Source | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | 309 | 3.718 | 0.0167 | No |
| 2 | RFC4 | NA | RFC4 Entrez, Source | replication factor C (activator 1) 4, 37kDa | 751 | 2.636 | 0.0161 | No |
| 3 | HSPA4L | NA | HSPA4L Entrez, Source | heat shock 70kDa protein 4-like | 923 | 2.391 | 0.0284 | No |
| 4 | MTOR | NA | 1269 | 1.965 | 0.0271 | No | ||
| 5 | VDAC3 | NA | VDAC3 Entrez, Source | voltage-dependent anion channel 3 | 1299 | 1.935 | 0.0432 | No |
| 6 | ELOVL3 | NA | ELOVL3 Entrez, Source | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 | 1399 | 1.847 | 0.0545 | No |
| 7 | ACTL7B | NA | ACTL7B Entrez, Source | actin-like 7B | 1510 | 1.756 | 0.0644 | No |
| 8 | RPL39L | NA | RPL39L Entrez, Source | ribosomal protein L39-like | 1624 | 1.663 | 0.0733 | No |
| 9 | SEPT4 | NA | SEPT4 Entrez, Source | septin 4 | 1732 | 1.577 | 0.0817 | No |
| 10 | SLC12A2 | NA | SLC12A2 Entrez, Source | solute carrier family 12 (sodium/potassium/chloride transporters), member 2 | 1911 | 1.466 | 0.0852 | No |
| 11 | GSG1 | NA | GSG1 Entrez, Source | germ cell associated 1 | 1948 | 1.444 | 0.0964 | No |
| 12 | GAD1 | NA | GAD1 Entrez, Source | glutamate decarboxylase 1 (brain, 67kDa) | 2048 | 1.394 | 0.1036 | No |
| 13 | CAMK4 | NA | CAMK4 Entrez, Source | calcium/calmodulin-dependent protein kinase IV | 2780 | 1.067 | 0.0724 | No |
| 14 | STAM2 | NA | STAM2 Entrez, Source | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 | 2875 | 1.038 | 0.0767 | No |
| 15 | GRM8 | NA | GRM8 Entrez, Source | glutamate receptor, metabotropic 8 | 2975 | 0.999 | 0.0803 | No |
| 16 | PCSK1N | NA | PCSK1N Entrez, Source | proprotein convertase subtilisin/kexin type 1 inhibitor | 3055 | 0.973 | 0.0847 | No |
| 17 | TSSK2 | NA | TSSK2 Entrez, Source | testis-specific serine kinase 2 | 3081 | 0.968 | 0.0922 | No |
| 18 | EZH2 | NA | EZH2 Entrez, Source | enhancer of zeste homolog 2 (Drosophila) | 3248 | 0.928 | 0.0914 | No |
| 19 | DMC1 | NA | DMC1 Entrez, Source | DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) | 3319 | 0.907 | 0.0958 | No |
| 20 | AGFG1 | NA | 3428 | 0.877 | 0.0977 | No | ||
| 21 | HSPA1L | NA | HSPA1L Entrez, Source | heat shock 70kDa protein 1-like | 3713 | 0.828 | 0.0894 | No |
| 22 | BUB1 | NA | BUB1 Entrez, Source | BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) | 3781 | 0.813 | 0.0931 | No |
| 23 | CCT6B | NA | CCT6B Entrez, Source | chaperonin containing TCP1, subunit 6B (zeta 2) | 4001 | 0.762 | 0.0878 | No |
| 24 | DMRT1 | NA | DMRT1 Entrez, Source | doublesex and mab-3 related transcription factor 1 | 4076 | 0.745 | 0.0905 | No |
| 25 | ADCYAP1 | NA | ADCYAP1 Entrez, Source | adenylate cyclase activating polypeptide 1 (pituitary) | 4534 | 0.650 | 0.0708 | No |
| 26 | IL12RB2 | NA | IL12RB2 Entrez, Source | interleukin 12 receptor, beta 2 | 4607 | 0.637 | 0.0726 | No |
| 27 | SNAP91 | NA | SNAP91 Entrez, Source | synaptosomal-associated protein, 91kDa homolog (mouse) | 4944 | 0.570 | 0.0590 | No |
| 28 | MAP7 | NA | MAP7 Entrez, Source | microtubule-associated protein 7 | 5043 | 0.547 | 0.0585 | No |
| 29 | ARL4A | NA | ARL4A Entrez, Source | ADP-ribosylation factor-like 4A | 5045 | 0.546 | 0.0634 | No |
| 30 | CHFR | NA | CHFR Entrez, Source | checkpoint with forkhead and ring finger domains | 5311 | 0.499 | 0.0532 | No |
| 31 | CNIH2 | NA | CNIH2 Entrez, Source | cornichon homolog 2 (Drosophila) | 5780 | 0.432 | 0.0309 | No |
| 32 | NOS1 | NA | NOS1 Entrez, Source | nitric oxide synthase 1 (neuronal) | 5924 | 0.424 | 0.0268 | No |
| 33 | PGK2 | NA | PGK2 Entrez, Source | phosphoglycerate kinase 2 | 6053 | 0.418 | 0.0234 | No |
| 34 | GSTM3 | NA | GSTM3 Entrez, Source | glutathione S-transferase M3 (brain) | 6384 | 0.384 | 0.0085 | No |
| 35 | SHE | NA | SHE Entrez, Source | Src homology 2 domain containing E | 6600 | 0.350 | -0.0004 | No |
| 36 | ADAD1 | NA | 6795 | 0.323 | -0.0083 | No | ||
| 37 | ZC3H14 | NA | ZC3H14 Entrez, Source | zinc finger CCCH-type containing 14 | 6809 | 0.320 | -0.0061 | No |
| 38 | DBF4 | NA | DBF4 Entrez, Source | DBF4 homolog (S. cerevisiae) | 7217 | 0.255 | -0.0266 | No |
| 39 | NPHP1 | NA | NPHP1 Entrez, Source | nephronophthisis 1 (juvenile) | 7225 | 0.254 | -0.0246 | No |
| 40 | PAPOLB | NA | PAPOLB Entrez, Source | poly(A) polymerase beta (testis specific) | 7361 | 0.232 | -0.0301 | No |
| 41 | SIRT1 | NA | SIRT1 Entrez, Source | sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) | 7482 | 0.213 | -0.0349 | No |
| 42 | HIST1H1T | NA | HIST1H1T Entrez, Source | histone cluster 1, H1t | 7812 | 0.169 | -0.0517 | No |
| 43 | SCG5 | NA | SCG5 Entrez, Source | secretogranin V (7B2 protein) | 7878 | 0.162 | -0.0539 | No |
| 44 | SCG3 | NA | SCG3 Entrez, Source | secretogranin III | 7892 | 0.159 | -0.0532 | No |
| 45 | SLC2A5 | NA | SLC2A5 Entrez, Source | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | 8093 | 0.134 | -0.0631 | No |
| 46 | MAST2 | NA | MAST2 Entrez, Source | microtubule associated serine/threonine kinase 2 | 8106 | 0.133 | -0.0626 | No |
| 47 | ALOX15 | NA | ALOX15 Entrez, Source | arachidonate 15-lipoxygenase | 8346 | 0.102 | -0.0751 | No |
| 48 | CCNA1 | NA | CCNA1 Entrez, Source | cyclin A1 | 8359 | 0.100 | -0.0748 | No |
| 49 | NPY5R | NA | NPY5R Entrez, Source | neuropeptide Y receptor Y5 | 8460 | 0.086 | -0.0796 | No |
| 50 | TSN | NA | TSN Entrez, Source | translin | 8850 | 0.036 | -0.1011 | No |
| 51 | IP6K1 | NA | 8964 | 0.018 | -0.1073 | No | ||
| 52 | TULP2 | NA | TULP2 Entrez, Source | tubby like protein 2 | 8976 | 0.018 | -0.1077 | No |
| 53 | PCSK4 | NA | PCSK4 Entrez, Source | proprotein convertase subtilisin/kexin type 4 | 9063 | 0.012 | -0.1124 | No |
| 54 | MTNR1A | NA | MTNR1A Entrez, Source | melatonin receptor 1A | 9084 | 0.009 | -0.1135 | No |
| 55 | POMC | NA | POMC Entrez, Source | proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin) | 9208 | 0.000 | -0.1204 | No |
| 56 | CST8 | NA | CST8 Entrez, Source | cystatin 8 (cystatin-related epididymal specific) | 9271 | 0.000 | -0.1238 | No |
| 57 | CRISP2 | NA | CRISP2 Entrez, Source | cysteine-rich secretory protein 2 | 9345 | 0.000 | -0.1279 | No |
| 58 | PIAS2 | NA | PIAS2 Entrez, Source | protein inhibitor of activated STAT, 2 | 9430 | -0.004 | -0.1326 | No |
| 59 | OAZ3 | NA | OAZ3 Entrez, Source | ornithine decarboxylase antizyme 3 | 9537 | -0.020 | -0.1383 | No |
| 60 | ACRBP | NA | ACRBP Entrez, Source | acrosin binding protein | 9587 | -0.028 | -0.1408 | No |
| 61 | TKTL1 | NA | TKTL1 Entrez, Source | transketolase-like 1 | 9729 | -0.046 | -0.1483 | No |
| 62 | CDKN3 | NA | CDKN3 Entrez, Source | cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase) | 9823 | -0.055 | -0.1530 | No |
| 63 | NEK2 | NA | NEK2 Entrez, Source | NIMA (never in mitosis gene a)-related kinase 2 | 9964 | -0.067 | -0.1603 | No |
| 64 | PACRG | NA | PACRG Entrez, Source | PARK2 co-regulated | 9967 | -0.067 | -0.1598 | No |
| 65 | ADAM2 | NA | ADAM2 Entrez, Source | ADAM metallopeptidase domain 2 (fertilin beta) | 10121 | -0.079 | -0.1676 | No |
| 66 | NAA11 | NA | 10252 | -0.092 | -0.1740 | No | ||
| 67 | HTR5A | NA | HTR5A Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 5A | 10278 | -0.096 | -0.1746 | No |
| 68 | DNAJB8 | NA | DNAJB8 Entrez, Source | DnaJ (Hsp40) homolog, subfamily B, member 8 | 10434 | -0.114 | -0.1822 | No |
| 69 | NEFH | NA | NEFH Entrez, Source | neurofilament, heavy polypeptide 200kDa | 10450 | -0.116 | -0.1820 | No |
| 70 | SYCP1 | NA | SYCP1 Entrez, Source | synaptonemal complex protein 1 | 10672 | -0.150 | -0.1930 | No |
| 71 | MEP1B | NA | MEP1B Entrez, Source | meprin A, beta | 10858 | -0.177 | -0.2017 | No |
| 72 | CSNK2A2 | NA | CSNK2A2 Entrez, Source | casein kinase 2, alpha prime polypeptide | 10951 | -0.191 | -0.2051 | No |
| 73 | LDHC | NA | LDHC Entrez, Source | lactate dehydrogenase C | 10954 | -0.191 | -0.2035 | No |
| 74 | TALDO1 | NA | TALDO1 Entrez, Source | transaldolase 1 | 11110 | -0.213 | -0.2102 | No |
| 75 | GPR182 | NA | 11250 | -0.232 | -0.2159 | No | ||
| 76 | PHF7 | NA | PHF7 Entrez, Source | PHD finger protein 7 | 11350 | -0.247 | -0.2192 | No |
| 77 | DDX4 | NA | DDX4 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 | 11357 | -0.247 | -0.2173 | No |
| 78 | TEKT2 | NA | TEKT2 Entrez, Source | tektin 2 (testicular) | 11398 | -0.253 | -0.2172 | No |
| 79 | CLGN | NA | CLGN Entrez, Source | calmegin | 11492 | -0.270 | -0.2199 | No |
| 80 | BRAF | NA | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 11539 | -0.277 | -0.2200 | No |
| 81 | ACRV1 | NA | ACRV1 Entrez, Source | acrosomal vesicle protein 1 | 11698 | -0.295 | -0.2261 | No |
| 82 | PSMG1 | NA | 11967 | -0.334 | -0.2381 | No | ||
| 83 | TUBA3C | NA | 12088 | -0.352 | -0.2416 | No | ||
| 84 | THEG | NA | THEG Entrez, Source | Theg homolog (mouse) | 12517 | -0.411 | -0.2618 | No |
| 85 | YBX2 | NA | YBX2 Entrez, Source | Y box binding protein 2 | 12665 | -0.427 | -0.2661 | No |
| 86 | ART3 | NA | ART3 Entrez, Source | ADP-ribosyltransferase 3 | 12812 | -0.445 | -0.2702 | No |
| 87 | DPEP3 | NA | DPEP3 Entrez, Source | dipeptidase 3 | 12910 | -0.451 | -0.2716 | No |
| 88 | RAD17 | NA | RAD17 Entrez, Source | RAD17 homolog (S. pombe) | 13503 | -0.536 | -0.2998 | No |
| 89 | CLPB | NA | CLPB Entrez, Source | ClpB caseinolytic peptidase B homolog (E. coli) | 13554 | -0.547 | -0.2976 | No |
| 90 | AURKA | NA | AURKA Entrez, Source | aurora kinase A | 13620 | -0.562 | -0.2961 | No |
| 91 | COIL | NA | COIL Entrez, Source | coilin | 13655 | -0.569 | -0.2928 | No |
| 92 | PRKAR2A | NA | PRKAR2A Entrez, Source | protein kinase, cAMP-dependent, regulatory, type II, alpha | 13683 | -0.573 | -0.2891 | No |
| 93 | KIF2C | NA | KIF2C Entrez, Source | kinesin family member 2C | 13733 | -0.582 | -0.2865 | No |
| 94 | MLLT10 | NA | MLLT10 Entrez, Source | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 14330 | -0.708 | -0.3134 | No |
| 95 | PHKG2 | NA | PHKG2 Entrez, Source | phosphorylase kinase, gamma 2 (testis) | 14666 | -0.792 | -0.3249 | No |
| 96 | IFT88 | NA | IFT88 Entrez, Source | intraflagellar transport 88 homolog (Chlamydomonas) | 14889 | -0.841 | -0.3297 | No |
| 97 | HSPA2 | NA | HSPA2 Entrez, Source | heat shock 70kDa protein 2 | 15081 | -0.888 | -0.3322 | Yes |
| 98 | PGS1 | NA | PGS1 Entrez, Source | phosphatidylglycerophosphate synthase 1 | 15084 | -0.890 | -0.3242 | Yes |
| 99 | AKAP4 | NA | AKAP4 Entrez, Source | A kinase (PRKA) anchor protein 4 | 15118 | -0.895 | -0.3179 | Yes |
| 100 | TOPBP1 | NA | TOPBP1 Entrez, Source | topoisomerase (DNA) II binding protein 1 | 15199 | -0.913 | -0.3140 | Yes |
| 101 | IDE | NA | IDE Entrez, Source | insulin-degrading enzyme | 15245 | -0.927 | -0.3080 | Yes |
| 102 | MLF1 | NA | MLF1 Entrez, Source | myeloid leukemia factor 1 | 15315 | -0.945 | -0.3033 | Yes |
| 103 | CLVS1 | NA | 15327 | -0.948 | -0.2952 | Yes | ||
| 104 | TCP11 | NA | TCP11 Entrez, Source | t-complex 11 (mouse) | 15417 | -0.972 | -0.2913 | Yes |
| 105 | GMCL1 | NA | GMCL1 Entrez, Source | germ cell-less homolog 1 (Drosophila) | 15614 | -1.033 | -0.2928 | Yes |
| 106 | NCAPH | NA | NCAPH Entrez, Source | non-SMC condensin I complex, subunit H | 16030 | -1.187 | -0.3052 | Yes |
| 107 | PEBP1 | NA | PEBP1 Entrez, Source | phosphatidylethanolamine binding protein 1 | 16430 | -1.378 | -0.3150 | Yes |
| 108 | DDX25 | NA | DDX25 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 25 | 16566 | -1.441 | -0.3093 | Yes |
| 109 | CHRM4 | NA | CHRM4 Entrez, Source | cholinergic receptor, muscarinic 4 | 16569 | -1.442 | -0.2963 | Yes |
| 110 | STRBP | NA | STRBP Entrez, Source | spermatid perinuclear RNA binding protein | 16598 | -1.469 | -0.2844 | Yes |
| 111 | DCC | NA | DCC Entrez, Source | deleted in colorectal carcinoma | 16599 | -1.469 | -0.2709 | Yes |
| 112 | CDK1 | NA | 16637 | -1.491 | -0.2594 | Yes | ||
| 113 | PARP2 | NA | PARP2 Entrez, Source | poly (ADP-ribose) polymerase family, member 2 | 16739 | -1.557 | -0.2508 | Yes |
| 114 | NF2 | NA | NF2 Entrez, Source | neurofibromin 2 (bilateral acoustic neuroma) | 16827 | -1.628 | -0.2407 | Yes |
| 115 | CCNB2 | NA | CCNB2 Entrez, Source | cyclin B2 | 16828 | -1.630 | -0.2258 | Yes |
| 116 | TTK | NA | TTK Entrez, Source | TTK protein kinase | 16883 | -1.669 | -0.2136 | Yes |
| 117 | SPATA6 | NA | SPATA6 Entrez, Source | spermatogenesis associated 6 | 17272 | -2.117 | -0.2159 | Yes |
| 118 | TNNI3 | NA | TNNI3 Entrez, Source | troponin I type 3 (cardiac) | 17322 | -2.211 | -0.1984 | Yes |
| 119 | GAPDHS | NA | GAPDHS Entrez, Source | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | 17386 | -2.305 | -0.1809 | Yes |
| 120 | LPIN1 | NA | LPIN1 Entrez, Source | lipin 1 | 17464 | -2.429 | -0.1630 | Yes |
| 121 | HOXB1 | NA | HOXB1 Entrez, Source | homeobox B1 | 17555 | -2.601 | -0.1442 | Yes |
| 122 | JAM3 | NA | JAM3 Entrez, Source | junctional adhesion molecule 3 | 17589 | -2.733 | -0.1210 | Yes |
| 123 | GFI1 | NA | GFI1 Entrez, Source | growth factor independent 1 | 17674 | -3.015 | -0.0982 | Yes |
| 124 | ACE | NA | ACE Entrez, Source | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | 17704 | -3.112 | -0.0713 | Yes |
| 125 | TLE4 | NA | TLE4 Entrez, Source | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 17924 | -4.527 | -0.0421 | Yes |
| 126 | IL13RA2 | NA | IL13RA2 Entrez, Source | interleukin 13 receptor, alpha 2 | 17959 | -4.906 | 0.0008 | Yes |
