Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY |
| Enrichment Score (ES) | 0.5008989 |
| Normalized Enrichment Score (NES) | 1.5828997 |
| Nominal p-value | 0.015527951 |
| FDR q-value | 0.008418923 |
| FWER p-Value | 0.095 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | GPX3 | NA | GPX3 Entrez, Source | glutathione peroxidase 3 (plasma) | 13 | 4.944 | 0.0903 | Yes |
| 2 | GLRX | NA | GLRX Entrez, Source | glutaredoxin (thioltransferase) | 515 | 3.147 | 0.1203 | Yes |
| 3 | GSR | NA | GSR Entrez, Source | glutathione reductase | 576 | 2.988 | 0.1720 | Yes |
| 4 | MBP | NA | MBP Entrez, Source | myelin basic protein | 595 | 2.955 | 0.2254 | Yes |
| 5 | FTL | NA | FTL Entrez, Source | ferritin, light polypeptide | 802 | 2.544 | 0.2607 | Yes |
| 6 | SRXN1 | NA | SRXN1 Entrez, Source | sulfiredoxin 1 homolog (S. cerevisiae) | 858 | 2.466 | 0.3031 | Yes |
| 7 | G6PD | NA | G6PD Entrez, Source | glucose-6-phosphate dehydrogenase | 875 | 2.439 | 0.3471 | Yes |
| 8 | GCLC | NA | GCLC Entrez, Source | glutamate-cysteine ligase, catalytic subunit | 988 | 2.302 | 0.3832 | Yes |
| 9 | TXNRD1 | NA | TXNRD1 Entrez, Source | thioredoxin reductase 1 | 1023 | 2.267 | 0.4231 | Yes |
| 10 | NQO1 | NA | NQO1 Entrez, Source | NAD(P)H dehydrogenase, quinone 1 | 1308 | 1.922 | 0.4426 | Yes |
| 11 | MGST1 | NA | MGST1 Entrez, Source | microsomal glutathione S-transferase 1 | 1401 | 1.843 | 0.4714 | Yes |
| 12 | PRNP | NA | PRNP Entrez, Source | prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) | 1741 | 1.569 | 0.4814 | Yes |
| 13 | IPCEF1 | NA | 2114 | 1.350 | 0.4855 | Yes | ||
| 14 | ABCC1 | NA | ABCC1 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 2339 | 1.239 | 0.4958 | Yes |
| 15 | GCLM | NA | GCLM Entrez, Source | glutamate-cysteine ligase, modifier subunit | 2621 | 1.126 | 0.5009 | Yes |
| 16 | MSRA | NA | MSRA Entrez, Source | methionine sulfoxide reductase A | 3151 | 0.948 | 0.4889 | No |
| 17 | GLRX2 | NA | GLRX2 Entrez, Source | glutaredoxin 2 | 3325 | 0.905 | 0.4959 | No |
| 18 | GPX4 | NA | GPX4 Entrez, Source | glutathione peroxidase 4 (phospholipid hydroperoxidase) | 4809 | 0.592 | 0.4240 | No |
| 19 | EGLN2 | NA | EGLN2 Entrez, Source | egl nine homolog 2 (C. elegans) | 4975 | 0.563 | 0.4252 | No |
| 20 | HMOX2 | NA | HMOX2 Entrez, Source | heme oxygenase (decycling) 2 | 5485 | 0.480 | 0.4057 | No |
| 21 | PFKP | NA | PFKP Entrez, Source | phosphofructokinase, platelet | 5944 | 0.422 | 0.3879 | No |
| 22 | STK25 | NA | STK25 Entrez, Source | serine/threonine kinase 25 (STE20 homolog, yeast) | 6394 | 0.382 | 0.3699 | No |
| 23 | ATOX1 | NA | ATOX1 Entrez, Source | ATX1 antioxidant protein 1 homolog (yeast) | 6937 | 0.300 | 0.3452 | No |
| 24 | TXN | NA | TXN Entrez, Source | thioredoxin | 7365 | 0.231 | 0.3256 | No |
| 25 | SOD1 | NA | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 7495 | 0.211 | 0.3223 | No |
| 26 | MPO | NA | MPO Entrez, Source | myeloperoxidase | 8140 | 0.128 | 0.2887 | No |
| 27 | LSP1 | NA | LSP1 Entrez, Source | lymphocyte-specific protein 1 | 8409 | 0.092 | 0.2755 | No |
| 28 | SBNO2 | NA | SBNO2 Entrez, Source | strawberry notch homolog 2 (Drosophila) | 8666 | 0.058 | 0.2623 | No |
| 29 | CDKN2D | NA | CDKN2D Entrez, Source | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 8702 | 0.052 | 0.2613 | No |
| 30 | NDUFA6 | NA | NDUFA6 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa | 8760 | 0.042 | 0.2589 | No |
| 31 | PRDX2 | NA | PRDX2 Entrez, Source | peroxiredoxin 2 | 10148 | -0.082 | 0.1830 | No |
| 32 | PRDX1 | NA | PRDX1 Entrez, Source | peroxiredoxin 1 | 10354 | -0.102 | 0.1735 | No |
| 33 | SCAF4 | NA | 10420 | -0.113 | 0.1719 | No | ||
| 34 | OXSR1 | NA | OXSR1 Entrez, Source | oxidative-stress responsive 1 | 10479 | -0.121 | 0.1709 | No |
| 35 | PRDX4 | NA | PRDX4 Entrez, Source | peroxiredoxin 4 | 11268 | -0.234 | 0.1313 | No |
| 36 | PDLIM1 | NA | PDLIM1 Entrez, Source | PDZ and LIM domain 1 (elfin) | 11833 | -0.319 | 0.1057 | No |
| 37 | CAT | NA | CAT Entrez, Source | catalase | 12749 | -0.444 | 0.0628 | No |
| 38 | PRDX6 | NA | PRDX6 Entrez, Source | peroxiredoxin 6 | 12874 | -0.448 | 0.0642 | No |
| 39 | NDUFS2 | NA | NDUFS2 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) | 13304 | -0.504 | 0.0495 | No |
| 40 | NDUFB4 | NA | NDUFB4 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa | 15028 | -0.874 | -0.0305 | No |
| 41 | SOD2 | NA | SOD2 Entrez, Source | superoxide dismutase 2, mitochondrial | 15368 | -0.961 | -0.0317 | No |
| 42 | ERCC2 | NA | ERCC2 Entrez, Source | excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D) | 16327 | -1.321 | -0.0608 | No |
| 43 | FES | NA | FES Entrez, Source | feline sarcoma oncogene | 16858 | -1.649 | -0.0600 | No |
| 44 | JUNB | NA | JUNB Entrez, Source | jun B proto-oncogene | 17026 | -1.794 | -0.0363 | No |
| 45 | TXNRD2 | NA | TXNRD2 Entrez, Source | thioredoxin reductase 2 | 17422 | -2.369 | -0.0147 | No |
| 46 | HHEX | NA | HHEX Entrez, Source | homeobox, hematopoietically expressed | 17490 | -2.468 | 0.0270 | No |
