Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_PEROXISOME |
| Enrichment Score (ES) | -0.2354251 |
| Normalized Enrichment Score (NES) | -0.93107593 |
| Nominal p-value | 0.60596025 |
| FDR q-value | 0.7447823 |
| FWER p-Value | 1.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CRABP2 | NA | CRABP2 Entrez, Source | cellular retinoic acid binding protein 2 | 229 | 4.010 | 0.0262 | No |
| 2 | HSD3B7 | NA | HSD3B7 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 286 | 3.766 | 0.0596 | No |
| 3 | SLC27A2 | NA | SLC27A2 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 2 | 446 | 3.335 | 0.0831 | No |
| 4 | CLN8 | NA | CLN8 Entrez, Source | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) | 477 | 3.261 | 0.1131 | No |
| 5 | SEMA3C | NA | SEMA3C Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 556 | 3.054 | 0.1385 | No |
| 6 | ABCC5 | NA | ABCC5 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 772 | 2.601 | 0.1517 | No |
| 7 | EHHADH | NA | EHHADH Entrez, Source | enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | 1038 | 2.247 | 0.1587 | No |
| 8 | SLC35B2 | NA | SLC35B2 Entrez, Source | solute carrier family 35, member B2 | 1167 | 2.076 | 0.1717 | No |
| 9 | PEX14 | NA | PEX14 Entrez, Source | peroxisomal biogenesis factor 14 | 1295 | 1.937 | 0.1835 | No |
| 10 | EPHX2 | NA | EPHX2 Entrez, Source | epoxide hydrolase 2, cytoplasmic | 1564 | 1.713 | 0.1851 | No |
| 11 | ATXN1 | NA | ATXN1 Entrez, Source | ataxin 1 | 1754 | 1.560 | 0.1897 | No |
| 12 | IDH1 | NA | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 1999 | 1.421 | 0.1899 | No |
| 13 | SLC23A2 | NA | SLC23A2 Entrez, Source | solute carrier family 23 (nucleobase transporters), member 2 | 2340 | 1.239 | 0.1829 | No |
| 14 | CEL | NA | CEL Entrez, Source | carboxyl ester lipase (bile salt-stimulated lipase) | 2370 | 1.226 | 0.1932 | No |
| 15 | HSD17B11 | NA | 2457 | 1.194 | 0.2000 | No | ||
| 16 | MVP | NA | MVP Entrez, Source | major vault protein | 2474 | 1.187 | 0.2106 | No |
| 17 | ACOT8 | NA | ACOT8 Entrez, Source | acyl-CoA thioesterase 8 | 2712 | 1.094 | 0.2080 | No |
| 18 | ABCB9 | NA | ABCB9 Entrez, Source | ATP-binding cassette, sub-family B (MDR/TAP), member 9 | 2896 | 1.030 | 0.2077 | No |
| 19 | ABCD2 | NA | ABCD2 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 2 | 3125 | 0.954 | 0.2043 | No |
| 20 | ISOC1 | NA | ISOC1 Entrez, Source | isochorismatase domain containing 1 | 3374 | 0.889 | 0.1990 | No |
| 21 | STS | NA | STS Entrez, Source | steroid sulfatase (microsomal), arylsulfatase C, isozyme S | 3392 | 0.883 | 0.2067 | No |
| 22 | DHRS3 | NA | DHRS3 Entrez, Source | dehydrogenase/reductase (SDR family) member 3 | 3435 | 0.874 | 0.2128 | No |
| 23 | ACOX1 | NA | ACOX1 Entrez, Source | acyl-Coenzyme A oxidase 1, palmitoyl | 3448 | 0.871 | 0.2206 | No |
| 24 | PEX6 | NA | PEX6 Entrez, Source | peroxisomal biogenesis factor 6 | 3801 | 0.809 | 0.2088 | No |
| 25 | CTBP1 | NA | CTBP1 Entrez, Source | C-terminal binding protein 1 | 3860 | 0.797 | 0.2133 | No |
| 26 | TOP2A | NA | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 4150 | 0.728 | 0.2042 | No |
| 27 | HMGCL | NA | HMGCL Entrez, Source | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) | 4332 | 0.694 | 0.2008 | No |
| 28 | DIO1 | NA | DIO1 Entrez, Source | deiodinase, iodothyronine, type I | 4413 | 0.675 | 0.2029 | No |
| 29 | ALB | NA | ALB Entrez, Source | albumin | 4457 | 0.666 | 0.2069 | No |
| 30 | HSD17B4 | NA | HSD17B4 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 4 | 4681 | 0.622 | 0.2005 | No |
| 31 | ERCC3 | NA | ERCC3 Entrez, Source | excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) | 4939 | 0.570 | 0.1917 | No |
| 32 | SLC25A4 | NA | SLC25A4 Entrez, Source | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 | 4997 | 0.559 | 0.1939 | No |
| 33 | ABCD1 | NA | ABCD1 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 1 | 6365 | 0.387 | 0.1212 | No |
| 34 | ITGB1BP1 | NA | ITGB1BP1 Entrez, Source | integrin beta 1 binding protein 1 | 6716 | 0.332 | 0.1048 | No |
| 35 | SULT2B1 | NA | SULT2B1 Entrez, Source | sulfotransferase family, cytosolic, 2B, member 1 | 7141 | 0.267 | 0.0837 | No |
| 36 | ALDH1A1 | NA | ALDH1A1 Entrez, Source | aldehyde dehydrogenase 1 family, member A1 | 7260 | 0.248 | 0.0795 | No |
| 37 | HSD11B2 | NA | HSD11B2 Entrez, Source | hydroxysteroid (11-beta) dehydrogenase 2 | 7417 | 0.222 | 0.0730 | No |
| 38 | SOD1 | NA | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 7495 | 0.211 | 0.0707 | No |
| 39 | ELOVL5 | NA | ELOVL5 Entrez, Source | ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) | 7578 | 0.201 | 0.0681 | No |
| 40 | ECI2 | NA | 7730 | 0.180 | 0.0614 | No | ||
| 41 | GSTK1 | NA | GSTK1 Entrez, Source | glutathione S-transferase kappa 1 | 8082 | 0.134 | 0.0430 | No |
| 42 | HRAS | NA | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 8120 | 0.131 | 0.0422 | No |
| 43 | HAO2 | NA | HAO2 Entrez, Source | hydroxyacid oxidase 2 (long chain) | 8266 | 0.111 | 0.0352 | No |
| 44 | ACSL1 | NA | ACSL1 Entrez, Source | acyl-CoA synthetase long-chain family member 1 | 8603 | 0.066 | 0.0170 | No |
| 45 | MLYCD | NA | MLYCD Entrez, Source | malonyl-CoA decarboxylase | 8890 | 0.030 | 0.0013 | No |
| 46 | RXRG | NA | RXRG Entrez, Source | retinoid X receptor, gamma | 9227 | 0.000 | -0.0175 | No |
| 47 | TTR | NA | TTR Entrez, Source | transthyretin (prealbumin, amyloidosis type I) | 9301 | 0.000 | -0.0215 | No |
| 48 | SCP2 | NA | SCP2 Entrez, Source | sterol carrier protein 2 | 9491 | -0.013 | -0.0320 | No |
| 49 | ABCB1 | NA | ABCB1 Entrez, Source | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 9818 | -0.054 | -0.0497 | No |
| 50 | MSH2 | NA | MSH2 Entrez, Source | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | 10163 | -0.085 | -0.0681 | No |
| 51 | PRDX1 | NA | PRDX1 Entrez, Source | peroxiredoxin 1 | 10354 | -0.102 | -0.0778 | No |
| 52 | LONP2 | NA | 10452 | -0.116 | -0.0820 | No | ||
| 53 | PEX2 | NA | 10673 | -0.150 | -0.0929 | No | ||
| 54 | GNPAT | NA | GNPAT Entrez, Source | glyceronephosphate O-acyltransferase | 10802 | -0.170 | -0.0984 | No |
| 55 | CDK7 | NA | CDK7 Entrez, Source | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 11014 | -0.200 | -0.1083 | No |
| 56 | CRAT | NA | CRAT Entrez, Source | carnitine acetyltransferase | 11109 | -0.213 | -0.1115 | No |
| 57 | PEX11A | NA | PEX11A Entrez, Source | peroxisomal biogenesis factor 11A | 11326 | -0.243 | -0.1212 | No |
| 58 | NUDT19 | NA | NUDT19 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 19 | 11725 | -0.299 | -0.1405 | No |
| 59 | SIAH1 | NA | SIAH1 Entrez, Source | seven in absentia homolog 1 (Drosophila) | 11921 | -0.329 | -0.1483 | No |
| 60 | ABCD3 | NA | ABCD3 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 3 | 12210 | -0.370 | -0.1608 | No |
| 61 | ECH1 | NA | ECH1 Entrez, Source | enoyl Coenzyme A hydratase 1, peroxisomal | 12276 | -0.380 | -0.1607 | No |
| 62 | YWHAH | NA | YWHAH Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 12614 | -0.418 | -0.1755 | No |
| 63 | CAT | NA | CAT Entrez, Source | catalase | 12749 | -0.444 | -0.1787 | No |
| 64 | PEX11B | NA | PEX11B Entrez, Source | peroxisomal biogenesis factor 11B | 12998 | -0.455 | -0.1881 | No |
| 65 | SLC25A17 | NA | SLC25A17 Entrez, Source | solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 | 13063 | -0.465 | -0.1872 | No |
| 66 | CNBP | NA | CNBP Entrez, Source | CCHC-type zinc finger, nucleic acid binding protein | 13217 | -0.492 | -0.1910 | No |
| 67 | FIS1 | NA | FIS1 Entrez, Source | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 13269 | -0.501 | -0.1890 | No |
| 68 | SCGB1A1 | NA | SCGB1A1 Entrez, Source | secretoglobin, family 1A, member 1 (uteroglobin) | 13288 | -0.502 | -0.1851 | No |
| 69 | PEX13 | NA | PEX13 Entrez, Source | peroxisome biogenesis factor 13 | 13420 | -0.521 | -0.1874 | No |
| 70 | RETSAT | NA | RETSAT Entrez, Source | retinol saturase (all-trans-retinol 13,14-reductase) | 13613 | -0.561 | -0.1927 | No |
| 71 | VPS4B | NA | VPS4B Entrez, Source | vacuolar protein sorting 4 homolog B (S. cerevisiae) | 13966 | -0.626 | -0.2063 | No |
| 72 | BCL10 | NA | BCL10 Entrez, Source | B-cell CLL/lymphoma 10 | 14053 | -0.647 | -0.2048 | No |
| 73 | ALDH9A1 | NA | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 14538 | -0.763 | -0.2245 | No |
| 74 | PRDX5 | NA | PRDX5 Entrez, Source | peroxiredoxin 5 | 14735 | -0.810 | -0.2276 | Yes |
| 75 | SERPINA6 | NA | SERPINA6 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 | 14870 | -0.839 | -0.2269 | Yes |
| 76 | SLC25A19 | NA | SLC25A19 Entrez, Source | solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 19 | 14967 | -0.859 | -0.2239 | Yes |
| 77 | ABCC8 | NA | ABCC8 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 | 15128 | -0.895 | -0.2242 | Yes |
| 78 | IDE | NA | IDE Entrez, Source | insulin-degrading enzyme | 15245 | -0.927 | -0.2217 | Yes |
| 79 | SOD2 | NA | SOD2 Entrez, Source | superoxide dismutase 2, mitochondrial | 15368 | -0.961 | -0.2191 | Yes |
| 80 | ABCB4 | NA | ABCB4 Entrez, Source | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | 15489 | -0.995 | -0.2162 | Yes |
| 81 | PABPC1 | NA | PABPC1 Entrez, Source | poly(A) binding protein, cytoplasmic 1 | 15656 | -1.048 | -0.2153 | Yes |
| 82 | TSPO | NA | TSPO Entrez, Source | translocator protein (18kDa) | 15660 | -1.050 | -0.2053 | Yes |
| 83 | ACAA1 | NA | ACAA1 Entrez, Source | acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase) | 15691 | -1.059 | -0.1967 | Yes |
| 84 | PEX5 | NA | PEX5 Entrez, Source | peroxisomal biogenesis factor 5 | 15823 | -1.104 | -0.1933 | Yes |
| 85 | CACNA1B | NA | CACNA1B Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1B subunit | 15950 | -1.153 | -0.1891 | Yes |
| 86 | RDH11 | NA | RDH11 Entrez, Source | retinol dehydrogenase 11 (all-trans/9-cis/11-cis) | 16016 | -1.181 | -0.1813 | Yes |
| 87 | ERCC1 | NA | ERCC1 Entrez, Source | excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) | 16032 | -1.189 | -0.1705 | Yes |
| 88 | ACSL5 | NA | ACSL5 Entrez, Source | acyl-CoA synthetase long-chain family member 5 | 16261 | -1.285 | -0.1708 | Yes |
| 89 | CLN6 | NA | CLN6 Entrez, Source | ceroid-lipofuscinosis, neuronal 6, late infantile, variant | 16352 | -1.337 | -0.1629 | Yes |
| 90 | NR1I2 | NA | NR1I2 Entrez, Source | nuclear receptor subfamily 1, group I, member 2 | 16393 | -1.360 | -0.1519 | Yes |
| 91 | ACSL4 | NA | ACSL4 Entrez, Source | acyl-CoA synthetase long-chain family member 4 | 16418 | -1.372 | -0.1399 | Yes |
| 92 | SMARCC1 | NA | SMARCC1 Entrez, Source | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 16487 | -1.409 | -0.1300 | Yes |
| 93 | IDI1 | NA | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 16724 | -1.548 | -0.1282 | Yes |
| 94 | FDPS | NA | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 16738 | -1.557 | -0.1138 | Yes |
| 95 | CRABP1 | NA | CRABP1 Entrez, Source | cellular retinoic acid binding protein 1 | 17247 | -2.077 | -0.1220 | Yes |
| 96 | FADS1 | NA | FADS1 Entrez, Source | fatty acid desaturase 1 | 17341 | -2.232 | -0.1055 | Yes |
| 97 | DLG4 | NA | DLG4 Entrez, Source | discs, large homolog 4 (Drosophila) | 17558 | -2.602 | -0.0923 | Yes |
| 98 | IDH2 | NA | IDH2 Entrez, Source | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 17605 | -2.752 | -0.0681 | Yes |
| 99 | FABP6 | NA | FABP6 Entrez, Source | fatty acid binding protein 6, ileal (gastrotropin) | 17633 | -2.820 | -0.0422 | Yes |
| 100 | DHCR24 | NA | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 17710 | -3.134 | -0.0160 | Yes |
| 101 | CADM1 | NA | 17717 | -3.164 | 0.0144 | Yes |
