Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_PANCREAS_BETA_CELLS |
| Enrichment Score (ES) | -0.21453941 |
| Normalized Enrichment Score (NES) | -0.70565337 |
| Nominal p-value | 0.9265823 |
| FDR q-value | 0.9802975 |
| FWER p-Value | 1.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | DPP4 | NA | DPP4 Entrez, Source | dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2) | 213 | 4.083 | 0.1231 | No |
| 2 | FOXA2 | NA | FOXA2 Entrez, Source | forkhead box A2 | 1219 | 2.024 | 0.1339 | No |
| 3 | SLC2A2 | NA | SLC2A2 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 2 | 2310 | 1.250 | 0.1145 | No |
| 4 | MAFB | NA | MAFB Entrez, Source | v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) | 2428 | 1.200 | 0.1476 | No |
| 5 | PAX4 | NA | PAX4 Entrez, Source | paired box gene 4 | 3168 | 0.945 | 0.1376 | No |
| 6 | GCK | NA | GCK Entrez, Source | glucokinase (hexokinase 4, maturity onset diabetes of the young 2) | 3592 | 0.843 | 0.1419 | No |
| 7 | PAK3 | NA | PAK3 Entrez, Source | p21 (CDKN1A)-activated kinase 3 | 3677 | 0.833 | 0.1647 | No |
| 8 | G6PC2 | NA | G6PC2 Entrez, Source | glucose-6-phosphatase, catalytic, 2 | 4286 | 0.705 | 0.1542 | No |
| 9 | CHGA | NA | CHGA Entrez, Source | chromogranin A (parathyroid secretory protein 1) | 4707 | 0.615 | 0.1511 | No |
| 10 | PCSK2 | NA | PCSK2 Entrez, Source | proprotein convertase subtilisin/kexin type 2 | 5157 | 0.526 | 0.1434 | No |
| 11 | STXBP1 | NA | STXBP1 Entrez, Source | syntaxin binding protein 1 | 5809 | 0.428 | 0.1213 | No |
| 12 | FOXO1 | NA | 6360 | 0.388 | 0.1035 | No | ||
| 13 | VDR | NA | VDR Entrez, Source | vitamin D (1,25- dihydroxyvitamin D3) receptor | 6594 | 0.351 | 0.1021 | No |
| 14 | NEUROD1 | NA | NEUROD1 Entrez, Source | neurogenic differentiation 1 | 6745 | 0.327 | 0.1045 | No |
| 15 | SCGN | NA | SCGN Entrez, Source | secretagogin, EF-hand calcium binding protein | 7451 | 0.218 | 0.0724 | No |
| 16 | IAPP | NA | IAPP Entrez, Source | islet amyloid polypeptide | 7464 | 0.215 | 0.0788 | No |
| 17 | SST | NA | SST Entrez, Source | somatostatin | 7818 | 0.169 | 0.0648 | No |
| 18 | DCX | NA | DCX Entrez, Source | doublecortex; lissencephaly, X-linked (doublecortin) | 7868 | 0.164 | 0.0674 | No |
| 19 | PKLR | NA | PKLR Entrez, Source | pyruvate kinase, liver and RBC | 8096 | 0.133 | 0.0592 | No |
| 20 | GCG | NA | GCG Entrez, Source | glucagon | 8800 | 0.040 | 0.0213 | No |
| 21 | INSM1 | NA | INSM1 Entrez, Source | insulinoma-associated 1 | 9112 | 0.009 | 0.0043 | No |
| 22 | SRP14 | NA | SRP14 Entrez, Source | signal recognition particle 14kDa (homologous Alu RNA binding protein) | 9567 | -0.026 | -0.0202 | No |
| 23 | SRP9 | NA | SRP9 Entrez, Source | signal recognition particle 9kDa | 11918 | -0.328 | -0.1403 | No |
| 24 | SYT13 | NA | SYT13 Entrez, Source | synaptotagmin XIII | 12181 | -0.366 | -0.1428 | No |
| 25 | PDX1 | NA | 12289 | -0.383 | -0.1362 | No | ||
| 26 | ISL1 | NA | ISL1 Entrez, Source | ISL1 transcription factor, LIM/homeodomain, (islet-1) | 12626 | -0.419 | -0.1411 | No |
| 27 | SRPRB | NA | SRPRB Entrez, Source | signal recognition particle receptor, B subunit | 13273 | -0.501 | -0.1605 | No |
| 28 | PCSK1 | NA | PCSK1 Entrez, Source | proprotein convertase subtilisin/kexin type 1 | 13501 | -0.536 | -0.1555 | No |
| 29 | SPCS1 | NA | SPCS1 Entrez, Source | signal peptidase complex subunit 1 homolog (S. cerevisiae) | 14091 | -0.656 | -0.1666 | No |
| 30 | AKT3 | NA | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 14156 | -0.671 | -0.1480 | No |
| 31 | ABCC8 | NA | ABCC8 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 | 15128 | -0.895 | -0.1726 | No |
| 32 | PAX6 | NA | PAX6 Entrez, Source | paired box gene 6 (aniridia, keratitis) | 15882 | -1.128 | -0.1773 | Yes |
| 33 | ELP4 | NA | ELP4 Entrez, Source | elongation protein 4 homolog (S. cerevisiae) | 15897 | -1.134 | -0.1406 | Yes |
| 34 | SEC11A | NA | 16162 | -1.243 | -0.1142 | Yes | ||
| 35 | HNF1A | NA | 16722 | -1.547 | -0.0942 | Yes | ||
| 36 | NKX6-1 | NA | NKX6-1 Entrez, Source | NK6 transcription factor related, locus 1 (Drosophila) | 16741 | -1.559 | -0.0437 | Yes |
| 37 | LMO2 | NA | LMO2 Entrez, Source | LIM domain only 2 (rhombotin-like 1) | 17759 | -3.401 | 0.0120 | Yes |
