Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1w6a
GeneSetHALLMARK_P53_PATHWAY
Enrichment Score (ES)0.3879579
Normalized Enrichment Score (NES)1.5128552
Nominal p-value0.002617801
FDR q-value0.014983841
FWER p-Value0.206
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_P53_PATHWAY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1S100A4NAS100A4
Entrez,  Source
S100 calcium binding protein A4794.5770.0144Yes
2NUPR1NANUPR1
Entrez,  Source
-914.5420.0324Yes
3ITGB4NAITGB4
Entrez,  Source
integrin, beta 41264.3900.0485Yes
4TGFANATGFA
Entrez,  Source
transforming growth factor, alpha1314.3650.0663Yes
5TPD52L1NATPD52L1
Entrez,  Source
tumor protein D52-like 11654.2540.0819Yes
6HIST1H1CNAHIST1H1C
Entrez,  Source
histone cluster 1, H1c2343.9940.0945Yes
7SLC7A11NASLC7A11
Entrez,  Source
solute carrier family 7, (cationic amino acid transporter, y+ system) member 112403.9770.1105Yes
8CASP1NACASP1
Entrez,  Source
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)3023.7320.1224Yes
9JAG2NAJAG2
Entrez,  Source
jagged 24003.4330.1311Yes
10EPHX1NAEPHX1
Entrez,  Source
epoxide hydrolase 1, microsomal (xenobiotic)4293.3670.1433Yes
11CTSDNACTSD
Entrez,  Source
cathepsin D (lysosomal aspartyl peptidase)4763.2650.1542Yes
12F2RNAF2R
Entrez,  Source
coagulation factor II (thrombin) receptor5613.0410.1619Yes
13HMOX1NAHMOX1
Entrez,  Source
heme oxygenase (decycling) 16142.9230.1710Yes
14FUCA1NAFUCA1
Entrez,  Source
fucosidase, alpha-L- 1, tissue6182.9120.1828Yes
15IER3NAIER3
Entrez,  Source
immediate early response 36222.9080.1946Yes
16EPHA2NAEPHA2
Entrez,  Source
EPH receptor A26502.8490.2048Yes
17ST14NAST14
Entrez,  Source
suppression of tumorigenicity 14 (colon carcinoma)6762.7790.2148Yes
18DDIT3NADDIT3
Entrez,  Source
DNA-damage-inducible transcript 36772.7670.2262Yes
19SLC3A2NASLC3A2
Entrez,  Source
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 27382.6510.2337Yes
20TNFSF9NATNFSF9
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 97492.6390.2440Yes
21RGS16NARGS16
Entrez,  Source
regulator of G-protein signalling 167542.6300.2546Yes
22ABCC5NAABCC5
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 57722.6010.2643Yes
23ABHD4NAABHD4
Entrez,  Source
abhydrolase domain containing 48252.5100.2717Yes
24DDIT4NADDIT4
Entrez,  Source
DNA-damage-inducible transcript 48442.4810.2809Yes
25CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)8882.4130.2884Yes
26HSPA4LNAHSPA4L
Entrez,  Source
heat shock 70kDa protein 4-like9232.3910.2963Yes
27ZMAT3NAZMAT3
Entrez,  Source
zinc finger, matrin type 39402.3630.3051Yes
28KIF13BNAKIF13B
Entrez,  Source
kinesin family member 13B10402.2450.3088Yes
29KLF4NAKLF4
Entrez,  Source
Kruppel-like factor 4 (gut)11652.0770.3103Yes
30PHLDA3NAPHLDA3
Entrez,  Source
pleckstrin homology-like domain, family A, member 311722.0700.3185Yes
31GM2ANAGM2A
Entrez,  Source
GM2 ganglioside activator12581.9810.3218Yes
32CCND3NACCND3
Entrez,  Source
cyclin D313091.9220.3269Yes
33TOB1NATOB1
Entrez,  Source
transducer of ERBB2, 113311.9000.3336Yes
34HEXIM1NAHEXIM1
Entrez,  Source
hexamethylene bis-acetamide inducible 113561.8810.3399Yes
35LRMPNALRMP
Entrez,  Source
lymphoid-restricted membrane protein13641.8730.3472Yes
36TRAF4NATRAF4
Entrez,  Source
TNF receptor-associated factor 414161.8270.3519Yes
37BAK1NABAK1
Entrez,  Source
BCL2-antagonist/killer 114421.8090.3579Yes
38RNF19BNA14921.7680.3624Yes
39KRT17NAKRT17
Entrez,  Source
keratin 1715431.7270.3667Yes
40POLHNAPOLH
Entrez,  Source
polymerase (DNA directed), eta15581.7170.3730Yes
41INHBBNAINHBB
Entrez,  Source
inhibin, beta B (activin AB beta polypeptide)17111.5920.3710Yes
42FASNAFAS
Entrez,  Source
Fas (TNF receptor superfamily, member 6)17161.5890.3773Yes
43CTSFNACTSF
Entrez,  Source
cathepsin F18431.5020.3764Yes
44CSRNP2NA19061.4680.3789Yes
45NINJ1NANINJ1
Entrez,  Source
ninjurin 119471.4450.3826Yes
46SAT1NASAT1
Entrez,  Source
spermidine/spermine N1-acetyltransferase 120291.4090.3838Yes
47MXD4NAMXD4
Entrez,  Source
MAX dimerization protein 420581.3870.3880Yes
48RRADNARRAD
Entrez,  Source
Ras-related associated with diabetes21991.3050.3855No
49CDK5R1NACDK5R1
Entrez,  Source
cyclin-dependent kinase 5, regulatory subunit 1 (p35)22851.2620.3859No
50NHLH2NANHLH2
Entrez,  Source
nescient helix loop helix 224471.1940.3817No
51RXRANARXRA
Entrez,  Source
retinoid X receptor, alpha27391.0850.3698No
52EPS8L2NAEPS8L2
Entrez,  Source
EPS8-like 227941.0610.3711No
53MDM2NAMDM2
Entrez,  Source
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)29141.0220.3686No
54TSC22D1NATSC22D1
Entrez,  Source
TSC22 domain family, member 130160.9880.3670No
55SOCS1NASOCS1
Entrez,  Source
suppressor of cytokine signaling 130870.9660.3671No
56TRIB3NATRIB3
Entrez,  Source
tribbles homolog 3 (Drosophila)33680.8910.3550No
57PRMT2NAPRMT2
Entrez,  Source
protein arginine methyltransferase 234000.8820.3569No
58HBEGFNAHBEGF
Entrez,  Source
heparin-binding EGF-like growth factor34510.8700.3576No
59HINT1NAHINT1
Entrez,  Source
histidine triad nucleotide binding protein 134950.8580.3587No
60SLC35D1NASLC35D1
Entrez,  Source
solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D135020.8560.3619No
61NOTCH1NANOTCH1
Entrez,  Source
Notch homolog 1, translocation-associated (Drosophila)36010.8410.3599No
62BAIAP2NABAIAP2
Entrez,  Source
BAI1-associated protein 236420.8360.3610No
63CCNKNACCNK
Entrez,  Source
cyclin K36440.8360.3644No
64TNNI1NATNNI1
Entrez,  Source
troponin I type 1 (skeletal, slow)38650.7950.3553No
65RCHY1NARCHY1
Entrez,  Source
ring finger and CHY zinc finger domain containing 140720.7450.3468No
66ALOX15BNAALOX15B
Entrez,  Source
arachidonate 15-lipoxygenase, type B41580.7270.3450No
67WWP1NAWWP1
Entrez,  Source
WW domain containing E3 ubiquitin protein ligase 142450.7120.3431No
68NDRG1NANDRG1
Entrez,  Source
N-myc downstream regulated gene 143310.6940.3412No
69S100A10NAS100A10
Entrez,  Source
S100 calcium binding protein A1043900.6810.3407No
70IER5NAIER5
Entrez,  Source
immediate early response 544520.6670.3400No
71TSPYL2NATSPYL2
Entrez,  Source
TSPY-like 247350.6090.3267No
72DGKANADGKA
Entrez,  Source
diacylglycerol kinase, alpha 80kDa47370.6090.3291No
73PLK2NAPLK2
Entrez,  Source
polo-like kinase 2 (Drosophila)47970.5950.3283No
74TAP1NATAP1
Entrez,  Source
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)49610.5660.3214No
75H2AFJNAH2AFJ
Entrez,  Source
H2A histone family, member J49880.5600.3223No
76STEAP3NASTEAP3
Entrez,  Source
STEAP family member 350290.5490.3223No
77CGRRF1NACGRRF1
Entrez,  Source
cell growth regulator with ring finger domain 151300.5300.3188No
78GLS2NAGLS2
Entrez,  Source
glutaminase 2 (liver, mitochondrial)53390.4940.3092No
79PMM1NAPMM1
Entrez,  Source
phosphomannomutase 153850.4890.3086No
80MAPKAPK3NAMAPKAPK3
Entrez,  Source
mitogen-activated protein kinase-activated protein kinase 355890.4630.2991No
81PPP1R15ANAPPP1R15A
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 15A56660.4500.2967No
82TXNIPNATXNIP
Entrez,  Source
thioredoxin interacting protein63360.3920.2607No
83IRAK1NAIRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 163390.3920.2622No
84HDAC3NAHDAC3
Entrez,  Source
histone deacetylase 363400.3920.2638No
85TRAFD1NATRAFD1
Entrez,  Source
TRAF-type zinc finger domain containing 163820.3840.2631No
86TM7SF3NATM7SF3
Entrez,  Source
transmembrane 7 superfamily member 364600.3730.2603No
87SLC19A2NASLC19A2
Entrez,  Source
solute carrier family 19 (thiamine transporter), member 264770.3710.2609No
88ISCUNA65300.3620.2595No
89VDRNAVDR
Entrez,  Source
vitamin D (1,25- dihydroxyvitamin D3) receptor65940.3510.2574No
90PERPNAPERP
Entrez,  Source
PERP, TP53 apoptosis effector66210.3470.2573No
91PLXNB2NAPLXNB2
Entrez,  Source
plexin B266550.3420.2569No
92VWA5ANA66830.3370.2567No
93RAB40CNARAB40C
Entrez,  Source
RAB40C, member RAS oncogene family67410.3270.2549No
94CLCA2NACLCA2
Entrez,  Source
chloride channel, calcium activated, family member 269570.2960.2440No
95JUNNAJUN
Entrez,  Source
jun oncogene71970.2580.2316No
96FOSNAFOS
Entrez,  Source
v-fos FBJ murine osteosarcoma viral oncogene homolog72650.2470.2289No
97RAP2BNARAP2B
Entrez,  Source
RAP2B, member of RAS oncogene family72940.2420.2283No
98MKNK2NAMKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 274390.2200.2211No
99BLCAPNABLCAP
Entrez,  Source
bladder cancer associated protein74610.2160.2208No
100SEC61A1NASEC61A1
Entrez,  Source
Sec61 alpha 1 subunit (S. cerevisiae)75800.2010.2150No
101HRASNAHRAS
Entrez,  Source
v-Ha-ras Harvey rat sarcoma viral oncogene homolog81200.1310.1852No
102APAF1NAAPAF1
Entrez,  Source
apoptotic peptidase activating factor81840.1220.1822No
103VAMP8NAVAMP8
Entrez,  Source
vesicle-associated membrane protein 8 (endobrevin)82200.1170.1807No
104IFI30NAIFI30
Entrez,  Source
interferon, gamma-inducible protein 3082400.1150.1801No
105POM121NAPOM121
Entrez,  Source
POM121 membrane glycoprotein (rat)84350.0890.1696No
106TGFB1NATGFB1
Entrez,  Source
transforming growth factor, beta 1 (Camurati-Engelmann disease)84500.0870.1691No
107RAD9ANARAD9A
Entrez,  Source
RAD9 homolog A (S. pombe)89580.0190.1407No
108AK1NAAK1
Entrez,  Source
adenylate kinase 191320.0070.1310No
109CDKN2ANACDKN2A
Entrez,  Source
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)93000.0000.1216No
110SERTAD3NASERTAD3
Entrez,  Source
SERTA domain containing 39603-0.0300.1048No
111BAXNABAX
Entrez,  Source
BCL2-associated X protein9792-0.0510.0944No
112ZFP36L1NAZFP36L1
Entrez,  Source
zinc finger protein 36, C3H type-like 19820-0.0540.0931No
113ZBTB16NAZBTB16
Entrez,  Source
zinc finger and BTB domain containing 169918-0.0640.0879No
114PLK3NAPLK3
Entrez,  Source
polo-like kinase 3 (Drosophila)9931-0.0650.0875No
115ACVR1BNAACVR1B
Entrez,  Source
activin A receptor, type IB10124-0.0790.0770No
116ANKRA2NAANKRA2
Entrez,  Source
ankyrin repeat, family A (RFXANK-like), 210133-0.0800.0769No
117WRAP73NA10361-0.1030.0646No
118PROCRNAPROCR
Entrez,  Source
protein C receptor, endothelial (EPCR)10414-0.1120.0621No
119GPX2NAGPX2
Entrez,  Source
glutathione peroxidase 2 (gastrointestinal)10544-0.1300.0554No
120SP1NASP1
Entrez,  Source
Sp1 transcription factor10729-0.1580.0457No
121MXD1NAMXD1
Entrez,  Source
MAX dimerization protein 110789-0.1680.0431No
122BTG1NABTG1
Entrez,  Source
B-cell translocation gene 1, anti-proliferative10899-0.1840.0377No
123CD82NACD82
Entrez,  Source
CD82 molecule11143-0.2180.0249No
124RAD51CNARAD51C
Entrez,  Source
RAD51 homolog C (S. cerevisiae)11241-0.2320.0204No
125CCP110NA11314-0.2410.0174No
126CDKN2AIPNA11519-0.2740.0070No
127CDKN2BNACDKN2B
Entrez,  Source
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)11530-0.2750.0076No
128DDB2NADDB2
Entrez,  Source
damage-specific DNA binding protein 2, 48kDa11578-0.2820.0061No
129PPM1DNAPPM1D
Entrez,  Source
protein phosphatase 1D magnesium-dependent, delta isoform11702-0.2960.0004No
130IP6K2NA11775-0.308-0.0024No
131FBXW7NAFBXW7
Entrez,  Source
F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)11783-0.309-0.0015No
132EI24NAEI24
Entrez,  Source
etoposide induced 2.4 mRNA11835-0.319-0.0030No
133TCN2NATCN2
Entrez,  Source
transcobalamin II; macrocytic anemia11996-0.339-0.0106No
134RPS27LNARPS27L
Entrez,  Source
ribosomal protein S27-like12428-0.406-0.0332No
135NOL8NANOL8
Entrez,  Source
nucleolar protein 812604-0.416-0.0413No
136PCNANAPCNA
Entrez,  Source
proliferating cell nuclear antigen13241-0.495-0.0751No
137RRP8NA13527-0.542-0.0889No
138RETSATNARETSAT
Entrez,  Source
retinol saturase (all-trans-retinol 13,14-reductase)13613-0.561-0.0913No
139ERCC5NAERCC5
Entrez,  Source
me))13876-0.610-0.1036No
140LDHBNALDHB
Entrez,  Source
lactate dehydrogenase B13998-0.634-0.1078No
141RPL36NARPL36
Entrez,  Source
ribosomal protein L3614038-0.644-0.1073No
142CCNG1NACCNG1
Entrez,  Source
cyclin G114071-0.652-0.1064No
143CD81NACD81
Entrez,  Source
CD81 molecule14089-0.656-0.1047No
144RPL18NARPL18
Entrez,  Source
ribosomal protein L1814332-0.708-0.1154No
145TCHHNATCHH
Entrez,  Source
trichohyalin14475-0.749-0.1203No
146SDC1NASDC1
Entrez,  Source
syndecan 114863-0.838-0.1386No
147PTPN14NAPTPN14
Entrez,  Source
protein tyrosine phosphatase, non-receptor type 1415089-0.891-0.1476No
148APPNAAPP
Entrez,  Source
amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)15153-0.903-0.1474No
149FOXO3NA15226-0.922-0.1477No
150SESN1NASESN1
Entrez,  Source
sestrin 115240-0.926-0.1446No
151RHBDF2NARHBDF2
Entrez,  Source
rhomboid 5 homolog 2 (Drosophila)15481-0.993-0.1540No
152TM4SF1NATM4SF1
Entrez,  Source
transmembrane 4 L six family member 115663-1.051-0.1599No
153TP63NA15667-1.052-0.1557No
154XPCNAXPC
Entrez,  Source
xeroderma pigmentosum, complementation group C15685-1.057-0.1523No
155SERPINB5NASERPINB5
Entrez,  Source
serpin peptidase inhibitor, clade B (ovalbumin), member 515690-1.059-0.1482No
156GADD45ANAGADD45A
Entrez,  Source
growth arrest and DNA-damage-inducible, alpha15708-1.064-0.1448No
157DRAM1NA15753-1.079-0.1428No
158FDXRNAFDXR
Entrez,  Source
ferredoxin reductase15764-1.082-0.1390No
159FAM162ANA16037-1.190-0.1494No
160CCND2NACCND2
Entrez,  Source
cyclin D216061-1.200-0.1457No
161TRIAP1NATRIAP1
Entrez,  Source
TP53 regulated inhibitor of apoptosis 116145-1.236-0.1453No
162DNTTIP2NADNTTIP2
Entrez,  Source
deoxynucleotidyltransferase, terminal, interacting protein 216160-1.243-0.1410No
163TAX1BP3NATAX1BP3
Entrez,  Source
Tax1 (human T-cell leukemia virus type I) binding protein 316167-1.244-0.1362No
164RB1NARB1
Entrez,  Source
retinoblastoma 1 (including osteosarcoma)16178-1.250-0.1316No
165DCXRNADCXR
Entrez,  Source
dicarbonyl/L-xylulose reductase16185-1.251-0.1268No
166DEF6NADEF6
Entrez,  Source
differentially expressed in FDCP 6 homolog (mouse)16231-1.276-0.1241No
167STOMNASTOM
Entrez,  Source
stomatin16303-1.306-0.1227No
168PRKAB1NAPRKAB1
Entrez,  Source
protein kinase, AMP-activated, beta 1 non-catalytic subunit16379-1.350-0.1214No
169SFNNASFN
Entrez,  Source
stratifin16410-1.369-0.1175No
170RPS12NARPS12
Entrez,  Source
ribosomal protein S1216556-1.439-0.1197No
171RALGDSNARALGDS
Entrez,  Source
ral guanine nucleotide dissociation stimulator16615-1.481-0.1169No
172ABATNAABAT
Entrez,  Source
4-aminobutyrate aminotransferase16644-1.497-0.1123No
173LIFNALIF
Entrez,  Source
leukemia inhibitory factor (cholinergic differentiation factor)16734-1.553-0.1109No
174TPRKBNATPRKB
Entrez,  Source
TP53RK binding protein16923-1.697-0.1145No
175SPHK1NASPHK1
Entrez,  Source
sphingosine kinase 117256-2.092-0.1246No
176AENNA17282-2.131-0.1173No
177TP53NATP53
Entrez,  Source
tumor protein p53 (Li-Fraumeni syndrome)17294-2.152-0.1090No
178NUDT15NANUDT15
Entrez,  Source
nudix (nucleoside diphosphate linked moiety X)-type motif 1517306-2.180-0.1007No
179CEBPANACEBPA
Entrez,  Source
CCAAT/enhancer binding protein (C/EBP), alpha17324-2.214-0.0925No
180PTPRENAPTPRE
Entrez,  Source
protein tyrosine phosphatase, receptor type, E17374-2.287-0.0859No
181ADANAADA
Entrez,  Source
adenosine deaminase17404-2.332-0.0780No
182CDH13NACDH13
Entrez,  Source
cadherin 13, H-cadherin (heart)17527-2.555-0.0743No
183PDGFANAPDGFA
Entrez,  Source
platelet-derived growth factor alpha polypeptide17541-2.598-0.0644No
184PITPNC1NAPITPNC1
Entrez,  Source
phosphatidylinositol transfer protein, cytoplasmic 117610-2.769-0.0568No
185ZNF365NAZNF365
Entrez,  Source
zinc finger protein 36517706-3.119-0.0493No
186BMP2NABMP2
Entrez,  Source
bone morphogenetic protein 217763-3.423-0.0384No
187IL1ANAIL1A
Entrez,  Source
interleukin 1, alpha17815-3.646-0.0263No
188BTG2NABTG2
Entrez,  Source
BTG family, member 217816-3.647-0.0113No
189FGF13NAFGF13
Entrez,  Source
fibroblast growth factor 1317958-4.9040.0009No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_P53_PATHWAY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_P53_PATHWAY: Random ES distribution   
Gene set null distribution of ES for HALLMARK_P53_PATHWAY