Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_MITOTIC_SPINDLE
Enrichment Score (ES)-0.30879545
Normalized Enrichment Score (NES)-1.3454635
Nominal p-value0.017857144
FDR q-value0.06765814
FWER p-Value0.34
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_MITOTIC_SPINDLE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DOCK2NADOCK2
Entrez,  Source
dedicator of cytokinesis 21864.1680.0129No
2SHROOM2NASHROOM2
Entrez,  Source
shroom family member 22703.8350.0298No
3CLIP2NA4603.3020.0377No
4DSTNADST
Entrez,  Source
dystonin6742.7810.0413No
5ECT2NAECT2
Entrez,  Source
epithelial cell transforming sequence 2 oncogene7832.5740.0496No
6KIF1BNAKIF1B
Entrez,  Source
kinesin family member 1B12302.0100.0358No
7DYNC1H1NADYNC1H1
Entrez,  Source
dynein, cytoplasmic 1, heavy chain 113461.8870.0399No
8PKD2NAPKD2
Entrez,  Source
polycystic kidney disease 2 (autosomal dominant)13911.8520.0479No
9PDLIM5NAPDLIM5
Entrez,  Source
PDZ and LIM domain 514721.7840.0534No
10BCL2L11NABCL2L11
Entrez,  Source
BCL2-like 11 (apoptosis facilitator)15961.6890.0559No
11PCM1NAPCM1
Entrez,  Source
pericentriolar material 116371.6530.0630No
12MID1NAMID1
Entrez,  Source
midline 1 (Opitz/BBB syndrome)17241.5840.0670No
13MYO9BNAMYO9B
Entrez,  Source
myosin IXB17731.5420.0730No
14ARHGAP5NAARHGAP5
Entrez,  Source
Rho GTPase activating protein 519771.4320.0696No
15CCDC88ANA20781.3750.0717No
16OPHN1NAOPHN1
Entrez,  Source
oligophrenin 124311.1990.0586No
17RAPGEF6NARAPGEF6
Entrez,  Source
Rap guanine nucleotide exchange factor (GEF) 624431.1960.0647No
18CD2APNACD2AP
Entrez,  Source
CD2-associated protein25521.1580.0651No
19ALS2NAALS2
Entrez,  Source
amyotrophic lateral sclerosis 2 (juvenile)26551.1130.0656No
20FGD4NAFGD4
Entrez,  Source
FYVE, RhoGEF and PH domain containing 426851.1020.0702No
21SPTAN1NASPTAN1
Entrez,  Source
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)27511.0780.0725No
22CLASP1NACLASP1
Entrez,  Source
cytoplasmic linker associated protein 127821.0660.0768No
23BCRNABCR
Entrez,  Source
breakpoint cluster region29271.0140.0744No
24WASF2NAWASF2
Entrez,  Source
WAS protein family, member 229691.0010.0777No
25NOTCH2NANOTCH2
Entrez,  Source
Notch homolog 2 (Drosophila)32240.9340.0687No
26SSH2NASSH2
Entrez,  Source
slingshot homolog 2 (Drosophila)32340.9310.0734No
27ARF6NAARF6
Entrez,  Source
ADP-ribosylation factor 632650.9220.0769No
28KLC1NA32880.9160.0808No
29PREX1NAPREX1
Entrez,  Source
-34110.8800.0789No
30EZRNA34520.8700.0815No
31NF1NANF1
Entrez,  Source
neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)34770.8640.0850No
32BCAR1NABCAR1
Entrez,  Source
breast cancer anti-estrogen resistance 135890.8430.0835No
33PCGF5NAPCGF5
Entrez,  Source
polycomb group ring finger 537230.8260.0806No
34SYNPONASYNPO
Entrez,  Source
synaptopodin37570.8200.0834No
35BUB1NABUB1
Entrez,  Source
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)37810.8130.0867No
36CAPZBNACAPZB
Entrez,  Source
capping protein (actin filament) muscle Z-line, beta37930.8110.0906No
37DLG1NADLG1
Entrez,  Source
discs, large homolog 1 (Drosophila)39990.7620.0833No
38PALLDNAPALLD
Entrez,  Source
palladin, cytoskeletal associated protein41050.7390.0816No
39TOP2ANATOP2A
Entrez,  Source
topoisomerase (DNA) II alpha 170kDa41500.7280.0832No
40WASLNAWASL
Entrez,  Source
Wiskott-Aldrich syndrome-like44070.6770.0726No
41CDC42BPANACDC42BPA
Entrez,  Source
CDC42 binding protein kinase alpha (DMPK-like)44220.6740.0756No
42GSNNAGSN
Entrez,  Source
gelsolin (amyloidosis, Finnish type)44410.6700.0783No
43CEP72NACEP72
Entrez,  Source
centrosomal protein 72kDa46320.6330.0712No
44RAB3GAP1NARAB3GAP1
Entrez,  Source
RAB3 GTPase activating protein subunit 1 (catalytic)46750.6240.0723No
45ARHGAP27NAARHGAP27
Entrez,  Source
Rho GTPase activating protein 2746850.6210.0753No
46SPTBN1NASPTBN1
Entrez,  Source
spectrin, beta, non-erythrocytic 147640.6040.0743No
47SOS1NASOS1
Entrez,  Source
son of sevenless homolog 1 (Drosophila)47680.6030.0775No
48TSC1NATSC1
Entrez,  Source
tuberous sclerosis 147850.5990.0800No
49ATG4BNAATG4B
Entrez,  Source
ATG4 autophagy related 4 homolog B (S. cerevisiae)48160.5910.0816No
50RASA1NARASA1
Entrez,  Source
RAS p21 protein activator (GTPase activating protein) 150010.5580.0744No
51SMC1ANASMC1A
Entrez,  Source
structural maintenance of chromosomes 1A50050.5570.0773No
52FLNBNAFLNB
Entrez,  Source
filamin B, beta (actin binding protein 278)50240.5510.0794No
53NINNANIN
Entrez,  Source
ninein (GSK3B interacting protein)52770.5040.0681No
54SHROOM1NASHROOM1
Entrez,  Source
shroom family member 153430.4930.0672No
55TLK1NATLK1
Entrez,  Source
tousled-like kinase 154880.4790.0617No
56ARHGEF12NAARHGEF12
Entrez,  Source
Rho guanine nucleotide exchange factor (GEF) 1256310.4550.0563No
57NCK2NANCK2
Entrez,  Source
NCK adaptor protein 256450.4530.0581No
58CDC42NACDC42
Entrez,  Source
cell division cycle 42 (GTP binding protein, 25kDa)62480.4080.0266No
59KIF3BNAKIF3B
Entrez,  Source
kinesin family member 3B62900.3990.0265No
60RFC1NARFC1
Entrez,  Source
replication factor C (activator 1) 1, 145kDa63740.3850.0240No
61RAPGEF5NARAPGEF5
Entrez,  Source
Rap guanine nucleotide exchange factor (GEF) 565190.3630.0179No
62HDAC6NAHDAC6
Entrez,  Source
histone deacetylase 668160.3190.0031No
63PAFAH1B1NAPAFAH1B1
Entrez,  Source
platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa68450.3150.0033No
64RANBP9NARANBP9
Entrez,  Source
RAN binding protein 969770.294-0.0025No
65CEP250NACEP250
Entrez,  Source
centrosomal protein 250kDa70100.288-0.0027No
66ROCK1NAROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 171490.266-0.0089No
67SUN2NA73150.239-0.0169No
68HOOK3NAHOOK3
Entrez,  Source
hook homolog 3 (Drosophila)73900.227-0.0197No
69TUBA4ANA74200.222-0.0201No
70CSNK1DNACSNK1D
Entrez,  Source
casein kinase 1, delta75810.201-0.0280No
71ARHGEF11NAARHGEF11
Entrez,  Source
Rho guanine nucleotide exchange factor (GEF) 1178560.165-0.0425No
72TUBD1NATUBD1
Entrez,  Source
tubulin, delta 179760.149-0.0483No
73DYNLL2NADYNLL2
Entrez,  Source
dynein, light chain, LC8-type 280250.143-0.0502No
74CTTNNACTTN
Entrez,  Source
cortactin81070.132-0.0541No
75NCK1NANCK1
Entrez,  Source
NCK adaptor protein 181120.132-0.0535No
76ACTN4NAACTN4
Entrez,  Source
actinin, alpha 481210.131-0.0533No
77ARL8ANAARL8A
Entrez,  Source
ADP-ribosylation factor-like 8A81470.128-0.0540No
78ABRNAABR
Entrez,  Source
active BCR-related gene81630.125-0.0541No
79CYTH2NA84220.090-0.0681No
80ARFIP2NAARFIP2
Entrez,  Source
ADP-ribosylation factor interacting protein 2 (arfaptin 2)84740.084-0.0705No
81EPB41NAEPB41
Entrez,  Source
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)84980.079-0.0713No
82ARHGDIANAARHGDIA
Entrez,  Source
Rho GDP dissociation inhibitor (GDI) alpha85990.067-0.0766No
83APCNAAPC
Entrez,  Source
adenomatosis polyposis coli86960.054-0.0817No
84STK38LNASTK38L
Entrez,  Source
serine/threonine kinase 38 like89500.021-0.0958No
85NET1NANET1
Entrez,  Source
neuroepithelial cell transforming gene 189560.020-0.0960No
86RICTORNARICTOR
Entrez,  Source
-89590.019-0.0960No
87SAC3D1NASAC3D1
Entrez,  Source
SAC3 domain containing 191310.007-0.1056No
88CDC27NACDC27
Entrez,  Source
cell division cycle 279473-0.010-0.1247No
89ABI1NAABI1
Entrez,  Source
abl-interactor 19521-0.019-0.1272No
90TUBGCP2NATUBGCP2
Entrez,  Source
tubulin, gamma complex associated protein 29618-0.033-0.1324No
91CENPENACENPE
Entrez,  Source
centromere protein E, 312kDa9666-0.039-0.1349No
92NEK2NANEK2
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 29964-0.067-0.1512No
93RABGAP1NARABGAP1
Entrez,  Source
RAB GTPase activating protein 19971-0.068-0.1512No
94LMNB1NALMNB1
Entrez,  Source
lamin B110250-0.092-0.1663No
95CDK5RAP2NACDK5RAP2
Entrez,  Source
CDK5 regulatory subunit associated protein 210697-0.154-0.1905No
96MAP1SNAMAP1S
Entrez,  Source
microtubule-associated protein 1S10734-0.158-0.1916No
97ARHGEF2NAARHGEF2
Entrez,  Source
rho/rac guanine nucleotide exchange factor (GEF) 210870-0.179-0.1982No
98BIN1NABIN1
Entrez,  Source
bridging integrator 110875-0.180-0.1974No
99TAOK2NATAOK2
Entrez,  Source
TAO kinase 210885-0.181-0.1969No
100ARFGEF1NAARFGEF1
Entrez,  Source
ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)11033-0.203-0.2041No
101ARHGEF3NAARHGEF3
Entrez,  Source
Rho guanine nucleotide exchange factor (GEF) 311243-0.232-0.2145No
102LATS1NALATS1
Entrez,  Source
LATS, large tumor suppressor, homolog 1 (Drosophila)11244-0.232-0.2132No
103ABL1NAABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 111310-0.241-0.2155No
104NUSAP1NANUSAP1
Entrez,  Source
nucleolar and spindle associated protein 111442-0.261-0.2214No
105MARK4NAMARK4
Entrez,  Source
MAP/microtubule affinity-regulating kinase 411593-0.283-0.2283No
106CDC42EP4NACDC42EP4
Entrez,  Source
CDC42 effector protein (Rho GTPase binding) 411664-0.291-0.2306No
107RACGAP1NARACGAP1
Entrez,  Source
Rac GTPase activating protein 111711-0.297-0.2315No
108PCNTNAPCNT
Entrez,  Source
pericentrin (kendrin)11712-0.297-0.2298No
109RALBP1NARALBP1
Entrez,  Source
ralA binding protein 112111-0.355-0.2502No
110KIFAP3NAKIFAP3
Entrez,  Source
kinesin-associated protein 312165-0.364-0.2512No
111PXNNAPXN
Entrez,  Source
paxillin12305-0.385-0.2568No
112NDC80NA12660-0.426-0.2744No
113CEP57NACEP57
Entrez,  Source
centrosomal protein 57kDa12694-0.433-0.2738No
114NUMA1NANUMA1
Entrez,  Source
nuclear mitotic apparatus protein 112751-0.444-0.2744No
115STAU1NASTAU1
Entrez,  Source
staufen, RNA binding protein, homolog 1 (Drosophila)13026-0.459-0.2873No
116PPP4R2NAPPP4R2
Entrez,  Source
protein phosphatase 4, regulatory subunit 213049-0.463-0.2859No
117UXTNAUXT
Entrez,  Source
ubiquitously-expressed transcript13061-0.464-0.2839No
118BIRC5NABIRC5
Entrez,  Source
baculoviral IAP repeat-containing 5 (survivin)13169-0.482-0.2873No
119CKAP5NACKAP5
Entrez,  Source
cytoskeleton associated protein 513197-0.488-0.2860No
120CEP192NACEP192
Entrez,  Source
centrosomal protein 192kDa13498-0.535-0.2999No
121YWHAENAYWHAE
Entrez,  Source
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide13591-0.556-0.3020No
122AURKANAAURKA
Entrez,  Source
aurora kinase A13620-0.562-0.3004No
123KIF5BNAKIF5B
Entrez,  Source
kinesin family member 5B13622-0.562-0.2973No
124MYH9NAMYH9
Entrez,  Source
myosin, heavy chain 9, non-muscle13628-0.563-0.2944No
125KIF2CNAKIF2C
Entrez,  Source
kinesin family member 2C13733-0.582-0.2970No
126SEPT9NASEPT9
Entrez,  Source
septin 913804-0.596-0.2976No
127TUBGCP5NATUBGCP5
Entrez,  Source
tubulin, gamma complex associated protein 513877-0.610-0.2982No
128GEMIN4NAGEMIN4
Entrez,  Source
gem (nuclear organelle) associated protein 414066-0.650-0.3051Yes
129FLNANAFLNA
Entrez,  Source
filamin A, alpha (actin binding protein 280)14074-0.652-0.3019Yes
130DLGAP5NA14080-0.653-0.2985Yes
131PLK1NAPLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)14126-0.664-0.2973Yes
132LRPPRCNALRPPRC
Entrez,  Source
leucine-rich PPR-motif containing14133-0.665-0.2939Yes
133ANLNNAANLN
Entrez,  Source
anillin, actin binding protein14159-0.671-0.2915Yes
134AKAP13NAAKAP13
Entrez,  Source
A kinase (PRKA) anchor protein 1314217-0.685-0.2909Yes
135CDC42EP2NACDC42EP2
Entrez,  Source
CDC42 effector protein (Rho GTPase binding) 214446-0.739-0.2996Yes
136ESPL1NAESPL1
Entrez,  Source
extra spindle poles like 1 (S. cerevisiae)14462-0.745-0.2963Yes
137MAPRE1NAMAPRE1
Entrez,  Source
microtubule-associated protein, RP/EB family, member 114509-0.756-0.2946Yes
138RHOT2NARHOT2
Entrez,  Source
ras homolog gene family, member T214533-0.762-0.2916Yes
139RASAL2NARASAL2
Entrez,  Source
RAS protein activator like 214588-0.774-0.2903Yes
140TPX2NATPX2
Entrez,  Source
TPX2, microtubule-associated, homolog (Xenopus laevis)14659-0.790-0.2898Yes
141VCLNAVCL
Entrez,  Source
vinculin14667-0.793-0.2858Yes
142CLIP1NA14769-0.817-0.2869Yes
143INCENPNAINCENP
Entrez,  Source
inner centromere protein antigens 135/155kDa14792-0.825-0.2835Yes
144KATNB1NAKATNB1
Entrez,  Source
katanin p80 (WD repeat containing) subunit B 114823-0.834-0.2805Yes
145CENPFNACENPF
Entrez,  Source
centromere protein F, 350/400ka (mitosin)14921-0.849-0.2812Yes
146KATNA1NAKATNA1
Entrez,  Source
katanin p60 (ATPase-containing) subunit A 115051-0.880-0.2835Yes
147ARHGAP10NAARHGAP10
Entrez,  Source
Rho GTPase activating protein 1015140-0.898-0.2834Yes
148KIF4ANAKIF4A
Entrez,  Source
kinesin family member 4A15178-0.909-0.2804Yes
149TBCDNATBCD
Entrez,  Source
tubulin-specific chaperone d15219-0.919-0.2775Yes
150FBXO5NAFBXO5
Entrez,  Source
F-box protein 515300-0.942-0.2767Yes
151ITSN1NAITSN1
Entrez,  Source
intersectin 1 (SH3 domain protein)15343-0.954-0.2737Yes
152TUBGCP6NATUBGCP6
Entrez,  Source
tubulin, gamma complex associated protein 615397-0.968-0.2713Yes
153KNTC1NAKNTC1
Entrez,  Source
kinetochore associated 115484-0.994-0.2705Yes
154PLEKHG2NAPLEKHG2
Entrez,  Source
pleckstrin homology domain containing, family G (with RhoGef domain) member 215562-1.015-0.2692Yes
155MAP3K11NAMAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1115581-1.023-0.2644Yes
156KIF11NAKIF11
Entrez,  Source
kinesin family member 1115778-1.086-0.2694Yes
157CNTROBNACNTROB
Entrez,  Source
centrobin, centrosomal BRCA2 interacting protein15781-1.087-0.2634Yes
158KIF3CNAKIF3C
Entrez,  Source
kinesin family member 3C15854-1.118-0.2612Yes
159SMC4NASMC4
Entrez,  Source
structural maintenance of chromosomes 415859-1.120-0.2551Yes
160ARHGEF7NAARHGEF7
Entrez,  Source
Rho guanine nucleotide exchange factor (GEF) 715863-1.120-0.2490Yes
161LLGL1NALLGL1
Entrez,  Source
lethal giant larvae homolog 1 (Drosophila)15864-1.121-0.2427Yes
162RASA2NARASA2
Entrez,  Source
RAS p21 protein activator 215930-1.147-0.2399Yes
163CDC42EP1NACDC42EP1
Entrez,  Source
CDC42 effector protein (Rho GTPase binding) 115974-1.162-0.2358Yes
164TRIONATRIO
Entrez,  Source
triple functional domain (PTPRF interacting)16055-1.198-0.2336Yes
165ARHGAP29NAARHGAP29
Entrez,  Source
Rho GTPase activating protein 2916166-1.244-0.2328Yes
166MID1IP1NAMID1IP1
Entrez,  Source
MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))16171-1.247-0.2260Yes
167CNTRLNA16174-1.249-0.2191Yes
168KIF22NAKIF22
Entrez,  Source
kinesin family member 2216180-1.250-0.2124Yes
169WASF1NAWASF1
Entrez,  Source
WAS protein family, member 116203-1.260-0.2066Yes
170KIF20BNA16234-1.276-0.2011Yes
171TUBGCP3NATUBGCP3
Entrez,  Source
tubulin, gamma complex associated protein 316433-1.379-0.2045Yes
172FGD6NAFGD6
Entrez,  Source
FYVE, RhoGEF and PH domain containing 616491-1.410-0.1998Yes
173SMC3NASMC3
Entrez,  Source
structural maintenance of chromosomes 316499-1.412-0.1923Yes
174CDK1NA16637-1.491-0.1916Yes
175NEDD9NANEDD9
Entrez,  Source
neural precursor cell expressed, developmentally down-regulated 916666-1.508-0.1847Yes
176KIF15NAKIF15
Entrez,  Source
kinesin family member 1516686-1.522-0.1772Yes
177ARAP3NA16695-1.527-0.1691Yes
178PIF1NA16751-1.564-0.1634Yes
179CCNB2NACCNB2
Entrez,  Source
cyclin B216828-1.630-0.1586Yes
180ARHGAP4NAARHGAP4
Entrez,  Source
Rho GTPase activating protein 416831-1.635-0.1495Yes
181TTKNATTK
Entrez,  Source
TTK protein kinase16883-1.669-0.1430Yes
182MYO1ENAMYO1E
Entrez,  Source
myosin IE16925-1.698-0.1358Yes
183PRC1NAPRC1
Entrez,  Source
protein regulator of cytokinesis 116957-1.732-0.1278Yes
184FSCN1NAFSCN1
Entrez,  Source
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)16978-1.750-0.1191Yes
185KPTNNAKPTN
Entrez,  Source
kaptin (actin binding protein)17000-1.770-0.1104Yes
186EPB41L2NAEPB41L2
Entrez,  Source
erythrocyte membrane protein band 4.1-like 217044-1.808-0.1027Yes
187MARCKSNAMARCKS
Entrez,  Source
myristoylated alanine-rich protein kinase C substrate17061-1.825-0.0933Yes
188DOCK4NADOCK4
Entrez,  Source
dedicator of cytokinesis 417099-1.875-0.0849Yes
189KIF23NAKIF23
Entrez,  Source
kinesin family member 2317105-1.883-0.0746Yes
190CENPJNACENPJ
Entrez,  Source
centromere protein J17165-1.962-0.0669Yes
191FARP1NAFARP1
Entrez,  Source
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)17307-2.180-0.0626Yes
192ALMS1NAALMS1
Entrez,  Source
Alstrom syndrome 117497-2.489-0.0593Yes
193RHOFNARHOF
Entrez,  Source
ras homolog gene family, member F (in filopodia)17539-2.589-0.0471Yes
194BRCA2NABRCA2
Entrez,  Source
breast cancer 2, early onset17561-2.614-0.0336Yes
195MYH10NAMYH10
Entrez,  Source
myosin, heavy chain 10, non-muscle17657-2.912-0.0226Yes
196TIAM1NATIAM1
Entrez,  Source
T-cell lymphoma invasion and metastasis 117748-3.371-0.0087Yes
197SORBS2NASORBS2
Entrez,  Source
sorbin and SH3 domain containing 217839-3.8120.0076Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_MITOTIC_SPINDLE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_MITOTIC_SPINDLE: Random ES distribution   
Gene set null distribution of ES for HALLMARK_MITOTIC_SPINDLE