Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1w6a
GeneSetHALLMARK_KRAS_SIGNALING_UP
Enrichment Score (ES)0.44745335
Normalized Enrichment Score (NES)1.7411355
Nominal p-value0.0
FDR q-value0.001389255
FWER p-Value0.01
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_KRAS_SIGNALING_UP   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1TSPAN7NATSPAN7
Entrez,  Source
tetraspanin 7674.6320.0115Yes
2ST6GAL1NAST6GAL1
Entrez,  Source
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1784.5800.0260Yes
3RELNNARELN
Entrez,  Source
reelin874.5580.0405Yes
4CXCR4NACXCR4
Entrez,  Source
chemokine (C-X-C motif) receptor 4904.5460.0553Yes
5EREGNAEREG
Entrez,  Source
epiregulin974.5280.0699Yes
6HKDC1NAHKDC1
Entrez,  Source
hexokinase domain containing 11144.4500.0836Yes
7CSF2RANACSF2RA
Entrez,  Source
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)1334.3590.0969Yes
8GPNMBNAGPNMB
Entrez,  Source
glycoprotein (transmembrane) nmb1474.3070.1103Yes
9SNAP25NASNAP25
Entrez,  Source
synaptosomal-associated protein, 25kDa1574.2820.1239Yes
10ANXA10NAANXA10
Entrez,  Source
annexin A101584.2740.1380Yes
11PRRX1NAPRRX1
Entrez,  Source
paired related homeobox 11774.1970.1508Yes
12DOCK2NADOCK2
Entrez,  Source
dedicator of cytokinesis 21864.1680.1640Yes
13GALNT3NAGALNT3
Entrez,  Source
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)1954.1390.1772Yes
14IL1RL2NAIL1RL2
Entrez,  Source
interleukin 1 receptor-like 22094.0990.1899Yes
15CMKLR1NACMKLR1
Entrez,  Source
chemokine-like receptor 12553.8820.2001Yes
16ID2NAID2
Entrez,  Source
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein2723.8260.2118Yes
17BIRC3NABIRC3
Entrez,  Source
baculoviral IAP repeat-containing 32733.8240.2244Yes
18BTCNABTC
Entrez,  Source
betacellulin2763.8200.2368Yes
19TSPAN1NATSPAN1
Entrez,  Source
tetraspanin 13373.6510.2455Yes
20TNFRSF1BNATNFRSF1B
Entrez,  Source
tumor necrosis factor receptor superfamily, member 1B3423.6280.2572Yes
21SEMA3BNASEMA3B
Entrez,  Source
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B3603.5560.2679Yes
22JUPNAJUP
Entrez,  Source
junction plakoglobin3773.4960.2785Yes
23GPRC5BNAGPRC5B
Entrez,  Source
G protein-coupled receptor, family C, group 5, member B4343.3560.2864Yes
24ANGPTL4NAANGPTL4
Entrez,  Source
angiopoietin-like 44753.2720.2949Yes
25ITGA2NAITGA2
Entrez,  Source
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)4833.2530.3052Yes
26GLRXNAGLRX
Entrez,  Source
glutaredoxin (thioltransferase)5153.1470.3138Yes
27PLATNAPLAT
Entrez,  Source
plasminogen activator, tissue5163.1470.3241Yes
28F2RL1NAF2RL1
Entrez,  Source
coagulation factor II (thrombin) receptor-like 15583.0490.3318Yes
29CFHNACFH
Entrez,  Source
complement factor H5812.9800.3404Yes
30PLAUNAPLAU
Entrez,  Source
plasminogen activator, urokinase6002.9490.3491Yes
31FUCA1NAFUCA1
Entrez,  Source
fucosidase, alpha-L- 1, tissue6182.9120.3577Yes
32MALLNAMALL
Entrez,  Source
mal, T-cell differentiation protein-like7252.6710.3605Yes
33ETV5NAETV5
Entrez,  Source
ets variant gene 5 (ets-related molecule)7282.6600.3692Yes
34CA2NACA2
Entrez,  Source
carbonic anhydrase II7372.6530.3774Yes
35RGS16NARGS16
Entrez,  Source
regulator of G-protein signalling 167542.6300.3852Yes
36EPHB2NAEPHB2
Entrez,  Source
EPH receptor B27842.5740.3920Yes
37ZNF639NAZNF639
Entrez,  Source
zinc finger protein 6398052.5420.3992Yes
38GUCY1A3NAGUCY1A3
Entrez,  Source
guanylate cyclase 1, soluble, alpha 38202.5150.4067Yes
39CPENACPE
Entrez,  Source
carboxypeptidase E10272.2640.4026Yes
40KCNN4NAKCNN4
Entrez,  Source
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 410322.2580.4098Yes
41PTGS2NAPTGS2
Entrez,  Source
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)10852.1900.4141Yes
42KLF4NAKLF4
Entrez,  Source
Kruppel-like factor 4 (gut)11652.0770.4164Yes
43ETV1NAETV1
Entrez,  Source
ets variant gene 111842.0540.4222Yes
44CFBNACFB
Entrez,  Source
complement factor B11972.0410.4282Yes
45NGFNA12791.9560.4301Yes
46LY96NALY96
Entrez,  Source
lymphocyte antigen 9616651.6370.4138Yes
47CXCL10NACXCL10
Entrez,  Source
chemokine (C-X-C motif) ligand 1016721.6340.4189Yes
48TSPAN13NATSPAN13
Entrez,  Source
tetraspanin 1317361.5740.4205Yes
49CAB39LNACAB39L
Entrez,  Source
calcium binding protein 39-like17481.5640.4250Yes
50IL7RNAIL7R
Entrez,  Source
interleukin 7 receptor19391.4520.4191Yes
51ADAM8NAADAM8
Entrez,  Source
ADAM metallopeptidase domain 819561.4410.4229Yes
52TMEM100NATMEM100
Entrez,  Source
transmembrane protein 10020961.3630.4196Yes
53PRKG2NAPRKG2
Entrez,  Source
protein kinase, cGMP-dependent, type II21051.3580.4236Yes
54PECAM1NAPECAM1
Entrez,  Source
platelet/endothelial cell adhesion molecule (CD31 antigen)21481.3340.4256Yes
55EMP1NAEMP1
Entrez,  Source
epithelial membrane protein 121501.3320.4300Yes
56KIF5CNAKIF5C
Entrez,  Source
kinesin family member 5C21581.3280.4339Yes
57NRP1NANRP1
Entrez,  Source
neuropilin 121911.3090.4364Yes
58TRAF1NATRAF1
Entrez,  Source
TNF receptor-associated factor 121921.3090.4407Yes
59SCN1BNASCN1B
Entrez,  Source
sodium channel, voltage-gated, type I, beta22641.2730.4409Yes
60SPP1NASPP1
Entrez,  Source
secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)23991.2150.4374Yes
61MAFBNAMAFB
Entrez,  Source
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)24281.2000.4398Yes
62TOR1AIP2NATOR1AIP2
Entrez,  Source
torsin A interacting protein 224611.1930.4419Yes
63SLPINASLPI
Entrez,  Source
secretory leukocyte peptidase inhibitor25301.1670.4419Yes
64ADAM17NAADAM17
Entrez,  Source
ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)25331.1650.4456Yes
65CBLNACBL
Entrez,  Source
Cas-Br-M (murine) ecotropic retroviral transforming sequence26581.1110.4423Yes
66CSF2NACSF2
Entrez,  Source
colony stimulating factor 2 (granulocyte-macrophage)27091.0950.4431Yes
67DUSP6NADUSP6
Entrez,  Source
dual specificity phosphatase 627221.0910.4460Yes
68IGF2NAIGF2
Entrez,  Source
insulin-like growth factor 2 (somatomedin A)27601.0750.4475Yes
69TRIB2NATRIB2
Entrez,  Source
tribbles homolog 2 (Drosophila)30080.9900.4368No
70PCSK1NNAPCSK1N
Entrez,  Source
proprotein convertase subtilisin/kexin type 1 inhibitor30550.9730.4374No
71CROTNACROT
Entrez,  Source
carnitine O-octanoyltransferase32540.9250.4293No
72HBEGFNAHBEGF
Entrez,  Source
heparin-binding EGF-like growth factor34510.8700.4212No
73TLR8NATLR8
Entrez,  Source
toll-like receptor 834760.8640.4227No
74IL33NA37780.8140.4084No
75BTBD3NABTBD3
Entrez,  Source
BTB (POZ) domain containing 338240.8050.4085No
76IGFBP3NAIGFBP3
Entrez,  Source
insulin-like growth factor binding protein 338530.7990.4096No
77GADD45GNAGADD45G
Entrez,  Source
growth arrest and DNA-damage-inducible, gamma38660.7950.4115No
78PIGRNAPIGR
Entrez,  Source
polymeric immunoglobulin receptor39560.7710.4091No
79FLT4NAFLT4
Entrez,  Source
fms-related tyrosine kinase 440000.7620.4091No
80NAP1L2NANAP1L2
Entrez,  Source
nucleosome assembly protein 1-like 241740.7240.4018No
81ANO1NA43450.6900.3945No
82G0S2NAG0S2
Entrez,  Source
G0/G1switch 243660.6860.3956No
83CD37NACD37
Entrez,  Source
CD37 molecule44660.6640.3923No
84WDR33NAWDR33
Entrez,  Source
WD repeat domain 3347300.6110.3795No
85SPRY2NASPRY2
Entrez,  Source
sprouty homolog 2 (Drosophila)48030.5940.3774No
86SNAP91NASNAP91
Entrez,  Source
synaptosomal-associated protein, 91kDa homolog (mouse)49440.5700.3714No
87MAP7NAMAP7
Entrez,  Source
microtubule-associated protein 750430.5470.3677No
88TFPINATFPI
Entrez,  Source
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)50870.5390.3670No
89NINNANIN
Entrez,  Source
ninein (GSK3B interacting protein)52770.5040.3581No
90IKZF1NAIKZF1
Entrez,  Source
IKAROS family zinc finger 1 (Ikaros)53500.4920.3556No
91CCL20NACCL20
Entrez,  Source
chemokine (C-C motif) ligand 2054700.4820.3505No
92APODNAAPOD
Entrez,  Source
apolipoprotein D55340.4720.3485No
93PPP1R15ANAPPP1R15A
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 15A56660.4500.3426No
94SATB1NASATB1
Entrez,  Source
special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA's)57330.4390.3404No
95AVL9NA58040.4290.3378No
96GYPCNAGYPC
Entrez,  Source
glycophorin C (Gerbich blood group)59790.4180.3294No
97FGF9NAFGF9
Entrez,  Source
fibroblast growth factor 9 (glia-activating factor)63010.3980.3127No
98VWA5ANA66830.3370.2924No
99CLEC4ANACLEC4A
Entrez,  Source
C-type lectin domain family 4, member A70900.2760.2705No
100LAT2NALAT2
Entrez,  Source
linker for activation of T cells family, member 271110.2720.2702No
101EVI5NAEVI5
Entrez,  Source
ecotropic viral integration site 571180.2710.2708No
102PLAURNAPLAUR
Entrez,  Source
plasminogen activator, urokinase receptor76760.1880.2401No
103SCG5NASCG5
Entrez,  Source
secretogranin V (7B2 protein)78780.1620.2293No
104ZNF277NAZNF277
Entrez,  Source
zinc finger protein 27778810.1610.2297No
105SCG3NASCG3
Entrez,  Source
secretogranin III78920.1590.2297No
106AKT2NAAKT2
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 281930.1200.2132No
107HOXD11NAHOXD11
Entrez,  Source
homeobox D1182040.1200.2130No
108ANKHNAANKH
Entrez,  Source
ankylosis, progressive homolog (mouse)82290.1160.2121No
109RBM4NARBM4
Entrez,  Source
RNA binding motif protein 487190.0490.1847No
110MYCNNAMYCN
Entrez,  Source
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)88240.0380.1790No
111ADAMDEC1NAADAMDEC1
Entrez,  Source
ADAM-like, decysin 193040.0000.1521No
112HIST1H2BBNAHIST1H2BB
Entrez,  Source
histone cluster 1, H2bb9702-0.0430.1299No
113DNMBPNADNMBP
Entrez,  Source
dynamin binding protein9766-0.0480.1265No
114ABCB1NAABCB1
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 19818-0.0540.1238No
115EPB41L3NAEPB41L3
Entrez,  Source
erythrocyte membrane protein band 4.1-like 39957-0.0660.1163No
116IL10RANAIL10RA
Entrez,  Source
interleukin 10 receptor, alpha10061-0.0740.1107No
117WNT7ANAWNT7A
Entrez,  Source
wingless-type MMTV integration site family, member 7A10285-0.0960.0985No
118SPON1NASPON1
Entrez,  Source
spondin 1, extracellular matrix protein10336-0.1000.0960No
119TNNT2NATNNT2
Entrez,  Source
troponin T type 2 (cardiac)10433-0.1140.0910No
120MAP3K1NAMAP3K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase 110539-0.1300.0855No
121SPARCL1NASPARCL1
Entrez,  Source
SPARC-like 1 (mast9, hevin)10674-0.1500.0785No
122CBR4NACBR4
Entrez,  Source
carbonyl reductase 410807-0.1710.0716No
123ITGBL1NAITGBL1
Entrez,  Source
integrin, beta-like 1 (with EGF-like repeat domains)10848-0.1770.0700No
124ARG1NAARG1
Entrez,  Source
arginase, liver11050-0.2060.0593No
125DCBLD2NADCBLD2
Entrez,  Source
discoidin, CUB and LCCL domain containing 211289-0.2380.0467No
126NR0B2NANR0B2
Entrez,  Source
nuclear receptor subfamily 0, group B, member 211431-0.2590.0396No
127TMEM176ANATMEM176A
Entrez,  Source
transmembrane protein 176A11517-0.2730.0358No
128NR1H4NANR1H4
Entrez,  Source
nuclear receptor subfamily 1, group H, member 411622-0.2860.0309No
129MMP10NAMMP10
Entrez,  Source
matrix metallopeptidase 10 (stromelysin 2)11797-0.3110.0221No
130ALDH1A2NAALDH1A2
Entrez,  Source
aldehyde dehydrogenase 1 family, member A211821-0.3160.0218No
131PTCD2NAPTCD2
Entrez,  Source
pentatricopeptide repeat domain 211916-0.3280.0176No
132HDAC9NAHDAC9
Entrez,  Source
histone deacetylase 911934-0.3300.0178No
133MMDNAMMD
Entrez,  Source
monocyte to macrophage differentiation-associated11978-0.3370.0165No
134AMMECR1NAAMMECR1
Entrez,  Source
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region, gene 112318-0.386-0.0013No
135STRNNASTRN
Entrez,  Source
striatin, calmodulin binding protein12574-0.412-0.0143No
136USP12NAUSP12
Entrez,  Source
ubiquitin specific peptidase 1212582-0.413-0.0134No
137IRF8NAIRF8
Entrez,  Source
interferon regulatory factor 812681-0.431-0.0175No
138PTBP2NAPTBP2
Entrez,  Source
polypyrimidine tract binding protein 212731-0.440-0.0188No
139CFHR2NACFHR2
Entrez,  Source
complement factor H-related 212771-0.445-0.0195No
140RBP4NARBP4
Entrez,  Source
retinol binding protein 4, plasma12809-0.445-0.0201No
141TPH1NATPH1
Entrez,  Source
tryptophan hydroxylase 1 (tryptophan 5-monooxygenase)12974-0.452-0.0278No
142PEG3NAPEG3
Entrez,  Source
paternally expressed 313028-0.460-0.0293No
143CBX8NACBX8
Entrez,  Source
chromobox homolog 8 (Pc class homolog, Drosophila)13163-0.480-0.0353No
144YRDCNAYRDC
Entrez,  Source
yrdC domain containing (E. coli)13358-0.511-0.0445No
145PPBPNAPPBP
Entrez,  Source
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)13456-0.528-0.0482No
146CDADC1NACDADC1
Entrez,  Source
cytidine and dCMP deaminase domain containing 113669-0.571-0.0583No
147RABGAP1LNARABGAP1L
Entrez,  Source
RAB GTPase activating protein 1-like13754-0.586-0.0611No
148BPGMNABPGM
Entrez,  Source
2,3-bisphosphoglycerate mutase14019-0.640-0.0738No
149PDCD1LG2NAPDCD1LG2
Entrez,  Source
programmed cell death 1 ligand 214363-0.717-0.0907No
150PSMB8NAPSMB8
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)14537-0.763-0.0980No
151ATG10NAATG10
Entrez,  Source
ATG10 autophagy related 10 homolog (S. cerevisiae)14539-0.763-0.0955No
152GNG11NAGNG11
Entrez,  Source
guanine nucleotide binding protein (G protein), gamma 1114616-0.782-0.0972No
153F13A1NAF13A1
Entrez,  Source
coagulation factor XIII, A1 polypeptide14763-0.816-0.1027No
154TMEM158NATMEM158
Entrez,  Source
transmembrane protein 15814799-0.827-0.1020No
155ITGB2NAITGB2
Entrez,  Source
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)14916-0.848-0.1057No
156FBXO4NAFBXO4
Entrez,  Source
F-box protein 415202-0.914-0.1187No
157USH1CNAUSH1C
Entrez,  Source
Usher syndrome 1C (autosomal recessive, severe)15451-0.984-0.1294No
158PLEK2NAPLEK2
Entrez,  Source
pleckstrin 216025-1.184-0.1578No
159C3AR1NAC3AR1
Entrez,  Source
complement component 3a receptor 116041-1.192-0.1547No
160CCND2NACCND2
Entrez,  Source
cyclin D216061-1.200-0.1518No
161IL2RGNAIL2RG
Entrez,  Source
interleukin 2 receptor, gamma (severe combined immunodeficiency)16106-1.217-0.1503No
162FCER1GNAFCER1G
Entrez,  Source
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide16114-1.221-0.1467No
163MAP4K1NAMAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 116129-1.228-0.1434No
164SERPINA3NASERPINA3
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 316227-1.274-0.1447No
165ETS1NAETS1
Entrez,  Source
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)16397-1.363-0.1497No
166TNFAIP3NATNFAIP3
Entrez,  Source
tumor necrosis factor, alpha-induced protein 316490-1.410-0.1503No
167ETV4NAETV4
Entrez,  Source
ets variant gene 4 (E1A enhancer binding protein, E1AF)16690-1.524-0.1564No
168LIFNALIF
Entrez,  Source
leukemia inhibitory factor (cholinergic differentiation factor)16734-1.553-0.1537No
169SOX9NASOX9
Entrez,  Source
SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)16885-1.671-0.1567No
170PTPRRNAPTPRR
Entrez,  Source
protein tyrosine phosphatase, receptor type, R17056-1.822-0.1603No
171TRIB1NATRIB1
Entrez,  Source
tribbles homolog 1 (Drosophila)17163-1.958-0.1598No
172MTMR10NAMTMR10
Entrez,  Source
myotubularin related protein 1017175-1.976-0.1539No
173GFPT2NAGFPT2
Entrez,  Source
glutamine-fructose-6-phosphate transaminase 217179-1.979-0.1476No
174MMP11NAMMP11
Entrez,  Source
matrix metallopeptidase 11 (stromelysin 3)17268-2.113-0.1456No
175PRDM1NAPRDM1
Entrez,  Source
PR domain containing 1, with ZNF domain17312-2.195-0.1408No
176LAPTM5NALAPTM5
Entrez,  Source
lysosomal associated multispanning membrane protein 517367-2.269-0.1363No
177IL1BNAIL1B
Entrez,  Source
interleukin 1, beta17373-2.282-0.1291No
178ALDH1A3NAALDH1A3
Entrez,  Source
aldehyde dehydrogenase 1 family, member A317470-2.441-0.1265No
179TMEM176BNATMEM176B
Entrez,  Source
transmembrane protein 176B17556-2.601-0.1227No
180AKAP12NAAKAP12
Entrez,  Source
A kinase (PRKA) anchor protein (gravin) 1217571-2.633-0.1149No
181MPZL2NA17654-2.903-0.1099No
182HSD11B1NAHSD11B1
Entrez,  Source
hydroxysteroid (11-beta) dehydrogenase 117669-2.989-0.1009No
183ACENAACE
Entrez,  Source
angiotensin I converting enzyme (peptidyl-dipeptidase A) 117704-3.112-0.0926No
184BMP2NABMP2
Entrez,  Source
bone morphogenetic protein 217763-3.423-0.0846No
185CTSSNACTSS
Entrez,  Source
cathepsin S17772-3.468-0.0736No
186ENGNAENG
Entrez,  Source
endoglin (Osler-Rendu-Weber syndrome 1)17844-3.835-0.0650No
187MMP9NAMMP9
Entrez,  Source
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)17854-3.963-0.0525No
188SDCCAG8NASDCCAG8
Entrez,  Source
serologically defined colon cancer antigen 817867-4.048-0.0398No
189INHBANAINHBA
Entrez,  Source
inhibin, beta A (activin A, activin AB alpha polypeptide)17879-4.121-0.0269No
190LCP1NALCP1
Entrez,  Source
lymphocyte cytosolic protein 1 (L-plastin)17956-4.858-0.0152No
191GABRA3NAGABRA3
Entrez,  Source
gamma-aminobutyric acid (GABA) A receptor, alpha 317960-4.9210.0008No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_KRAS_SIGNALING_UP   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_KRAS_SIGNALING_UP: Random ES distribution   
Gene set null distribution of ES for HALLMARK_KRAS_SIGNALING_UP