Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1w6a
GeneSetHALLMARK_KRAS_SIGNALING_DN
Enrichment Score (ES)0.35917792
Normalized Enrichment Score (NES)1.377322
Nominal p-value0.014030612
FDR q-value0.049035136
FWER p-Value0.662
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_KRAS_SIGNALING_DN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1EFHD1NAEFHD1
Entrez,  Source
EF-hand domain family, member D164.9680.0280Yes
2GPRC5CNAGPRC5C
Entrez,  Source
G protein-coupled receptor, family C, group 5, member C254.8830.0549Yes
3SERPINB2NASERPINB2
Entrez,  Source
serpin peptidase inhibitor, clade B (ovalbumin), member 2494.7260.0805Yes
4AKR1B10NAAKR1B10
Entrez,  Source
aldo-keto reductase family 1, member B10 (aldose reductase)2174.0650.0944Yes
5RSAD2NARSAD2
Entrez,  Source
radical S-adenosyl methionine domain containing 22363.9920.1161Yes
6FAM46CNAFAM46C
Entrez,  Source
family with sequence similarity 46, member C2883.7630.1347Yes
7CYP39A1NACYP39A1
Entrez,  Source
cytochrome P450, family 39, subfamily A, polypeptide 14613.3000.1439Yes
8IFI44LNAIFI44L
Entrez,  Source
interferon-induced protein 44-like4903.2310.1608Yes
9NR4A2NANR4A2
Entrez,  Source
nuclear receptor subfamily 4, group A, member 25223.1290.1769Yes
10MX1NAMX1
Entrez,  Source
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)5423.0910.1934Yes
11CAMK1DNACAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID5932.9590.2075Yes
12EGFNAEGF
Entrez,  Source
epidermal growth factor (beta-urogastrone)6642.7990.2196Yes
13SKILNASKIL
Entrez,  Source
SKI-like7052.7210.2328Yes
14MFSD6NA7142.6980.2478Yes
15FGFR3NAFGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)7582.6230.2603Yes
16PTPRJNAPTPRJ
Entrez,  Source
protein tyrosine phosphatase, receptor type, J8322.5030.2705Yes
17TEX15NATEX15
Entrez,  Source
testis expressed sequence 158622.4600.2829Yes
18MTHFRNAMTHFR
Entrez,  Source
5,10-methylenetetrahydrofolate reductase (NADPH)8772.4360.2960Yes
19THRBNATHRB
Entrez,  Source
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)9532.3400.3052Yes
20BMPR1BNABMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB10682.2040.3114Yes
21KRT15NAKRT15
Entrez,  Source
keratin 1510902.1800.3226Yes
22LFNGNALFNG
Entrez,  Source
lunatic fringe homolog (Drosophila)10922.1770.3350Yes
23TGM1NATGM1
Entrez,  Source
transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)12481.9920.3376Yes
24EPHA5NAEPHA5
Entrez,  Source
EPH receptor A513481.8870.3429Yes
25EDN2NAEDN2
Entrez,  Source
endothelin 213931.8510.3509Yes
26KCND1NAKCND1
Entrez,  Source
potassium voltage-gated channel, Shal-related subfamily, member 114321.8170.3592Yes
27P2RX6NA19911.4240.3359No
28IGFBP2NAIGFBP2
Entrez,  Source
insulin-like growth factor binding protein 2, 36kDa20071.4170.3432No
29ADRA2CNAADRA2C
Entrez,  Source
adrenergic, alpha-2C-, receptor23091.2500.3334No
30SHOX2NASHOX2
Entrez,  Source
short stature homeobox 224211.2070.3341No
31SLC16A7NASLC16A7
Entrez,  Source
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)27021.0970.3246No
32CCDC106NACCDC106
Entrez,  Source
coiled-coil domain containing 10629571.0020.3160No
33SLC29A3NASLC29A3
Entrez,  Source
solute carrier family 29 (nucleoside transporters), member 329681.0010.3212No
34DLK2NA30270.9830.3235No
35CALML5NACALML5
Entrez,  Source
calmodulin-like 530650.9710.3270No
36PAX4NAPAX4
Entrez,  Source
paired box gene 431680.9450.3266No
37PAX3NAPAX3
Entrez,  Source
paired box gene 3 (Waardenburg syndrome 1)31690.9450.3320No
38H2AFY2NAH2AFY2
Entrez,  Source
H2A histone family, member Y233510.8960.3270No
39TGFB2NATGFB2
Entrez,  Source
transforming growth factor, beta 233890.8830.3299No
40YPEL1NAYPEL1
Entrez,  Source
yippee-like 1 (Drosophila)34180.8780.3334No
41COPZ2NACOPZ2
Entrez,  Source
coatomer protein complex, subunit zeta 237190.8260.3212No
42SYNPONASYNPO
Entrez,  Source
synaptopodin37570.8200.3238No
43IRS4NAIRS4
Entrez,  Source
insulin receptor substrate 437960.8100.3263No
44TAS2R4NATAS2R4
Entrez,  Source
taste receptor, type 2, member 438040.8090.3305No
45GAMTNAGAMT
Entrez,  Source
guanidinoacetate N-methyltransferase38270.8040.3339No
46CHST2NACHST2
Entrez,  Source
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 239200.7800.3332No
47CLDN16NACLDN16
Entrez,  Source
claudin 1641830.7230.3226No
48PKP1NAPKP1
Entrez,  Source
plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)44890.6590.3092No
49WNT16NAWNT16
Entrez,  Source
wingless-type MMTV integration site family, member 1645280.6520.3108No
50SLC6A3NASLC6A3
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, dopamine), member 345710.6430.3121No
51COL2A1NACOL2A1
Entrez,  Source
collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)46590.6270.3108No
52ENTPD7NAENTPD7
Entrez,  Source
ectonucleoside triphosphate diphosphohydrolase 746840.6210.3130No
53CPEB3NACPEB3
Entrez,  Source
cytoplasmic polyadenylation element binding protein 347710.6010.3116No
54RIBC2NARIBC2
Entrez,  Source
RIB43A domain with coiled-coils 249720.5630.3036No
55STAG3NASTAG3
Entrez,  Source
stromal antigen 349810.5610.3063No
56RYR2NARYR2
Entrez,  Source
ryanodine receptor 2 (cardiac)50500.5460.3056No
57KCNMB1NAKCNMB1
Entrez,  Source
potassium large conductance calcium-activated channel, subfamily M, beta member 152400.5110.2979No
58EDARNAEDAR
Entrez,  Source
ectodysplasin A receptor52860.5030.2982No
59NTF3NANTF3
Entrez,  Source
neurotrophin 353620.4910.2968No
60SNCBNASNCB
Entrez,  Source
synuclein, beta56260.4560.2846No
61GP1BANAGP1BA
Entrez,  Source
glycoprotein Ib (platelet), alpha polypeptide57170.4410.2821No
62AMBNNAAMBN
Entrez,  Source
ameloblastin (enamel matrix protein)57220.4400.2844No
63RGS11NARGS11
Entrez,  Source
regulator of G-protein signalling 1158190.4280.2814No
64KRT1NAKRT1
Entrez,  Source
keratin 1 (epidermolytic hyperkeratosis)58750.4280.2808No
65NOS1NANOS1
Entrez,  Source
nitric oxide synthase 1 (neuronal)59240.4240.2805No
66BARD1NABARD1
Entrez,  Source
BRCA1 associated RING domain 160770.4170.2744No
67SSTR4NASSTR4
Entrez,  Source
somatostatin receptor 461090.4150.2750No
68NGBNANGB
Entrez,  Source
neuroglobin61250.4150.2765No
69KCNN1NAKCNN1
Entrez,  Source
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 163490.3900.2662No
70SLC38A3NASLC38A3
Entrez,  Source
solute carrier family 38, member 365360.3610.2578No
71NRIP2NANRIP2
Entrez,  Source
nuclear receptor interacting protein 265880.3520.2569No
72THNSL2NA67100.3330.2520No
73CCR8NACCR8
Entrez,  Source
chemokine (C-C motif) receptor 867790.3250.2501No
74SOX10NASOX10
Entrez,  Source
SRY (sex determining region Y)-box 1067910.3240.2513No
75ACTC1NAACTC1
Entrez,  Source
actin, alpha, cardiac muscle 172130.2550.2291No
76SLC5A5NASLC5A5
Entrez,  Source
solute carrier family 5 (sodium iodide symporter), member 573850.2290.2208No
77HSD11B2NAHSD11B2
Entrez,  Source
hydroxysteroid (11-beta) dehydrogenase 274170.2220.2203No
78KLHDC8ANAKLHDC8A
Entrez,  Source
kelch domain containing 8A75910.2000.2117No
79P2RY4NAP2RY4
Entrez,  Source
pyrimidinergic receptor P2Y, G-protein coupled, 476720.1890.2083No
80MYO15ANAMYO15A
Entrez,  Source
myosin XVA76980.1850.2080No
81CLDN8NACLDN8
Entrez,  Source
claudin 879510.1510.1947No
82CKMNACKM
Entrez,  Source
creatine kinase, muscle80410.1410.1905No
83CDKAL1NACDKAL1
Entrez,  Source
CDK5 regulatory subunit associated protein 1-like 182090.1190.1818No
84MSH5NAMSH5
Entrez,  Source
mutS homolog 5 (E. coli)83070.1070.1769No
85CCNA1NACCNA1
Entrez,  Source
cyclin A183590.1000.1746No
86RYR1NARYR1
Entrez,  Source
ryanodine receptor 1 (skeletal)84130.0920.1722No
87MEFVNAMEFV
Entrez,  Source
Mediterranean fever85070.0780.1674No
88MYOTNAMYOT
Entrez,  Source
myotilin86240.0630.1612No
89SIDT1NASIDT1
Entrez,  Source
SID1 transmembrane family, member 186340.0610.1611No
90SCN10ANASCN10A
Entrez,  Source
sodium channel, voltage-gated, type X, alpha87980.0400.1522No
91SPHK2NASPHK2
Entrez,  Source
sphingosine kinase 288550.0350.1492No
92PDE6BNAPDE6B
Entrez,  Source
phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness 3, autosomal dominant)90680.0110.1374No
93HTR1BNAHTR1B
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 1B91870.0000.1307No
94CLPSNACLPS
Entrez,  Source
colipase, pancreatic92300.0000.1284No
95ARHGDIGNAARHGDIG
Entrez,  Source
Rho GDP dissociation inhibitor (GDI) gamma92410.0000.1278No
96TFF2NATFF2
Entrez,  Source
trefoil factor 2 (spasmolytic protein 1)92890.0000.1252No
97FGF16NAFGF16
Entrez,  Source
fibroblast growth factor 1692980.0000.1247No
98CALCBNACALCB
Entrez,  Source
calcitonin-related polypeptide, beta93380.0000.1225No
99CNTFRNACNTFR
Entrez,  Source
ciliary neurotrophic factor receptor93390.0000.1225No
100INSL5NAINSL5
Entrez,  Source
insulin-like 593770.0000.1204No
101NUDT11NANUDT11
Entrez,  Source
nudix (nucleoside diphosphate linked moiety X)-type motif 119408-0.0000.1188No
102NPHS1NANPHS1
Entrez,  Source
nephrosis 1, congenital, Finnish type (nephrin)9449-0.0060.1166No
103MAST3NAMAST3
Entrez,  Source
microtubule associated serine/threonine kinase 39487-0.0120.1145No
104TFAP2BNATFAP2B
Entrez,  Source
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)9529-0.0190.1123No
105TGNATG
Entrez,  Source
thyroglobulin9588-0.0280.1092No
106SLC6A14NASLC6A14
Entrez,  Source
solute carrier family 6 (amino acid transporter), member 149698-0.0420.1034No
107MYH7NAMYH7
Entrez,  Source
myosin, heavy chain 7, cardiac muscle, beta9742-0.0460.1012No
108KRT4NAKRT4
Entrez,  Source
keratin 49910-0.0640.0922No
109ZBTB16NAZBTB16
Entrez,  Source
zinc finger and BTB domain containing 169918-0.0640.0922No
110IDUANAIDUA
Entrez,  Source
iduronidase, alpha-L-9966-0.0670.0899No
111ABCB11NAABCB11
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 119991-0.0690.0889No
112CDH16NACDH16
Entrez,  Source
cadherin 16, KSP-cadherin9997-0.0700.0891No
113PLAG1NAPLAG1
Entrez,  Source
pleiomorphic adenoma gene 110330-0.0990.0710No
114CD80NACD80
Entrez,  Source
CD80 molecule10403-0.1110.0676No
115GRID2NAGRID2
Entrez,  Source
glutamate receptor, ionotropic, delta 210510-0.1260.0623No
116SERPINA10NASERPINA10
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1010579-0.1360.0593No
117ABCG4NAABCG4
Entrez,  Source
ATP-binding cassette, sub-family G (WHITE), member 410774-0.1650.0493No
118KRT5NAKRT5
Entrez,  Source
keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)10904-0.1840.0431No
119IL12BNAIL12B
Entrez,  Source
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)11133-0.2160.0315No
120CACNA1FNACACNA1F
Entrez,  Source
calcium channel, voltage-dependent, alpha 1F subunit11321-0.2420.0224No
121CPA2NACPA2
Entrez,  Source
carboxypeptidase A2 (pancreatic)11471-0.2660.0156No
122GDNFNAGDNF
Entrez,  Source
glial cell derived neurotrophic factor11662-0.2900.0065No
123GTF3C5NAGTF3C5
Entrez,  Source
general transcription factor IIIC, polypeptide 5, 63kDa11931-0.329-0.0066No
124ARPP21NA12067-0.348-0.0122No
125SLC12A3NASLC12A3
Entrez,  Source
solute carrier family 12 (sodium/chloride transporters), member 312212-0.370-0.0182No
126PDCD1NAPDCD1
Entrez,  Source
programmed cell death 112256-0.376-0.0185No
127PDK2NAPDK2
Entrez,  Source
pyruvate dehydrogenase kinase, isozyme 212266-0.378-0.0168No
128GP2NAGP2
Entrez,  Source
glycoprotein 2 (zymogen granule membrane)12288-0.383-0.0158No
129CLSTN3NACLSTN3
Entrez,  Source
calsyntenin 312320-0.387-0.0154No
130KCNQ2NAKCNQ2
Entrez,  Source
potassium voltage-gated channel, KQT-like subfamily, member 212459-0.411-0.0208No
131FSHBNAFSHB
Entrez,  Source
follicle stimulating hormone, beta polypeptide12475-0.411-0.0193No
132CD40LGNACD40LG
Entrez,  Source
CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome)12489-0.411-0.0177No
133OXTNAOXT
Entrez,  Source
oxytocin, prepro- (neurophysin I)12503-0.411-0.0160No
134CAPN9NACAPN9
Entrez,  Source
calpain 912552-0.411-0.0164No
135KRT13NAKRT13
Entrez,  Source
keratin 1312555-0.411-0.0142No
136TSHBNATSHB
Entrez,  Source
thyroid stimulating hormone, beta12558-0.411-0.0119No
137YBX2NAYBX2
Entrez,  Source
Y box binding protein 212665-0.427-0.0154No
138CACNG1NACACNG1
Entrez,  Source
calcium channel, voltage-dependent, gamma subunit 112798-0.445-0.0203No
139IFNGNAIFNG
Entrez,  Source
interferon, gamma12804-0.445-0.0181No
140ITIH3NAITIH3
Entrez,  Source
inter-alpha (globulin) inhibitor H312854-0.445-0.0183No
141PNMTNAPNMT
Entrez,  Source
phenylethanolamine N-methyltransferase13208-0.490-0.0353No
142SCGB1A1NASCGB1A1
Entrez,  Source
secretoglobin, family 1A, member 1 (uteroglobin)13288-0.502-0.0369No
143ATP4ANAATP4A
Entrez,  Source
ATPase, H+/K+ exchanging, alpha polypeptide13325-0.506-0.0360No
144CPB1NACPB1
Entrez,  Source
carboxypeptidase B1 (tissue)13338-0.509-0.0338No
145TLX1NATLX1
Entrez,  Source
T-cell leukemia homeobox 113389-0.515-0.0337No
146SMPXNASMPX
Entrez,  Source
small muscle protein, X-linked13426-0.522-0.0327No
147GPR3NAGPR3
Entrez,  Source
G protein-coupled receptor 313475-0.531-0.0324No
148KCNE2NAKCNE2
Entrez,  Source
potassium voltage-gated channel, Isk-related family, member 213923-0.619-0.0540No
149UPK3BNAUPK3B
Entrez,  Source
uroplakin 3B13953-0.624-0.0520No
150CYP11B2NACYP11B2
Entrez,  Source
cytochrome P450, family 11, subfamily B, polypeptide 214115-0.661-0.0573No
151NR6A1NANR6A1
Entrez,  Source
nuclear receptor subfamily 6, group A, member 114153-0.670-0.0556No
152EDN1NAEDN1
Entrez,  Source
endothelin 114208-0.684-0.0547No
153PRODHNAPRODH
Entrez,  Source
proline dehydrogenase (oxidase) 114413-0.729-0.0620No
154CHRNGNACHRNG
Entrez,  Source
cholinergic receptor, nicotinic, gamma14567-0.771-0.0662No
155KLK7NAKLK7
Entrez,  Source
kallikrein 7 (chymotryptic, stratum corneum)14739-0.811-0.0712No
156ALOX12BNAALOX12B
Entrez,  Source
arachidonate 12-lipoxygenase, 12R type15180-0.910-0.0907No
157SNNNASNN
Entrez,  Source
stannin15436-0.978-0.0995No
158DTNBNADTNB
Entrez,  Source
dystrobrevin, beta15683-1.057-0.1073No
159ATP6V1B1NAATP6V1B1
Entrez,  Source
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (Renal tubular acidosis with deafness)15798-1.094-0.1074No
160BRDTNABRDT
Entrez,  Source
bromodomain, testis-specific16152-1.239-0.1202No
161CELSR2NACELSR2
Entrez,  Source
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)16222-1.271-0.1168No
162PTGFRNAPTGFR
Entrez,  Source
prostaglandin F receptor (FP)16348-1.333-0.1162No
163ITGB1BP2NAITGB1BP2
Entrez,  Source
integrin beta 1 binding protein (melusin) 216415-1.371-0.1121No
164ASB7NAASB7
Entrez,  Source
ankyrin repeat and SOCS box-containing 716488-1.409-0.1081No
165C5NAC5
Entrez,  Source
complement component 516535-1.431-0.1025No
166DCCNADCC
Entrez,  Source
deleted in colorectal carcinoma16599-1.469-0.0977No
167TCF7L1NATCF7L1
Entrez,  Source
transcription factor 7-like 1 (T-cell specific, HMG-box)16609-1.475-0.0898No
168FGGYNA16619-1.483-0.0818No
169HNF1ANA16722-1.547-0.0787No
170SLC25A23NASLC25A23
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 2316742-1.560-0.0709No
171LYPD3NALYPD3
Entrez,  Source
LY6/PLAUR domain containing 316895-1.678-0.0699No
172CD207NACD207
Entrez,  Source
CD207 molecule, langerin17103-1.878-0.0708No
173GPR19NAGPR19
Entrez,  Source
G protein-coupled receptor 1917150-1.935-0.0623No
174HTR1DNAHTR1D
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 1D17238-2.064-0.0554No
175TNNI3NATNNI3
Entrez,  Source
troponin I type 3 (cardiac)17322-2.211-0.0475No
176SPTBN2NASPTBN2
Entrez,  Source
spectrin, beta, non-erythrocytic 217361-2.258-0.0367No
177SGK1NA17564-2.620-0.0331No
178TFCP2L1NATFCP2L1
Entrez,  Source
transcription factor CP2-like 117696-3.081-0.0229No
179SLC30A3NASLC30A3
Entrez,  Source
solute carrier family 30 (zinc transporter), member 317697-3.087-0.0053No
180BTG2NABTG2
Entrez,  Source
BTG family, member 217816-3.6470.0089No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_KRAS_SIGNALING_DN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_KRAS_SIGNALING_DN: Random ES distribution   
Gene set null distribution of ES for HALLMARK_KRAS_SIGNALING_DN