Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1w6a
GeneSetHALLMARK_INTERFERON_GAMMA_RESPONSE
Enrichment Score (ES)0.54991835
Normalized Enrichment Score (NES)2.127378
Nominal p-value0.0
FDR q-value0.0
FWER p-Value0.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_INTERFERON_GAMMA_RESPONSE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1BST2NABST2
Entrez,  Source
bone marrow stromal cell antigen 224.9810.0192Yes
2CD74NACD74
Entrez,  Source
CD74 molecule, major histocompatibility complex, class II invariant chain54.9730.0384Yes
3HLA-DRB1NAHLA-DRB1
Entrez,  Source
major histocompatibility complex, class II, DR beta 184.9600.0575Yes
4TNFSF10NATNFSF10
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 10864.5590.0708Yes
5IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)1484.3010.0841Yes
6OASLNAOASL
Entrez,  Source
2'-5'-oligoadenylate synthetase-like1504.2970.1007Yes
7IFIT1NAIFIT1
Entrez,  Source
interferon-induced protein with tetratricopeptide repeats 11564.2820.1170Yes
8CIITANACIITA
Entrez,  Source
class II, major histocompatibility complex, transactivator1684.2450.1328Yes
9OAS2NAOAS2
Entrez,  Source
2'-5'-oligoadenylate synthetase 2, 69/71kDa2034.1210.1469Yes
10IFIT2NAIFIT2
Entrez,  Source
interferon-induced protein with tetratricopeptide repeats 22054.1130.1628Yes
11RSAD2NARSAD2
Entrez,  Source
radical S-adenosyl methionine domain containing 22363.9920.1765Yes
12CMKLR1NACMKLR1
Entrez,  Source
chemokine-like receptor 12553.8820.1906Yes
13SAMD9LNASAMD9L
Entrez,  Source
sterile alpha motif domain containing 9-like2813.7820.2038Yes
14HLA-DMANAHLA-DMA
Entrez,  Source
major histocompatibility complex, class II, DM alpha2943.7470.2177Yes
15CASP1NACASP1
Entrez,  Source
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)3023.7320.2318Yes
16ISG15NAISG15
Entrez,  Source
ISG15 ubiquitin-like modifier3263.6830.2447Yes
17IFIT3NAIFIT3
Entrez,  Source
interferon-induced protein with tetratricopeptide repeats 33293.6680.2588Yes
18RTP4NARTP4
Entrez,  Source
receptor transporter protein 43923.4500.2687Yes
19PTPN6NAPTPN6
Entrez,  Source
protein tyrosine phosphatase, non-receptor type 64073.4170.2812Yes
20IFIH1NAIFIH1
Entrez,  Source
interferon induced with helicase C domain 14133.4040.2941Yes
21STAT4NASTAT4
Entrez,  Source
signal transducer and activator of transcription 44733.2750.3035Yes
22IFI44LNAIFI44L
Entrez,  Source
interferon-induced protein 44-like4903.2310.3151Yes
23CD38NACD38
Entrez,  Source
CD38 molecule5333.1090.3248Yes
24MX1NAMX1
Entrez,  Source
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)5423.0910.3363Yes
25MX2NAMX2
Entrez,  Source
myxovirus (influenza virus) resistance 2 (mouse)5573.0510.3474Yes
26FPR1NAFPR1
Entrez,  Source
formyl peptide receptor 15653.0290.3587Yes
27SLAMF7NASLAMF7
Entrez,  Source
SLAM family member 75693.0120.3702Yes
28CFHNACFH
Entrez,  Source
complement factor H5812.9800.3811Yes
29DDX60NA5882.9680.3923Yes
30IFI44NAIFI44
Entrez,  Source
interferon-induced protein 446382.8820.4007Yes
31C1RNAC1R
Entrez,  Source
complement component 1, r subcomponent6942.7340.4082Yes
32DHX58NA7402.6510.4160Yes
33HERC6NAHERC6
Entrez,  Source
hect domain and RLD 67962.5500.4228Yes
34MT2ANAMT2A
Entrez,  Source
metallothionein 2A8362.4920.4302Yes
35GBP4NAGBP4
Entrez,  Source
guanylate binding protein 48742.4410.4376Yes
36CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)8882.4130.4462Yes
37USP18NAUSP18
Entrez,  Source
ubiquitin specific peptidase 189172.3970.4539Yes
38SERPING1NASERPING1
Entrez,  Source
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)9932.2940.4586Yes
39SECTM1NASECTM1
Entrez,  Source
secreted and transmembrane 110312.2600.4653Yes
40NAMPTNA10472.2320.4731Yes
41IRF7NAIRF7
Entrez,  Source
interferon regulatory factor 710582.2150.4811Yes
42PTGS2NAPTGS2
Entrez,  Source
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)10852.1900.4882Yes
43IRF5NAIRF5
Entrez,  Source
interferon regulatory factor 511362.1290.4936Yes
44CXCL11NACXCL11
Entrez,  Source
chemokine (C-X-C motif) ligand 1111802.0560.4992Yes
45CFBNACFB
Entrez,  Source
complement factor B11972.0410.5062Yes
46ST8SIA4NAST8SIA4
Entrez,  Source
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 412282.0130.5123Yes
47CMPK2NA12871.9430.5165Yes
48UBE2L6NAUBE2L6
Entrez,  Source
ubiquitin-conjugating enzyme E2L 614121.8340.5167Yes
49TAPBPNATAPBP
Entrez,  Source
TAP binding protein (tapasin)15261.7390.5171Yes
50CXCL10NACXCL10
Entrez,  Source
chemokine (C-X-C motif) ligand 1016721.6340.5152Yes
51DDX58NADDX58
Entrez,  Source
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5816831.6160.5209Yes
52FASNAFAS
Entrez,  Source
Fas (TNF receptor superfamily, member 6)17161.5890.5253Yes
53SP110NASP110
Entrez,  Source
SP110 nuclear body protein17681.5450.5284Yes
54XAF1NA18451.5020.5300Yes
55TRIM26NATRIM26
Entrez,  Source
tripartite motif-containing 2619071.4680.5322Yes
56ICAM1NAICAM1
Entrez,  Source
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor19971.4220.5327Yes
57TOR1BNATOR1B
Entrez,  Source
torsin family 1, member B (torsin B)20371.4020.5360Yes
58RBCK1NARBCK1
Entrez,  Source
RanBP-type and C3HC4-type zinc finger containing 121781.3200.5332Yes
59PIM1NAPIM1
Entrez,  Source
pim-1 oncogene23671.2270.5274Yes
60STAT2NASTAT2
Entrez,  Source
signal transducer and activator of transcription 2, 113kDa24121.2110.5296Yes
61IRF1NAIRF1
Entrez,  Source
interferon regulatory factor 124391.1970.5328Yes
62RAPGEF6NARAPGEF6
Entrez,  Source
Rap guanine nucleotide exchange factor (GEF) 624431.1960.5373Yes
63EIF2AK2NAEIF2AK2
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 224731.1870.5402Yes
64MVPNAMVP
Entrez,  Source
major vault protein24741.1870.5448Yes
65VAMP5NAVAMP5
Entrez,  Source
vesicle-associated membrane protein 5 (myobrevin)25901.1410.5428Yes
66PSME1NAPSME1
Entrez,  Source
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)27431.0820.5384Yes
67WARSNAWARS
Entrez,  Source
tryptophanyl-tRNA synthetase27851.0650.5403Yes
68PARP12NAPARP12
Entrez,  Source
poly (ADP-ribose) polymerase family, member 1228631.0410.5400Yes
69IDO1NA28891.0330.5426Yes
70APOL6NAAPOL6
Entrez,  Source
apolipoprotein L, 629291.0140.5443Yes
71IL7NAIL7
Entrez,  Source
interleukin 730590.9730.5408Yes
72RNF31NARNF31
Entrez,  Source
ring finger protein 3130630.9710.5444Yes
73SOCS1NASOCS1
Entrez,  Source
suppressor of cytokine signaling 130870.9660.5469Yes
74ST3GAL5NAST3GAL5
Entrez,  Source
ST3 beta-galactoside alpha-2,3-sialyltransferase 531000.9630.5499Yes
75IRF9NA32330.9320.5461No
76ISOC1NAISOC1
Entrez,  Source
isochorismatase domain containing 133740.8890.5417No
77STAT1NASTAT1
Entrez,  Source
signal transducer and activator of transcription 1, 91kDa37690.8170.5227No
78C1SNAC1S
Entrez,  Source
complement component 1, s subcomponent38470.8000.5215No
79IL18BPNAIL18BP
Entrez,  Source
interleukin 18 binding protein38820.7900.5226No
80IL15RANAIL15RA
Entrez,  Source
interleukin 15 receptor, alpha39170.7820.5237No
81MARCH1NAMARCH1
Entrez,  Source
membrane-associated ring finger (C3HC4) 139790.7660.5233No
82PSME2NAPSME2
Entrez,  Source
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)40950.7410.5197No
83NCOA3NANCOA3
Entrez,  Source
nuclear receptor coactivator 342290.7140.5150No
84JAK2NAJAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)43250.6960.5123No
85LGALS3BPNALGALS3BP
Entrez,  Source
lectin, galactoside-binding, soluble, 3 binding protein43880.6810.5115No
86NFKBIANANFKBIA
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha44750.6620.5092No
87HLA-GNAHLA-G
Entrez,  Source
HLA-G histocompatibility antigen, class I, G45770.6420.5060No
88TRIM25NATRIM25
Entrez,  Source
tripartite motif-containing 2546680.6250.5034No
89CCL5NACCL5
Entrez,  Source
chemokine (C-C motif) ligand 546740.6240.5055No
90HLA-ANAHLA-A
Entrez,  Source
major histocompatibility complex, class I, A47200.6130.5053No
91LAP3NALAP3
Entrez,  Source
leucine aminopeptidase 347520.6060.5059No
92ISG20NAISG20
Entrez,  Source
interferon stimulated exonuclease gene 20kDa48780.5810.5012No
93TAP1NATAP1
Entrez,  Source
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)49610.5660.4987No
94ARL4ANAARL4A
Entrez,  Source
ADP-ribosylation factor-like 4A50450.5460.4962No
95ZNFX1NAZNFX1
Entrez,  Source
zinc finger, NFX1-type containing 150480.5460.4982No
96CASP8NACASP8
Entrez,  Source
caspase 8, apoptosis-related cysteine peptidase52700.5050.4877No
97LCP2NALCP2
Entrez,  Source
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)55820.4630.4720No
98AUTS2NAAUTS2
Entrez,  Source
autism susceptibility candidate 255870.4630.4736No
99VCAM1NAVCAM1
Entrez,  Source
vascular cell adhesion molecule 157500.4370.4662No
100PFKPNAPFKP
Entrez,  Source
phosphofructokinase, platelet59440.4220.4570No
101HLA-DQA1NAHLA-DQA1
Entrez,  Source
major histocompatibility complex, class II, DQ alpha 161160.4150.4489No
102FGL2NAFGL2
Entrez,  Source
fibrinogen-like 262400.4090.4436No
103TXNIPNATXNIP
Entrez,  Source
thioredoxin interacting protein63360.3920.4398No
104TDRD7NATDRD7
Entrez,  Source
tudor domain containing 763450.3910.4409No
105TRAFD1NATRAFD1
Entrez,  Source
TRAF-type zinc finger domain containing 163820.3840.4403No
106SOCS3NASOCS3
Entrez,  Source
suppressor of cytokine signaling 364470.3740.4382No
107P2RY14NAP2RY14
Entrez,  Source
purinergic receptor P2Y, G-protein coupled, 1466760.3380.4267No
108SPPL2ANASPPL2A
Entrez,  Source
-68620.3130.4175No
109CASP7NACASP7
Entrez,  Source
caspase 7, apoptosis-related cysteine peptidase70710.2780.4068No
110PTPN2NAPTPN2
Entrez,  Source
protein tyrosine phosphatase, non-receptor type 270920.2750.4068No
111PSMB2NAPSMB2
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 271320.2680.4056No
112CD274NACD274
Entrez,  Source
CD274 molecule72160.2550.4019No
113EPSTI1NAEPSTI1
Entrez,  Source
epithelial stromal interaction 1 (breast)73370.2360.3961No
114PSMB10NAPSMB10
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 1074430.2190.3911No
115PSMA3NAPSMA3
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 374940.2110.3891No
116CD69NACD69
Entrez,  Source
CD69 molecule75690.2020.3857No
117ZBP1NAZBP1
Entrez,  Source
Z-DNA binding protein 175730.2020.3863No
118SAMHD1NASAMHD1
Entrez,  Source
SAM domain and HD domain 177140.1830.3791No
119TRIM21NATRIM21
Entrez,  Source
tripartite motif-containing 2179410.1520.3670No
120IFI35NAIFI35
Entrez,  Source
interferon-induced protein 3580010.1460.3643No
121HIF1ANAHIF1A
Entrez,  Source
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)81110.1320.3586No
122VAMP8NAVAMP8
Entrez,  Source
vesicle-associated membrane protein 8 (endobrevin)82200.1170.3530No
123IFI30NAIFI30
Entrez,  Source
interferon, gamma-inducible protein 3082400.1150.3524No
124SELPNASELP
Entrez,  Source
selectin P (granule membrane protein 140kDa, antigen CD62)84400.0880.3415No
125CSF2RBNACSF2RB
Entrez,  Source
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)84560.0860.3410No
126PARP14NAPARP14
Entrez,  Source
poly (ADP-ribose) polymerase family, member 1485270.0770.3374No
127NMINANMI
Entrez,  Source
N-myc (and STAT) interactor87540.0440.3248No
128HLA-BNAHLA-B
Entrez,  Source
major histocompatibility complex, class I, B87590.0430.3248No
129CCL7NACCL7
Entrez,  Source
chemokine (C-C motif) ligand 793920.0000.2892No
130LYSMD2NALYSMD2
Entrez,  Source
LysM, putative peptidoglycan-binding, domain containing 29420-0.0030.2877No
131OGFRNAOGFR
Entrez,  Source
opioid growth factor receptor9452-0.0070.2860No
132IFNAR2NAIFNAR2
Entrez,  Source
interferon (alpha, beta and omega) receptor 29672-0.0400.2738No
133GPR18NAGPR18
Entrez,  Source
G protein-coupled receptor 189673-0.0400.2740No
134TRIM14NATRIM14
Entrez,  Source
tripartite motif-containing 149682-0.0410.2737No
135FCGR1ANAFCGR1A
Entrez,  Source
Fc fragment of IgG, high affinity Ia, receptor (CD64)9795-0.0510.2676No
136ITGB7NAITGB7
Entrez,  Source
integrin, beta 79842-0.0570.2652No
137STAT3NASTAT3
Entrez,  Source
signal transducer and activator of transcription 3 (acute-phase response factor)9852-0.0580.2650No
138GZMANAGZMA
Entrez,  Source
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)9874-0.0620.2640No
139CXCL9NACXCL9
Entrez,  Source
chemokine (C-X-C motif) ligand 910000-0.0700.2573No
140IL10RANAIL10RA
Entrez,  Source
interleukin 10 receptor, alpha10061-0.0740.2542No
141ADARNAADAR
Entrez,  Source
adenosine deaminase, RNA-specific10155-0.0830.2493No
142PSMA2NAPSMA2
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 210652-0.1480.2219No
143ARID5BNAARID5B
Entrez,  Source
AT rich interactive domain 5B (MRF1-like)10658-0.1480.2222No
144TNFAIP6NATNFAIP6
Entrez,  Source
tumor necrosis factor, alpha-induced protein 610779-0.1660.2161No
145PMLNAPML
Entrez,  Source
promyelocytic leukemia10783-0.1660.2166No
146CD86NACD86
Entrez,  Source
CD86 molecule10856-0.1770.2132No
147IRF4NAIRF4
Entrez,  Source
interferon regulatory factor 410890-0.1820.2121No
148BTG1NABTG1
Entrez,  Source
B-cell translocation gene 1, anti-proliferative10899-0.1840.2123No
149PTPN1NAPTPN1
Entrez,  Source
protein tyrosine phosphatase, non-receptor type 111121-0.2150.2007No
150B2MNAB2M
Entrez,  Source
beta-2-microglobulin11181-0.2240.1983No
151SRINASRI
Entrez,  Source
sorcin11416-0.2570.1861No
152XCL1NAXCL1
Entrez,  Source
chemokine (C motif) ligand 111513-0.2730.1818No
153PSMB9NAPSMB9
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)12068-0.3490.1520No
154NOD1NA12119-0.3570.1506No
155RIPK2NARIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 212241-0.3740.1452No
156SLC25A28NASLC25A28
Entrez,  Source
solute carrier family 25, member 2812452-0.4100.1350No
157IL15NAIL15
Entrez,  Source
interleukin 1512600-0.4160.1283No
158RIPK1NARIPK1
Entrez,  Source
receptor (TNFRSF)-interacting serine-threonine kinase 112607-0.4170.1296No
159IRF8NAIRF8
Entrez,  Source
interferon regulatory factor 812681-0.4310.1272No
160IRF2NAIRF2
Entrez,  Source
interferon regulatory factor 212738-0.4410.1257No
161KLRK1NAKLRK1
Entrez,  Source
killer cell lectin-like receptor subfamily K, member 112784-0.4450.1249No
162GBP6NAGBP6
Entrez,  Source
guanylate binding protein family, member 613020-0.4580.1135No
163GCH1NAGCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)13276-0.5010.1011No
164IL4RNAIL4R
Entrez,  Source
interleukin 4 receptor13336-0.5080.0997No
165PDE4BNAPDE4B
Entrez,  Source
phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)13627-0.5630.0856No
166NLRC5NA13696-0.5750.0840No
167MYD88NAMYD88
Entrez,  Source
myeloid differentiation primary response gene (88)13793-0.5930.0809No
168CCL2NACCL2
Entrez,  Source
chemokine (C-C motif) ligand 213859-0.6060.0796No
169BPGMNABPGM
Entrez,  Source
2,3-bisphosphoglycerate mutase14019-0.6400.0731No
170CASP4NACASP4
Entrez,  Source
caspase 4, apoptosis-related cysteine peptidase14105-0.6600.0709No
171PSMB8NAPSMB8
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)14537-0.7630.0496No
172NFKB1NANFKB1
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)14554-0.7680.0517No
173BANK1NABANK1
Entrez,  Source
B-cell scaffold protein with ankyrin repeats 114557-0.7690.0546No
174PLA2G4ANAPLA2G4A
Entrez,  Source
phospholipase A2, group IVA (cytosolic, calcium-dependent)14893-0.8420.0390No
175METTL7BNAMETTL7B
Entrez,  Source
methyltransferase like 7B15254-0.9300.0223No
176PLSCR1NAPLSCR1
Entrez,  Source
phospholipid scramblase 115338-0.9510.0214No
177SOD2NASOD2
Entrez,  Source
superoxide dismutase 2, mitochondrial15368-0.9610.0235No
178PNPT1NAPNPT1
Entrez,  Source
polyribonucleotide nucleotidyltransferase 115478-0.9920.0212No
179IFI27NAIFI27
Entrez,  Source
interferon, alpha-inducible protein 2715560-1.0150.0205No
180TNFAIP2NATNFAIP2
Entrez,  Source
tumor necrosis factor, alpha-induced protein 215804-1.0970.0111No
181LATS2NALATS2
Entrez,  Source
LATS, large tumor suppressor, homolog 2 (Drosophila)15836-1.1090.0137No
182NUP93NANUP93
Entrez,  Source
nucleoporin 93kDa16131-1.2300.0019No
183LY6ENALY6E
Entrez,  Source
lymphocyte antigen 6 complex, locus E16427-1.376-0.0093No
184TNFAIP3NATNFAIP3
Entrez,  Source
tumor necrosis factor, alpha-induced protein 316490-1.410-0.0074No
185PNPNA16529-1.430-0.0040No
186OAS3NAOAS3
Entrez,  Source
2'-5'-oligoadenylate synthetase 3, 100kDa16587-1.454-0.0015No
187BATF2NABATF2
Entrez,  Source
basic leucine zipper transcription factor, ATF-like 216653-1.5020.0006No
188PELI1NAPELI1
Entrez,  Source
pellino homolog 1 (Drosophila)16771-1.5800.0002No
189SSPNNASSPN
Entrez,  Source
sarcospan (Kras oncogene-associated gene)16888-1.6730.0001No
190IFITM3NAIFITM3
Entrez,  Source
interferon induced transmembrane protein 3 (1-8U)16936-1.7090.0041No
191CASP3NACASP3
Entrez,  Source
caspase 3, apoptosis-related cysteine peptidase17177-1.978-0.0017No
192MTHFD2NAMTHFD2
Entrez,  Source
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase17262-2.1010.0017No
193EIF4E3NAEIF4E3
Entrez,  Source
eukaryotic translation initiation factor 4E member 317428-2.3800.0017No
194IL2RBNAIL2RB
Entrez,  Source
interleukin 2 receptor, beta17450-2.4120.0098No
195CD40NACD40
Entrez,  Source
CD40 molecule, TNF receptor superfamily member 517453-2.4140.0191No
196IFITM2NAIFITM2
Entrez,  Source
interferon induced transmembrane protein 2 (1-8D)17569-2.6280.0228No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_INTERFERON_GAMMA_RESPONSE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_INTERFERON_GAMMA_RESPONSE: Random ES distribution   
Gene set null distribution of ES for HALLMARK_INTERFERON_GAMMA_RESPONSE