Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | HALLMARK_INTERFERON_ALPHA_RESPONSE |
| Enrichment Score (ES) | 0.64841557 |
| Normalized Enrichment Score (NES) | 2.329605 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | BST2 | NA | BST2 Entrez, Source | bone marrow stromal cell antigen 2 | 2 | 4.981 | 0.0327 | Yes |
| 2 | CD74 | NA | CD74 Entrez, Source | CD74 molecule, major histocompatibility complex, class II invariant chain | 5 | 4.973 | 0.0653 | Yes |
| 3 | CSF1 | NA | CSF1 Entrez, Source | colony stimulating factor 1 (macrophage) | 109 | 4.487 | 0.0890 | Yes |
| 4 | SELL | NA | SELL Entrez, Source | selectin L (lymphocyte adhesion molecule 1) | 146 | 4.309 | 0.1154 | Yes |
| 5 | OASL | NA | OASL Entrez, Source | 2'-5'-oligoadenylate synthetase-like | 150 | 4.297 | 0.1435 | Yes |
| 6 | IFIT2 | NA | IFIT2 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 2 | 205 | 4.113 | 0.1675 | Yes |
| 7 | RSAD2 | NA | RSAD2 Entrez, Source | radical S-adenosyl methionine domain containing 2 | 236 | 3.992 | 0.1921 | Yes |
| 8 | GMPR | NA | GMPR Entrez, Source | guanosine monophosphate reductase | 251 | 3.905 | 0.2170 | Yes |
| 9 | SAMD9L | NA | SAMD9L Entrez, Source | sterile alpha motif domain containing 9-like | 281 | 3.782 | 0.2403 | Yes |
| 10 | LAMP3 | NA | LAMP3 Entrez, Source | lysosomal-associated membrane protein 3 | 298 | 3.738 | 0.2640 | Yes |
| 11 | CASP1 | NA | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 302 | 3.732 | 0.2883 | Yes |
| 12 | ISG15 | NA | ISG15 Entrez, Source | ISG15 ubiquitin-like modifier | 326 | 3.683 | 0.3113 | Yes |
| 13 | IFIT3 | NA | IFIT3 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 3 | 329 | 3.668 | 0.3353 | Yes |
| 14 | RTP4 | NA | RTP4 Entrez, Source | receptor transporter protein 4 | 392 | 3.450 | 0.3545 | Yes |
| 15 | IFIH1 | NA | IFIH1 Entrez, Source | interferon induced with helicase C domain 1 | 413 | 3.404 | 0.3758 | Yes |
| 16 | OAS1 | NA | OAS1 Entrez, Source | 2',5'-oligoadenylate synthetase 1, 40/46kDa | 420 | 3.385 | 0.3977 | Yes |
| 17 | GBP2 | NA | GBP2 Entrez, Source | guanylate binding protein 2, interferon-inducible | 436 | 3.356 | 0.4190 | Yes |
| 18 | IFI44L | NA | IFI44L Entrez, Source | interferon-induced protein 44-like | 490 | 3.231 | 0.4373 | Yes |
| 19 | MX1 | NA | MX1 Entrez, Source | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 542 | 3.091 | 0.4548 | Yes |
| 20 | DDX60 | NA | 588 | 2.968 | 0.4718 | Yes | ||
| 21 | SAMD9 | NA | SAMD9 Entrez, Source | sterile alpha motif domain containing 9 | 590 | 2.963 | 0.4912 | Yes |
| 22 | CCRL2 | NA | CCRL2 Entrez, Source | chemokine (C-C motif) receptor-like 2 | 611 | 2.925 | 0.5093 | Yes |
| 23 | IFI44 | NA | IFI44 Entrez, Source | interferon-induced protein 44 | 638 | 2.882 | 0.5268 | Yes |
| 24 | DHX58 | NA | 740 | 2.651 | 0.5386 | Yes | ||
| 25 | IFITM1 | NA | IFITM1 Entrez, Source | interferon induced transmembrane protein 1 (9-27) | 748 | 2.639 | 0.5556 | Yes |
| 26 | HERC6 | NA | HERC6 Entrez, Source | hect domain and RLD 6 | 796 | 2.550 | 0.5697 | Yes |
| 27 | GBP4 | NA | GBP4 Entrez, Source | guanylate binding protein 4 | 874 | 2.441 | 0.5815 | Yes |
| 28 | USP18 | NA | USP18 Entrez, Source | ubiquitin specific peptidase 18 | 917 | 2.397 | 0.5949 | Yes |
| 29 | IRF7 | NA | IRF7 Entrez, Source | interferon regulatory factor 7 | 1058 | 2.215 | 0.6017 | Yes |
| 30 | CXCL11 | NA | CXCL11 Entrez, Source | chemokine (C-X-C motif) ligand 11 | 1180 | 2.056 | 0.6084 | Yes |
| 31 | CMPK2 | NA | 1287 | 1.943 | 0.6153 | Yes | ||
| 32 | FAM46A | NA | FAM46A Entrez, Source | family with sequence similarity 46, member A | 1347 | 1.887 | 0.6244 | Yes |
| 33 | UBE2L6 | NA | UBE2L6 Entrez, Source | ubiquitin-conjugating enzyme E2L 6 | 1412 | 1.834 | 0.6329 | Yes |
| 34 | NCOA7 | NA | NCOA7 Entrez, Source | nuclear receptor coactivator 7 | 1419 | 1.827 | 0.6446 | Yes |
| 35 | CXCL10 | NA | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 1672 | 1.634 | 0.6412 | Yes |
| 36 | SP110 | NA | SP110 Entrez, Source | SP110 nuclear body protein | 1768 | 1.545 | 0.6461 | Yes |
| 37 | TRIM26 | NA | TRIM26 Entrez, Source | tripartite motif-containing 26 | 1907 | 1.468 | 0.6480 | Yes |
| 38 | STAT2 | NA | STAT2 Entrez, Source | signal transducer and activator of transcription 2, 113kDa | 2412 | 1.211 | 0.6278 | Yes |
| 39 | IRF1 | NA | IRF1 Entrez, Source | interferon regulatory factor 1 | 2439 | 1.197 | 0.6342 | Yes |
| 40 | EIF2AK2 | NA | EIF2AK2 Entrez, Source | eukaryotic translation initiation factor 2-alpha kinase 2 | 2473 | 1.187 | 0.6402 | Yes |
| 41 | MOV10 | NA | MOV10 Entrez, Source | Mov10, Moloney leukemia virus 10, homolog (mouse) | 2738 | 1.085 | 0.6325 | Yes |
| 42 | PSME1 | NA | PSME1 Entrez, Source | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | 2743 | 1.082 | 0.6394 | Yes |
| 43 | WARS | NA | WARS Entrez, Source | tryptophanyl-tRNA synthetase | 2785 | 1.065 | 0.6442 | Yes |
| 44 | PARP12 | NA | PARP12 Entrez, Source | poly (ADP-ribose) polymerase family, member 12 | 2863 | 1.041 | 0.6467 | Yes |
| 45 | IL7 | NA | IL7 Entrez, Source | interleukin 7 | 3059 | 0.973 | 0.6422 | Yes |
| 46 | RNF31 | NA | RNF31 Entrez, Source | ring finger protein 31 | 3063 | 0.971 | 0.6484 | Yes |
| 47 | IRF9 | NA | 3233 | 0.932 | 0.6451 | No | ||
| 48 | NUB1 | NA | NUB1 Entrez, Source | negative regulator of ubiquitin-like proteins 1 | 3478 | 0.863 | 0.6371 | No |
| 49 | CNP | NA | CNP Entrez, Source | 2',3'-cyclic nucleotide 3' phosphodiesterase | 3488 | 0.860 | 0.6423 | No |
| 50 | C1S | NA | C1S Entrez, Source | complement component 1, s subcomponent | 3847 | 0.800 | 0.6275 | No |
| 51 | PSME2 | NA | PSME2 Entrez, Source | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | 4095 | 0.741 | 0.6186 | No |
| 52 | CD47 | NA | CD47 Entrez, Source | CD47 molecule | 4270 | 0.708 | 0.6135 | No |
| 53 | HLA-C | NA | HLA-C Entrez, Source | major histocompatibility complex, class I, C | 4338 | 0.693 | 0.6143 | No |
| 54 | LGALS3BP | NA | LGALS3BP Entrez, Source | lectin, galactoside-binding, soluble, 3 binding protein | 4388 | 0.681 | 0.6161 | No |
| 55 | TRIM25 | NA | TRIM25 Entrez, Source | tripartite motif-containing 25 | 4668 | 0.625 | 0.6046 | No |
| 56 | LAP3 | NA | LAP3 Entrez, Source | leucine aminopeptidase 3 | 4752 | 0.606 | 0.6039 | No |
| 57 | LPAR6 | NA | 4806 | 0.593 | 0.6049 | No | ||
| 58 | ISG20 | NA | ISG20 Entrez, Source | interferon stimulated exonuclease gene 20kDa | 4878 | 0.581 | 0.6047 | No |
| 59 | TAP1 | NA | TAP1 Entrez, Source | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 4961 | 0.566 | 0.6038 | No |
| 60 | CASP8 | NA | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 5270 | 0.505 | 0.5899 | No |
| 61 | TXNIP | NA | TXNIP Entrez, Source | thioredoxin interacting protein | 6336 | 0.392 | 0.5330 | No |
| 62 | TDRD7 | NA | TDRD7 Entrez, Source | tudor domain containing 7 | 6345 | 0.391 | 0.5351 | No |
| 63 | TRAFD1 | NA | TRAFD1 Entrez, Source | TRAF-type zinc finger domain containing 1 | 6382 | 0.384 | 0.5356 | No |
| 64 | EPSTI1 | NA | EPSTI1 Entrez, Source | epithelial stromal interaction 1 (breast) | 7337 | 0.236 | 0.4838 | No |
| 65 | TRIM5 | NA | TRIM5 Entrez, Source | tripartite motif-containing 5 | 7434 | 0.221 | 0.4799 | No |
| 66 | PSMA3 | NA | PSMA3 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 3 | 7494 | 0.211 | 0.4780 | No |
| 67 | TRIM21 | NA | TRIM21 Entrez, Source | tripartite motif-containing 21 | 7941 | 0.152 | 0.4540 | No |
| 68 | IFI35 | NA | IFI35 Entrez, Source | interferon-induced protein 35 | 8001 | 0.146 | 0.4517 | No |
| 69 | IFI30 | NA | IFI30 Entrez, Source | interferon, gamma-inducible protein 30 | 8240 | 0.115 | 0.4391 | No |
| 70 | TMEM140 | NA | TMEM140 Entrez, Source | transmembrane protein 140 | 8442 | 0.087 | 0.4285 | No |
| 71 | PARP14 | NA | PARP14 Entrez, Source | poly (ADP-ribose) polymerase family, member 14 | 8527 | 0.077 | 0.4243 | No |
| 72 | NMI | NA | NMI Entrez, Source | N-myc (and STAT) interactor | 8754 | 0.044 | 0.4119 | No |
| 73 | OGFR | NA | OGFR Entrez, Source | opioid growth factor receptor | 9452 | -0.007 | 0.3730 | No |
| 74 | TRIM14 | NA | TRIM14 Entrez, Source | tripartite motif-containing 14 | 9682 | -0.041 | 0.3604 | No |
| 75 | UBA7 | NA | 9692 | -0.042 | 0.3602 | No | ||
| 76 | ADAR | NA | ADAR Entrez, Source | adenosine deaminase, RNA-specific | 10155 | -0.083 | 0.3349 | No |
| 77 | PROCR | NA | PROCR Entrez, Source | protein C receptor, endothelial (EPCR) | 10414 | -0.112 | 0.3212 | No |
| 78 | B2M | NA | B2M Entrez, Source | beta-2-microglobulin | 11181 | -0.224 | 0.2799 | No |
| 79 | PSMB9 | NA | PSMB9 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) | 12068 | -0.349 | 0.2326 | No |
| 80 | RIPK2 | NA | RIPK2 Entrez, Source | receptor-interacting serine-threonine kinase 2 | 12241 | -0.374 | 0.2254 | No |
| 81 | SLC25A28 | NA | SLC25A28 Entrez, Source | solute carrier family 25, member 28 | 12452 | -0.410 | 0.2164 | No |
| 82 | IL15 | NA | IL15 Entrez, Source | interleukin 15 | 12600 | -0.416 | 0.2109 | No |
| 83 | IRF2 | NA | IRF2 Entrez, Source | interferon regulatory factor 2 | 12738 | -0.441 | 0.2062 | No |
| 84 | IL4R | NA | IL4R Entrez, Source | interleukin 4 receptor | 13336 | -0.508 | 0.1761 | No |
| 85 | PARP9 | NA | PARP9 Entrez, Source | poly (ADP-ribose) polymerase family, member 9 | 13586 | -0.555 | 0.1658 | No |
| 86 | PSMB8 | NA | PSMB8 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | 14537 | -0.763 | 0.1177 | No |
| 87 | PLSCR1 | NA | PLSCR1 Entrez, Source | phospholipid scramblase 1 | 15338 | -0.951 | 0.0792 | No |
| 88 | PNPT1 | NA | PNPT1 Entrez, Source | polyribonucleotide nucleotidyltransferase 1 | 15478 | -0.992 | 0.0780 | No |
| 89 | IFI27 | NA | IFI27 Entrez, Source | interferon, alpha-inducible protein 27 | 15560 | -1.015 | 0.0801 | No |
| 90 | ELF1 | NA | ELF1 Entrez, Source | E74-like factor 1 (ets domain transcription factor) | 15757 | -1.081 | 0.0763 | No |
| 91 | LY6E | NA | LY6E Entrez, Source | lymphocyte antigen 6 complex, locus E | 16427 | -1.376 | 0.0479 | No |
| 92 | BATF2 | NA | BATF2 Entrez, Source | basic leucine zipper transcription factor, ATF-like 2 | 16653 | -1.502 | 0.0452 | No |
| 93 | IFITM3 | NA | IFITM3 Entrez, Source | interferon induced transmembrane protein 3 (1-8U) | 16936 | -1.709 | 0.0407 | No |
| 94 | IFITM2 | NA | IFITM2 Entrez, Source | interferon induced transmembrane protein 2 (1-8D) | 17569 | -2.628 | 0.0226 | No |
