Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | HALLMARK_IL6_JAK_STAT3_SIGNALING |
| Enrichment Score (ES) | 0.50055385 |
| Normalized Enrichment Score (NES) | 1.7687607 |
| Nominal p-value | 0.0 |
| FDR q-value | 4.9589295E-4 |
| FWER p-Value | 0.003 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | TLR2 | NA | TLR2 Entrez, Source | toll-like receptor 2 | 71 | 4.610 | 0.0414 | Yes |
| 2 | CSF1 | NA | CSF1 Entrez, Source | colony stimulating factor 1 (macrophage) | 109 | 4.487 | 0.0836 | Yes |
| 3 | IL1R1 | NA | IL1R1 Entrez, Source | interleukin 1 receptor, type I | 124 | 4.410 | 0.1262 | Yes |
| 4 | CSF2RA | NA | CSF2RA Entrez, Source | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | 133 | 4.359 | 0.1687 | Yes |
| 5 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 148 | 4.301 | 0.2103 | Yes |
| 6 | TNFRSF1B | NA | TNFRSF1B Entrez, Source | tumor necrosis factor receptor superfamily, member 1B | 342 | 3.628 | 0.2352 | Yes |
| 7 | CRLF2 | NA | CRLF2 Entrez, Source | cytokine receptor-like factor 2 | 367 | 3.530 | 0.2687 | Yes |
| 8 | CD38 | NA | CD38 Entrez, Source | CD38 molecule | 533 | 3.109 | 0.2901 | Yes |
| 9 | TNFRSF21 | NA | TNFRSF21 Entrez, Source | tumor necrosis factor receptor superfamily, member 21 | 539 | 3.100 | 0.3203 | Yes |
| 10 | CD14 | NA | CD14 Entrez, Source | CD14 molecule | 571 | 2.998 | 0.3481 | Yes |
| 11 | HMOX1 | NA | HMOX1 Entrez, Source | heme oxygenase (decycling) 1 | 614 | 2.923 | 0.3746 | Yes |
| 12 | CXCL11 | NA | CXCL11 Entrez, Source | chemokine (C-X-C motif) ligand 11 | 1180 | 2.056 | 0.3632 | Yes |
| 13 | IL1R2 | NA | IL1R2 Entrez, Source | interleukin 1 receptor, type II | 1207 | 2.032 | 0.3818 | Yes |
| 14 | BAK1 | NA | BAK1 Entrez, Source | BCL2-antagonist/killer 1 | 1442 | 1.809 | 0.3865 | Yes |
| 15 | CXCL10 | NA | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 1672 | 1.634 | 0.3898 | Yes |
| 16 | FAS | NA | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 1716 | 1.589 | 0.4031 | Yes |
| 17 | CD9 | NA | CD9 Entrez, Source | CD9 molecule | 1847 | 1.500 | 0.4106 | Yes |
| 18 | TNFRSF1A | NA | TNFRSF1A Entrez, Source | tumor necrosis factor receptor superfamily, member 1A | 1923 | 1.460 | 0.4208 | Yes |
| 19 | IL6ST | NA | IL6ST Entrez, Source | interleukin 6 signal transducer (gp130, oncostatin M receptor) | 2163 | 1.326 | 0.4205 | Yes |
| 20 | PF4 | NA | PF4 Entrez, Source | platelet factor 4 (chemokine (C-X-C motif) ligand 4) | 2166 | 1.324 | 0.4334 | Yes |
| 21 | PIM1 | NA | PIM1 Entrez, Source | pim-1 oncogene | 2367 | 1.227 | 0.4343 | Yes |
| 22 | STAT2 | NA | STAT2 Entrez, Source | signal transducer and activator of transcription 2, 113kDa | 2412 | 1.211 | 0.4438 | Yes |
| 23 | IRF1 | NA | IRF1 Entrez, Source | interferon regulatory factor 1 | 2439 | 1.197 | 0.4541 | Yes |
| 24 | CBL | NA | CBL Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 2658 | 1.111 | 0.4529 | Yes |
| 25 | CSF2 | NA | CSF2 Entrez, Source | colony stimulating factor 2 (granulocyte-macrophage) | 2709 | 1.095 | 0.4608 | Yes |
| 26 | STAM2 | NA | STAM2 Entrez, Source | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 | 2875 | 1.038 | 0.4619 | Yes |
| 27 | IL7 | NA | IL7 Entrez, Source | interleukin 7 | 3059 | 0.973 | 0.4612 | Yes |
| 28 | SOCS1 | NA | SOCS1 Entrez, Source | suppressor of cytokine signaling 1 | 3087 | 0.966 | 0.4692 | Yes |
| 29 | LTBR | NA | LTBR Entrez, Source | lymphotoxin beta receptor (TNFR superfamily, member 3) | 3145 | 0.950 | 0.4754 | Yes |
| 30 | OSMR | NA | OSMR Entrez, Source | oncostatin M receptor | 3192 | 0.941 | 0.4821 | Yes |
| 31 | IRF9 | NA | 3233 | 0.932 | 0.4890 | Yes | ||
| 32 | MAP3K8 | NA | MAP3K8 Entrez, Source | mitogen-activated protein kinase kinase kinase 8 | 3360 | 0.893 | 0.4908 | Yes |
| 33 | TNFRSF12A | NA | TNFRSF12A Entrez, Source | tumor necrosis factor receptor superfamily, member 12A | 3468 | 0.868 | 0.4933 | Yes |
| 34 | LEPR | NA | LEPR Entrez, Source | leptin receptor | 3494 | 0.858 | 0.5004 | Yes |
| 35 | STAT1 | NA | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 3769 | 0.817 | 0.4931 | Yes |
| 36 | IL12RB1 | NA | IL12RB1 Entrez, Source | interleukin 12 receptor, beta 1 | 3840 | 0.801 | 0.4971 | Yes |
| 37 | IL15RA | NA | IL15RA Entrez, Source | interleukin 15 receptor, alpha | 3917 | 0.782 | 0.5006 | Yes |
| 38 | IFNAR1 | NA | IFNAR1 Entrez, Source | interferon (alpha, beta and omega) receptor 1 | 4251 | 0.711 | 0.4889 | No |
| 39 | IL10RB | NA | IL10RB Entrez, Source | interleukin 10 receptor, beta | 4319 | 0.697 | 0.4921 | No |
| 40 | IL3RA | NA | IL3RA Entrez, Source | interleukin 3 receptor, alpha (low affinity) | 4543 | 0.647 | 0.4860 | No |
| 41 | CCR1 | NA | CCR1 Entrez, Source | chemokine (C-C motif) receptor 1 | 5287 | 0.503 | 0.4494 | No |
| 42 | IL18R1 | NA | IL18R1 Entrez, Source | interleukin 18 receptor 1 | 5570 | 0.465 | 0.4382 | No |
| 43 | IFNGR1 | NA | IFNGR1 Entrez, Source | interferon gamma receptor 1 | 6371 | 0.386 | 0.3973 | No |
| 44 | SOCS3 | NA | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 6447 | 0.374 | 0.3968 | No |
| 45 | PTPN2 | NA | PTPN2 Entrez, Source | protein tyrosine phosphatase, non-receptor type 2 | 7092 | 0.275 | 0.3635 | No |
| 46 | JUN | NA | JUN Entrez, Source | jun oncogene | 7197 | 0.258 | 0.3602 | No |
| 47 | CXCL13 | NA | CXCL13 Entrez, Source | chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant) | 7301 | 0.241 | 0.3568 | No |
| 48 | PLA2G2A | NA | PLA2G2A Entrez, Source | phospholipase A2, group IIA (platelets, synovial fluid) | 7620 | 0.196 | 0.3410 | No |
| 49 | ITGA4 | NA | ITGA4 Entrez, Source | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | 7633 | 0.196 | 0.3422 | No |
| 50 | HAX1 | NA | HAX1 Entrez, Source | HCLS1 associated protein X-1 | 8415 | 0.091 | 0.2995 | No |
| 51 | TGFB1 | NA | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 8450 | 0.087 | 0.2984 | No |
| 52 | CSF2RB | NA | CSF2RB Entrez, Source | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 8456 | 0.086 | 0.2990 | No |
| 53 | IL2RA | NA | IL2RA Entrez, Source | interleukin 2 receptor, alpha | 8687 | 0.055 | 0.2867 | No |
| 54 | REG1A | NA | REG1A Entrez, Source | regenerating islet-derived 1 alpha (pancreatic stone protein, pancreatic thread protein) | 9113 | 0.009 | 0.2630 | No |
| 55 | CNTFR | NA | CNTFR Entrez, Source | ciliary neurotrophic factor receptor | 9339 | 0.000 | 0.2504 | No |
| 56 | CCL7 | NA | CCL7 Entrez, Source | chemokine (C-C motif) ligand 7 | 9392 | 0.000 | 0.2475 | No |
| 57 | CD36 | NA | CD36 Entrez, Source | CD36 molecule (thrombospondin receptor) | 9407 | -0.000 | 0.2467 | No |
| 58 | IFNGR2 | NA | IFNGR2 Entrez, Source | interferon gamma receptor 2 (interferon gamma transducer 1) | 9453 | -0.007 | 0.2443 | No |
| 59 | CXCL3 | NA | CXCL3 Entrez, Source | chemokine (C-X-C motif) ligand 3 | 9722 | -0.045 | 0.2298 | No |
| 60 | STAT3 | NA | STAT3 Entrez, Source | signal transducer and activator of transcription 3 (acute-phase response factor) | 9852 | -0.058 | 0.2231 | No |
| 61 | TNF | NA | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 9956 | -0.066 | 0.2180 | No |
| 62 | CXCL9 | NA | CXCL9 Entrez, Source | chemokine (C-X-C motif) ligand 9 | 10000 | -0.070 | 0.2163 | No |
| 63 | ACVR1B | NA | ACVR1B Entrez, Source | activin A receptor, type IB | 10124 | -0.079 | 0.2102 | No |
| 64 | CD44 | NA | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 10782 | -0.166 | 0.1751 | No |
| 65 | PTPN1 | NA | PTPN1 Entrez, Source | protein tyrosine phosphatase, non-receptor type 1 | 11121 | -0.215 | 0.1583 | No |
| 66 | PIK3R5 | NA | PIK3R5 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 5, p101 | 11218 | -0.228 | 0.1552 | No |
| 67 | DNTT | NA | DNTT Entrez, Source | deoxynucleotidyltransferase, terminal | 11643 | -0.288 | 0.1344 | No |
| 68 | GRB2 | NA | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 12041 | -0.344 | 0.1156 | No |
| 69 | CSF3R | NA | CSF3R Entrez, Source | colony stimulating factor 3 receptor (granulocyte) | 12554 | -0.411 | 0.0910 | No |
| 70 | ACVRL1 | NA | ACVRL1 Entrez, Source | activin A receptor type II-like 1 | 12745 | -0.444 | 0.0847 | No |
| 71 | PTPN11 | NA | PTPN11 Entrez, Source | protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | 13042 | -0.462 | 0.0727 | No |
| 72 | IL4R | NA | IL4R Entrez, Source | interleukin 4 receptor | 13336 | -0.508 | 0.0614 | No |
| 73 | INHBE | NA | INHBE Entrez, Source | inhibin, beta E | 13359 | -0.511 | 0.0652 | No |
| 74 | IL17RB | NA | IL17RB Entrez, Source | interleukin 17 receptor B | 13441 | -0.526 | 0.0658 | No |
| 75 | ITGB3 | NA | ITGB3 Entrez, Source | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 13638 | -0.565 | 0.0604 | No |
| 76 | MYD88 | NA | MYD88 Entrez, Source | myeloid differentiation primary response gene (88) | 13793 | -0.593 | 0.0577 | No |
| 77 | TYK2 | NA | TYK2 Entrez, Source | tyrosine kinase 2 | 14116 | -0.662 | 0.0462 | No |
| 78 | IL13RA1 | NA | IL13RA1 Entrez, Source | interleukin 13 receptor, alpha 1 | 15282 | -0.936 | -0.0097 | No |
| 79 | A2M | NA | A2M Entrez, Source | alpha-2-macroglobulin | 15303 | -0.943 | -0.0016 | No |
| 80 | IL2RG | NA | IL2RG Entrez, Source | interleukin 2 receptor, gamma (severe combined immunodeficiency) | 16106 | -1.217 | -0.0344 | No |
| 81 | PDGFC | NA | PDGFC Entrez, Source | platelet derived growth factor C | 16116 | -1.222 | -0.0229 | No |
| 82 | IL17RA | NA | IL17RA Entrez, Source | interleukin 17 receptor A | 16159 | -1.242 | -0.0130 | No |
| 83 | LTB | NA | LTB Entrez, Source | lymphotoxin beta (TNF superfamily, member 3) | 16661 | -1.507 | -0.0262 | No |
| 84 | CXCL1 | NA | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 16731 | -1.552 | -0.0147 | No |
| 85 | IL9R | NA | IL9R Entrez, Source | interleukin 9 receptor | 17185 | -1.986 | -0.0205 | No |
| 86 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 17373 | -2.282 | -0.0085 | No |
| 87 | EBI3 | NA | EBI3 Entrez, Source | Epstein-Barr virus induced gene 3 | 17898 | -4.265 | 0.0042 | No |
