Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1w6a
GeneSetHALLMARK_HYPOXIA
Enrichment Score (ES)0.39365387
Normalized Enrichment Score (NES)1.5339555
Nominal p-value0.002610966
FDR q-value0.011814468
FWER p-Value0.153
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_HYPOXIA   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1S100A4NAS100A4
Entrez,  Source
S100 calcium binding protein A4794.5770.0135Yes
2CXCR4NACXCR4
Entrez,  Source
chemokine (C-X-C motif) receptor 4904.5460.0308Yes
3IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)1484.3010.0445Yes
4WISP2NAWISP2
Entrez,  Source
WNT1 inducible signaling pathway protein 21494.2990.0614Yes
5LOXNALOX
Entrez,  Source
lysyl oxidase4543.3120.0573Yes
6ANGPTL4NAANGPTL4
Entrez,  Source
angiopoietin-like 44753.2720.0690Yes
7GLRXNAGLRX
Entrez,  Source
glutaredoxin (thioltransferase)5153.1470.0792Yes
8KLHL24NAKLHL24
Entrez,  Source
kelch-like 24 (Drosophila)5513.0640.0892Yes
9B4GALNT2NAB4GALNT2
Entrez,  Source
beta-1,4-N-acetyl-galactosaminyl transferase 25543.0600.1011Yes
10PPARGC1ANAPPARGC1A
Entrez,  Source
peroxisome proliferative activated receptor, gamma, coactivator 1, alpha5663.0280.1124Yes
11HS3ST1NAHS3ST1
Entrez,  Source
heparan sulfate (glucosamine) 3-O-sulfotransferase 15822.9780.1233Yes
12SELENBP1NASELENBP1
Entrez,  Source
selenium binding protein 15912.9610.1344Yes
13HMOX1NAHMOX1
Entrez,  Source
heme oxygenase (decycling) 16142.9230.1447Yes
14SERPINE1NASERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 16202.9100.1558Yes
15IER3NAIER3
Entrez,  Source
immediate early response 36222.9080.1672Yes
16DDIT3NADDIT3
Entrez,  Source
DNA-damage-inducible transcript 36772.7670.1750Yes
17DTNANADTNA
Entrez,  Source
dystrobrevin, alpha6912.7380.1850Yes
18ERRFI1NAERRFI1
Entrez,  Source
ERBB receptor feedback inhibitor 17942.5630.1894Yes
19VLDLRNAVLDLR
Entrez,  Source
very low density lipoprotein receptor7982.5500.1992Yes
20MT2ANAMT2A
Entrez,  Source
metallothionein 2A8362.4920.2069Yes
21DDIT4NADDIT4
Entrez,  Source
DNA-damage-inducible transcript 48442.4810.2163Yes
22GPC1NAGPC1
Entrez,  Source
glypican 18462.4790.2259Yes
23F3NAF3
Entrez,  Source
coagulation factor III (thromboplastin, tissue factor)8762.4380.2339Yes
24CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)8882.4130.2427Yes
25PLIN2NA9262.3900.2500Yes
26IGFBP1NAIGFBP1
Entrez,  Source
insulin-like growth factor binding protein 19292.3880.2593Yes
27STC2NASTC2
Entrez,  Source
stanniocalcin 210652.2070.2604Yes
28FOSL2NAFOSL2
Entrez,  Source
FOS-like antigen 211332.1310.2650Yes
29GPC4NAGPC4
Entrez,  Source
glypican 411422.1230.2729Yes
30STBD1NA11472.1100.2809Yes
31CHST3NACHST3
Entrez,  Source
carbohydrate (chondroitin 6) sulfotransferase 312182.0250.2849Yes
32CSRP2NACSRP2
Entrez,  Source
cysteine and glycine-rich protein 212312.0080.2922Yes
33BNIP3LNABNIP3L
Entrez,  Source
BCL2/adenovirus E1B 19kDa interacting protein 3-like12411.9940.2995Yes
34PLAC8NAPLAC8
Entrez,  Source
placenta-specific 812521.9850.3067Yes
35PHKG1NAPHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)12561.9830.3143Yes
36TGFB3NATGFB3
Entrez,  Source
transforming growth factor, beta 313451.8870.3168Yes
37CA12NACA12
Entrez,  Source
carbonic anhydrase XII13651.8730.3231Yes
38EDN2NAEDN2
Entrez,  Source
endothelin 213931.8510.3288Yes
39P4HA2NAP4HA2
Entrez,  Source
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II14301.8190.3339Yes
40VEGFANA15011.7650.3369Yes
41ENO1NAENO1
Entrez,  Source
enolase 1, (alpha)15061.7600.3436Yes
42PRKCANAPRKCA
Entrez,  Source
protein kinase C, alpha15941.6910.3454Yes
43GCNT2NAGCNT2
Entrez,  Source
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)16051.6830.3514Yes
44ADORA2BNAADORA2B
Entrez,  Source
adenosine A2b receptor16851.6150.3533Yes
45TPBGNATPBG
Entrez,  Source
trophoblast glycoprotein17231.5840.3575Yes
46IDSNAIDS
Entrez,  Source
iduronate 2-sulfatase (Hunter syndrome)17811.5380.3603Yes
47MT1ENAMT1E
Entrez,  Source
metallothionein 1E (functional)18421.5050.3628Yes
48CCNG2NACCNG2
Entrez,  Source
cyclin G219551.4420.3622Yes
49CASP6NACASP6
Entrez,  Source
caspase 6, apoptosis-related cysteine peptidase19961.4220.3655Yes
50NR3C1NANR3C1
Entrez,  Source
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)20171.4110.3699Yes
51SLC2A3NASLC2A3
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 320361.4020.3744Yes
52ALDOBNAALDOB
Entrez,  Source
aldolase B, fructose-bisphosphate20811.3740.3774Yes
53SLC6A6NASLC6A6
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, taurine), member 621611.3270.3781Yes
54PIM1NAPIM1
Entrez,  Source
pim-1 oncogene23671.2270.3714Yes
55DUSP1NADUSP1
Entrez,  Source
dual specificity phosphatase 124091.2110.3739Yes
56TESNATES
Entrez,  Source
testis derived transcript (3 LIM domains)24951.1820.3737Yes
57COL5A1NACOL5A1
Entrez,  Source
collagen, type V, alpha 125111.1740.3775Yes
58TMEM45ANATMEM45A
Entrez,  Source
transmembrane protein 45A25181.1720.3818Yes
59HSPA5NAHSPA5
Entrez,  Source
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)25431.1610.3850Yes
60CITED2NACITED2
Entrez,  Source
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 226091.1320.3858Yes
61ATP7ANAATP7A
Entrez,  Source
ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome)26271.1220.3892Yes
62CYR61NACYR61
Entrez,  Source
cysteine-rich, angiogenic inducer, 6126821.1030.3905Yes
63SDC2NASDC2
Entrez,  Source
syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan)28151.0550.3872Yes
64NDST2NANDST2
Entrez,  Source
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 228301.0500.3906Yes
65CPNACP
Entrez,  Source
ceruloplasmin (ferroxidase)28491.0440.3937Yes
66CDKN1BNACDKN1B
Entrez,  Source
cyclin-dependent kinase inhibitor 1B (p27, Kip1)29421.0080.3924No
67PGFNAPGF
Entrez,  Source
placental growth factor, vascular endothelial growth factor-related protein31320.9530.3856No
68PAMNAPAM
Entrez,  Source
peptidylglycine alpha-amidating monooxygenase31340.9520.3892No
69NFIL3NANFIL3
Entrez,  Source
nuclear factor, interleukin 3 regulated32070.9390.3889No
70HDLBPNAHDLBP
Entrez,  Source
high density lipoprotein binding protein (vigilin)32900.9150.3879No
71BCL2NABCL2
Entrez,  Source
B-cell CLL/lymphoma 234090.8800.3847No
72TPST2NATPST2
Entrez,  Source
tyrosylprotein sulfotransferase 235180.8500.3819No
73GCKNAGCK
Entrez,  Source
glucokinase (hexokinase 4, maturity onset diabetes of the young 2)35920.8430.3811No
74HAS1NAHAS1
Entrez,  Source
hyaluronan synthase 136150.8400.3832No
75ZFP36NAZFP36
Entrez,  Source
zinc finger protein 36, C3H type, homolog (mouse)37740.8160.3775No
76STC1NASTC1
Entrez,  Source
stanniocalcin 137950.8110.3796No
77IGFBP3NAIGFBP3
Entrez,  Source
insulin-like growth factor binding protein 338530.7990.3795No
78RBPJNA39000.7850.3800No
79NDST1NANDST1
Entrez,  Source
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 139080.7840.3827No
80CHST2NACHST2
Entrez,  Source
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 239200.7800.3851No
81EGFRNAEGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)42600.7100.3689No
82NDRG1NANDRG1
Entrez,  Source
N-myc downstream regulated gene 143310.6940.3677No
83PKP1NAPKP1
Entrez,  Source
plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)44890.6590.3614No
84ISG20NAISG20
Entrez,  Source
interferon stimulated exonuclease gene 20kDa48780.5810.3419No
85B3GALT6NAB3GALT6
Entrez,  Source
UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 649240.5730.3416No
86FBP1NAFBP1
Entrez,  Source
fructose-1,6-bisphosphatase 149370.5710.3432No
87TIPARPNATIPARP
Entrez,  Source
TCDD-inducible poly(ADP-ribose) polymerase50660.5430.3381No
88GPC3NAGPC3
Entrez,  Source
glypican 352610.5080.3292No
89ADMNAADM
Entrez,  Source
adrenomedullin52920.5020.3295No
90PCK1NAPCK1
Entrez,  Source
phosphoenolpyruvate carboxykinase 1 (soluble)55350.4720.3177No
91PPP1R15ANAPPP1R15A
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 15A56660.4500.3122No
92KIF5ANAKIF5A
Entrez,  Source
kinesin family member 5A59310.4240.2990No
93LXNNALXN
Entrez,  Source
latexin59420.4220.3001No
94PFKPNAPFKP
Entrez,  Source
phosphofructokinase, platelet59440.4220.3017No
95DPYSL4NADPYSL4
Entrez,  Source
dihydropyrimidinase-like 464680.3710.2737No
96SAP30NASAP30
Entrez,  Source
Sin3A-associated protein, 30kDa65930.3510.2681No
97SULT2B1NASULT2B1
Entrez,  Source
sulfotransferase family, cytosolic, 2B, member 171410.2670.2384No
98JUNNAJUN
Entrez,  Source
jun oncogene71970.2580.2363No
99FOSNAFOS
Entrez,  Source
v-fos FBJ murine osteosarcoma viral oncogene homolog72650.2470.2336No
100IRS2NAIRS2
Entrez,  Source
insulin receptor substrate 274150.2230.2261No
101GAPDHNAGAPDH
Entrez,  Source
glyceraldehyde-3-phosphate dehydrogenase74900.2120.2227No
102PLAURNAPLAUR
Entrez,  Source
plasminogen activator, urokinase receptor76760.1880.2131No
103KLF6NAKLF6
Entrez,  Source
Kruppel-like factor 676950.1850.2128No
104SIAH2NASIAH2
Entrez,  Source
seven in absentia homolog 2 (Drosophila)78050.1700.2073No
105INHANAINHA
Entrez,  Source
inhibin, alpha79310.1530.2009No
106ENO2NAENO2
Entrez,  Source
enolase 2 (gamma, neuronal)80630.1370.1941No
107SLC2A5NASLC2A5
Entrez,  Source
solute carrier family 2 (facilitated glucose/fructose transporter), member 580930.1340.1929No
108PKLRNAPKLR
Entrez,  Source
pyruvate kinase, liver and RBC80960.1330.1934No
109SLC2A1NASLC2A1
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 182140.1180.1872No
110TPD52NATPD52
Entrez,  Source
tumor protein D5283270.1040.1814No
111JMJD6NA83860.0960.1785No
112CAV1NACAV1
Entrez,  Source
caveolin 1, caveolae protein, 22kDa84340.0890.1762No
113SDC3NASDC3
Entrez,  Source
syndecan 3 (N-syndecan)86380.0610.1650No
114GPINAGPI
Entrez,  Source
glucose phosphate isomerase86850.0560.1626No
115GBE1NAGBE1
Entrez,  Source
glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen disease, glycogen storage disease type IV)88760.0330.1521No
116PFKFB3NAPFKFB3
Entrez,  Source
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 389010.0280.1508No
117PGM1NAPGM1
Entrez,  Source
phosphoglucomutase 189230.0250.1497No
118HK1NAHK1
Entrez,  Source
hexokinase 19476-0.0100.1188No
119TKTL1NATKTL1
Entrez,  Source
transketolase-like 19729-0.0460.1048No
120PPP1R3CNAPPP1R3C
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 3C9768-0.0480.1028No
121MAP3K1NAMAP3K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase 110539-0.1300.0600No
122WSB1NAWSB1
Entrez,  Source
WD repeat and SOCS box-containing 110887-0.1820.0412No
123BTG1NABTG1
Entrez,  Source
B-cell translocation gene 1, anti-proliferative10899-0.1840.0413No
124LDHCNALDHC
Entrez,  Source
lactate dehydrogenase C10954-0.1910.0390No
125CTGFNACTGF
Entrez,  Source
connective tissue growth factor10993-0.1960.0377No
126NAGKNANAGK
Entrez,  Source
N-acetylglucosamine kinase11295-0.2390.0217No
127KDELR3NAKDELR3
Entrez,  Source
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 311685-0.2930.0010No
128SDC4NASDC4
Entrez,  Source
syndecan 4 (amphiglycan, ryudocan)11969-0.335-0.0136No
129PGM2NAPGM2
Entrez,  Source
phosphoglucomutase 212027-0.341-0.0155No
130GRHPRNAGRHPR
Entrez,  Source
glyoxylate reductase/hydroxypyruvate reductase12143-0.361-0.0206No
131SCARB1NASCARB1
Entrez,  Source
scavenger receptor class B, member 112172-0.365-0.0207No
132EFNA1NAEFNA1
Entrez,  Source
ephrin-A112204-0.369-0.0210No
133ALDOANAALDOA
Entrez,  Source
aldolase A, fructose-bisphosphate12225-0.371-0.0207No
134DCNNADCN
Entrez,  Source
decorin12465-0.411-0.0325No
135CDKN1CNACDKN1C
Entrez,  Source
cyclin-dependent kinase inhibitor 1C (p57, Kip2)12628-0.419-0.0399No
136MAFFNAMAFF
Entrez,  Source
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)13007-0.456-0.0594No
137TPI1NATPI1
Entrez,  Source
triosephosphate isomerase 113027-0.459-0.0587No
138PDK1NAPDK1
Entrez,  Source
pyruvate dehydrogenase kinase, isozyme 113039-0.461-0.0575No
139PFKLNAPFKL
Entrez,  Source
phosphofructokinase, liver13103-0.473-0.0592No
140ILVBLNAILVBL
Entrez,  Source
ilvB (bacterial acetolactate synthase)-like13236-0.494-0.0646No
141RRAGDNARRAGD
Entrez,  Source
Ras-related GTP binding D13254-0.497-0.0636No
142NCANNA13295-0.502-0.0639No
143EXT1NAEXT1
Entrez,  Source
exostoses (multiple) 113367-0.513-0.0659No
144MYH9NAMYH9
Entrez,  Source
myosin, heavy chain 9, non-muscle13628-0.563-0.0783No
145MXI1NAMXI1
Entrez,  Source
MAX interactor 113879-0.610-0.0900No
146PNRC1NAPNRC1
Entrez,  Source
proline-rich nuclear receptor coactivator 114009-0.637-0.0947No
147P4HA1NAP4HA1
Entrez,  Source
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I14118-0.662-0.0982No
148BGNNABGN
Entrez,  Source
biglycan14175-0.677-0.0987No
149NEDD4LNANEDD4L
Entrez,  Source
neural precursor cell expressed, developmentally down-regulated 4-like14279-0.696-0.1017No
150LDHANALDHA
Entrez,  Source
lactate dehydrogenase A14365-0.717-0.1037No
151GYS1NAGYS1
Entrez,  Source
glycogen synthase 1 (muscle)14389-0.721-0.1022No
152VHLNAVHL
Entrez,  Source
von Hippel-Lindau tumor suppressor14469-0.747-0.1037No
153PRDX5NAPRDX5
Entrez,  Source
peroxiredoxin 514735-0.810-0.1154No
154LALBANALALBA
Entrez,  Source
lactalbumin, alpha-14872-0.839-0.1198No
155FOXO3NA15226-0.922-0.1360No
156MIFNAMIF
Entrez,  Source
macrophage migration inhibitory factor (glycosylation-inhibiting factor)15271-0.933-0.1348No
157PGAM2NAPGAM2
Entrez,  Source
phosphoglycerate mutase 2 (muscle)15317-0.945-0.1336No
158ANKZF1NAANKZF1
Entrez,  Source
ankyrin repeat and zinc finger domain containing 115462-0.987-0.1378No
159KDM3ANA15906-1.138-0.1583No
160FAM162ANA16037-1.190-0.1609No
161GALK1NAGALK1
Entrez,  Source
galactokinase 116127-1.226-0.1611No
162SLC37A4NASLC37A4
Entrez,  Source
solute carrier family 37 (glycerol-6-phosphate transporter), member 416367-1.344-0.1693No
163XPNPEP1NAXPNPEP1
Entrez,  Source
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble16394-1.360-0.1654No
164ETS1NAETS1
Entrez,  Source
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)16397-1.363-0.1601No
165TNFAIP3NATNFAIP3
Entrez,  Source
tumor necrosis factor, alpha-induced protein 316490-1.410-0.1598No
166SLC25A1NASLC25A1
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 116517-1.424-0.1556No
167PGK1NAPGK1
Entrez,  Source
phosphoglycerate kinase 116681-1.519-0.1588No
168ANXA2NAANXA2
Entrez,  Source
annexin A216698-1.528-0.1537No
169PYGMNAPYGM
Entrez,  Source
phosphorylase, glycogen; muscle (McArdle syndrome, glycogen storage disease type V)16800-1.602-0.1531No
170AK4NA16899-1.681-0.1520No
171UGP2NAUGP2
Entrez,  Source
UDP-glucose pyrophosphorylase 216946-1.721-0.1479No
172ZNF292NAZNF292
Entrez,  Source
zinc finger protein 29216967-1.739-0.1422No
173PDK3NAPDK3
Entrez,  Source
pyruvate dehydrogenase kinase, isozyme 317013-1.782-0.1377No
174GAANAGAA
Entrez,  Source
glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II)17021-1.788-0.1311No
175HOXB9NAHOXB9
Entrez,  Source
homeobox B917058-1.823-0.1259No
176KLF7NAKLF7
Entrez,  Source
Kruppel-like factor 7 (ubiquitous)17201-2.008-0.1260No
177HK2NAHK2
Entrez,  Source
hexokinase 217222-2.037-0.1192No
178TGM2NATGM2
Entrez,  Source
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)17349-2.244-0.1174No
179ENO3NAENO3
Entrez,  Source
enolase 3 (beta, muscle)17352-2.246-0.1087No
180SRPXNASRPX
Entrez,  Source
sushi-repeat-containing protein, X-linked17364-2.263-0.1005No
181GAPDHSNAGAPDHS
Entrez,  Source
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic17386-2.305-0.0926No
182HEXANAHEXA
Entrez,  Source
hexosaminidase A (alpha polypeptide)17427-2.374-0.0855No
183BHLHE40NA17439-2.394-0.0767No
184AKAP12NAAKAP12
Entrez,  Source
A kinase (PRKA) anchor protein (gravin) 1217571-2.633-0.0738No
185EFNA3NAEFNA3
Entrez,  Source
ephrin-A317599-2.743-0.0645No
186AMPD3NAAMPD3
Entrez,  Source
adenosine monophosphate deaminase (isoform E)17665-2.964-0.0565No
187PDGFBNAPDGFB
Entrez,  Source
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)17712-3.137-0.0468No
188BCANNABCAN
Entrez,  Source
brevican17778-3.489-0.0368No
189TGFBINATGFBI
Entrez,  Source
transforming growth factor, beta-induced, 68kDa17833-3.753-0.0251No
190RORANARORA
Entrez,  Source
RAR-related orphan receptor A17887-4.171-0.0117No
191ALDOCNAALDOC
Entrez,  Source
aldolase C, fructose-bisphosphate17891-4.2030.0047No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_HYPOXIA   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_HYPOXIA: Random ES distribution   
Gene set null distribution of ES for HALLMARK_HYPOXIA