Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | HALLMARK_HEDGEHOG_SIGNALING |
| Enrichment Score (ES) | 0.48517498 |
| Normalized Enrichment Score (NES) | 1.4358523 |
| Nominal p-value | 0.041009463 |
| FDR q-value | 0.03105586 |
| FWER p-Value | 0.429 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | ACHE | NA | ACHE Entrez, Source | acetylcholinesterase (Yt blood group) | 61 | 4.673 | 0.0897 | Yes |
| 2 | DPYSL2 | NA | DPYSL2 Entrez, Source | dihydropyrimidinase-like 2 | 365 | 3.537 | 0.1433 | Yes |
| 3 | RTN1 | NA | RTN1 Entrez, Source | reticulon 1 | 419 | 3.389 | 0.2079 | Yes |
| 4 | UNC5C | NA | UNC5C Entrez, Source | unc-5 homolog C (C. elegans) | 752 | 2.635 | 0.2420 | Yes |
| 5 | VLDLR | NA | VLDLR Entrez, Source | very low density lipoprotein receptor | 798 | 2.550 | 0.2903 | Yes |
| 6 | NRP2 | NA | NRP2 Entrez, Source | neuropilin 2 | 891 | 2.409 | 0.3332 | Yes |
| 7 | VEGFA | NA | 1501 | 1.765 | 0.3344 | Yes | ||
| 8 | NRCAM | NA | NRCAM Entrez, Source | neuronal cell adhesion molecule | 1585 | 1.699 | 0.3636 | Yes |
| 9 | PLG | NA | PLG Entrez, Source | plasminogen | 1857 | 1.494 | 0.3783 | Yes |
| 10 | CELSR1 | NA | CELSR1 Entrez, Source | cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila) | 1957 | 1.440 | 0.4015 | Yes |
| 11 | NRP1 | NA | NRP1 Entrez, Source | neuropilin 1 | 2191 | 1.309 | 0.4146 | Yes |
| 12 | SCG2 | NA | SCG2 Entrez, Source | secretogranin II (chromogranin C) | 2249 | 1.280 | 0.4369 | Yes |
| 13 | CDK5R1 | NA | CDK5R1 Entrez, Source | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | 2285 | 1.262 | 0.4602 | Yes |
| 14 | OPHN1 | NA | OPHN1 Entrez, Source | oligophrenin 1 | 2431 | 1.199 | 0.4760 | Yes |
| 15 | SLIT1 | NA | SLIT1 Entrez, Source | slit homolog 1 (Drosophila) | 2839 | 1.047 | 0.4742 | Yes |
| 16 | HEY2 | NA | HEY2 Entrez, Source | hairy/enhancer-of-split related with YRPW motif 2 | 2997 | 0.992 | 0.4852 | Yes |
| 17 | NF1 | NA | NF1 Entrez, Source | neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) | 3477 | 0.864 | 0.4757 | No |
| 18 | RASA1 | NA | RASA1 Entrez, Source | RAS p21 protein activator (GTPase activating protein) 1 | 5001 | 0.558 | 0.4019 | No |
| 19 | SHH | NA | SHH Entrez, Source | sonic hedgehog homolog (Drosophila) | 8741 | 0.045 | 0.1944 | No |
| 20 | CNTFR | NA | CNTFR Entrez, Source | ciliary neurotrophic factor receptor | 9339 | 0.000 | 0.1611 | No |
| 21 | TLE1 | NA | TLE1 Entrez, Source | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | 10416 | -0.113 | 0.1034 | No |
| 22 | PML | NA | PML Entrez, Source | promyelocytic leukemia | 10783 | -0.166 | 0.0863 | No |
| 23 | CDK6 | NA | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 11618 | -0.286 | 0.0455 | No |
| 24 | THY1 | NA | THY1 Entrez, Source | Thy-1 cell surface antigen | 12981 | -0.453 | -0.0214 | No |
| 25 | MYH9 | NA | MYH9 Entrez, Source | myosin, heavy chain 9, non-muscle | 13628 | -0.563 | -0.0462 | No |
| 26 | PTCH1 | NA | PTCH1 Entrez, Source | patched homolog 1 (Drosophila) | 14377 | -0.719 | -0.0735 | No |
| 27 | HEY1 | NA | HEY1 Entrez, Source | hairy/enhancer-of-split related with YRPW motif 1 | 14406 | -0.727 | -0.0606 | No |
| 28 | TLE3 | NA | TLE3 Entrez, Source | transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) | 14812 | -0.829 | -0.0667 | No |
| 29 | LDB1 | NA | LDB1 Entrez, Source | LIM domain binding 1 | 14945 | -0.854 | -0.0570 | No |
| 30 | CRMP1 | NA | CRMP1 Entrez, Source | collapsin response mediator protein 1 | 15800 | -1.094 | -0.0828 | No |
| 31 | ETS2 | NA | ETS2 Entrez, Source | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) | 16498 | -1.412 | -0.0935 | No |
| 32 | NKX6-1 | NA | NKX6-1 Entrez, Source | NK6 transcription factor related, locus 1 (Drosophila) | 16741 | -1.559 | -0.0759 | No |
| 33 | GLI1 | NA | GLI1 Entrez, Source | glioma-associated oncogene homolog 1 (zinc finger protein) | 16789 | -1.593 | -0.0468 | No |
| 34 | L1CAM | NA | L1CAM Entrez, Source | L1 cell adhesion molecule | 17216 | -2.028 | -0.0301 | No |
| 35 | AMOT | NA | AMOT Entrez, Source | angiomotin | 17810 | -3.626 | 0.0091 | No |
