Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_G2M_CHECKPOINT
Enrichment Score (ES)-0.42492688
Normalized Enrichment Score (NES)-1.8492482
Nominal p-value0.0
FDR q-value0.0012802472
FWER p-Value0.004
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_G2M_CHECKPOINT   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1HIST1H2BKNAHIST1H2BK
Entrez,  Source
histone cluster 1, H2bk5183.140-0.0084No
2EGFNAEGF
Entrez,  Source
epidermal growth factor (beta-urogastrone)6642.7990.0020No
3MT2ANAMT2A
Entrez,  Source
metallothionein 2A8362.4920.0088No
4ODC1NAODC1
Entrez,  Source
ornithine decarboxylase 116761.629-0.0276No
5HMGA1NAHMGA1
Entrez,  Source
high mobility group AT-hook 118801.485-0.0292No
6SLC12A2NASLC12A2
Entrez,  Source
solute carrier family 12 (sodium/potassium/chloride transporters), member 219111.466-0.0212No
7EFNA5NAEFNA5
Entrez,  Source
ephrin-A521191.348-0.0239No
8WRNNAWRN
Entrez,  Source
Werner syndrome27281.088-0.0509No
9CDC25BNACDC25B
Entrez,  Source
cell division cycle 25B27811.067-0.0468No
10SLC7A5NASLC7A5
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 528371.048-0.0430No
11CDKN1BNACDKN1B
Entrez,  Source
cyclin-dependent kinase inhibitor 1B (p27, Kip1)29421.008-0.0421No
12NOTCH2NANOTCH2
Entrez,  Source
Notch homolog 2 (Drosophila)32240.934-0.0518No
13EZH2NAEZH2
Entrez,  Source
enhancer of zeste homolog 2 (Drosophila)32480.928-0.0469No
14DTYMKNADTYMK
Entrez,  Source
deoxythymidylate kinase (thymidylate kinase)36400.837-0.0634No
15TRA2BNA37010.830-0.0613No
16LIG3NALIG3
Entrez,  Source
ligase III, DNA, ATP-dependent37110.828-0.0563No
17BUB1NABUB1
Entrez,  Source
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)37810.813-0.0548No
18TOP2ANATOP2A
Entrez,  Source
topoisomerase (DNA) II alpha 170kDa41500.728-0.0707No
19CDC6NACDC6
Entrez,  Source
CDC6 cell division cycle 6 homolog (S. cerevisiae)43050.700-0.0747No
20E2F3NAE2F3
Entrez,  Source
E2F transcription factor 345630.644-0.0849No
21MAPK14NAMAPK14
Entrez,  Source
mitogen-activated protein kinase 1446640.626-0.0864No
22PRIM2NA47100.615-0.0849No
23PTTG1NAPTTG1
Entrez,  Source
pituitary tumor-transforming 148190.590-0.0871No
24HSPA8NAHSPA8
Entrez,  Source
heat shock 70kDa protein 848840.579-0.0868No
25CUL3NACUL3
Entrez,  Source
cullin 349330.571-0.0858No
26CCND1NACCND1
Entrez,  Source
cyclin D149460.569-0.0827No
27PURANAPURA
Entrez,  Source
purine-rich element binding protein A49780.562-0.0807No
28SMC1ANASMC1A
Entrez,  Source
structural maintenance of chromosomes 1A50050.557-0.0785No
29CCNT1NACCNT1
Entrez,  Source
cyclin T150060.556-0.0748No
30FOXN3NA50550.545-0.0739No
31ATF5NAATF5
Entrez,  Source
activating transcription factor 553810.490-0.0889No
32PRMT5NAPRMT5
Entrez,  Source
protein arginine methyltransferase 555490.468-0.0952No
33CUL1NACUL1
Entrez,  Source
cullin 157000.445-0.1007No
34RBM14NARBM14
Entrez,  Source
RNA binding motif protein 1457770.433-0.1021No
35BARD1NABARD1
Entrez,  Source
BRCA1 associated RING domain 160770.417-0.1162No
36UBE2SNAUBE2S
Entrez,  Source
ubiquitin-conjugating enzyme E2S63700.386-0.1301No
37RAD54LNARAD54L
Entrez,  Source
RAD54-like (S. cerevisiae)64820.370-0.1339No
38TACC3NATACC3
Entrez,  Source
transforming, acidic coiled-coil containing protein 365530.358-0.1354No
39SAP30NASAP30
Entrez,  Source
Sin3A-associated protein, 30kDa65930.351-0.1353No
40CUL5NACUL5
Entrez,  Source
cullin 568040.321-0.1450No
41PAFAH1B1NAPAFAH1B1
Entrez,  Source
platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa68450.315-0.1452No
42PBKNAPBK
Entrez,  Source
PDZ binding kinase69890.292-0.1513No
43ARID4ANAARID4A
Entrez,  Source
AT rich interactive domain 4A (RBP1-like)71740.262-0.1599No
44DBF4NADBF4
Entrez,  Source
DBF4 homolog (S. cerevisiae)72170.255-0.1606No
45H2AFVNAH2AFV
Entrez,  Source
H2A histone family, member V72970.242-0.1634No
46HMGN2NAHMGN2
Entrez,  Source
high-mobility group nucleosomal binding domain 274220.222-0.1689No
47HIF1ANAHIF1A
Entrez,  Source
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)81110.132-0.2067No
48DR1NADR1
Entrez,  Source
down-regulator of transcription 1, TBP-binding (negative cofactor 2)81920.121-0.2104No
49SUV39H1NASUV39H1
Entrez,  Source
suppressor of variegation 3-9 homolog 1 (Drosophila)84020.093-0.2216No
50TGFB1NATGFB1
Entrez,  Source
transforming growth factor, beta 1 (Camurati-Engelmann disease)84500.087-0.2236No
51YTHDC1NAYTHDC1
Entrez,  Source
YTH domain containing 188780.032-0.2474No
52HMGB3NAHMGB3
Entrez,  Source
high-mobility group box 390490.013-0.2569No
53H2AFZNAH2AFZ
Entrez,  Source
H2A histone family, member Z9425-0.003-0.2780No
54CDC27NACDC27
Entrez,  Source
cell division cycle 279473-0.010-0.2806No
55SLC38A1NASLC38A1
Entrez,  Source
solute carrier family 38, member 19497-0.014-0.2818No
56ORC5NA9523-0.019-0.2830No
57TROAPNATROAP
Entrez,  Source
trophinin associated protein (tastin)9571-0.026-0.2855No
58SRSF1NA9650-0.037-0.2897No
59CENPENACENPE
Entrez,  Source
centromere protein E, 312kDa9666-0.039-0.2902No
60H2AFXNAH2AFX
Entrez,  Source
H2A histone family, member X9779-0.049-0.2962No
61CDKN3NACDKN3
Entrez,  Source
cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)9823-0.055-0.2983No
62NCLNANCL
Entrez,  Source
nucleolin9838-0.057-0.2987No
63NEK2NANEK2
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 29964-0.067-0.3053No
64POLENAPOLE
Entrez,  Source
polymerase (DNA directed), epsilon10020-0.071-0.3079No
65KPNB1NAKPNB1
Entrez,  Source
karyopherin (importin) beta 110060-0.074-0.3096No
66BCL3NABCL3
Entrez,  Source
B-cell CLL/lymphoma 310071-0.076-0.3097No
67HNRNPDNA10146-0.082-0.3133No
68SS18NASS18
Entrez,  Source
synovial sarcoma translocation, chromosome 1810238-0.091-0.3178No
69LMNB1NALMNB1
Entrez,  Source
lamin B110250-0.092-0.3178No
70MCM3NAMCM3
Entrez,  Source
MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)10258-0.093-0.3176No
71CCNFNACCNF
Entrez,  Source
cyclin F10276-0.096-0.3179No
72SFPQNASFPQ
Entrez,  Source
splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)10429-0.114-0.3257No
73HUS1NAHUS1
Entrez,  Source
HUS1 checkpoint homolog (S. pombe)10529-0.128-0.3304No
74G3BP1NA10546-0.130-0.3305No
75PAPD7NA10712-0.156-0.3387No
76PMLNAPML
Entrez,  Source
promyelocytic leukemia10783-0.166-0.3416No
77RPA2NARPA2
Entrez,  Source
replication protein A2, 32kDa10881-0.181-0.3458No
78CDC20NACDC20
Entrez,  Source
CDC20 cell division cycle 20 homolog (S. cerevisiae)11005-0.198-0.3514No
79CENPANACENPA
Entrez,  Source
centromere protein A11140-0.218-0.3575No
80UPF1NAUPF1
Entrez,  Source
UPF1 regulator of nonsense transcripts homolog (yeast)11267-0.234-0.3631No
81ABL1NAABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 111310-0.241-0.3638No
82CBX1NACBX1
Entrez,  Source
chromobox homolog 1 (HP1 beta homolog Drosophila )11320-0.242-0.3627No
83STMN1NASTMN1
Entrez,  Source
stathmin 1/oncoprotein 1811345-0.246-0.3625No
84NUSAP1NANUSAP1
Entrez,  Source
nucleolar and spindle associated protein 111442-0.261-0.3661No
85DDX39ANA11520-0.274-0.3687No
86CHEK1NACHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)11651-0.289-0.3741No
87SRSF10NA11655-0.290-0.3723No
88RACGAP1NARACGAP1
Entrez,  Source
Rac GTPase activating protein 111711-0.297-0.3734No
89CKS2NACKS2
Entrez,  Source
CDC28 protein kinase regulatory subunit 211789-0.309-0.3757No
90RAD23BNARAD23B
Entrez,  Source
RAD23 homolog B (S. cerevisiae)12339-0.389-0.4040No
91TOP1NATOP1
Entrez,  Source
topoisomerase (DNA) I12351-0.392-0.4021No
92DKC1NADKC1
Entrez,  Source
dyskeratosis congenita 1, dyskerin12369-0.393-0.4004No
93NUP50NANUP50
Entrez,  Source
nucleoporin 50kDa12385-0.397-0.3986No
94NDC80NA12660-0.426-0.4112No
95MCM6NAMCM6
Entrez,  Source
MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)12750-0.444-0.4133No
96NUMA1NANUMA1
Entrez,  Source
nuclear mitotic apparatus protein 112751-0.444-0.4104No
97GSPT1NAGSPT1
Entrez,  Source
G1 to S phase transition 112888-0.450-0.4150No
98LBRNALBR
Entrez,  Source
lamin B receptor13065-0.465-0.4219Yes
99MNAT1NAMNAT1
Entrez,  Source
menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)13118-0.476-0.4216Yes
100KPNA2NAKPNA2
Entrez,  Source
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)13139-0.479-0.4196Yes
101BIRC5NABIRC5
Entrez,  Source
baculoviral IAP repeat-containing 5 (survivin)13169-0.482-0.4180Yes
102FANCCNAFANCC
Entrez,  Source
Fanconi anemia, complementation group C13198-0.488-0.4164Yes
103E2F2NAE2F2
Entrez,  Source
E2F transcription factor 213257-0.498-0.4164Yes
104CTCFNACTCF
Entrez,  Source
CCCTC-binding factor (zinc finger protein)13315-0.506-0.4162Yes
105TNPO2NATNPO2
Entrez,  Source
transportin 2 (importin 3, karyopherin beta 2b)13377-0.514-0.4162Yes
106UCK2NAUCK2
Entrez,  Source
uridine-cytidine kinase 213528-0.542-0.4211Yes
107SNRPD1NASNRPD1
Entrez,  Source
small nuclear ribonucleoprotein D1 polypeptide 16kDa13588-0.555-0.4208Yes
108HNRNPUNA13598-0.558-0.4176Yes
109AURKANAAURKA
Entrez,  Source
aurora kinase A13620-0.562-0.4150Yes
110KIF5BNAKIF5B
Entrez,  Source
kinesin family member 5B13622-0.562-0.4114Yes
111KIF2CNAKIF2C
Entrez,  Source
kinesin family member 2C13733-0.582-0.4137Yes
112E2F1NAE2F1
Entrez,  Source
E2F transcription factor 113748-0.585-0.4106Yes
113SMC2NASMC2
Entrez,  Source
structural maintenance of chromosomes 213763-0.588-0.4075Yes
114CUL4ANACUL4A
Entrez,  Source
cullin 4A13875-0.609-0.4098Yes
115ILF3NAILF3
Entrez,  Source
interleukin enhancer binding factor 3, 90kDa13887-0.612-0.4063Yes
116RBL1NARBL1
Entrez,  Source
retinoblastoma-like 1 (p107)13911-0.617-0.4035Yes
117CDK4NACDK4
Entrez,  Source
cyclin-dependent kinase 413941-0.622-0.4011Yes
118POLA2NAPOLA2
Entrez,  Source
polymerase (DNA directed), alpha 2 (70kD subunit)13950-0.623-0.3974Yes
119SMAD3NASMAD3
Entrez,  Source
SMAD, mothers against DPP homolog 3 (Drosophila)14025-0.642-0.3973Yes
120PLK1NAPLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)14126-0.664-0.3985Yes
121CDC7NACDC7
Entrez,  Source
CDC7 cell division cycle 7 (S. cerevisiae)14187-0.679-0.3974Yes
122CCNA2NACCNA2
Entrez,  Source
cyclin A214235-0.689-0.3955Yes
123EWSR1NAEWSR1
Entrez,  Source
Ewing sarcoma breakpoint region 114318-0.705-0.3955Yes
124EXO1NAEXO1
Entrez,  Source
exonuclease 114354-0.715-0.3927Yes
125STILNASTIL
Entrez,  Source
SCL/TAL1 interrupting locus14381-0.720-0.3894Yes
126PRPF4BNAPRPF4B
Entrez,  Source
PRP4 pre-mRNA processing factor 4 homolog B (yeast)14428-0.733-0.3872Yes
127ESPL1NAESPL1
Entrez,  Source
extra spindle poles like 1 (S. cerevisiae)14462-0.745-0.3841Yes
128CDC45NA14502-0.753-0.3813Yes
129RASAL2NARASAL2
Entrez,  Source
RAS protein activator like 214588-0.774-0.3810Yes
130RAD21NARAD21
Entrez,  Source
RAD21 homolog (S. pombe)14590-0.774-0.3759Yes
131CHAF1ANACHAF1A
Entrez,  Source
chromatin assembly factor 1, subunit A (p150)14607-0.780-0.3717Yes
132CKS1BNACKS1B
Entrez,  Source
CDC28 protein kinase regulatory subunit 1B14611-0.781-0.3667Yes
133TPX2NATPX2
Entrez,  Source
TPX2, microtubule-associated, homolog (Xenopus laevis)14659-0.790-0.3641Yes
134SRSF2NA14774-0.818-0.3651Yes
135INCENPNAINCENP
Entrez,  Source
inner centromere protein antigens 135/155kDa14792-0.825-0.3606Yes
136NUP98NANUP98
Entrez,  Source
nucleoporin 98kDa14806-0.828-0.3559Yes
137TLE3NATLE3
Entrez,  Source
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)14812-0.829-0.3507Yes
138MYBL2NAMYBL2
Entrez,  Source
v-myb myeloblastosis viral oncogene homolog (avian)-like 214832-0.835-0.3462Yes
139CENPFNACENPF
Entrez,  Source
centromere protein F, 350/400ka (mitosin)14921-0.849-0.3455Yes
140POLQNAPOLQ
Entrez,  Source
polymerase (DNA directed), theta15033-0.876-0.3460Yes
141KATNA1NAKATNA1
Entrez,  Source
katanin p60 (ATPase-containing) subunit A 115051-0.880-0.3411Yes
142MYCNAMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)15055-0.881-0.3355Yes
143TRAIPNATRAIP
Entrez,  Source
TRAF interacting protein15155-0.903-0.3351Yes
144TMPONATMPO
Entrez,  Source
thymopoietin15165-0.906-0.3296Yes
145KIF4ANAKIF4A
Entrez,  Source
kinesin family member 4A15178-0.909-0.3243Yes
146CDC25ANACDC25A
Entrez,  Source
cell division cycle 25A15209-0.915-0.3199Yes
147FBXO5NAFBXO5
Entrez,  Source
F-box protein 515300-0.942-0.3187Yes
148HIRANAHIRA
Entrez,  Source
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)15339-0.951-0.3146Yes
149MAD2L1NAMAD2L1
Entrez,  Source
MAD2 mitotic arrest deficient-like 1 (yeast)15344-0.954-0.3085Yes
150AMD1NAAMD1
Entrez,  Source
adenosylmethionine decarboxylase 115427-0.976-0.3067Yes
151ATRXNAATRX
Entrez,  Source
alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)15438-0.979-0.3008Yes
152MCM5NAMCM5
Entrez,  Source
MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)15464-0.988-0.2956Yes
153MTF2NAMTF2
Entrez,  Source
metal response element binding transcription factor 215513-1.001-0.2917Yes
154MEIS2NAMEIS2
Entrez,  Source
Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse)15557-1.014-0.2874Yes
155CDKN2CNACDKN2C
Entrez,  Source
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)15593-1.025-0.2826Yes
156NASPNANASP
Entrez,  Source
nuclear autoantigenic sperm protein (histone-binding)15623-1.035-0.2774Yes
157MCM2NAMCM2
Entrez,  Source
MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)15624-1.036-0.2706Yes
158PLK4NAPLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)15631-1.039-0.2640Yes
159E2F4NAE2F4
Entrez,  Source
E2F transcription factor 4, p107/p130-binding15750-1.078-0.2636Yes
160KIF11NAKIF11
Entrez,  Source
kinesin family member 1115778-1.086-0.2579Yes
161ORC6NA15806-1.098-0.2522Yes
162SMC4NASMC4
Entrez,  Source
structural maintenance of chromosomes 415859-1.120-0.2477Yes
163BUB3NABUB3
Entrez,  Source
BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)15915-1.142-0.2432Yes
164STAG1NASTAG1
Entrez,  Source
stromal antigen 116118-1.222-0.2465Yes
165KIF22NAKIF22
Entrez,  Source
kinesin family member 2216180-1.250-0.2417Yes
166KIF20BNA16234-1.276-0.2362Yes
167CHMP1ANA16323-1.316-0.2325Yes
168SMARCC1NASMARCC1
Entrez,  Source
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 116487-1.409-0.2323Yes
169TFDP1NATFDP1
Entrez,  Source
transcription factor Dp-116542-1.434-0.2259Yes
170ODF2NAODF2
Entrez,  Source
outer dense fiber of sperm tails 216548-1.436-0.2167Yes
171CDK1NA16637-1.491-0.2118Yes
172SYNCRIPNASYNCRIP
Entrez,  Source
synaptotagmin binding, cytoplasmic RNA interacting protein16677-1.516-0.2040Yes
173KIF15NAKIF15
Entrez,  Source
kinesin family member 1516686-1.522-0.1943Yes
174XPO1NAXPO1
Entrez,  Source
exportin 1 (CRM1 homolog, yeast)16773-1.582-0.1887Yes
175RPS6KA5NARPS6KA5
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 516817-1.622-0.1804Yes
176CCNB2NACCNB2
Entrez,  Source
cyclin B216828-1.630-0.1702Yes
177TTKNATTK
Entrez,  Source
TTK protein kinase16883-1.669-0.1622Yes
178MKI67NAMKI67
Entrez,  Source
antigen identified by monoclonal antibody Ki-6716911-1.689-0.1526Yes
179PRC1NAPRC1
Entrez,  Source
protein regulator of cytokinesis 116957-1.732-0.1437Yes
180SLC7A1NASLC7A1
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 116964-1.737-0.1325Yes
181AURKBNAAURKB
Entrez,  Source
aurora kinase B17006-1.776-0.1231Yes
182NOLC1NANOLC1
Entrez,  Source
nucleolar and coiled-body phosphoprotein 117035-1.802-0.1127Yes
183MARCKSNAMARCKS
Entrez,  Source
myristoylated alanine-rich protein kinase C substrate17061-1.825-0.1021Yes
184KIF23NAKIF23
Entrez,  Source
kinesin family member 2317105-1.883-0.0921Yes
185GINS2NAGINS2
Entrez,  Source
GINS complex subunit 2 (Psf2 homolog)17171-1.970-0.0827Yes
186SQLENASQLE
Entrez,  Source
squalene epoxidase17217-2.029-0.0718Yes
187PDS5BNA17253-2.088-0.0600Yes
188HMMRNAHMMR
Entrez,  Source
hyaluronan-mediated motility receptor (RHAMM)17255-2.092-0.0462Yes
189MEIS1NAMEIS1
Entrez,  Source
Meis1, myeloid ecotropic viral integration site 1 homolog (mouse)17258-2.096-0.0325Yes
190CASP8AP2NACASP8AP2
Entrez,  Source
CASP8 associated protein 217335-2.226-0.0220Yes
191HOXC10NAHOXC10
Entrez,  Source
homeobox C1017339-2.229-0.0075Yes
192BRCA2NABRCA2
Entrez,  Source
breast cancer 2, early onset17561-2.614-0.0026Yes
193DMDNADMD
Entrez,  Source
dystrophin (muscular dystrophy, Duchenne and Becker types)17848-3.9040.0071Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_G2M_CHECKPOINT   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_G2M_CHECKPOINT: Random ES distribution   
Gene set null distribution of ES for HALLMARK_G2M_CHECKPOINT