Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1w6a
GeneSetHALLMARK_ESTROGEN_RESPONSE_EARLY
Enrichment Score (ES)0.42002562
Normalized Enrichment Score (NES)1.620735
Nominal p-value0.0
FDR q-value0.006451955
FWER p-Value0.06
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_ESTROGEN_RESPONSE_EARLY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1KRT19NAKRT19
Entrez,  Source
keratin 1904.9920.0206Yes
2CLIC3NACLIC3
Entrez,  Source
chloride intracellular channel 3374.7990.0383Yes
3SYBUNA584.6880.0565Yes
4SLC1A4NASLC1A4
Entrez,  Source
solute carrier family 1 (glutamate/neutral amino acid transporter), member 41234.4160.0711Yes
5WISP2NAWISP2
Entrez,  Source
WNT1 inducible signaling pathway protein 21494.2990.0874Yes
6TPD52L1NATPD52L1
Entrez,  Source
tumor protein D52-like 11654.2540.1040Yes
7CALCRNACALCR
Entrez,  Source
calcitonin receptor1724.2330.1211Yes
8AREGNAAREG
Entrez,  Source
amphiregulin (schwannoma-derived growth factor)2324.0000.1343Yes
9P2RY2NAP2RY2
Entrez,  Source
purinergic receptor P2Y, G-protein coupled, 22613.8710.1486Yes
10SYT12NASYT12
Entrez,  Source
synaptotagmin XII3403.6340.1592Yes
11GJA1NAGJA1
Entrez,  Source
gap junction protein, alpha 1, 43kDa (connexin 43)3473.6070.1737Yes
12SEMA3BNASEMA3B
Entrez,  Source
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B3603.5560.1877Yes
13IGFBP4NAIGFBP4
Entrez,  Source
insulin-like growth factor binding protein 43723.5080.2015Yes
14ESRP2NA3833.4700.2153Yes
15SLC27A2NASLC27A2
Entrez,  Source
solute carrier family 27 (fatty acid transporter), member 24463.3350.2255Yes
16RHOBTB3NARHOBTB3
Entrez,  Source
Rho-related BTB domain containing 34863.2460.2367Yes
17ELF3NAELF3
Entrez,  Source
E74-like factor 3 (ets domain transcription factor, epithelial-specific )5483.0760.2459Yes
18AQP3NAAQP3
Entrez,  Source
aquaporin 3 (Gill blood group)5782.9870.2566Yes
19SCNN1ANASCNN1A
Entrez,  Source
sodium channel, nonvoltage-gated 1 alpha6152.9180.2666Yes
20FAM102ANAFAM102A
Entrez,  Source
family with sequence similarity 102, member A6212.9090.2783Yes
21MLPHNAMLPH
Entrez,  Source
melanophilin6572.8260.2879Yes
22SLC7A2NASLC7A2
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 27232.6730.2953Yes
23SLC26A2NASLC26A2
Entrez,  Source
solute carrier family 26 (sulfate transporter), member 27592.6230.3041Yes
24FHL2NAFHL2
Entrez,  Source
four and a half LIM domains 28302.5040.3105Yes
25SLC1A1NASLC1A1
Entrez,  Source
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 19382.3690.3142Yes
26RHODNARHOD
Entrez,  Source
ras homolog gene family, member D10552.2200.3169Yes
27STC2NASTC2
Entrez,  Source
stanniocalcin 210652.2070.3254Yes
28KRT15NAKRT15
Entrez,  Source
keratin 1510902.1800.3331Yes
29REEP1NAREEP1
Entrez,  Source
receptor accessory protein 111002.1690.3415Yes
30KLF4NAKLF4
Entrez,  Source
Kruppel-like factor 4 (gut)11652.0770.3465Yes
31TOB1NATOB1
Entrez,  Source
transducer of ERBB2, 113311.9000.3450Yes
32CA12NACA12
Entrez,  Source
carbonic anhydrase XII13651.8730.3509Yes
33PODXLNAPODXL
Entrez,  Source
podocalyxin-like14371.8130.3543Yes
34KRT8NAKRT8
Entrez,  Source
keratin 814471.8050.3613Yes
35DLC1NADLC1
Entrez,  Source
deleted in liver cancer 114831.7730.3666Yes
36MICBNAMICB
Entrez,  Source
MHC class I polypeptide-related sequence B15441.7270.3703Yes
37WWC1NAWWC1
Entrez,  Source
WW, C2 and coiled-coil domain containing 115921.6910.3746Yes
38AFF1NAAFF1
Entrez,  Source
AF4/FMR2 family, member 116491.6480.3783Yes
39TSKUNA16501.6460.3851Yes
40PTGESNAPTGES
Entrez,  Source
prostaglandin E synthase16741.6310.3905Yes
41PGRNAPGR
Entrez,  Source
progesterone receptor16871.6140.3965Yes
42INHBBNAINHBB
Entrez,  Source
inhibin, beta B (activin AB beta polypeptide)17111.5920.4017Yes
43TPBGNATPBG
Entrez,  Source
trophoblast glycoprotein17231.5840.4076Yes
44OVOL2NAOVOL2
Entrez,  Source
ovo-like 2 (Drosophila)18091.5250.4091Yes
45CELSR1NACELSR1
Entrez,  Source
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)19571.4400.4068Yes
46MYBL1NAMYBL1
Entrez,  Source
v-myb myeloblastosis viral oncogene homolog (avian)-like 119871.4250.4110Yes
47ALDH3B1NAALDH3B1
Entrez,  Source
aldehyde dehydrogenase 3 family, member B120981.3620.4104Yes
48IL6STNAIL6ST
Entrez,  Source
interleukin 6 signal transducer (gp130, oncostatin M receptor)21631.3260.4123Yes
49ADCY9NAADCY9
Entrez,  Source
adenylate cyclase 922921.2590.4103Yes
50B4GALT1NAB4GALT1
Entrez,  Source
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 123711.2260.4110Yes
51SLC16A1NASLC16A1
Entrez,  Source
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)25741.1460.4043Yes
52PMAIP1NAPMAIP1
Entrez,  Source
phorbol-12-myristate-13-acetate-induced protein 125881.1420.4083Yes
53SNX24NASNX24
Entrez,  Source
sorting nexing 2428071.0580.4004Yes
54SLC7A5NASLC7A5
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 528371.0480.4031Yes
55RARANARARA
Entrez,  Source
retinoic acid receptor, alpha28581.0410.4062Yes
56SLC22A5NASLC22A5
Entrez,  Source
solute carrier family 22 (organic cation transporter), member 528621.0410.4104Yes
57KCNK15NAKCNK15
Entrez,  Source
potassium channel, subfamily K, member 1528931.0320.4129Yes
58DEPTORNA29201.0190.4156Yes
59RAPGEFL1NARAPGEFL1
Entrez,  Source
Rap guanine nucleotide exchange factor (GEF)-like 130060.9900.4149Yes
60RASGRP1NARASGRP1
Entrez,  Source
RAS guanyl releasing protein 1 (calcium and DAG-regulated)30190.9860.4183Yes
61ANXA9NAANXA9
Entrez,  Source
annexin A930610.9730.4200Yes
62ITPK1NAITPK1
Entrez,  Source
inositol 1,3,4-triphosphate 5/6 kinase32600.9240.4127No
63BLVRBNABLVRB
Entrez,  Source
biliverdin reductase B (flavin reductase (NADPH))32990.9120.4143No
64TFF3NATFF3
Entrez,  Source
trefoil factor 3 (intestinal)33820.8850.4133No
65BCL2NABCL2
Entrez,  Source
B-cell CLL/lymphoma 234090.8800.4155No
66DHRS3NADHRS3
Entrez,  Source
dehydrogenase/reductase (SDR family) member 334350.8740.4177No
67HRNAHR
Entrez,  Source
hairless homolog (mouse)34910.8590.4181No
68TBC1D30NA39060.7840.3981No
69OPN3NAOPN3
Entrez,  Source
opsin 3 (encephalopsin, panopsin)39150.7820.4009No
70KLF10NAKLF10
Entrez,  Source
Kruppel-like factor 1040290.7560.3976No
71TMPRSS3NATMPRSS3
Entrez,  Source
transmembrane protease, serine 341450.7290.3942No
72JAK2NAJAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)43250.6960.3869No
73ELOVL2NAELOVL2
Entrez,  Source
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 243270.6950.3898No
74MYBNAMYB
Entrez,  Source
v-myb myeloblastosis viral oncogene homolog (avian)43340.6930.3923No
75ADCY1NAADCY1
Entrez,  Source
adenylate cyclase 1 (brain)43960.6790.3916No
76KAZNNA44550.6660.3911No
77PLA2G16NA45080.6550.3909No
78BCL11BNABCL11B
Entrez,  Source
B-cell CLL/lymphoma 11B (zinc finger protein)46430.6300.3860No
79HSPB8NAHSPB8
Entrez,  Source
heat shock 22kDa protein 848200.5900.3785No
80CCND1NACCND1
Entrez,  Source
cyclin D149460.5690.3738No
81FLNBNAFLNB
Entrez,  Source
filamin B, beta (actin binding protein 278)50240.5510.3717No
82TIPARPNATIPARP
Entrez,  Source
TCDD-inducible poly(ADP-ribose) polymerase50660.5430.3717No
83PDZK1NAPDZK1
Entrez,  Source
PDZ domain containing 150720.5420.3736No
84GLANAGLA
Entrez,  Source
galactosidase, alpha52430.5110.3662No
85CXCL12NACXCL12
Entrez,  Source
chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)54530.4830.3564No
86TMEM164NATMEM164
Entrez,  Source
transmembrane protein 16456190.4570.3490No
87ABLIM1NAABLIM1
Entrez,  Source
actin binding LIM protein 157120.4410.3456No
88TTC39ANA57130.4410.3475No
89ENDOD1NAENDOD1
Entrez,  Source
endonuclease domain containing 158010.4290.3443No
90ARNAAR
Entrez,  Source
androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)59130.4270.3398No
91CANT1NACANT1
Entrez,  Source
calcium activated nucleotidase 163300.3920.3181No
92FKBP4NAFKBP4
Entrez,  Source
FK506 binding protein 4, 59kDa63860.3840.3165No
93NXT1NANXT1
Entrez,  Source
NTF2-like export factor 164060.3800.3170No
94MUC1NAMUC1
Entrez,  Source
mucin 1, cell surface associated64520.3730.3161No
95SLC19A2NASLC19A2
Entrez,  Source
solute carrier family 19 (thiamine transporter), member 264770.3710.3162No
96FKBP5NAFKBP5
Entrez,  Source
FK506 binding protein 565240.3630.3151No
97KRT18NAKRT18
Entrez,  Source
keratin 1870290.2850.2880No
98NPY1RNANPY1R
Entrez,  Source
neuropeptide Y receptor Y170940.2750.2855No
99SULT2B1NASULT2B1
Entrez,  Source
sulfotransferase family, cytosolic, 2B, member 171410.2670.2840No
100RAB17NARAB17
Entrez,  Source
RAB17, member RAS oncogene family72510.2500.2789No
101ZNF185NAZNF185
Entrez,  Source
zinc finger protein 185 (LIM domain)72580.2490.2796No
102FOSNAFOS
Entrez,  Source
v-fos FBJ murine osteosarcoma viral oncogene homolog72650.2470.2803No
103LAD1NALAD1
Entrez,  Source
ladinin 174850.2130.2688No
104ELOVL5NAELOVL5
Entrez,  Source
ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)75780.2010.2645No
105KDM4BNA76020.1990.2640No
106KLK10NAKLK10
Entrez,  Source
kallikrein 1076840.1870.2602No
107OLFM1NAOLFM1
Entrez,  Source
olfactomedin 176910.1860.2607No
108RAB31NARAB31
Entrez,  Source
RAB31, member RAS oncogene family77560.1770.2578No
109DYNLT3NADYNLT3
Entrez,  Source
dynein, light chain, Tctex-type 377800.1740.2572No
110EGR3NAEGR3
Entrez,  Source
early growth response 378030.1710.2567No
111SIAH2NASIAH2
Entrez,  Source
seven in absentia homolog 2 (Drosophila)78050.1700.2573No
112SLC24A3NASLC24A3
Entrez,  Source
solute carrier family 24 (sodium/potassium/calcium exchanger), member 378620.1640.2548No
113RBBP8NARBBP8
Entrez,  Source
retinoblastoma binding protein 880230.1430.2464No
114MED13LNA80350.1410.2464No
115KCNK5NAKCNK5
Entrez,  Source
potassium channel, subfamily K, member 580430.1400.2466No
116SLC2A1NASLC2A1
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 182140.1180.2375No
117SLC39A6NASLC39A6
Entrez,  Source
solute carrier family 39 (zinc transporter), member 683160.1050.2323No
118XBP1NAXBP1
Entrez,  Source
X-box binding protein 184170.0910.2270No
119CHPT1NACHPT1
Entrez,  Source
choline phosphotransferase 184480.0870.2257No
120FRKNAFRK
Entrez,  Source
fyn-related kinase84690.0850.2249No
121PRSS23NAPRSS23
Entrez,  Source
protease, serine, 2386020.0660.2177No
122SEC14L2NASEC14L2
Entrez,  Source
SEC14-like 2 (S. cerevisiae)89400.0220.1989No
123AMFRNAAMFR
Entrez,  Source
autocrine motility factor receptor90350.0140.1937No
124HES1NAHES1
Entrez,  Source
hairy and enhancer of split 1, (Drosophila)9450-0.0070.1704No
125WFS1NAWFS1
Entrez,  Source
Wolfram syndrome 1 (wolframin)9468-0.0090.1695No
126MYOFNA9506-0.0150.1675No
127MED24NA9615-0.0320.1615No
128NBL1NANBL1
Entrez,  Source
neuroblastoma, suppression of tumorigenicity 19765-0.0470.1533No
129SYNGR1NASYNGR1
Entrez,  Source
synaptogyrin 19977-0.0680.1417No
130UNC119NAUNC119
Entrez,  Source
unc-119 homolog (C. elegans)9994-0.0700.1411No
131MSMBNAMSMB
Entrez,  Source
microseminoprotein, beta-10007-0.0700.1407No
132MREGNA10373-0.1060.1207No
133NADSYN1NANADSYN1
Entrez,  Source
NAD synthetase 110494-0.1230.1144No
134GAB2NAGAB2
Entrez,  Source
GRB2-associated binding protein 210716-0.1560.1026No
135CD44NACD44
Entrez,  Source
CD44 molecule (Indian blood group)10782-0.1660.0997No
136RETNARET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)11239-0.2310.0750No
137PEX11ANAPEX11A
Entrez,  Source
peroxisomal biogenesis factor 11A11326-0.2430.0711No
138SH3BP5NASH3BP5
Entrez,  Source
SH3-domain binding protein 5 (BTK-associated)11459-0.2650.0648No
139ADD3NAADD3
Entrez,  Source
adducin 3 (gamma)11657-0.2900.0549No
140MPPED2NAMPPED2
Entrez,  Source
metallophosphoesterase domain containing 211810-0.3130.0476No
141CBFA2T3NACBFA2T3
Entrez,  Source
core-binding factor, runt domain, alpha subunit 2; translocated to, 311844-0.3210.0471No
142ARL3NAARL3
Entrez,  Source
ADP-ribosylation factor-like 311991-0.3380.0403No
143TFF1NATFF1
Entrez,  Source
trefoil factor 1 (breast cancer, estrogen-inducible sequence expressed in)12151-0.3610.0328No
144SCARB1NASCARB1
Entrez,  Source
scavenger receptor class B, member 112172-0.3650.0332No
145KRT13NAKRT13
Entrez,  Source
keratin 1312555-0.4110.0134No
146FOXC1NAFOXC1
Entrez,  Source
forkhead box C112682-0.4310.0081No
147ABHD2NAABHD2
Entrez,  Source
abhydrolase domain containing 212885-0.449-0.0014No
148AKAP1NAAKAP1
Entrez,  Source
A kinase (PRKA) anchor protein 112999-0.455-0.0059No
149SOX3NASOX3
Entrez,  Source
SRY (sex determining region Y)-box 313162-0.480-0.0130No
150NAV2NANAV2
Entrez,  Source
neuron navigator 213193-0.487-0.0127No
151SLC9A3R1NASLC9A3R1
Entrez,  Source
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 113252-0.496-0.0139No
152UGCGNAUGCG
Entrez,  Source
UDP-glucose ceramide glucosyltransferase13397-0.517-0.0199No
153IL17RBNAIL17RB
Entrez,  Source
interleukin 17 receptor B13441-0.526-0.0201No
154INPP5FNAINPP5F
Entrez,  Source
inositol polyphosphate-5-phosphatase F13844-0.604-0.0403No
155RRP12NA14178-0.677-0.0562No
156DHRS2NADHRS2
Entrez,  Source
dehydrogenase/reductase (SDR family) member 214234-0.688-0.0565No
157MYBBP1ANAMYBBP1A
Entrez,  Source
MYB binding protein (P160) 1a14254-0.691-0.0547No
158SLC37A1NASLC37A1
Entrez,  Source
solute carrier family 37 (glycerol-3-phosphate transporter), member 114284-0.697-0.0534No
159GREB1NAGREB1
Entrez,  Source
-14425-0.732-0.0583No
160ASB13NAASB13
Entrez,  Source
ankyrin repeat and SOCS box-containing 1314586-0.774-0.0641No
161SVILNASVIL
Entrez,  Source
supervillin15021-0.872-0.0849No
162MYCNAMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)15055-0.881-0.0832No
163MAST4NAMAST4
Entrez,  Source
microtubule associated serine/threonine kinase family member 415130-0.896-0.0836No
164ABCA3NAABCA3
Entrez,  Source
ATP-binding cassette, sub-family A (ABC1), member 315200-0.913-0.0838No
165CALB2NACALB2
Entrez,  Source
calbindin 2, 29kDa (calretinin)15498-0.998-0.0963No
166BAG1NABAG1
Entrez,  Source
BCL2-associated athanogene15519-1.003-0.0933No
167PAPSS2NAPAPSS2
Entrez,  Source
3'-phosphoadenosine 5'-phosphosulfate synthase 215536-1.007-0.0901No
168PPIFNAPPIF
Entrez,  Source
peptidylprolyl isomerase F (cyclophilin F)15620-1.034-0.0905No
169TUBB2BNATUBB2B
Entrez,  Source
tubulin, beta 2B15630-1.038-0.0867No
170CLDN7NACLDN7
Entrez,  Source
claudin 715646-1.041-0.0833No
171OLFML3NAOLFML3
Entrez,  Source
olfactomedin-like 315689-1.059-0.0813No
172ELF1NAELF1
Entrez,  Source
E74-like factor 1 (ets domain transcription factor)15757-1.081-0.0806No
173NCOR2NANCOR2
Entrez,  Source
nuclear receptor co-repressor 215839-1.111-0.0806No
174PDLIM3NAPDLIM3
Entrez,  Source
PDZ and LIM domain 315846-1.115-0.0763No
175GFRA1NAGFRA1
Entrez,  Source
GDNF family receptor alpha 116155-1.241-0.0886No
176FDFT1NAFDFT1
Entrez,  Source
farnesyl-diphosphate farnesyltransferase 116183-1.251-0.0849No
177CELSR2NACELSR2
Entrez,  Source
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)16222-1.271-0.0818No
178THSD4NATHSD4
Entrez,  Source
thrombospondin, type I, domain containing 416406-1.368-0.0865No
179SFNNASFN
Entrez,  Source
stratifin16410-1.369-0.0810No
180ABATNAABAT
Entrez,  Source
4-aminobutyrate aminotransferase16644-1.497-0.0880No
181IGF1RNAIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor16802-1.603-0.0902No
182TGIF2NATGIF2
Entrez,  Source
TGFB-induced factor 2 (TALE family homeobox)17147-1.928-0.1016No
183DHCR7NADHCR7
Entrez,  Source
7-dehydrocholesterol reductase17178-1.978-0.0951No
184TFAP2CNATFAP2C
Entrez,  Source
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)17229-2.056-0.0895No
185FASNNAFASN
Entrez,  Source
fatty acid synthase17303-2.176-0.0846No
186FARP1NAFARP1
Entrez,  Source
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)17307-2.180-0.0758No
187TGM2NATGM2
Entrez,  Source
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)17349-2.244-0.0689No
188BHLHE40NA17439-2.394-0.0640No
189LRIG1NALRIG1
Entrez,  Source
leucine-rich repeats and immunoglobulin-like domains 117630-2.807-0.0632No
190RPS6KA2NARPS6KA2
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 217664-2.960-0.0528No
191CISHNACISH
Entrez,  Source
cytokine inducible SH2-containing protein17672-3.000-0.0409No
192TIAM1NATIAM1
Entrez,  Source
T-cell lymphoma invasion and metastasis 117748-3.371-0.0312No
193NRIP1NANRIP1
Entrez,  Source
nuclear receptor interacting protein 117768-3.445-0.0181No
194CYP26B1NACYP26B1
Entrez,  Source
cytochrome P450, family 26, subfamily B, polypeptide 117795-3.551-0.0049No
195MAPTNAMAPT
Entrez,  Source
microtubule-associated protein tau17811-3.6270.0092No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_ESTROGEN_RESPONSE_EARLY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_ESTROGEN_RESPONSE_EARLY: Random ES distribution   
Gene set null distribution of ES for HALLMARK_ESTROGEN_RESPONSE_EARLY