Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_E2F_TARGETS
Enrichment Score (ES)-0.527442
Normalized Enrichment Score (NES)-2.3278637
Nominal p-value0.0
FDR q-value0.0
FWER p-Value0.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_E2F_TARGETS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)8882.413-0.0328No
2HMGA1NAHMGA1
Entrez,  Source
high mobility group AT-hook 118801.485-0.0779No
3GINS4NAGINS4
Entrez,  Source
GINS complex subunit 4 (Sld5 homolog)19511.444-0.0716No
4CDC25BNACDC25B
Entrez,  Source
cell division cycle 25B27811.067-0.1106No
5CDKN1BNACDKN1B
Entrez,  Source
cyclin-dependent kinase inhibitor 1B (p27, Kip1)29421.008-0.1124No
6EZH2NAEZH2
Entrez,  Source
enhancer of zeste homolog 2 (Drosophila)32480.928-0.1230No
7TRA2BNA37010.830-0.1425No
8SPAG5NASPAG5
Entrez,  Source
sperm associated antigen 538020.809-0.1424No
9MXD3NAMXD3
Entrez,  Source
MAX dimerization protein 339290.778-0.1439No
10TOP2ANATOP2A
Entrez,  Source
topoisomerase (DNA) II alpha 170kDa41500.728-0.1511No
11PRIM2NA47100.615-0.1782No
12PTTG1NAPTTG1
Entrez,  Source
pituitary tumor-transforming 148190.590-0.1800No
13PSMC3IPNAPSMC3IP
Entrez,  Source
PSMC3 interacting protein48690.582-0.1786No
14SMC1ANASMC1A
Entrez,  Source
structural maintenance of chromosomes 1A50050.557-0.1823No
15RBBP7NARBBP7
Entrez,  Source
retinoblastoma binding protein 754440.484-0.2035No
16TFRCNATFRC
Entrez,  Source
transferrin receptor (p90, CD71)54820.481-0.2021No
17CBX5NACBX5
Entrez,  Source
chromobox homolog 5 (HP1 alpha homolog, Drosophila)55300.472-0.2014No
18BARD1NABARD1
Entrez,  Source
BRCA1 associated RING domain 160770.417-0.2291No
19TUBBNATUBB
Entrez,  Source
tubulin, beta63510.389-0.2417No
20UBE2SNAUBE2S
Entrez,  Source
ubiquitin-conjugating enzyme E2S63700.386-0.2400No
21RFC1NARFC1
Entrez,  Source
replication factor C (activator 1) 1, 145kDa63740.385-0.2374No
22TACC3NATACC3
Entrez,  Source
transforming, acidic coiled-coil containing protein 365530.358-0.2449No
23RRM2NARRM2
Entrez,  Source
ribonucleotide reductase M2 polypeptide67250.331-0.2521No
24CDCA3NACDCA3
Entrez,  Source
cell division cycle associated 371750.262-0.2755No
25PPP1R8NAPPP1R8
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 872690.247-0.2790No
26CCNE1NACCNE1
Entrez,  Source
cyclin E173520.234-0.2819No
27LYARNALYAR
Entrez,  Source
-75970.199-0.2942No
28RAD50NARAD50
Entrez,  Source
RAD50 homolog (S. cerevisiae)76670.190-0.2968No
29ORC2NA77010.184-0.2973No
30DEKNADEK
Entrez,  Source
DEK oncogene (DNA binding)82570.112-0.3277No
31SUV39H1NASUV39H1
Entrez,  Source
suppressor of variegation 3-9 homolog 1 (Drosophila)84020.093-0.3352No
32DONSONNADONSON
Entrez,  Source
downstream neighbor of SON87640.042-0.3552No
33TUBG1NATUBG1
Entrez,  Source
tubulin, gamma 187960.041-0.3566No
34NUP153NANUP153
Entrez,  Source
nucleoporin 153kDa89260.024-0.3637No
35POP7NAPOP7
Entrez,  Source
processing of precursor 7, ribonuclease P subunit (S. cerevisiae)89680.018-0.3659No
36HMGB3NAHMGB3
Entrez,  Source
high-mobility group box 390490.013-0.3703No
37CDKN2ANACDKN2A
Entrez,  Source
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)93000.000-0.3843No
38H2AFZNAH2AFZ
Entrez,  Source
H2A histone family, member Z9425-0.003-0.3913No
39EIF2S1NAEIF2S1
Entrez,  Source
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa9520-0.018-0.3965No
40RFC2NARFC2
Entrez,  Source
replication factor C (activator 1) 2, 40kDa9589-0.028-0.4001No
41PAICSNAPAICS
Entrez,  Source
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase9605-0.030-0.4007No
42SRSF1NA9650-0.037-0.4029No
43CENPENACENPE
Entrez,  Source
centromere protein E, 312kDa9666-0.039-0.4035No
44DCKNADCK
Entrez,  Source
deoxycytidine kinase9679-0.041-0.4039No
45H2AFXNAH2AFX
Entrez,  Source
H2A histone family, member X9779-0.049-0.4091No
46CDKN3NACDKN3
Entrez,  Source
cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)9823-0.055-0.4111No
47POLENAPOLE
Entrez,  Source
polymerase (DNA directed), epsilon10020-0.071-0.4216No
48PNNNAPNN
Entrez,  Source
pinin, desmosome associated protein10026-0.071-0.4214No
49HNRNPDNA10146-0.082-0.4275No
50MSH2NAMSH2
Entrez,  Source
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)10163-0.085-0.4278No
51LMNB1NALMNB1
Entrez,  Source
lamin B110250-0.092-0.4320No
52MCM3NAMCM3
Entrez,  Source
MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)10258-0.093-0.4317No
53SNRPBNASNRPB
Entrez,  Source
small nuclear ribonucleoprotein polypeptides B and B110268-0.094-0.4316No
54SLBPNASLBP
Entrez,  Source
stem-loop (histone) binding protein10474-0.120-0.4422No
55HUS1NAHUS1
Entrez,  Source
HUS1 checkpoint homolog (S. pombe)10529-0.128-0.4444No
56UBR7NA10531-0.129-0.4435No
57NOP56NA10538-0.129-0.4429No
58TIMELESSNATIMELESS
Entrez,  Source
timeless homolog (Drosophila)10568-0.133-0.4436No
59TK1NATK1
Entrez,  Source
thymidine kinase 1, soluble10641-0.145-0.4466No
60BRMS1LNABRMS1L
Entrez,  Source
breast cancer metastasis-suppressor 1-like10695-0.154-0.4485No
61RPA2NARPA2
Entrez,  Source
replication protein A2, 32kDa10881-0.181-0.4576No
62CDC20NACDC20
Entrez,  Source
CDC20 cell division cycle 20 homolog (S. cerevisiae)11005-0.198-0.4631No
63TCF19NATCF19
Entrez,  Source
transcription factor 19 (SC1)11011-0.200-0.4620No
64ASF1ANAASF1A
Entrez,  Source
ASF1 anti-silencing function 1 homolog A (S. cerevisiae)11150-0.219-0.4682No
65RPA1NARPA1
Entrez,  Source
replication protein A1, 70kDa11194-0.226-0.4690No
66MELKNAMELK
Entrez,  Source
maternal embryonic leucine zipper kinase11236-0.231-0.4697No
67RAD51CNARAD51C
Entrez,  Source
RAD51 homolog C (S. cerevisiae)11241-0.232-0.4682No
68PRDX4NAPRDX4
Entrez,  Source
peroxiredoxin 411268-0.234-0.4680No
69CCP110NA11314-0.241-0.4688No
70STMN1NASTMN1
Entrez,  Source
stathmin 1/oncoprotein 1811345-0.246-0.4688No
71ING3NAING3
Entrez,  Source
inhibitor of growth family, member 311390-0.252-0.4695No
72DDX39ANA11520-0.274-0.4748No
73PRKDCNAPRKDC
Entrez,  Source
protein kinase, DNA-activated, catalytic polypeptide11616-0.286-0.4781No
74CHEK1NACHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)11651-0.289-0.4779No
75PPM1DNAPPM1D
Entrez,  Source
protein phosphatase 1D magnesium-dependent, delta isoform11702-0.296-0.4786No
76RACGAP1NARACGAP1
Entrez,  Source
Rac GTPase activating protein 111711-0.297-0.4770No
77UNGNAUNG
Entrez,  Source
uracil-DNA glycosylase11768-0.307-0.4779No
78DEPDC1NADEPDC1
Entrez,  Source
DEP domain containing 111780-0.308-0.4763No
79SPC25NA11784-0.309-0.4743No
80CKS2NACKS2
Entrez,  Source
CDC28 protein kinase regulatory subunit 211789-0.309-0.4723No
81MMS22LNA11915-0.328-0.4770No
82RANNARAN
Entrez,  Source
RAN, member RAS oncogene family11973-0.336-0.4779No
83RNASEH2ANARNASEH2A
Entrez,  Source
ribonuclease H2, subunit A12295-0.384-0.4932No
84SPC24NA12359-0.393-0.4939No
85MCM6NAMCM6
Entrez,  Source
MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)12750-0.444-0.5127No
86GSPT1NAGSPT1
Entrez,  Source
G1 to S phase transition 112888-0.450-0.5172No
87LBRNALBR
Entrez,  Source
lamin B receptor13065-0.465-0.5238Yes
88RAD1NARAD1
Entrez,  Source
RAD1 homolog (S. pombe)13075-0.467-0.5210Yes
89KPNA2NAKPNA2
Entrez,  Source
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)13139-0.479-0.5211Yes
90BIRC5NABIRC5
Entrez,  Source
baculoviral IAP repeat-containing 5 (survivin)13169-0.482-0.5193Yes
91NUP205NANUP205
Entrez,  Source
nucleoporin 205kDa13238-0.494-0.5196Yes
92PCNANAPCNA
Entrez,  Source
proliferating cell nuclear antigen13241-0.495-0.5162Yes
93CTCFNACTCF
Entrez,  Source
CCCTC-binding factor (zinc finger protein)13315-0.506-0.5167Yes
94NME1NANME1
Entrez,  Source
non-metastatic cells 1, protein (NM23A) expressed in13507-0.537-0.5236Yes
95PA2G4NAPA2G4
Entrez,  Source
proliferation-associated 2G4, 38kDa13512-0.539-0.5200Yes
96SSRP1NASSRP1
Entrez,  Source
structure specific recognition protein 113610-0.560-0.5215Yes
97AURKANAAURKA
Entrez,  Source
aurora kinase A13620-0.562-0.5180Yes
98RAD51AP1NARAD51AP1
Entrez,  Source
RAD51 associated protein 113632-0.564-0.5146Yes
99KIF2CNAKIF2C
Entrez,  Source
kinesin family member 2C13733-0.582-0.5161Yes
100PMS2NAPMS2
Entrez,  Source
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)13770-0.588-0.5139Yes
101POLD1NAPOLD1
Entrez,  Source
polymerase (DNA directed), delta 1, catalytic subunit 125kDa13802-0.595-0.5114Yes
102ILF3NAILF3
Entrez,  Source
interleukin enhancer binding factor 3, 90kDa13887-0.612-0.5118Yes
103CDK4NACDK4
Entrez,  Source
cyclin-dependent kinase 413941-0.622-0.5103Yes
104TRIP13NATRIP13
Entrez,  Source
thyroid hormone receptor interactor 1313947-0.623-0.5062Yes
105POLA2NAPOLA2
Entrez,  Source
polymerase (DNA directed), alpha 2 (70kD subunit)13950-0.623-0.5019Yes
106MCM7NAMCM7
Entrez,  Source
MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)13965-0.626-0.4982Yes
107CENPMNACENPM
Entrez,  Source
centromere protein M14004-0.635-0.4958Yes
108TBRG4NATBRG4
Entrez,  Source
transforming growth factor beta regulator 414028-0.642-0.4925Yes
109GINS3NAGINS3
Entrez,  Source
GINS complex subunit 3 (Psf3 homolog)14061-0.649-0.4897Yes
110DLGAP5NA14080-0.653-0.4861Yes
111PLK1NAPLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)14126-0.664-0.4839Yes
112ANP32ENAANP32E
Entrez,  Source
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E14194-0.681-0.4828Yes
113RPA3NARPA3
Entrez,  Source
replication protein A3, 14kDa14239-0.689-0.4803Yes
114DNMT1NADNMT1
Entrez,  Source
DNA (cytosine-5-)-methyltransferase 114265-0.693-0.4768Yes
115NAP1L1NANAP1L1
Entrez,  Source
nucleosome assembly protein 1-like 114296-0.700-0.4735Yes
116USP1NAUSP1
Entrez,  Source
ubiquitin specific peptidase 114319-0.705-0.4697Yes
117NCAPD2NANCAPD2
Entrez,  Source
non-SMC condensin I complex, subunit D214402-0.726-0.4692Yes
118RANBP1NARANBP1
Entrez,  Source
RAN binding protein 114407-0.728-0.4642Yes
119UBE2TNAUBE2T
Entrez,  Source
ubiquitin-conjugating enzyme E2T (putative)14410-0.728-0.4592Yes
120AK2NAAK2
Entrez,  Source
adenylate kinase 214411-0.728-0.4540Yes
121ESPL1NAESPL1
Entrez,  Source
extra spindle poles like 1 (S. cerevisiae)14462-0.745-0.4515Yes
122RAD21NARAD21
Entrez,  Source
RAD21 homolog (S. pombe)14590-0.774-0.4531Yes
123CKS1BNACKS1B
Entrez,  Source
CDC28 protein kinase regulatory subunit 1B14611-0.781-0.4487Yes
124POLD3NAPOLD3
Entrez,  Source
polymerase (DNA-directed), delta 3, accessory subunit14617-0.783-0.4434Yes
125ASF1BNAASF1B
Entrez,  Source
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)14648-0.787-0.4395Yes
126HELLSNAHELLS
Entrez,  Source
helicase, lymphoid-specific14681-0.795-0.4356Yes
127SRSF2NA14774-0.818-0.4350Yes
128MYBL2NAMYBL2
Entrez,  Source
v-myb myeloblastosis viral oncogene homolog (avian)-like 214832-0.835-0.4322Yes
129ATAD2NAATAD2
Entrez,  Source
ATPase family, AAA domain containing 214834-0.836-0.4263Yes
130LUC7L3NA14899-0.843-0.4239Yes
131MCM4NAMCM4
Entrez,  Source
MCM4 minichromosome maintenance deficient 4 (S. cerevisiae)14975-0.861-0.4220Yes
132XRCC6NAXRCC6
Entrez,  Source
X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa)14988-0.865-0.4165Yes
133CSE1LNACSE1L
Entrez,  Source
CSE1 chromosome segregation 1-like (yeast)15030-0.875-0.4126Yes
134PHF5ANAPHF5A
Entrez,  Source
PHD finger protein 5A15054-0.880-0.4077Yes
135MYCNAMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)15055-0.881-0.4014Yes
136BUB1BNABUB1B
Entrez,  Source
BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)15148-0.902-0.4001Yes
137TMPONATMPO
Entrez,  Source
thymopoietin15165-0.906-0.3946Yes
138CDCA8NACDCA8
Entrez,  Source
cell division cycle associated 815172-0.908-0.3885Yes
139KIF4ANAKIF4A
Entrez,  Source
kinesin family member 4A15178-0.909-0.3823Yes
140POLD2NAPOLD2
Entrez,  Source
polymerase (DNA directed), delta 2, regulatory subunit 50kDa15203-0.914-0.3771Yes
141CDC25ANACDC25A
Entrez,  Source
cell division cycle 25A15209-0.915-0.3709Yes
142DCLRE1BNADCLRE1B
Entrez,  Source
DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)15227-0.922-0.3653Yes
143NAA38NA15229-0.923-0.3588Yes
144MAD2L1NAMAD2L1
Entrez,  Source
MAD2 mitotic arrest deficient-like 1 (yeast)15344-0.954-0.3584Yes
145GINS1NAGINS1
Entrez,  Source
GINS complex subunit 1 (Psf1 homolog)15363-0.959-0.3526Yes
146NUP107NANUP107
Entrez,  Source
nucleoporin 107kDa15399-0.968-0.3476Yes
147BRCA1NABRCA1
Entrez,  Source
breast cancer 1, early onset15439-0.979-0.3429Yes
148ZW10NAZW10
Entrez,  Source
ZW10, kinetochore associated, homolog (Drosophila)15441-0.980-0.3359Yes
149MCM5NAMCM5
Entrez,  Source
MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)15464-0.988-0.3301Yes
150CDKN2CNACDKN2C
Entrez,  Source
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)15593-1.025-0.3300Yes
151PRPS1NAPRPS1
Entrez,  Source
phosphoribosyl pyrophosphate synthetase 115597-1.027-0.3229Yes
152NASPNANASP
Entrez,  Source
nuclear autoantigenic sperm protein (histone-binding)15623-1.035-0.3169Yes
153MCM2NAMCM2
Entrez,  Source
MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae)15624-1.036-0.3096Yes
154PLK4NAPLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)15631-1.039-0.3025Yes
155SMC6NASMC6
Entrez,  Source
structural maintenance of chromosomes 615672-1.054-0.2972Yes
156NBNNANBN
Entrez,  Source
nibrin15782-1.087-0.2956Yes
157ORC6NA15806-1.098-0.2891Yes
158SMC4NASMC4
Entrez,  Source
structural maintenance of chromosomes 415859-1.120-0.2841Yes
159MLH1NAMLH1
Entrez,  Source
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)15889-1.132-0.2776Yes
160E2F8NAE2F8
Entrez,  Source
E2F transcription factor 815977-1.163-0.2742Yes
161TIPINNATIPIN
Entrez,  Source
TIMELESS interacting protein15978-1.164-0.2660Yes
162DUTNADUT
Entrez,  Source
dUTP pyrophosphatase16000-1.177-0.2588Yes
163IPO7NAIPO7
Entrez,  Source
importin 716003-1.177-0.2505Yes
164CHEK2NACHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)16039-1.190-0.2440Yes
165WDR90NAWDR90
Entrez,  Source
WD repeat domain 9016089-1.209-0.2381Yes
166STAG1NASTAG1
Entrez,  Source
stromal antigen 116118-1.222-0.2310Yes
167HMGB2NAHMGB2
Entrez,  Source
high-mobility group box 216136-1.232-0.2232Yes
168KIF22NAKIF22
Entrez,  Source
kinesin family member 2216180-1.250-0.2167Yes
169PSIP1NAPSIP1
Entrez,  Source
PC4 and SFRS1 interacting protein 116189-1.252-0.2083Yes
170DSCC1NA16355-1.338-0.2080Yes
171LIG1NALIG1
Entrez,  Source
ligase I, DNA, ATP-dependent16383-1.354-0.1999Yes
172PAN2NA16402-1.365-0.1912Yes
173WEE1NAWEE1
Entrez,  Source
WEE1 homolog (S. pombe)16440-1.384-0.1834Yes
174SMC3NASMC3
Entrez,  Source
structural maintenance of chromosomes 316499-1.412-0.1766Yes
175CITNACIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)16602-1.471-0.1719Yes
176CDK1NA16637-1.491-0.1632Yes
177SHMT1NASHMT1
Entrez,  Source
serine hydroxymethyltransferase 1 (soluble)16673-1.515-0.1544Yes
178SYNCRIPNASYNCRIP
Entrez,  Source
synaptotagmin binding, cytoplasmic RNA interacting protein16677-1.516-0.1438Yes
179NUDT21NANUDT21
Entrez,  Source
nudix (nucleoside diphosphate linked moiety X)-type motif 2116711-1.538-0.1347Yes
180DCTPP1NA16757-1.567-0.1260Yes
181XPO1NAXPO1
Entrez,  Source
exportin 1 (CRM1 homolog, yeast)16773-1.582-0.1156Yes
182CCNB2NACCNB2
Entrez,  Source
cyclin B216828-1.630-0.1071Yes
183MKI67NAMKI67
Entrez,  Source
antigen identified by monoclonal antibody Ki-6716911-1.689-0.0996Yes
184AURKBNAAURKB
Entrez,  Source
aurora kinase B17006-1.776-0.0923Yes
185RFC3NARFC3
Entrez,  Source
replication factor C (activator 1) 3, 38kDa17031-1.799-0.0808Yes
186NOLC1NANOLC1
Entrez,  Source
nucleolar and coiled-body phosphoprotein 117035-1.802-0.0682Yes
187EXOSC8NAEXOSC8
Entrez,  Source
exosome component 817073-1.837-0.0572Yes
188DIAPH3NADIAPH3
Entrez,  Source
diaphanous homolog 3 (Drosophila)17169-1.969-0.0485Yes
189POLE4NAPOLE4
Entrez,  Source
polymerase (DNA-directed), epsilon 4 (p12 subunit)17248-2.078-0.0381Yes
190PDS5BNA17253-2.088-0.0235Yes
191HMMRNAHMMR
Entrez,  Source
hyaluronan-mediated motility receptor (RHAMM)17255-2.092-0.0086Yes
192MTHFD2NAMTHFD2
Entrez,  Source
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase17262-2.1010.0060Yes
193TP53NATP53
Entrez,  Source
tumor protein p53 (Li-Fraumeni syndrome)17294-2.1520.0196Yes
194BRCA2NABRCA2
Entrez,  Source
breast cancer 2, early onset17561-2.6140.0232Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_E2F_TARGETS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_E2F_TARGETS: Random ES distribution   
Gene set null distribution of ES for HALLMARK_E2F_TARGETS