Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_DNA_REPAIR
Enrichment Score (ES)-0.35037795
Normalized Enrichment Score (NES)-1.4952786
Nominal p-value0.0037313432
FDR q-value0.022582354
FWER p-Value0.093
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_DNA_REPAIR   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1NPR2NANPR2
Entrez,  Source
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)6852.749-0.0128No
2RFC4NARFC4
Entrez,  Source
replication factor C (activator 1) 4, 37kDa7512.6360.0082No
3POLBNAPOLB
Entrez,  Source
polymerase (DNA directed), beta8412.4880.0264No
4POLR2HNAPOLR2H
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide H10422.2420.0361No
5CMPK2NA12871.9430.0406No
6BRF2NABRF2
Entrez,  Source
BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like14111.8340.0508No
7POLHNAPOLH
Entrez,  Source
polymerase (DNA directed), eta15581.7170.0586No
8CDANACDA
Entrez,  Source
cytidine deaminase17051.5980.0654No
9NUDT9NANUDT9
Entrez,  Source
nudix (nucleoside diphosphate linked moiety X)-type motif 919821.4300.0632No
10SURF1NASURF1
Entrez,  Source
surfeit 122611.2750.0596No
11POLR2DNAPOLR2D
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide D23641.2280.0653No
12GMPR2NAGMPR2
Entrez,  Source
guanosine monophosphate reductase 230230.9840.0376No
13STX3NASTX3
Entrez,  Source
syntaxin 338220.8050.0003No
14NME3NANME3
Entrez,  Source
non-metastatic cells 3, protein expressed in39830.765-0.0015No
15DAD1NADAD1
Entrez,  Source
defender against cell death 139910.7640.0053No
16SNAPC5NASNAPC5
Entrez,  Source
small nuclear RNA activating complex, polypeptide 5, 19kDa40330.7550.0100No
17POLR1CNAPOLR1C
Entrez,  Source
polymerase (RNA) I polypeptide C, 30kDa42760.7070.0030No
18TAF13NATAF13
Entrez,  Source
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa43550.6890.0051No
19GPX4NAGPX4
Entrez,  Source
glutathione peroxidase 4 (phospholipid hydroperoxidase)48090.592-0.0148No
20ERCC3NAERCC3
Entrez,  Source
excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)49390.570-0.0167No
21VPS37BNAVPS37B
Entrez,  Source
vacuolar protein sorting 37 homolog B (S. cerevisiae)49650.565-0.0128No
22POLR2ANAPOLR2A
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa52120.516-0.0218No
23DCTN4NADCTN4
Entrez,  Source
dynactin 4 (p62)52230.513-0.0176No
24VPS37DNAVPS37D
Entrez,  Source
vacuolar protein sorting 37 homolog D (S. cerevisiae)54450.484-0.0255No
25TAF6NATAF6
Entrez,  Source
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa56520.452-0.0328No
26SMAD5NASMAD5
Entrez,  Source
SMAD, mothers against DPP homolog 5 (Drosophila)60820.416-0.0530No
27ADRM1NAADRM1
Entrez,  Source
adhesion regulating molecule 162080.414-0.0561No
28CANT1NACANT1
Entrez,  Source
calcium activated nucleotidase 163300.392-0.0592No
29RRM2BNARRM2B
Entrez,  Source
ribonucleotide reductase M2 B (TP53 inducible)63890.383-0.0589No
30ZNF707NAZNF707
Entrez,  Source
zinc finger protein 70765220.363-0.0629No
31AK3NAAK3
Entrez,  Source
adenylate kinase 365550.358-0.0614No
32ZNRD1NAZNRD1
Entrez,  Source
zinc ribbon domain containing 168760.309-0.0764No
33SUPT5HNASUPT5H
Entrez,  Source
suppressor of Ty 5 homolog (S. cerevisiae)70590.280-0.0840No
34SEC61A1NASEC61A1
Entrez,  Source
Sec61 alpha 1 subunit (S. cerevisiae)75800.201-0.1113No
35PDE6GNAPDE6G
Entrez,  Source
phosphodiesterase 6G, cGMP-specific, rod, gamma78380.167-0.1241No
36TAF10NATAF10
Entrez,  Source
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa80670.137-0.1357No
37CETN2NACETN2
Entrez,  Source
centrin, EF-hand protein, 281010.133-0.1363No
38ADCY6NAADCY6
Entrez,  Source
adenylate cyclase 681970.120-0.1405No
39POLLNAPOLL
Entrez,  Source
polymerase (DNA directed), lambda82390.115-0.1417No
40EDF1NAEDF1
Entrez,  Source
endothelial differentiation-related factor 183910.095-0.1493No
41POM121NAPOM121
Entrez,  Source
POM121 membrane glycoprotein (rat)84350.089-0.1509No
42TAF12NATAF12
Entrez,  Source
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa84370.088-0.1501No
43ITPANAITPA
Entrez,  Source
inosine triphosphatase (nucleoside triphosphate pyrophosphatase)84750.084-0.1514No
44DFNA5NADFNA5
Entrez,  Source
deafness, autosomal dominant 586610.058-0.1612No
45GTF2H1NAGTF2H1
Entrez,  Source
general transcription factor IIH, polypeptide 1, 62kDa86620.058-0.1607No
46UPF3BNAUPF3B
Entrez,  Source
UPF3 regulator of nonsense transcripts homolog B (yeast)87570.043-0.1655No
47CCNONA89380.022-0.1754No
48TAF9NATAF9
Entrez,  Source
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa89490.021-0.1758No
49NCBP2NANCBP2
Entrez,  Source
nuclear cap binding protein subunit 2, 20kDa91250.008-0.1855No
50SAC3D1NASAC3D1
Entrez,  Source
SAC3 domain containing 191310.007-0.1857No
51AK1NAAK1
Entrez,  Source
adenylate kinase 191320.007-0.1857No
52SDCBPNASDCBP
Entrez,  Source
syndecan binding protein (syntenin)9416-0.002-0.2015No
53ARL6IP1NAARL6IP1
Entrez,  Source
ADP-ribosylation factor-like 6 interacting protein 19524-0.019-0.2074No
54DGCR8NADGCR8
Entrez,  Source
DiGeorge syndrome critical region gene 89556-0.023-0.2089No
55RFC2NARFC2
Entrez,  Source
replication factor C (activator 1) 2, 40kDa9589-0.028-0.2104No
56GTF2F1NAGTF2F1
Entrez,  Source
general transcription factor IIF, polypeptide 1, 74kDa9844-0.057-0.2241No
57TARBP2NATARBP2
Entrez,  Source
Tar (HIV-1) RNA binding protein 29889-0.063-0.2260No
58EIF1BNAEIF1B
Entrez,  Source
eukaryotic translation initiation factor 1B10366-0.105-0.2517No
59POLR2CNAPOLR2C
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide C, 33kDa10372-0.106-0.2510No
60POLR2ENAPOLR2E
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa10876-0.180-0.2775No
61RPA2NARPA2
Entrez,  Source
replication protein A2, 32kDa10881-0.181-0.2761No
62NFX1NANFX1
Entrez,  Source
nuclear transcription factor, X-box binding 110905-0.185-0.2756No
63TMED2NATMED2
Entrez,  Source
transmembrane emp24 domain trafficking protein 211224-0.229-0.2913No
64POLR2JNAPOLR2J
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa11282-0.237-0.2923No
65MRPL40NAMRPL40
Entrez,  Source
mitochondrial ribosomal protein L4011360-0.247-0.2943No
66DDB1NADDB1
Entrez,  Source
damage-specific DNA binding protein 1, 127kDa11402-0.254-0.2942No
67ERCC4NAERCC4
Entrez,  Source
excision repair cross-complementing rodent repair deficiency, complementation group 411458-0.264-0.2949No
68SUPT4H1NASUPT4H1
Entrez,  Source
suppressor of Ty 4 homolog 1 (S. cerevisiae)11536-0.276-0.2966No
69RBX1NARBX1
Entrez,  Source
ring-box 111557-0.279-0.2951No
70DDB2NADDB2
Entrez,  Source
damage-specific DNA binding protein 2, 48kDa11578-0.282-0.2936No
71SNAPC4NASNAPC4
Entrez,  Source
small nuclear RNA activating complex, polypeptide 4, 190kDa11612-0.285-0.2928No
72POLR3GLNAPOLR3GL
Entrez,  Source
polymerase (RNA) III (DNA directed) polypeptide G (32kD) like11684-0.292-0.2940No
73VPS28NAVPS28
Entrez,  Source
vacuolar protein sorting 28 homolog (S. cerevisiae)11873-0.324-0.3016No
74GTF3C5NAGTF3C5
Entrez,  Source
general transcription factor IIIC, polypeptide 5, 63kDa11931-0.329-0.3017No
75TK2NATK2
Entrez,  Source
thymidine kinase 2, mitochondrial12046-0.345-0.3048No
76POLR3CNAPOLR3C
Entrez,  Source
polymerase (RNA) III (DNA directed) polypeptide C (62kD)12056-0.347-0.3021No
77USP11NAUSP11
Entrez,  Source
ubiquitin specific peptidase 1112076-0.350-0.2999No
78RNMTNARNMT
Entrez,  Source
RNA (guanine-7-) methyltransferase12275-0.379-0.3075No
79POLR2INAPOLR2I
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa12366-0.393-0.3089No
80POLR2GNAPOLR2G
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide G12688-0.432-0.3228No
81CSTF3NACSTF3
Entrez,  Source
cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa13096-0.471-0.3412No
82ZWINTNAZWINT
Entrez,  Source
ZW10 interactor13135-0.479-0.3389No
83TSG101NATSG101
Entrez,  Source
tumor susceptibility gene 10113232-0.494-0.3397No
84PCNANAPCNA
Entrez,  Source
proliferating cell nuclear antigen13241-0.495-0.3355No
85NME1NANME1
Entrez,  Source
non-metastatic cells 1, protein (NM23A) expressed in13507-0.537-0.3454Yes
86GTF2BNAGTF2B
Entrez,  Source
general transcription factor IIB13538-0.544-0.3420Yes
87GTF2H5NAGTF2H5
Entrez,  Source
general transcription factor IIH, polypeptide 513579-0.554-0.3390Yes
88RAE1NARAE1
Entrez,  Source
RAE1 RNA export 1 homolog (S. pombe)13593-0.556-0.3346Yes
89SSRP1NASSRP1
Entrez,  Source
structure specific recognition protein 113610-0.560-0.3302Yes
90PDE4BNAPDE4B
Entrez,  Source
phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)13627-0.563-0.3259Yes
91RAD52NARAD52
Entrez,  Source
RAD52 homolog (S. cerevisiae)13701-0.576-0.3246Yes
92CLP1NA13736-0.583-0.3211Yes
93RAD51NARAD51
Entrez,  Source
RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)13792-0.593-0.3186Yes
94POLD1NAPOLD1
Entrez,  Source
polymerase (DNA directed), delta 1, catalytic subunit 125kDa13802-0.595-0.3136Yes
95POLD4NAPOLD4
Entrez,  Source
polymerase (DNA-directed), delta 413855-0.605-0.3108Yes
96ERCC5NAERCC5
Entrez,  Source
me))13876-0.610-0.3063Yes
97ERCC8NAERCC8
Entrez,  Source
excision repair cross-complementing rodent repair deficiency, complementation group 813949-0.623-0.3045Yes
98POLA2NAPOLA2
Entrez,  Source
polymerase (DNA directed), alpha 2 (70kD subunit)13950-0.623-0.2987Yes
99RFC5NARFC5
Entrez,  Source
replication factor C (activator 1) 5, 36.5kDa14006-0.636-0.2958Yes
100BCAP31NABCAP31
Entrez,  Source
B-cell receptor-associated protein 3114058-0.649-0.2926Yes
101POLR2FNAPOLR2F
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide F14184-0.679-0.2933Yes
102RPA3NARPA3
Entrez,  Source
replication protein A3, 14kDa14239-0.689-0.2899Yes
103GUK1NAGUK1
Entrez,  Source
guanylate kinase 114241-0.689-0.2835Yes
104GTF2H3NAGTF2H3
Entrez,  Source
general transcription factor IIH, polypeptide 3, 34kDa14472-0.748-0.2894Yes
105PRIM1NAPRIM1
Entrez,  Source
primase, polypeptide 1, 49kDa14500-0.753-0.2839Yes
106POLD3NAPOLD3
Entrez,  Source
polymerase (DNA-directed), delta 3, accessory subunit14617-0.783-0.2831Yes
107ELLNAELL
Entrez,  Source
elongation factor RNA polymerase II14637-0.785-0.2769Yes
108SRSF6NA14702-0.803-0.2730Yes
109IMPDH2NAIMPDH2
Entrez,  Source
IMP (inosine monophosphate) dehydrogenase 214815-0.830-0.2715Yes
110TYMSNATYMS
Entrez,  Source
thymidylate synthetase14865-0.838-0.2664Yes
111POLR2KNAPOLR2K
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa15039-0.877-0.2679Yes
112NT5CNANT5C
Entrez,  Source
5', 3'-nucleotidase, cytosolic15278-0.934-0.2726Yes
113GTF2A2NAGTF2A2
Entrez,  Source
general transcription factor IIA, 2, 12kDa15293-0.941-0.2646Yes
114UMPSNAUMPS
Entrez,  Source
uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)15323-0.947-0.2573Yes
115TAF1CNATAF1C
Entrez,  Source
TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa15384-0.965-0.2517Yes
116HPRT1NAHPRT1
Entrez,  Source
hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome)15561-1.015-0.2521Yes
117FEN1NAFEN1
Entrez,  Source
flap structure-specific endonuclease 115662-1.051-0.2479Yes
118POLA1NAPOLA1
Entrez,  Source
polymerase (DNA directed), alpha 115670-1.054-0.2385Yes
119XPCNAXPC
Entrez,  Source
xeroderma pigmentosum, complementation group C15685-1.057-0.2294Yes
120RALANARALA
Entrez,  Source
v-ral simian leukemia viral oncogene homolog A (ras related)15722-1.068-0.2214Yes
121APRTNAAPRT
Entrez,  Source
adenine phosphoribosyltransferase15815-1.102-0.2163Yes
122AAASNAAAAS
Entrez,  Source
achalasia, adrenocortical insufficiency, alacrimia (Allgrove, triple-A)15995-1.174-0.2154Yes
123DUTNADUT
Entrez,  Source
dUTP pyrophosphatase16000-1.177-0.2046Yes
124ERCC1NAERCC1
Entrez,  Source
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)16032-1.189-0.1953Yes
125REV3LNAREV3L
Entrez,  Source
REV3-like, catalytic subunit of DNA polymerase zeta (yeast)16293-1.303-0.1977Yes
126ERCC2NAERCC2
Entrez,  Source
excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)16327-1.321-0.1872Yes
127LIG1NALIG1
Entrez,  Source
ligase I, DNA, ATP-dependent16383-1.354-0.1777Yes
128PNPNA16529-1.430-0.1724Yes
129MPGNAMPG
Entrez,  Source
N-methylpurine-DNA glycosylase16606-1.472-0.1630Yes
130COX17NACOX17
Entrez,  Source
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)16607-1.474-0.1492Yes
131NUDT21NANUDT21
Entrez,  Source
nudix (nucleoside diphosphate linked moiety X)-type motif 2116711-1.538-0.1406Yes
132NME4NANME4
Entrez,  Source
non-metastatic cells 4, protein expressed in16754-1.566-0.1284Yes
133SF3A3NASF3A3
Entrez,  Source
splicing factor 3a, subunit 3, 60kDa16797-1.600-0.1158Yes
134BCAMNABCAM
Entrez,  Source
basal cell adhesion molecule (Lutheran blood group)16834-1.637-0.1025Yes
135RFC3NARFC3
Entrez,  Source
replication factor C (activator 1) 3, 38kDa17031-1.799-0.0967Yes
136POLR1DNAPOLR1D
Entrez,  Source
polymerase (RNA) I polypeptide D, 16kDa17148-1.928-0.0853Yes
137POLE4NAPOLE4
Entrez,  Source
polymerase (DNA-directed), epsilon 4 (p12 subunit)17248-2.078-0.0714Yes
138TP53NATP53
Entrez,  Source
tumor protein p53 (Li-Fraumeni syndrome)17294-2.152-0.0538Yes
139ADANAADA
Entrez,  Source
adenosine deaminase17404-2.332-0.0382Yes
140DGUOKNADGUOK
Entrez,  Source
deoxyguanosine kinase17534-2.567-0.0215Yes
141HCLS1NAHCLS1
Entrez,  Source
hematopoietic cell-specific Lyn substrate 117963-4.9380.0006Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_DNA_REPAIR   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_DNA_REPAIR: Random ES distribution   
Gene set null distribution of ES for HALLMARK_DNA_REPAIR