Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1w6a
GeneSetHALLMARK_COMPLEMENT
Enrichment Score (ES)0.40389878
Normalized Enrichment Score (NES)1.5618637
Nominal p-value0.0025806453
FDR q-value0.009229267
FWER p-Value0.114
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_COMPLEMENT   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1C4BPBNAC4BPB
Entrez,  Source
complement component 4 binding protein, beta114.9500.0216Yes
2SERPINB2NASERPINB2
Entrez,  Source
serpin peptidase inhibitor, clade B (ovalbumin), member 2494.7260.0407Yes
3IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)1484.3010.0544Yes
4DPP4NADPP4
Entrez,  Source
dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2)2134.0830.0691Yes
5C2NAC2
Entrez,  Source
complement component 22713.8330.0831Yes
6CASP1NACASP1
Entrez,  Source
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)3023.7320.0981Yes
7ZFPM2NAZFPM2
Entrez,  Source
zinc finger protein, multitype 23683.5240.1103Yes
8CD55NACD55
Entrez,  Source
CD55 molecule, decay accelerating factor for complement (Cromer blood group)4313.3620.1218Yes
9CTSDNACTSD
Entrez,  Source
cathepsin D (lysosomal aspartyl peptidase)4763.2650.1340Yes
10CR2NACR2
Entrez,  Source
complement component (3d/Epstein Barr virus) receptor 25103.1610.1463Yes
11PLATNAPLAT
Entrez,  Source
plasminogen activator, tissue5163.1470.1601Yes
12CFHNACFH
Entrez,  Source
complement factor H5812.9800.1699Yes
13SERPINE1NASERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 16202.9100.1808Yes
14KYNUNAKYNU
Entrez,  Source
kynureninase (L-kynurenine hydrolase)6752.7810.1902Yes
15PIK3CANAPIK3CA
Entrez,  Source
phosphoinositide-3-kinase, catalytic, alpha polypeptide6932.7340.2015Yes
16C1RNAC1R
Entrez,  Source
complement component 1, r subcomponent6942.7340.2137Yes
17CA2NACA2
Entrez,  Source
carbonic anhydrase II7372.6530.2233Yes
18CTSBNACTSB
Entrez,  Source
cathepsin B7392.6510.2351Yes
19GNB4NAGNB4
Entrez,  Source
guanine nucleotide binding protein (G protein), beta polypeptide 47782.5920.2446Yes
20ADAM9NAADAM9
Entrez,  Source
ADAM metallopeptidase domain 9 (meltrin gamma)8402.4880.2523Yes
21F3NAF3
Entrez,  Source
coagulation factor III (thromboplastin, tissue factor)8762.4380.2612Yes
22L3MBTL4NAL3MBTL4
Entrez,  Source
l(3)mbt-like 4 (Drosophila)9022.4070.2706Yes
23SERPING1NASERPING1
Entrez,  Source
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)9932.2940.2758Yes
24LRP1NALRP1
Entrez,  Source
low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)10132.2760.2850Yes
25PPP2CBNAPPP2CB
Entrez,  Source
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform10162.2740.2951Yes
26IRF7NAIRF7
Entrez,  Source
interferon regulatory factor 710582.2150.3027Yes
27CASP9NACASP9
Entrez,  Source
caspase 9, apoptosis-related cysteine peptidase10812.1920.3113Yes
28PHEXNAPHEX
Entrez,  Source
phosphate regulating endopeptidase homolog, X-linked (hypophosphatemia, vitamin D resistant rickets)10912.1800.3205Yes
29CFBNACFB
Entrez,  Source
complement factor B11972.0410.3238Yes
30MMP14NAMMP14
Entrez,  Source
matrix metallopeptidase 14 (membrane-inserted)12022.0380.3327Yes
31CASP10NACASP10
Entrez,  Source
caspase 10, apoptosis-related cysteine peptidase13391.8950.3335Yes
32CPMNACPM
Entrez,  Source
carboxypeptidase M14041.8410.3382Yes
33TIMP2NATIMP2
Entrez,  Source
TIMP metallopeptidase inhibitor 214211.8260.3454Yes
34TMPRSS6NATMPRSS6
Entrez,  Source
transmembrane protease, serine 614251.8230.3534Yes
35HSPA1ANAHSPA1A
Entrez,  Source
heat shock 70kDa protein 1A16141.6750.3504Yes
36CDANACDA
Entrez,  Source
cytidine deaminase17051.5980.3525Yes
37GPD2NAGPD2
Entrez,  Source
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)18301.5110.3523Yes
38PLGNAPLG
Entrez,  Source
plasminogen18571.4940.3575Yes
39ERAP2NA18891.4770.3624Yes
40PRCPNAPRCP
Entrez,  Source
prolylcarboxypeptidase (angiotensinase C)20021.4200.3625Yes
41LTFNALTF
Entrez,  Source
lactotransferrin20271.4090.3674Yes
42TFPI2NATFPI2
Entrez,  Source
tissue factor pathway inhibitor 220681.3820.3714Yes
43BRPF3NABRPF3
Entrez,  Source
bromodomain and PHD finger containing, 322591.2760.3664Yes
44CDK5R1NACDK5R1
Entrez,  Source
cyclin-dependent kinase 5, regulatory subunit 1 (p35)22851.2620.3706Yes
45RABIFNARABIF
Entrez,  Source
RAB interacting factor23311.2420.3737Yes
46PIM1NAPIM1
Entrez,  Source
pim-1 oncogene23671.2270.3772Yes
47CR1NACR1
Entrez,  Source
complement component (3b/4b) receptor 1 (Knops blood group)24141.2100.3801Yes
48CEBPBNACEBPB
Entrez,  Source
CCAAT/enhancer binding protein (C/EBP), beta24221.2060.3851Yes
49PSEN1NAPSEN1
Entrez,  Source
presenilin 1 (Alzheimer disease 3)24261.2030.3903Yes
50IRF1NAIRF1
Entrez,  Source
interferon regulatory factor 124391.1970.3950Yes
51HSPA5NAHSPA5
Entrez,  Source
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)25431.1610.3944Yes
52CBLBNACBLB
Entrez,  Source
Cas-Br-M (murine) ecotropic retroviral transforming sequence b26901.1010.3911Yes
53DUSP6NADUSP6
Entrez,  Source
dual specificity phosphatase 627221.0910.3942Yes
54KCNIP3NAKCNIP3
Entrez,  Source
Kv channel interacting protein 3, calsenilin27461.0810.3978Yes
55CPNACP
Entrez,  Source
ceruloplasmin (ferroxidase)28491.0440.3967Yes
56STX4NASTX4
Entrez,  Source
syntaxin 428711.0390.4002Yes
57LGMNNALGMN
Entrez,  Source
legumain29481.0060.4005Yes
58RASGRP1NARASGRP1
Entrez,  Source
RAS guanyl releasing protein 1 (calcium and DAG-regulated)30190.9860.4009Yes
59MMP15NAMMP15
Entrez,  Source
matrix metallopeptidase 15 (membrane-inserted)30450.9750.4039Yes
60TIMP1NATIMP1
Entrez,  Source
TIMP metallopeptidase inhibitor 132840.9170.3946No
61C1SNAC1S
Entrez,  Source
complement component 1, s subcomponent38470.8000.3666No
62DOCK10NADOCK10
Entrez,  Source
dedicator of cytokinesis 1038680.7950.3691No
63ANXA5NAANXA5
Entrez,  Source
annexin A539030.7840.3707No
64RNF4NARNF4
Entrez,  Source
ring finger protein 442390.7130.3550No
65JAK2NAJAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)43250.6960.3534No
66WASNAWAS
Entrez,  Source
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)43470.6900.3553No
67EHD1NAEHD1
Entrez,  Source
EH-domain containing 145130.6540.3489No
68PCLONAPCLO
Entrez,  Source
piccolo (presynaptic cytomatrix protein)46020.6380.3468No
69CCL5NACCL5
Entrez,  Source
chemokine (C-C motif) ligand 546740.6240.3456No
70APOBEC3GNAAPOBEC3G
Entrez,  Source
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G46990.6160.3471No
71LAP3NALAP3
Entrez,  Source
leucine aminopeptidase 347520.6060.3468No
72LGALS3NALGALS3
Entrez,  Source
lectin, galactoside-binding, soluble, 3 (galectin 3)47780.5990.3481No
73F5NAF5
Entrez,  Source
coagulation factor V (proaccelerin, labile factor)51260.5310.3310No
74PRDM4NAPRDM4
Entrez,  Source
PR domain containing 451740.5230.3307No
75CTSONACTSO
Entrez,  Source
cathepsin O52450.5100.3290No
76CD46NACD46
Entrez,  Source
CD46 molecule, complement regulatory protein54680.4830.3187No
77LCP2NALCP2
Entrez,  Source
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)55820.4630.3144No
78RCE1NARCE1
Entrez,  Source
RCE1 homolog, prenyl protein peptidase (S. cerevisiae)57050.4430.3096No
79GP1BANAGP1BA
Entrez,  Source
glycoprotein Ib (platelet), alpha polypeptide57170.4410.3109No
80S100A12NAS100A12
Entrez,  Source
S100 calcium binding protein A1259770.4180.2982No
81FCN1NAFCN1
Entrez,  Source
ficolin (collagen/fibrinogen domain containing) 160300.4180.2972No
82HNF4ANAHNF4A
Entrez,  Source
hepatocyte nuclear factor 4, alpha62360.4090.2875No
83PCSK9NAPCSK9
Entrez,  Source
proprotein convertase subtilisin/kexin type 962610.4050.2880No
84FYNNAFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES63280.3930.2860No
85GATA3NAGATA3
Entrez,  Source
GATA binding protein 363580.3890.2861No
86GP9NAGP9
Entrez,  Source
glycoprotein IX (platelet)66090.3490.2736No
87USP14NAUSP14
Entrez,  Source
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)66420.3430.2734No
88SIRT6NASIRT6
Entrez,  Source
sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)67690.3250.2677No
89ATOX1NAATOX1
Entrez,  Source
ATX1 antioxidant protein 1 homolog (yeast)69370.3000.2597No
90RHOGNARHOG
Entrez,  Source
ras homolog gene family, member G (rho G)69470.2980.2605No
91CASP7NACASP7
Entrez,  Source
caspase 7, apoptosis-related cysteine peptidase70710.2780.2549No
92USP15NAUSP15
Entrez,  Source
ubiquitin specific peptidase 1572340.2530.2469No
93CALM1NACALM1
Entrez,  Source
calmodulin 1 (phosphorylase kinase, delta)73560.2330.2411No
94CASP5NACASP5
Entrez,  Source
caspase 5, apoptosis-related cysteine peptidase73830.2290.2407No
95LAMP2NALAMP2
Entrez,  Source
lysosomal-associated membrane protein 276160.1960.2285No
96PLAURNAPLAUR
Entrez,  Source
plasminogen activator, urokinase receptor76760.1880.2261No
97MMP13NAMMP13
Entrez,  Source
matrix metallopeptidase 13 (collagenase 3)76770.1880.2269No
98SH2B3NASH2B3
Entrez,  Source
SH2B adaptor protein 378660.1640.2171No
99SCG3NASCG3
Entrez,  Source
secretogranin III78920.1590.2164No
100PLA2G7NAPLA2G7
Entrez,  Source
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)79200.1550.2155No
101FDX1NAFDX1
Entrez,  Source
ferredoxin 181350.1280.2041No
102C9NAC9
Entrez,  Source
complement component 981680.1250.2028No
103ADRA2BNAADRA2B
Entrez,  Source
adrenergic, alpha-2B-, receptor82700.1110.1977No
104CSRP1NACSRP1
Entrez,  Source
cysteine and glycine-rich protein 184080.0920.1904No
105CTSCNACTSC
Entrez,  Source
cathepsin C87070.0510.1739No
106VCPIP1NAVCPIP1
Entrez,  Source
valosin containing protein (p97)/p47 complex interacting protein 190800.0090.1530No
107LIPANALIPA
Entrez,  Source
lipase A, lysosomal acid, cholesterol esterase (Wolman disease)91200.0080.1508No
108APOA4NAAPOA4
Entrez,  Source
apolipoprotein A-IV91910.0000.1469No
109GZMKNAGZMK
Entrez,  Source
granzyme K (granzyme 3; tryptase II)92340.0000.1445No
110CD36NACD36
Entrez,  Source
CD36 molecule (thrombospondin receptor)9407-0.0000.1349No
111CD59NACD59
Entrez,  Source
CD59 molecule, complement regulatory protein9435-0.0050.1334No
112F10NAF10
Entrez,  Source
coagulation factor X9456-0.0070.1323No
113MMP8NAMMP8
Entrez,  Source
matrix metallopeptidase 8 (neutrophil collagenase)9576-0.0260.1257No
114APOBEC3FNAAPOBEC3F
Entrez,  Source
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F9658-0.0380.1213No
115DUSP5NADUSP5
Entrez,  Source
dual specificity phosphatase 59791-0.0510.1141No
116GZMANAGZMA
Entrez,  Source
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)9874-0.0620.1098No
117ME1NAME1
Entrez,  Source
malic enzyme 1, NADP(+)-dependent, cytosolic10031-0.0720.1013No
118LYNNALYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog10237-0.0910.0902No
119F7NAF7
Entrez,  Source
coagulation factor VII (serum prothrombin conversion accelerator)10325-0.0990.0858No
120KCNIP2NAKCNIP2
Entrez,  Source
Kv channel interacting protein 210423-0.1130.0808No
121GNB2NAGNB2
Entrez,  Source
guanine nucleotide binding protein (G protein), beta polypeptide 210498-0.1240.0772No
122SRCNASRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10694-0.1540.0669No
123LTA4HNALTA4H
Entrez,  Source
leukotriene A4 hydrolase10705-0.1550.0671No
124GNAI3NAGNAI3
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 310843-0.1760.0602No
125DGKGNADGKG
Entrez,  Source
diacylglycerol kinase, gamma 90kDa10937-0.1890.0558No
126MMP12NAMMP12
Entrez,  Source
matrix metallopeptidase 12 (macrophage elastase)11095-0.2110.0479No
127KLKB1NAKLKB1
Entrez,  Source
kallikrein B, plasma (Fletcher factor) 111119-0.2140.0476No
128PRSS36NAPRSS36
Entrez,  Source
protease, serine, 3611183-0.2250.0450No
129PIK3R5NAPIK3R5
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 5, p10111218-0.2280.0441No
130PLEKNAPLEK
Entrez,  Source
pleckstrin11478-0.2680.0308No
131AKAP10NAAKAP10
Entrez,  Source
A kinase (PRKA) anchor protein 1011613-0.2850.0245No
132ANGNAANG
Entrez,  Source
angiogenin, ribonuclease, RNase A family, 511634-0.2880.0247No
133KLK1NAKLK1
Entrez,  Source
kallikrein 1, renal/pancreas/salivary11895-0.3270.0115No
134PPP4CNAPPP4C
Entrez,  Source
protein phosphatase 4 (formerly X), catalytic subunit11964-0.3340.0092No
135GRB2NAGRB2
Entrez,  Source
growth factor receptor-bound protein 212041-0.3440.0065No
136OLR1NAOLR1
Entrez,  Source
oxidised low density lipoprotein (lectin-like) receptor 112060-0.3470.0070No
137PSMB9NAPSMB9
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)12068-0.3490.0082No
138PDP1NA12121-0.3570.0069No
139DOCK9NADOCK9
Entrez,  Source
dedicator of cytokinesis 912274-0.3790.0000No
140CD40LGNACD40LG
Entrez,  Source
CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome)12489-0.411-0.0102No
141FN1NAFN1
Entrez,  Source
fibronectin 112699-0.434-0.0200No
142RAF1NARAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 112700-0.434-0.0180No
143IRF2NAIRF2
Entrez,  Source
interferon regulatory factor 212738-0.441-0.0181No
144CALM3NACALM3
Entrez,  Source
calmodulin 3 (phosphorylase kinase, delta)12891-0.450-0.0247No
145S100A13NAS100A13
Entrez,  Source
S100 calcium binding protein A1312976-0.452-0.0274No
146MAFFNAMAFF
Entrez,  Source
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)13007-0.456-0.0270No
147F8NAF8
Entrez,  Source
coagulation factor VIII, procoagulant component (hemophilia A)13126-0.477-0.0315No
148HPCAL4NAHPCAL4
Entrez,  Source
hippocalcin like 413206-0.490-0.0337No
149SPOCK2NASPOCK2
Entrez,  Source
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 213299-0.503-0.0367No
150GMFBNAGMFB
Entrez,  Source
glia maturation factor, beta13373-0.514-0.0385No
151DYRK2NADYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 213472-0.530-0.0416No
152KIF2ANAKIF2A
Entrez,  Source
kinesin heavy chain member 2A13493-0.534-0.0403No
153SERPINC1NASERPINC1
Entrez,  Source
serpin peptidase inhibitor, clade C (antithrombin), member 113702-0.576-0.0494No
154CASP4NACASP4
Entrez,  Source
caspase 4, apoptosis-related cysteine peptidase14105-0.660-0.0691No
155PFN1NAPFN1
Entrez,  Source
profilin 114577-0.772-0.0921No
156USP16NAUSP16
Entrez,  Source
ubiquitin specific peptidase 1614674-0.794-0.0939No
157GNAI2NAGNAI2
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 214733-0.810-0.0936No
158PLA2G4ANAPLA2G4A
Entrez,  Source
phospholipase A2, group IVA (cytosolic, calcium-dependent)14893-0.842-0.0987No
159PRSS3NAPRSS3
Entrez,  Source
protease, serine, 3 (mesotrypsin)15281-0.936-0.1163No
160PLSCR1NAPLSCR1
Entrez,  Source
phospholipid scramblase 115338-0.951-0.1152No
161ITIH1NAITIH1
Entrez,  Source
inter-alpha (globulin) inhibitor H115404-0.969-0.1145No
162ACTN2NAACTN2
Entrez,  Source
actinin, alpha 215457-0.986-0.1130No
163DGKHNADGKH
Entrez,  Source
diacylglycerol kinase, eta15701-1.062-0.1219No
164CTSHNACTSH
Entrez,  Source
cathepsin H15762-1.081-0.1204No
165LCKNALCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase15773-1.086-0.1161No
166ZEB1NA15785-1.089-0.1119No
167GCANAGCA
Entrez,  Source
grancalcin, EF-hand calcium binding protein15895-1.134-0.1129No
168FCER1GNAFCER1G
Entrez,  Source
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide16114-1.221-0.1197No
169APOC1NAAPOC1
Entrez,  Source
apolipoprotein C-I16377-1.349-0.1284No
170XPNPEP1NAXPNPEP1
Entrez,  Source
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble16394-1.360-0.1232No
171PREPNAPREP
Entrez,  Source
prolyl endopeptidase16469-1.399-0.1211No
172TNFAIP3NATNFAIP3
Entrez,  Source
tumor necrosis factor, alpha-induced protein 316490-1.410-0.1159No
173CXCL1NACXCL1
Entrez,  Source
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)16731-1.552-0.1224No
174COL4A2NACOL4A2
Entrez,  Source
collagen, type IV, alpha 216767-1.575-0.1174No
175SERPINA1NASERPINA1
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 116974-1.746-0.1211No
176DOCK4NADOCK4
Entrez,  Source
dedicator of cytokinesis 417099-1.875-0.1197No
177F2NAF2
Entrez,  Source
coagulation factor II (thrombin)17157-1.953-0.1141No
178CASP3NACASP3
Entrez,  Source
caspase 3, apoptosis-related cysteine peptidase17177-1.978-0.1063No
179ITGAMNAITGAM
Entrez,  Source
integrin, alpha M (complement component 3 receptor 3 subunit)17198-2.003-0.0985No
180PRKCDNAPRKCD
Entrez,  Source
protein kinase C, delta17443-2.401-0.1014No
181CDH13NACDH13
Entrez,  Source
cadherin 13, H-cadherin (heart)17527-2.555-0.0947No
182C3NAC3
Entrez,  Source
complement component 317698-3.089-0.0904No
183PDGFBNAPDGFB
Entrez,  Source
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)17712-3.137-0.0771No
184CTSSNACTSS
Entrez,  Source
cathepsin S17772-3.468-0.0648No
185GNG2NAGNG2
Entrez,  Source
guanine nucleotide binding protein (G protein), gamma 217843-3.833-0.0516No
186NOTCH4NANOTCH4
Entrez,  Source
Notch homolog 4 (Drosophila)17862-4.034-0.0345No
187PIK3CGNAPIK3CG
Entrez,  Source
phosphoinositide-3-kinase, catalytic, gamma polypeptide17882-4.130-0.0171No
188GNGT2NAGNGT2
Entrez,  Source
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 217967-4.9540.0004No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_COMPLEMENT   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_COMPLEMENT: Random ES distribution   
Gene set null distribution of ES for HALLMARK_COMPLEMENT