Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | HALLMARK_COAGULATION |
| Enrichment Score (ES) | 0.46332648 |
| Normalized Enrichment Score (NES) | 1.6978259 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0020116298 |
| FWER p-Value | 0.016 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | SERPINB2 | NA | SERPINB2 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 49 | 4.726 | 0.0248 | Yes |
| 2 | CRIP2 | NA | CRIP2 Entrez, Source | cysteine-rich protein 2 | 93 | 4.535 | 0.0487 | Yes |
| 3 | DPP4 | NA | DPP4 Entrez, Source | dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2) | 213 | 4.083 | 0.0658 | Yes |
| 4 | MASP2 | NA | MASP2 Entrez, Source | mannan-binding lectin serine peptidase 2 | 214 | 4.081 | 0.0896 | Yes |
| 5 | C2 | NA | C2 Entrez, Source | complement component 2 | 271 | 3.833 | 0.1088 | Yes |
| 6 | TIMP3 | NA | TIMP3 Entrez, Source | TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 316 | 3.702 | 0.1278 | Yes |
| 7 | F2RL2 | NA | F2RL2 Entrez, Source | coagulation factor II (thrombin) receptor-like 2 | 363 | 3.548 | 0.1459 | Yes |
| 8 | THBD | NA | THBD Entrez, Source | thrombomodulin | 371 | 3.510 | 0.1659 | Yes |
| 9 | ITGA2 | NA | ITGA2 Entrez, Source | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 483 | 3.253 | 0.1787 | Yes |
| 10 | PLAT | NA | PLAT Entrez, Source | plasminogen activator, tissue | 516 | 3.147 | 0.1952 | Yes |
| 11 | CFH | NA | CFH Entrez, Source | complement factor H | 581 | 2.980 | 0.2089 | Yes |
| 12 | PLAU | NA | PLAU Entrez, Source | plasminogen activator, urokinase | 600 | 2.949 | 0.2251 | Yes |
| 13 | SERPINE1 | NA | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 620 | 2.910 | 0.2410 | Yes |
| 14 | C1R | NA | C1R Entrez, Source | complement component 1, r subcomponent | 694 | 2.734 | 0.2528 | Yes |
| 15 | HTRA1 | NA | HTRA1 Entrez, Source | HtrA serine peptidase 1 | 733 | 2.657 | 0.2661 | Yes |
| 16 | CTSB | NA | CTSB Entrez, Source | cathepsin B | 739 | 2.651 | 0.2813 | Yes |
| 17 | CFI | NA | CFI Entrez, Source | complement factor I | 821 | 2.513 | 0.2913 | Yes |
| 18 | ADAM9 | NA | ADAM9 Entrez, Source | ADAM metallopeptidase domain 9 (meltrin gamma) | 840 | 2.488 | 0.3048 | Yes |
| 19 | F3 | NA | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 876 | 2.438 | 0.3170 | Yes |
| 20 | CFD | NA | CFD Entrez, Source | complement factor D (adipsin) | 942 | 2.357 | 0.3271 | Yes |
| 21 | MMP3 | NA | MMP3 Entrez, Source | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 977 | 2.317 | 0.3387 | Yes |
| 22 | SERPING1 | NA | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 993 | 2.294 | 0.3512 | Yes |
| 23 | BMP1 | NA | BMP1 Entrez, Source | bone morphogenetic protein 1 | 1009 | 2.283 | 0.3637 | Yes |
| 24 | LRP1 | NA | LRP1 Entrez, Source | low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) | 1013 | 2.276 | 0.3767 | Yes |
| 25 | CASP9 | NA | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 1081 | 2.192 | 0.3857 | Yes |
| 26 | CFB | NA | CFB Entrez, Source | complement factor B | 1197 | 2.041 | 0.3912 | Yes |
| 27 | MMP14 | NA | MMP14 Entrez, Source | matrix metallopeptidase 14 (membrane-inserted) | 1202 | 2.038 | 0.4028 | Yes |
| 28 | TMPRSS6 | NA | TMPRSS6 Entrez, Source | transmembrane protease, serine 6 | 1425 | 1.823 | 0.4010 | Yes |
| 29 | WDR1 | NA | WDR1 Entrez, Source | WD repeat domain 1 | 1455 | 1.801 | 0.4098 | Yes |
| 30 | FBN1 | NA | FBN1 Entrez, Source | fibrillin 1 | 1458 | 1.798 | 0.4202 | Yes |
| 31 | DUSP14 | NA | DUSP14 Entrez, Source | dual specificity phosphatase 14 | 1774 | 1.542 | 0.4115 | Yes |
| 32 | CD9 | NA | CD9 Entrez, Source | CD9 molecule | 1847 | 1.500 | 0.4162 | Yes |
| 33 | PLG | NA | PLG Entrez, Source | plasminogen | 1857 | 1.494 | 0.4244 | Yes |
| 34 | SH2B2 | NA | SH2B2 Entrez, Source | SH2B adaptor protein 2 | 1989 | 1.424 | 0.4253 | Yes |
| 35 | RGN | NA | RGN Entrez, Source | regucalcin (senescence marker protein-30) | 2061 | 1.385 | 0.4294 | Yes |
| 36 | TFPI2 | NA | TFPI2 Entrez, Source | tissue factor pathway inhibitor 2 | 2068 | 1.382 | 0.4371 | Yes |
| 37 | SPARC | NA | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 2097 | 1.363 | 0.4435 | Yes |
| 38 | PECAM1 | NA | PECAM1 Entrez, Source | platelet/endothelial cell adhesion molecule (CD31 antigen) | 2148 | 1.334 | 0.4484 | Yes |
| 39 | PF4 | NA | PF4 Entrez, Source | platelet factor 4 (chemokine (C-X-C motif) ligand 4) | 2166 | 1.324 | 0.4552 | Yes |
| 40 | RABIF | NA | RABIF Entrez, Source | RAB interacting factor | 2331 | 1.242 | 0.4532 | Yes |
| 41 | APOA1 | NA | APOA1 Entrez, Source | apolipoprotein A-I | 2434 | 1.198 | 0.4545 | Yes |
| 42 | HPN | NA | HPN Entrez, Source | hepsin (transmembrane protease, serine 1) | 2598 | 1.137 | 0.4520 | Yes |
| 43 | THBS1 | NA | THBS1 Entrez, Source | thrombospondin 1 | 2604 | 1.136 | 0.4583 | Yes |
| 44 | DUSP6 | NA | DUSP6 Entrez, Source | dual specificity phosphatase 6 | 2722 | 1.091 | 0.4581 | Yes |
| 45 | SIRT2 | NA | SIRT2 Entrez, Source | sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) | 2742 | 1.082 | 0.4633 | Yes |
| 46 | LGMN | NA | LGMN Entrez, Source | legumain | 2948 | 1.006 | 0.4577 | No |
| 47 | MMP15 | NA | MMP15 Entrez, Source | matrix metallopeptidase 15 (membrane-inserted) | 3045 | 0.975 | 0.4580 | No |
| 48 | PROZ | NA | PROZ Entrez, Source | protein Z, vitamin K-dependent plasma glycoprotein | 3178 | 0.944 | 0.4561 | No |
| 49 | TIMP1 | NA | TIMP1 Entrez, Source | TIMP metallopeptidase inhibitor 1 | 3284 | 0.917 | 0.4555 | No |
| 50 | F13B | NA | F13B Entrez, Source | coagulation factor XIII, B polypeptide | 3390 | 0.883 | 0.4548 | No |
| 51 | FGA | NA | FGA Entrez, Source | fibrinogen alpha chain | 3609 | 0.840 | 0.4475 | No |
| 52 | MMP2 | NA | MMP2 Entrez, Source | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 3614 | 0.840 | 0.4521 | No |
| 53 | C1S | NA | C1S Entrez, Source | complement component 1, s subcomponent | 3847 | 0.800 | 0.4438 | No |
| 54 | GSN | NA | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 4441 | 0.670 | 0.4144 | No |
| 55 | TF | NA | TF Entrez, Source | transferrin | 4798 | 0.595 | 0.3980 | No |
| 56 | ANXA1 | NA | ANXA1 Entrez, Source | annexin A1 | 4995 | 0.559 | 0.3902 | No |
| 57 | F11 | NA | F11 Entrez, Source | coagulation factor XI (plasma thromboplastin antecedent) | 5236 | 0.512 | 0.3798 | No |
| 58 | CTSO | NA | CTSO Entrez, Source | cathepsin O | 5245 | 0.510 | 0.3823 | No |
| 59 | GP1BA | NA | GP1BA Entrez, Source | glycoprotein Ib (platelet), alpha polypeptide | 5717 | 0.441 | 0.3584 | No |
| 60 | MSRB2 | NA | MSRB2 Entrez, Source | methionine sulfoxide reductase B2 | 5916 | 0.427 | 0.3498 | No |
| 61 | HMGCS2 | NA | HMGCS2 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | 6221 | 0.412 | 0.3352 | No |
| 62 | HNF4A | NA | HNF4A Entrez, Source | hepatocyte nuclear factor 4, alpha | 6236 | 0.409 | 0.3368 | No |
| 63 | FYN | NA | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 6328 | 0.393 | 0.3340 | No |
| 64 | ISCU | NA | 6530 | 0.362 | 0.3248 | No | ||
| 65 | GP9 | NA | GP9 Entrez, Source | glycoprotein IX (platelet) | 6609 | 0.349 | 0.3225 | No |
| 66 | MMP1 | NA | MMP1 Entrez, Source | matrix metallopeptidase 1 (interstitial collagenase) | 6718 | 0.332 | 0.3183 | No |
| 67 | LEFTY2 | NA | LEFTY2 Entrez, Source | left-right determination factor 2 | 7321 | 0.238 | 0.2860 | No |
| 68 | DCT | NA | DCT Entrez, Source | dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) | 7441 | 0.220 | 0.2806 | No |
| 69 | LAMP2 | NA | LAMP2 Entrez, Source | lysosomal-associated membrane protein 2 | 7616 | 0.196 | 0.2720 | No |
| 70 | F9 | NA | F9 Entrez, Source | coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B) | 7774 | 0.175 | 0.2642 | No |
| 71 | PEF1 | NA | PEF1 Entrez, Source | penta-EF-hand domain containing 1 | 7971 | 0.149 | 0.2541 | No |
| 72 | C9 | NA | C9 Entrez, Source | complement component 9 | 8168 | 0.125 | 0.2438 | No |
| 73 | CSRP1 | NA | CSRP1 Entrez, Source | cysteine and glycine-rich protein 1 | 8408 | 0.092 | 0.2310 | No |
| 74 | PRSS23 | NA | PRSS23 Entrez, Source | protease, serine, 23 | 8602 | 0.066 | 0.2205 | No |
| 75 | MEP1A | NA | MEP1A Entrez, Source | meprin A, alpha (PABA peptide hydrolase) | 8683 | 0.056 | 0.2164 | No |
| 76 | MMP7 | NA | MMP7 Entrez, Source | matrix metallopeptidase 7 (matrilysin, uterine) | 8953 | 0.020 | 0.2014 | No |
| 77 | CAPN2 | NA | CAPN2 Entrez, Source | calpain 2, (m/II) large subunit | 9055 | 0.013 | 0.1958 | No |
| 78 | F10 | NA | F10 Entrez, Source | coagulation factor X | 9456 | -0.007 | 0.1735 | No |
| 79 | C8A | NA | C8A Entrez, Source | complement component 8, alpha polypeptide | 9500 | -0.014 | 0.1711 | No |
| 80 | MMP8 | NA | MMP8 Entrez, Source | matrix metallopeptidase 8 (neutrophil collagenase) | 9576 | -0.026 | 0.1671 | No |
| 81 | ARF4 | NA | ARF4 Entrez, Source | ADP-ribosylation factor 4 | 9927 | -0.064 | 0.1478 | No |
| 82 | CTSK | NA | CTSK Entrez, Source | cathepsin K (pycnodysostosis) | 10261 | -0.093 | 0.1297 | No |
| 83 | GNB2 | NA | GNB2 Entrez, Source | guanine nucleotide binding protein (G protein), beta polypeptide 2 | 10498 | -0.124 | 0.1172 | No |
| 84 | LTA4H | NA | LTA4H Entrez, Source | leukotriene A4 hydrolase | 10705 | -0.155 | 0.1066 | No |
| 85 | RAC1 | NA | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 10982 | -0.195 | 0.0922 | No |
| 86 | KLKB1 | NA | KLKB1 Entrez, Source | kallikrein B, plasma (Fletcher factor) 1 | 11119 | -0.214 | 0.0859 | No |
| 87 | PLEK | NA | PLEK Entrez, Source | pleckstrin | 11478 | -0.268 | 0.0674 | No |
| 88 | ACOX2 | NA | ACOX2 Entrez, Source | acyl-Coenzyme A oxidase 2, branched chain | 11542 | -0.277 | 0.0654 | No |
| 89 | CPB2 | NA | CPB2 Entrez, Source | carboxypeptidase B2 (plasma, carboxypeptidase U) | 11569 | -0.281 | 0.0656 | No |
| 90 | ANG | NA | ANG Entrez, Source | angiogenin, ribonuclease, RNase A family, 5 | 11634 | -0.288 | 0.0637 | No |
| 91 | C8G | NA | C8G Entrez, Source | complement component 8, gamma polypeptide | 11727 | -0.300 | 0.0603 | No |
| 92 | MMP10 | NA | MMP10 Entrez, Source | matrix metallopeptidase 10 (stromelysin 2) | 11797 | -0.311 | 0.0582 | No |
| 93 | PROC | NA | PROC Entrez, Source | protein C (inactivator of coagulation factors Va and VIIIa) | 11893 | -0.327 | 0.0548 | No |
| 94 | OLR1 | NA | OLR1 Entrez, Source | oxidised low density lipoprotein (lectin-like) receptor 1 | 12060 | -0.347 | 0.0475 | No |
| 95 | USP11 | NA | USP11 Entrez, Source | ubiquitin specific peptidase 11 | 12076 | -0.350 | 0.0487 | No |
| 96 | FGG | NA | FGG Entrez, Source | fibrinogen gamma chain | 12431 | -0.407 | 0.0313 | No |
| 97 | FN1 | NA | FN1 Entrez, Source | fibronectin 1 | 12699 | -0.434 | 0.0188 | No |
| 98 | CPN1 | NA | CPN1 Entrez, Source | carboxypeptidase N, polypeptide 1, 50kD | 12786 | -0.445 | 0.0166 | No |
| 99 | APOC2 | NA | APOC2 Entrez, Source | apolipoprotein C-II | 12893 | -0.451 | 0.0133 | No |
| 100 | HRG | NA | HRG Entrez, Source | histidine-rich glycoprotein | 12898 | -0.451 | 0.0157 | No |
| 101 | S100A13 | NA | S100A13 Entrez, Source | S100 calcium binding protein A13 | 12976 | -0.452 | 0.0140 | No |
| 102 | MAFF | NA | MAFF Entrez, Source | v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) | 13007 | -0.456 | 0.0150 | No |
| 103 | PROS1 | NA | PROS1 Entrez, Source | protein S (alpha) | 13016 | -0.458 | 0.0172 | No |
| 104 | CAPN5 | NA | CAPN5 Entrez, Source | calpain 5 | 13047 | -0.463 | 0.0182 | No |
| 105 | F8 | NA | F8 Entrez, Source | coagulation factor VIII, procoagulant component (hemophilia A) | 13126 | -0.477 | 0.0166 | No |
| 106 | MBL2 | NA | MBL2 Entrez, Source | mannose-binding lectin (protein C) 2, soluble (opsonic defect) | 13245 | -0.495 | 0.0129 | No |
| 107 | ITGB3 | NA | ITGB3 Entrez, Source | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 13638 | -0.565 | -0.0058 | No |
| 108 | C8B | NA | C8B Entrez, Source | complement component 8, beta polypeptide | 13690 | -0.574 | -0.0053 | No |
| 109 | SERPINC1 | NA | SERPINC1 Entrez, Source | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 13702 | -0.576 | -0.0026 | No |
| 110 | VWF | NA | VWF Entrez, Source | von Willebrand factor | 13772 | -0.589 | -0.0030 | No |
| 111 | RAPGEF3 | NA | RAPGEF3 Entrez, Source | Rap guanine nucleotide exchange factor (GEF) 3 | 14247 | -0.690 | -0.0256 | No |
| 112 | GNG12 | NA | GNG12 Entrez, Source | guanine nucleotide binding protein (G protein), gamma 12 | 14775 | -0.819 | -0.0504 | No |
| 113 | MST1 | NA | MST1 Entrez, Source | macrophage stimulating 1 (hepatocyte growth factor-like) | 15277 | -0.934 | -0.0730 | No |
| 114 | A2M | NA | A2M Entrez, Source | alpha-2-macroglobulin | 15303 | -0.943 | -0.0689 | No |
| 115 | ITIH1 | NA | ITIH1 Entrez, Source | inter-alpha (globulin) inhibitor H1 | 15404 | -0.969 | -0.0689 | No |
| 116 | CTSH | NA | CTSH Entrez, Source | cathepsin H | 15762 | -1.081 | -0.0826 | No |
| 117 | GDA | NA | GDA Entrez, Source | guanine deaminase | 15922 | -1.146 | -0.0848 | No |
| 118 | APOC1 | NA | APOC1 Entrez, Source | apolipoprotein C-I | 16377 | -1.349 | -0.1024 | No |
| 119 | PREP | NA | PREP Entrez, Source | prolyl endopeptidase | 16469 | -1.399 | -0.0994 | No |
| 120 | COMP | NA | COMP Entrez, Source | cartilage oligomeric matrix protein | 16501 | -1.414 | -0.0929 | No |
| 121 | SERPINA1 | NA | SERPINA1 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 16974 | -1.746 | -0.1092 | No |
| 122 | F2 | NA | F2 Entrez, Source | coagulation factor II (thrombin) | 17157 | -1.953 | -0.1080 | No |
| 123 | KLF7 | NA | KLF7 Entrez, Source | Kruppel-like factor 7 (ubiquitous) | 17201 | -2.008 | -0.0987 | No |
| 124 | FURIN | NA | FURIN Entrez, Source | furin (paired basic amino acid cleaving enzyme) | 17206 | -2.014 | -0.0872 | No |
| 125 | S100A1 | NA | S100A1 Entrez, Source | S100 calcium binding protein A1 | 17266 | -2.110 | -0.0783 | No |
| 126 | MMP11 | NA | MMP11 Entrez, Source | matrix metallopeptidase 11 (stromelysin 3) | 17268 | -2.113 | -0.0660 | No |
| 127 | F12 | NA | F12 Entrez, Source | coagulation factor XII (Hageman factor) | 17344 | -2.238 | -0.0572 | No |
| 128 | CTSE | NA | CTSE Entrez, Source | cathepsin E | 17560 | -2.606 | -0.0541 | No |
| 129 | P2RY1 | NA | P2RY1 Entrez, Source | purinergic receptor P2Y, G-protein coupled, 1 | 17689 | -3.053 | -0.0435 | No |
| 130 | C3 | NA | C3 Entrez, Source | complement component 3 | 17698 | -3.089 | -0.0260 | No |
| 131 | PDGFB | NA | PDGFB Entrez, Source | platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) | 17712 | -3.137 | -0.0084 | No |
| 132 | MMP9 | NA | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 17854 | -3.963 | 0.0067 | No |
