Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_CHOLESTEROL_HOMEOSTASIS |
| Enrichment Score (ES) | -0.30881864 |
| Normalized Enrichment Score (NES) | -1.1745195 |
| Nominal p-value | 0.16666667 |
| FDR q-value | 0.21496382 |
| FWER p-Value | 0.825 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | MAL2 | NA | MAL2 Entrez, Source | mal, T-cell differentiation protein 2 | 19 | 4.923 | 0.0476 | No |
| 2 | LPL | NA | LPL Entrez, Source | lipoprotein lipase | 51 | 4.717 | 0.0926 | No |
| 3 | CPEB2 | NA | CPEB2 Entrez, Source | cytoplasmic polyadenylation element binding protein 2 | 279 | 3.797 | 0.1174 | No |
| 4 | SEMA3B | NA | SEMA3B Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 360 | 3.556 | 0.1481 | No |
| 5 | JAG1 | NA | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 495 | 3.207 | 0.1724 | No |
| 6 | ERRFI1 | NA | ERRFI1 Entrez, Source | ERBB receptor feedback inhibitor 1 | 794 | 2.563 | 0.1811 | No |
| 7 | CXCL16 | NA | CXCL16 Entrez, Source | chemokine (C-X-C motif) ligand 16 | 843 | 2.482 | 0.2029 | No |
| 8 | GSTM2 | NA | GSTM2 Entrez, Source | glutathione S-transferase M2 (muscle) | 912 | 2.406 | 0.2229 | No |
| 9 | TP53INP1 | NA | TP53INP1 Entrez, Source | tumor protein p53 inducible nuclear protein 1 | 1224 | 2.020 | 0.2256 | No |
| 10 | TM7SF2 | NA | TM7SF2 Entrez, Source | transmembrane 7 superfamily member 2 | 1628 | 1.661 | 0.2195 | No |
| 11 | CD9 | NA | CD9 Entrez, Source | CD9 molecule | 1847 | 1.500 | 0.2221 | No |
| 12 | FBXO6 | NA | FBXO6 Entrez, Source | F-box protein 6 | 1896 | 1.475 | 0.2340 | No |
| 13 | ANTXR2 | NA | ANTXR2 Entrez, Source | anthrax toxin receptor 2 | 2093 | 1.364 | 0.2366 | No |
| 14 | GNAI1 | NA | GNAI1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 2274 | 1.270 | 0.2391 | No |
| 15 | FAM129A | NA | 2491 | 1.183 | 0.2387 | No | ||
| 16 | LGMN | NA | LGMN Entrez, Source | legumain | 2948 | 1.006 | 0.2232 | No |
| 17 | NFIL3 | NA | NFIL3 Entrez, Source | nuclear factor, interleukin 3 regulated | 3207 | 0.939 | 0.2181 | No |
| 18 | AVPR1A | NA | AVPR1A Entrez, Source | arginine vasopressin receptor 1A | 3255 | 0.925 | 0.2246 | No |
| 19 | ATXN2 | NA | ATXN2 Entrez, Source | ataxin 2 | 3315 | 0.908 | 0.2303 | No |
| 20 | TRIB3 | NA | TRIB3 Entrez, Source | tribbles homolog 3 (Drosophila) | 3368 | 0.891 | 0.2362 | No |
| 21 | TNFRSF12A | NA | TNFRSF12A Entrez, Source | tumor necrosis factor receptor superfamily, member 12A | 3468 | 0.868 | 0.2393 | No |
| 22 | ALCAM | NA | ALCAM Entrez, Source | activated leukocyte cell adhesion molecule | 3764 | 0.818 | 0.2309 | No |
| 23 | ANXA5 | NA | ANXA5 Entrez, Source | annexin A5 | 3903 | 0.784 | 0.2309 | No |
| 24 | ANXA13 | NA | ANXA13 Entrez, Source | annexin A13 | 3973 | 0.767 | 0.2347 | No |
| 25 | GLDC | NA | GLDC Entrez, Source | glycine dehydrogenase (decarboxylating) | 4300 | 0.701 | 0.2234 | No |
| 26 | PMVK | NA | PMVK Entrez, Source | phosphomevalonate kinase | 4622 | 0.633 | 0.2117 | No |
| 27 | LGALS3 | NA | LGALS3 Entrez, Source | lectin, galactoside-binding, soluble, 3 (galectin 3) | 4778 | 0.599 | 0.2090 | No |
| 28 | ACTG1 | NA | ACTG1 Entrez, Source | actin, gamma 1 | 4890 | 0.579 | 0.2085 | No |
| 29 | ATF5 | NA | ATF5 Entrez, Source | activating transcription factor 5 | 5381 | 0.490 | 0.1860 | No |
| 30 | PCYT2 | NA | PCYT2 Entrez, Source | phosphate cytidylyltransferase 2, ethanolamine | 5590 | 0.463 | 0.1789 | No |
| 31 | CHKA | NA | CHKA Entrez, Source | choline kinase alpha | 5605 | 0.460 | 0.1827 | No |
| 32 | CBS | NA | CBS Entrez, Source | cystathionine-beta-synthase | 5674 | 0.448 | 0.1834 | No |
| 33 | PLAUR | NA | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 7676 | 0.188 | 0.0734 | No |
| 34 | GPX8 | NA | 7877 | 0.162 | 0.0639 | No | ||
| 35 | ACSS2 | NA | ACSS2 Entrez, Source | acyl-CoA synthetase short-chain family member 2 | 8100 | 0.133 | 0.0528 | No |
| 36 | S100A11 | NA | S100A11 Entrez, Source | S100 calcium binding protein A11 | 8428 | 0.090 | 0.0354 | No |
| 37 | EBP | NA | EBP Entrez, Source | emopamil binding protein (sterol isomerase) | 9472 | -0.010 | -0.0227 | No |
| 38 | NSDHL | NA | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 9856 | -0.058 | -0.0436 | No |
| 39 | ADH4 | NA | ADH4 Entrez, Source | alcohol dehydrogenase 4 (class II), pi polypeptide | 10677 | -0.151 | -0.0879 | No |
| 40 | TMEM97 | NA | TMEM97 Entrez, Source | transmembrane protein 97 | 11146 | -0.219 | -0.1118 | No |
| 41 | STX5 | NA | STX5 Entrez, Source | syntaxin 5 | 11180 | -0.224 | -0.1115 | No |
| 42 | ECH1 | NA | ECH1 Entrez, Source | enoyl Coenzyme A hydratase 1, peroxisomal | 12276 | -0.380 | -0.1689 | No |
| 43 | LDLR | NA | LDLR Entrez, Source | low density lipoprotein receptor (familial hypercholesterolemia) | 12407 | -0.400 | -0.1722 | No |
| 44 | FABP5 | NA | FABP5 Entrez, Source | fatty acid binding protein 5 (psoriasis-associated) | 13623 | -0.563 | -0.2345 | No |
| 45 | CYP51A1 | NA | CYP51A1 Entrez, Source | cytochrome P450, family 51, subfamily A, polypeptide 1 | 13626 | -0.563 | -0.2290 | No |
| 46 | PNRC1 | NA | PNRC1 Entrez, Source | proline-rich nuclear receptor coactivator 1 | 14009 | -0.637 | -0.2441 | No |
| 47 | PPARG | NA | PPARG Entrez, Source | peroxisome proliferative activated receptor, gamma | 14022 | -0.640 | -0.2384 | No |
| 48 | CTNNB1 | NA | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 14196 | -0.681 | -0.2413 | No |
| 49 | STARD4 | NA | STARD4 Entrez, Source | START domain containing 4, sterol regulated | 15088 | -0.891 | -0.2823 | No |
| 50 | PLSCR1 | NA | PLSCR1 Entrez, Source | phospholipid scramblase 1 | 15338 | -0.951 | -0.2868 | No |
| 51 | LSS | NA | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 15432 | -0.977 | -0.2823 | No |
| 52 | ACAT2 | NA | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 15510 | -1.001 | -0.2767 | No |
| 53 | ETHE1 | NA | ETHE1 Entrez, Source | ethylmalonic encephalopathy 1 | 16086 | -1.207 | -0.2969 | Yes |
| 54 | GUSB | NA | GUSB Entrez, Source | glucuronidase, beta | 16111 | -1.220 | -0.2862 | Yes |
| 55 | FDFT1 | NA | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 16183 | -1.251 | -0.2778 | Yes |
| 56 | IDI1 | NA | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 16724 | -1.548 | -0.2926 | Yes |
| 57 | FDPS | NA | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 16738 | -1.557 | -0.2779 | Yes |
| 58 | HSD17B7 | NA | HSD17B7 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 7 | 16819 | -1.623 | -0.2663 | Yes |
| 59 | ABCA2 | NA | ABCA2 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 2 | 17001 | -1.771 | -0.2589 | Yes |
| 60 | MVK | NA | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 17008 | -1.778 | -0.2417 | Yes |
| 61 | PDK3 | NA | PDK3 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 3 | 17013 | -1.782 | -0.2243 | Yes |
| 62 | DHCR7 | NA | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 17178 | -1.978 | -0.2139 | Yes |
| 63 | SQLE | NA | SQLE Entrez, Source | squalene epoxidase | 17217 | -2.029 | -0.1959 | Yes |
| 64 | FASN | NA | FASN Entrez, Source | fatty acid synthase | 17303 | -2.176 | -0.1792 | Yes |
| 65 | HMGCR | NA | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 17398 | -2.327 | -0.1614 | Yes |
| 66 | SREBF2 | NA | SREBF2 Entrez, Source | sterol regulatory element binding transcription factor 2 | 17429 | -2.383 | -0.1395 | Yes |
| 67 | HMGCS1 | NA | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 17531 | -2.561 | -0.1198 | Yes |
| 68 | MVD | NA | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 17563 | -2.616 | -0.0957 | Yes |
| 69 | FADS2 | NA | FADS2 Entrez, Source | fatty acid desaturase 2 | 17701 | -3.097 | -0.0727 | Yes |
| 70 | ALDOC | NA | ALDOC Entrez, Source | aldolase C, fructose-bisphosphate | 17891 | -4.203 | -0.0417 | Yes |
| 71 | SCD | NA | SCD Entrez, Source | stearoyl-CoA desaturase (delta-9-desaturase) | 17940 | -4.676 | 0.0019 | Yes |
