Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_BILE_ACID_METABOLISM |
| Enrichment Score (ES) | -0.2907584 |
| Normalized Enrichment Score (NES) | -1.17827 |
| Nominal p-value | 0.12962963 |
| FDR q-value | 0.23282906 |
| FWER p-Value | 0.815 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CH25H | NA | CH25H Entrez, Source | cholesterol 25-hydroxylase | 264 | 3.853 | 0.0172 | No |
| 2 | HSD3B7 | NA | HSD3B7 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 286 | 3.766 | 0.0473 | No |
| 3 | SLC27A2 | NA | SLC27A2 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 2 | 446 | 3.335 | 0.0661 | No |
| 4 | CYP39A1 | NA | CYP39A1 Entrez, Source | cytochrome P450, family 39, subfamily A, polypeptide 1 | 461 | 3.300 | 0.0927 | No |
| 5 | NR3C2 | NA | NR3C2 Entrez, Source | nuclear receptor subfamily 3, group C, member 2 | 629 | 2.898 | 0.1074 | No |
| 6 | BMP6 | NA | BMP6 Entrez, Source | bone morphogenetic protein 6 | 682 | 2.751 | 0.1273 | No |
| 7 | NPC1 | NA | NPC1 Entrez, Source | Niemann-Pick disease, type C1 | 924 | 2.390 | 0.1336 | No |
| 8 | SLC35B2 | NA | SLC35B2 Entrez, Source | solute carrier family 35, member B2 | 1167 | 2.076 | 0.1373 | No |
| 9 | ABCA5 | NA | ABCA5 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 5 | 1515 | 1.755 | 0.1324 | No |
| 10 | EPHX2 | NA | EPHX2 Entrez, Source | epoxide hydrolase 2, cytoplasmic | 1564 | 1.713 | 0.1440 | No |
| 11 | ABCA4 | NA | ABCA4 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 4 | 1581 | 1.703 | 0.1572 | No |
| 12 | ATXN1 | NA | ATXN1 Entrez, Source | ataxin 1 | 1754 | 1.560 | 0.1605 | No |
| 13 | IDH1 | NA | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 1999 | 1.421 | 0.1587 | No |
| 14 | SLC29A1 | NA | SLC29A1 Entrez, Source | solute carrier family 29 (nucleoside transporters), member 1 | 2025 | 1.410 | 0.1690 | No |
| 15 | PEX12 | NA | PEX12 Entrez, Source | peroxisomal biogenesis factor 12 | 2057 | 1.388 | 0.1787 | No |
| 16 | SLC23A1 | NA | SLC23A1 Entrez, Source | solute carrier family 23 (nucleobase transporters), member 1 | 2122 | 1.346 | 0.1863 | No |
| 17 | SLC23A2 | NA | SLC23A2 Entrez, Source | solute carrier family 23 (nucleobase transporters), member 2 | 2340 | 1.239 | 0.1845 | No |
| 18 | APOA1 | NA | APOA1 Entrez, Source | apolipoprotein A-I | 2434 | 1.198 | 0.1892 | No |
| 19 | HSD17B11 | NA | 2457 | 1.194 | 0.1979 | No | ||
| 20 | GCLM | NA | GCLM Entrez, Source | glutamate-cysteine ligase, modifier subunit | 2621 | 1.126 | 0.1981 | No |
| 21 | RXRA | NA | RXRA Entrez, Source | retinoid X receptor, alpha | 2739 | 1.085 | 0.2006 | No |
| 22 | ABCD2 | NA | ABCD2 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 2 | 3125 | 0.954 | 0.1869 | No |
| 23 | CROT | NA | CROT Entrez, Source | carnitine O-octanoyltransferase | 3254 | 0.925 | 0.1874 | No |
| 24 | ISOC1 | NA | ISOC1 Entrez, Source | isochorismatase domain containing 1 | 3374 | 0.889 | 0.1882 | No |
| 25 | PEX6 | NA | PEX6 Entrez, Source | peroxisomal biogenesis factor 6 | 3801 | 0.809 | 0.1710 | No |
| 26 | PHYH | NA | PHYH Entrez, Source | phytanoyl-CoA 2-hydroxylase | 4089 | 0.742 | 0.1611 | No |
| 27 | ALDH8A1 | NA | ALDH8A1 Entrez, Source | aldehyde dehydrogenase 8 family, member A1 | 4268 | 0.708 | 0.1570 | No |
| 28 | DIO1 | NA | DIO1 Entrez, Source | deiodinase, iodothyronine, type I | 4413 | 0.675 | 0.1546 | No |
| 29 | ABCA9 | NA | ABCA9 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 9 | 4680 | 0.623 | 0.1449 | No |
| 30 | HSD17B4 | NA | HSD17B4 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 4 | 4681 | 0.622 | 0.1500 | No |
| 31 | ABCA8 | NA | ABCA8 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 8 | 4947 | 0.569 | 0.1399 | No |
| 32 | AMACR | NA | AMACR Entrez, Source | alpha-methylacyl-CoA racemase | 5406 | 0.486 | 0.1183 | No |
| 33 | AR | NA | AR Entrez, Source | androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) | 5913 | 0.427 | 0.0935 | No |
| 34 | ABCD1 | NA | ABCD1 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 1 | 6365 | 0.387 | 0.0715 | No |
| 35 | NUDT12 | NA | NUDT12 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 12 | 6569 | 0.355 | 0.0631 | No |
| 36 | AQP9 | NA | AQP9 Entrez, Source | aquaporin 9 | 6765 | 0.326 | 0.0549 | No |
| 37 | SOAT2 | NA | SOAT2 Entrez, Source | sterol O-acyltransferase 2 | 6771 | 0.325 | 0.0573 | No |
| 38 | EFHC1 | NA | EFHC1 Entrez, Source | EF-hand domain (C-terminal) containing 1 | 7065 | 0.280 | 0.0432 | No |
| 39 | SULT2B1 | NA | SULT2B1 Entrez, Source | sulfotransferase family, cytosolic, 2B, member 1 | 7141 | 0.267 | 0.0412 | No |
| 40 | CYP7A1 | NA | CYP7A1 Entrez, Source | cytochrome P450, family 7, subfamily A, polypeptide 1 | 7181 | 0.261 | 0.0412 | No |
| 41 | PEX1 | NA | PEX1 Entrez, Source | peroxisome biogenesis factor 1 | 7249 | 0.251 | 0.0395 | No |
| 42 | ALDH1A1 | NA | ALDH1A1 Entrez, Source | aldehyde dehydrogenase 1 family, member A1 | 7260 | 0.248 | 0.0410 | No |
| 43 | SOD1 | NA | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 7495 | 0.211 | 0.0297 | No |
| 44 | CYP7B1 | NA | CYP7B1 Entrez, Source | cytochrome P450, family 7, subfamily B, polypeptide 1 | 7717 | 0.182 | 0.0188 | No |
| 45 | OPTN | NA | OPTN Entrez, Source | optineurin | 7835 | 0.168 | 0.0137 | No |
| 46 | CYP27A1 | NA | CYP27A1 Entrez, Source | cytochrome P450, family 27, subfamily A, polypeptide 1 | 7891 | 0.159 | 0.0119 | No |
| 47 | GSTK1 | NA | GSTK1 Entrez, Source | glutathione S-transferase kappa 1 | 8082 | 0.134 | 0.0024 | No |
| 48 | SLCO1A2 | NA | SLCO1A2 Entrez, Source | solute carrier organic anion transporter family, member 1A2 | 8461 | 0.086 | -0.0181 | No |
| 49 | PNPLA8 | NA | PNPLA8 Entrez, Source | patatin-like phospholipase domain containing 8 | 8467 | 0.086 | -0.0176 | No |
| 50 | PFKM | NA | PFKM Entrez, Source | phosphofructokinase, muscle | 8531 | 0.076 | -0.0205 | No |
| 51 | ACSL1 | NA | ACSL1 Entrez, Source | acyl-CoA synthetase long-chain family member 1 | 8603 | 0.066 | -0.0240 | No |
| 52 | MLYCD | NA | MLYCD Entrez, Source | malonyl-CoA decarboxylase | 8890 | 0.030 | -0.0397 | No |
| 53 | RXRG | NA | RXRG Entrez, Source | retinoid X receptor, gamma | 9227 | 0.000 | -0.0585 | No |
| 54 | TTR | NA | TTR Entrez, Source | transthyretin (prealbumin, amyloidosis type I) | 9301 | 0.000 | -0.0626 | No |
| 55 | SCP2 | NA | SCP2 Entrez, Source | sterol carrier protein 2 | 9491 | -0.013 | -0.0731 | No |
| 56 | PECR | NA | PECR Entrez, Source | peroxisomal trans-2-enoyl-CoA reductase | 9929 | -0.064 | -0.0970 | No |
| 57 | BBOX1 | NA | BBOX1 Entrez, Source | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 10102 | -0.078 | -0.1060 | No |
| 58 | LONP2 | NA | 10452 | -0.116 | -0.1246 | No | ||
| 59 | ABCG8 | NA | ABCG8 Entrez, Source | ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2) | 10536 | -0.129 | -0.1281 | No |
| 60 | PIPOX | NA | PIPOX Entrez, Source | pipecolic acid oxidase | 10599 | -0.141 | -0.1304 | No |
| 61 | ABCG4 | NA | ABCG4 Entrez, Source | ATP-binding cassette, sub-family G (WHITE), member 4 | 10774 | -0.165 | -0.1388 | No |
| 62 | GNPAT | NA | GNPAT Entrez, Source | glyceronephosphate O-acyltransferase | 10802 | -0.170 | -0.1389 | No |
| 63 | PXMP2 | NA | PXMP2 Entrez, Source | peroxisomal membrane protein 2, 22kDa | 11210 | -0.227 | -0.1598 | No |
| 64 | PEX11A | NA | PEX11A Entrez, Source | peroxisomal biogenesis factor 11A | 11326 | -0.243 | -0.1642 | No |
| 65 | NR0B2 | NA | NR0B2 Entrez, Source | nuclear receptor subfamily 0, group B, member 2 | 11431 | -0.259 | -0.1679 | No |
| 66 | NR1H4 | NA | NR1H4 Entrez, Source | nuclear receptor subfamily 1, group H, member 4 | 11622 | -0.286 | -0.1762 | No |
| 67 | ABCD3 | NA | ABCD3 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 3 | 12210 | -0.370 | -0.2060 | No |
| 68 | SLC27A5 | NA | SLC27A5 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 5 | 12364 | -0.393 | -0.2113 | No |
| 69 | AGXT | NA | AGXT Entrez, Source | alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase) | 12482 | -0.411 | -0.2144 | No |
| 70 | CYP8B1 | NA | CYP8B1 Entrez, Source | cytochrome P450, family 8, subfamily B, polypeptide 1 | 12661 | -0.426 | -0.2208 | No |
| 71 | CAT | NA | CAT Entrez, Source | catalase | 12749 | -0.444 | -0.2220 | No |
| 72 | PEX19 | NA | PEX19 Entrez, Source | peroxisomal biogenesis factor 19 | 13190 | -0.487 | -0.2426 | No |
| 73 | ABCA6 | NA | ABCA6 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 6 | 13199 | -0.488 | -0.2390 | No |
| 74 | PEX26 | NA | PEX26 Entrez, Source | peroxisome biogenesis factor 26 | 13310 | -0.505 | -0.2410 | No |
| 75 | PEX13 | NA | PEX13 Entrez, Source | peroxisome biogenesis factor 13 | 13420 | -0.521 | -0.2427 | No |
| 76 | RETSAT | NA | RETSAT Entrez, Source | retinol saturase (all-trans-retinol 13,14-reductase) | 13613 | -0.561 | -0.2488 | No |
| 77 | RBP1 | NA | RBP1 Entrez, Source | retinol binding protein 1, cellular | 13650 | -0.568 | -0.2461 | No |
| 78 | KLF1 | NA | KLF1 Entrez, Source | Kruppel-like factor 1 (erythroid) | 13819 | -0.599 | -0.2506 | No |
| 79 | ALDH9A1 | NA | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 14538 | -0.763 | -0.2844 | Yes |
| 80 | AKR1D1 | NA | AKR1D1 Entrez, Source | aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) | 14645 | -0.787 | -0.2838 | Yes |
| 81 | PEX16 | NA | PEX16 Entrez, Source | peroxisomal biogenesis factor 16 | 14717 | -0.806 | -0.2811 | Yes |
| 82 | PRDX5 | NA | PRDX5 Entrez, Source | peroxiredoxin 5 | 14735 | -0.810 | -0.2753 | Yes |
| 83 | SERPINA6 | NA | SERPINA6 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 | 14870 | -0.839 | -0.2759 | Yes |
| 84 | HSD3B1 | NA | HSD3B1 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | 15023 | -0.873 | -0.2772 | Yes |
| 85 | LIPE | NA | LIPE Entrez, Source | lipase, hormone-sensitive | 15029 | -0.875 | -0.2702 | Yes |
| 86 | BCAR3 | NA | BCAR3 Entrez, Source | breast cancer anti-estrogen resistance 3 | 15092 | -0.891 | -0.2663 | Yes |
| 87 | CYP46A1 | NA | CYP46A1 Entrez, Source | cytochrome P450, family 46, subfamily A, polypeptide 1 | 15171 | -0.907 | -0.2631 | Yes |
| 88 | ABCA3 | NA | ABCA3 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 3 | 15200 | -0.913 | -0.2571 | Yes |
| 89 | PAOX | NA | PAOX Entrez, Source | polyamine oxidase (exo-N4-amino) | 15428 | -0.976 | -0.2617 | Yes |
| 90 | FDXR | NA | FDXR Entrez, Source | ferredoxin reductase | 15764 | -1.082 | -0.2715 | Yes |
| 91 | LCK | NA | LCK Entrez, Source | lymphocyte-specific protein tyrosine kinase | 15773 | -1.086 | -0.2629 | Yes |
| 92 | SLC22A18 | NA | SLC22A18 Entrez, Source | solute carrier family 22 (organic cation transporter), member 18 | 15927 | -1.147 | -0.2619 | Yes |
| 93 | ACSL5 | NA | ACSL5 Entrez, Source | acyl-CoA synthetase long-chain family member 5 | 16261 | -1.285 | -0.2699 | Yes |
| 94 | GNMT | NA | GNMT Entrez, Source | glycine N-methyltransferase | 16363 | -1.341 | -0.2644 | Yes |
| 95 | NR1I2 | NA | NR1I2 Entrez, Source | nuclear receptor subfamily 1, group I, member 2 | 16393 | -1.360 | -0.2548 | Yes |
| 96 | IDI1 | NA | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 16724 | -1.548 | -0.2604 | Yes |
| 97 | HACL1 | NA | HACL1 Entrez, Source | 2-hydroxyacyl-CoA lyase 1 | 16743 | -1.560 | -0.2485 | Yes |
| 98 | PEX7 | NA | PEX7 Entrez, Source | peroxisomal biogenesis factor 7 | 16775 | -1.582 | -0.2371 | Yes |
| 99 | NEDD4 | NA | NEDD4 Entrez, Source | neural precursor cell expressed, developmentally down-regulated 4 | 16798 | -1.602 | -0.2250 | Yes |
| 100 | ABCA2 | NA | ABCA2 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 2 | 17001 | -1.771 | -0.2216 | Yes |
| 101 | PEX11G | NA | PEX11G Entrez, Source | peroxisomal biogenesis factor 11 gamma | 17010 | -1.779 | -0.2073 | Yes |
| 102 | HSD17B6 | NA | HSD17B6 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 6 | 17155 | -1.950 | -0.1992 | Yes |
| 103 | FADS1 | NA | FADS1 Entrez, Source | fatty acid desaturase 1 | 17341 | -2.232 | -0.1910 | Yes |
| 104 | DIO2 | NA | DIO2 Entrez, Source | deiodinase, iodothyronine, type II | 17506 | -2.515 | -0.1793 | Yes |
| 105 | IDH2 | NA | IDH2 Entrez, Source | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 17605 | -2.752 | -0.1620 | Yes |
| 106 | TFCP2L1 | NA | TFCP2L1 Entrez, Source | transcription factor CP2-like 1 | 17696 | -3.081 | -0.1414 | Yes |
| 107 | FADS2 | NA | FADS2 Entrez, Source | fatty acid desaturase 2 | 17701 | -3.097 | -0.1160 | Yes |
| 108 | DHCR24 | NA | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 17710 | -3.134 | -0.0904 | Yes |
| 109 | ABCA1 | NA | ABCA1 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 1 | 17737 | -3.297 | -0.0645 | Yes |
| 110 | HAO1 | NA | HAO1 Entrez, Source | hydroxyacid oxidase (glycolate oxidase) 1 | 17917 | -4.430 | -0.0378 | Yes |
| 111 | SULT1B1 | NA | SULT1B1 Entrez, Source | sulfotransferase family, cytosolic, 1B, member 1 | 17961 | -4.927 | 0.0007 | Yes |
