Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1w6a
GeneSetHALLMARK_APOPTOSIS
Enrichment Score (ES)0.3918661
Normalized Enrichment Score (NES)1.4818882
Nominal p-value0.011780105
FDR q-value0.020951593
FWER p-Value0.288
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_APOPTOSIS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1GPX3NAGPX3
Entrez,  Source
glutathione peroxidase 3 (plasma)134.9440.0238Yes
2TNFSF10NATNFSF10
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 10864.5590.0424Yes
3EREGNAEREG
Entrez,  Source
epiregulin974.5280.0643Yes
4IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)1484.3010.0829Yes
5BIRC3NABIRC3
Entrez,  Source
baculoviral IAP repeat-containing 32733.8240.0949Yes
6SLC20A1NASLC20A1
Entrez,  Source
solute carrier family 20 (phosphate transporter), member 12803.7900.1134Yes
7CASP1NACASP1
Entrez,  Source
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)3023.7320.1307Yes
8TIMP3NATIMP3
Entrez,  Source
TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)3163.7020.1484Yes
9ERBB3NAERBB3
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)3433.6230.1649Yes
10LUMNALUM
Entrez,  Source
lumican3563.5610.1819Yes
11SQSTM1NASQSTM1
Entrez,  Source
sequestosome 13763.4990.1982Yes
12PLATNAPLAT
Entrez,  Source
plasminogen activator, tissue5163.1470.2061Yes
13CD38NACD38
Entrez,  Source
CD38 molecule5333.1090.2206Yes
14F2RNAF2R
Entrez,  Source
coagulation factor II (thrombin) receptor5613.0410.2342Yes
15IL18NAIL18
Entrez,  Source
interleukin 18 (interferon-gamma-inducing factor)5643.0300.2491Yes
16CD14NACD14
Entrez,  Source
CD14 molecule5712.9980.2637Yes
17GSRNAGSR
Entrez,  Source
glutathione reductase5762.9880.2783Yes
18HMOX1NAHMOX1
Entrez,  Source
heme oxygenase (decycling) 16142.9230.2907Yes
19IER3NAIER3
Entrez,  Source
immediate early response 36222.9080.3047Yes
20DDIT3NADDIT3
Entrez,  Source
DNA-damage-inducible transcript 36772.7670.3154Yes
21TGFBR3NATGFBR3
Entrez,  Source
transforming growth factor, beta receptor III (betaglycan, 300kDa)7912.5630.3218Yes
22CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)8882.4130.3284Yes
23CASP9NACASP9
Entrez,  Source
caspase 9, apoptosis-related cysteine peptidase10812.1920.3285Yes
24IGFBP6NAIGFBP6
Entrez,  Source
insulin-like growth factor binding protein 611262.1430.3367Yes
25CTHNACTH
Entrez,  Source
cystathionase (cystathionine gamma-lyase)11582.0940.3454Yes
26BNIP3LNABNIP3L
Entrez,  Source
BCL2/adenovirus E1B 19kDa interacting protein 3-like12411.9940.3507Yes
27BCL2L1NABCL2L1
Entrez,  Source
BCL2-like 113601.8760.3533Yes
28DFFANADFFA
Entrez,  Source
DNA fragmentation factor, 45kDa, alpha polypeptide14061.8390.3600Yes
29TIMP2NATIMP2
Entrez,  Source
TIMP metallopeptidase inhibitor 214211.8260.3682Yes
30BCL2L11NABCL2L11
Entrez,  Source
BCL2-like 11 (apoptosis facilitator)15961.6890.3669Yes
31FASNAFAS
Entrez,  Source
Fas (TNF receptor superfamily, member 6)17161.5890.3681Yes
32CYLDNACYLD
Entrez,  Source
cylindromatosis (turban tumor syndrome)19681.4360.3611Yes
33CASP6NACASP6
Entrez,  Source
caspase 6, apoptosis-related cysteine peptidase19961.4220.3667Yes
34SAT1NASAT1
Entrez,  Source
spermidine/spermine N1-acetyltransferase 120291.4090.3719Yes
35EMP1NAEMP1
Entrez,  Source
epithelial membrane protein 121501.3320.3717Yes
36PPP2R5BNAPPP2R5B
Entrez,  Source
protein phosphatase 2, regulatory subunit B (B56), beta isoform21831.3160.3765Yes
37PSEN1NAPSEN1
Entrez,  Source
presenilin 1 (Alzheimer disease 3)24261.2030.3689Yes
38IRF1NAIRF1
Entrez,  Source
interferon regulatory factor 124391.1970.3741Yes
39PMAIP1NAPMAIP1
Entrez,  Source
phorbol-12-myristate-13-acetate-induced protein 125881.1420.3715Yes
40ERBB2NAERBB2
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)26251.1220.3750Yes
41RHOBNARHOB
Entrez,  Source
ras homolog gene family, member B26621.1090.3785Yes
42SPTAN1NASPTAN1
Entrez,  Source
spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)27511.0780.3789Yes
43ADD1NAADD1
Entrez,  Source
adducin 1 (alpha)27741.0690.3830Yes
44CDC25BNACDC25B
Entrez,  Source
cell division cycle 25B27811.0670.3880Yes
45RARANARARA
Entrez,  Source
retinoic acid receptor, alpha28581.0410.3889Yes
46CDKN1BNACDKN1B
Entrez,  Source
cyclin-dependent kinase inhibitor 1B (p27, Kip1)29421.0080.3892Yes
47SMAD7NASMAD7
Entrez,  Source
SMAD, mothers against DPP homolog 7 (Drosophila)31030.9610.3850Yes
48PSEN2NAPSEN2
Entrez,  Source
presenilin 2 (Alzheimer disease 4)32010.9400.3842Yes
49AVPR1ANAAVPR1A
Entrez,  Source
arginine vasopressin receptor 1A32550.9250.3859Yes
50TIMP1NATIMP1
Entrez,  Source
TIMP metallopeptidase inhibitor 132840.9170.3888Yes
51LMNANALMNA
Entrez,  Source
lamin A/C33710.8900.3884Yes
52TGFB2NATGFB2
Entrez,  Source
transforming growth factor, beta 233890.8830.3919Yes
53TNFRSF12ANATNFRSF12A
Entrez,  Source
tumor necrosis factor receptor superfamily, member 12A34680.8680.3918No
54MMP2NAMMP2
Entrez,  Source
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)36140.8400.3878No
55TOP2ANATOP2A
Entrez,  Source
topoisomerase (DNA) II alpha 170kDa41500.7280.3614No
56IGF2RNAIGF2R
Entrez,  Source
insulin-like growth factor 2 receptor41920.7210.3627No
57BCL2L2NABCL2L2
Entrez,  Source
BCL2-like 242120.7170.3652No
58XIAPNA42350.7130.3675No
59GSNNAGSN
Entrez,  Source
gelsolin (amyloidosis, Finnish type)44410.6700.3593No
60PDGFRBNAPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide47390.6090.3457No
61LGALS3NALGALS3
Entrez,  Source
lectin, galactoside-binding, soluble, 3 (galectin 3)47780.5990.3465No
62GPX4NAGPX4
Entrez,  Source
glutathione peroxidase 4 (phospholipid hydroperoxidase)48090.5920.3478No
63ISG20NAISG20
Entrez,  Source
interferon stimulated exonuclease gene 20kDa48780.5810.3468No
64CCND1NACCND1
Entrez,  Source
cyclin D149460.5690.3459No
65TAP1NATAP1
Entrez,  Source
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)49610.5660.3479No
66ANXA1NAANXA1
Entrez,  Source
annexin A149950.5590.3489No
67CASP8NACASP8
Entrez,  Source
caspase 8, apoptosis-related cysteine peptidase52700.5050.3360No
68ETF1NAETF1
Entrez,  Source
eukaryotic translation termination factor 153200.4980.3357No
69PRF1NAPRF1
Entrez,  Source
perforin 1 (pore forming protein)53830.4900.3347No
70SATB1NASATB1
Entrez,  Source
special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA's)57330.4390.3173No
71IFNB1NAIFNB1
Entrez,  Source
interferon, beta 1, fibroblast58490.4280.3129No
72CFLARNACFLAR
Entrez,  Source
CASP8 and FADD-like apoptosis regulator59510.4200.3093No
73CD2NACD2
Entrez,  Source
CD2 molecule60920.4150.3035No
74TXNIPNATXNIP
Entrez,  Source
thioredoxin interacting protein63360.3920.2919No
75IFNGR1NAIFNGR1
Entrez,  Source
interferon gamma receptor 163710.3860.2919No
76HSPB1NAHSPB1
Entrez,  Source
heat shock 27kDa protein 166810.3370.2762No
77DNAJA1NADNAJA1
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily A, member 169880.2920.2605No
78KRT18NAKRT18
Entrez,  Source
keratin 1870290.2850.2596No
79CASP7NACASP7
Entrez,  Source
caspase 7, apoptosis-related cysteine peptidase70710.2780.2587No
80ROCK1NAROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 171490.2660.2557No
81JUNNAJUN
Entrez,  Source
jun oncogene71970.2580.2544No
82GPX1NAGPX1
Entrez,  Source
glutathione peroxidase 172080.2560.2551No
83FASLGNAFASLG
Entrez,  Source
Fas ligand (TNF superfamily, member 6)74350.2200.2435No
84SOD1NASOD1
Entrez,  Source
superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))74950.2110.2412No
85CD69NACD69
Entrez,  Source
CD69 molecule75690.2020.2381No
86EGR3NAEGR3
Entrez,  Source
early growth response 378030.1710.2259No
87ENO2NAENO2
Entrez,  Source
enolase 2 (gamma, neuronal)80630.1370.2121No
88CREBBPNACREBBP
Entrez,  Source
CREB binding protein (Rubinstein-Taybi syndrome)81580.1260.2074No
89ANKHNAANKH
Entrez,  Source
ankylosis, progressive homolog (mouse)82290.1160.2040No
90CCNA1NACCNA1
Entrez,  Source
cyclin A183590.1000.1973No
91CAV1NACAV1
Entrez,  Source
caveolin 1, caveolae protein, 22kDa84340.0890.1936No
92RELANARELA
Entrez,  Source
v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)9422-0.0030.1382No
93EBPNAEBP
Entrez,  Source
emopamil binding protein (sterol isomerase)9472-0.0100.1355No
94GNA15NAGNA15
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)9758-0.0470.1198No
95BAXNABAX
Entrez,  Source
BCL2-associated X protein9792-0.0510.1182No
96TNFNATNF
Entrez,  Source
tumor necrosis factor (TNF superfamily, member 2)9956-0.0660.1093No
97GUCY2DNAGUCY2D
Entrez,  Source
guanylate cyclase 2D, membrane (retina-specific)10010-0.0700.1067No
98MADDNAMADD
Entrez,  Source
MAP-kinase activating death domain10017-0.0700.1067No
99VDAC2NAVDAC2
Entrez,  Source
voltage-dependent anion channel 210134-0.0810.1006No
100NEFHNANEFH
Entrez,  Source
neurofilament, heavy polypeptide 200kDa10450-0.1160.0835No
101CASP2NACASP2
Entrez,  Source
caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2)10590-0.1380.0764No
102CD44NACD44
Entrez,  Source
CD44 molecule (Indian blood group)10782-0.1660.0665No
103DNM1LNADNM1L
Entrez,  Source
dynamin 1-like10907-0.1850.0605No
104DNAJC3NADNAJC3
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily C, member 311072-0.2080.0523No
105PEA15NAPEA15
Entrez,  Source
phosphoprotein enriched in astrocytes 1511757-0.3050.0154No
106FEZ1NAFEZ1
Entrez,  Source
fasciculation and elongation protein zeta 1 (zygin I)12062-0.3480.0001No
107DCNNADCN
Entrez,  Source
decorin12465-0.411-0.0204No
108BIDNABID
Entrez,  Source
BH3 interacting domain death agonist12708-0.435-0.0319No
109BCL2L10NABCL2L10
Entrez,  Source
BCL2-like 10 (apoptosis facilitator)12810-0.445-0.0353No
110PTK2NAPTK2
Entrez,  Source
PTK2 protein tyrosine kinase 212873-0.447-0.0366No
111GCH1NAGCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)13276-0.501-0.0567No
112PPT1NAPPT1
Entrez,  Source
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)13398-0.517-0.0609No
113RETSATNARETSAT
Entrez,  Source
retinol saturase (all-trans-retinol 13,14-reductase)13613-0.561-0.0701No
114BMFNABMF
Entrez,  Source
Bcl2 modifying factor13614-0.561-0.0673No
115GADD45BNAGADD45B
Entrez,  Source
growth arrest and DNA-damage-inducible, beta13919-0.618-0.0813No
116BCL10NABCL10
Entrez,  Source
B-cell CLL/lymphoma 1014053-0.647-0.0856No
117BCAP31NABCAP31
Entrez,  Source
B-cell receptor-associated protein 3114058-0.649-0.0826No
118CASP4NACASP4
Entrez,  Source
caspase 4, apoptosis-related cysteine peptidase14105-0.660-0.0819No
119BGNNABGN
Entrez,  Source
biglycan14175-0.677-0.0824No
120CTNNB1NACTNNB1
Entrez,  Source
catenin (cadherin-associated protein), beta 1, 88kDa14196-0.681-0.0801No
121DAP3NADAP3
Entrez,  Source
death associated protein 314449-0.740-0.0906No
122RHOT2NARHOT2
Entrez,  Source
ras homolog gene family, member T214533-0.762-0.0915No
123CDK2NACDK2
Entrez,  Source
cyclin-dependent kinase 214755-0.815-0.0998No
124HGFNAHGF
Entrez,  Source
hepatocyte growth factor (hepapoietin A; scatter factor)15015-0.871-0.1100No
125APPNAAPP
Entrez,  Source
amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)15153-0.903-0.1132No
126H1F0NAH1F0
Entrez,  Source
H1 histone family, member 015185-0.911-0.1104No
127SOD2NASOD2
Entrez,  Source
superoxide dismutase 2, mitochondrial15368-0.961-0.1159No
128GSTM1NAGSTM1
Entrez,  Source
glutathione S-transferase M115434-0.977-0.1147No
129BRCA1NABRCA1
Entrez,  Source
breast cancer 1, early onset15439-0.979-0.1100No
130MCL1NAMCL1
Entrez,  Source
myeloid cell leukemia sequence 1 (BCL2-related)15602-1.029-0.1140No
131TSPONATSPO
Entrez,  Source
translocator protein (18kDa)15660-1.050-0.1120No
132GADD45ANAGADD45A
Entrez,  Source
growth arrest and DNA-damage-inducible, alpha15708-1.064-0.1094No
133FDXRNAFDXR
Entrez,  Source
ferredoxin reductase15764-1.082-0.1071No
134DIABLONADIABLO
Entrez,  Source
diablo homolog (Drosophila)15955-1.155-0.1120No
135CCND2NACCND2
Entrez,  Source
cyclin D216061-1.200-0.1120No
136HMGB2NAHMGB2
Entrez,  Source
high-mobility group box 216136-1.232-0.1100No
137RNASELNARNASEL
Entrez,  Source
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)16149-1.238-0.1045No
138PAK1NAPAK1
Entrez,  Source
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)16221-1.270-0.1022No
139LEF1NALEF1
Entrez,  Source
lymphoid enhancer-binding factor 116302-1.306-0.1002No
140WEE1NAWEE1
Entrez,  Source
WEE1 homolog (S. pombe)16440-1.384-0.1010No
141BTG3NABTG3
Entrez,  Source
BTG family, member 316636-1.491-0.1046No
142NEDD9NANEDD9
Entrez,  Source
neural precursor cell expressed, developmentally down-regulated 916666-1.508-0.0987No
143PPP3R1NAPPP3R1
Entrez,  Source
protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)16772-1.581-0.0967No
144IFITM3NAIFITM3
Entrez,  Source
interferon induced transmembrane protein 3 (1-8U)16936-1.709-0.0974No
145DPYDNADPYD
Entrez,  Source
dihydropyrimidine dehydrogenase17048-1.812-0.0946No
146BIKNABIK
Entrez,  Source
BCL2-interacting killer (apoptosis-inducing)17139-1.918-0.0902No
147F2NAF2
Entrez,  Source
coagulation factor II (thrombin)17157-1.953-0.0814No
148CASP3NACASP3
Entrez,  Source
caspase 3, apoptosis-related cysteine peptidase17177-1.978-0.0727No
149PLCB2NAPLCB2
Entrez,  Source
phospholipase C, beta 217218-2.032-0.0648No
150IL1BNAIL1B
Entrez,  Source
interleukin 1, beta17373-2.282-0.0621No
151DAPNADAP
Entrez,  Source
death-associated protein17467-2.432-0.0553No
152PDCD4NAPDCD4
Entrez,  Source
programmed cell death 4 (neoplastic transformation inhibitor)17485-2.462-0.0440No
153BMP2NABMP2
Entrez,  Source
bone morphogenetic protein 217763-3.423-0.0426No
154AIFM3NA17813-3.631-0.0273No
155IL1ANAIL1A
Entrez,  Source
interleukin 1, alpha17815-3.646-0.0092No
156BTG2NABTG2
Entrez,  Source
BTG family, member 217816-3.6470.0089No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_APOPTOSIS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_APOPTOSIS: Random ES distribution   
Gene set null distribution of ES for HALLMARK_APOPTOSIS