Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_APICAL_JUNCTION
Enrichment Score (ES)-0.2415098
Normalized Enrichment Score (NES)-1.0617591
Nominal p-value0.2718894
FDR q-value0.4499946
FWER p-Value0.98
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_APICAL_JUNCTION   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1CDH11NACDH11
Entrez,  Source
cadherin 11, type 2, OB-cadherin (osteoblast)44.9730.0235No
2ITGB4NAITGB4
Entrez,  Source
integrin, beta 41264.3900.0375No
3CLDN4NACLDN4
Entrez,  Source
claudin 41944.1430.0535No
4PCDH1NAPCDH1
Entrez,  Source
protocadherin 1 (cadherin-like 1)2653.8500.0679No
5SHROOM2NASHROOM2
Entrez,  Source
shroom family member 22703.8350.0859No
6ADAM23NAADAM23
Entrez,  Source
ADAM metallopeptidase domain 232913.7570.1027No
7JUPNAJUP
Entrez,  Source
junction plakoglobin3773.4960.1146No
8LAMA3NALAMA3
Entrez,  Source
laminin, alpha 33783.4900.1312No
9ITGA2NAITGA2
Entrez,  Source
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)4833.2530.1408No
10GRB7NAGRB7
Entrez,  Source
growth factor receptor-bound protein 76832.7490.1427No
11SLIT2NASLIT2
Entrez,  Source
slit homolog 2 (Drosophila)6982.7280.1549No
12CNTN1NACNTN1
Entrez,  Source
contactin 18112.5350.1607No
13ADAM9NAADAM9
Entrez,  Source
ADAM metallopeptidase domain 9 (meltrin gamma)8402.4880.1709No
14ITGA3NAITGA3
Entrez,  Source
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)9782.3170.1743No
15BMP1NABMP1
Entrez,  Source
bone morphogenetic protein 110092.2830.1835No
16IRS1NAIRS1
Entrez,  Source
insulin receptor substrate 110172.2740.1939No
17ICAM4NAICAM4
Entrez,  Source
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)13361.8980.1850No
18FBN1NAFBN1
Entrez,  Source
fibrillin 114581.7980.1868No
19ADRA1BNAADRA1B
Entrez,  Source
adrenergic, alpha-1B-, receptor14651.7930.1950No
20CTNNA1NACTNNA1
Entrez,  Source
catenin (cadherin-associated protein), alpha 1, 102kDa17561.5580.1861No
21ICAM1NAICAM1
Entrez,  Source
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor19971.4220.1794No
22CD99NACD99
Entrez,  Source
CD99 molecule20011.4200.1860No
23PIK3R3NAPIK3R3
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)21091.3540.1864No
24ATP1A3NAATP1A3
Entrez,  Source
ATPase, Na+/K+ transporting, alpha 3 polypeptide21391.3360.1911No
25PECAM1NAPECAM1
Entrez,  Source
platelet/endothelial cell adhesion molecule (CD31 antigen)21481.3340.1970No
26TRAF1NATRAF1
Entrez,  Source
TNF receptor-associated factor 121921.3090.2008No
27CD34NACD34
Entrez,  Source
CD34 molecule22411.2840.2042No
28GNAI1NAGNAI1
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 122741.2700.2085No
29FLNCNAFLNC
Entrez,  Source
filamin C, gamma (actin binding protein 280)23601.2300.2096No
30B4GALT1NAB4GALT1
Entrez,  Source
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 123711.2260.2148No
31AMIGO2NAAMIGO2
Entrez,  Source
adhesion molecule with Ig-like domain 224101.2110.2185No
32LDLRAP1NALDLRAP1
Entrez,  Source
low density lipoprotein receptor adaptor protein 124441.1960.2223No
33CLDN9NACLDN9
Entrez,  Source
claudin 925051.1770.2245No
34MDKNAMDK
Entrez,  Source
midkine (neurite growth-promoting factor 2)26591.1090.2212No
35STX4NASTX4
Entrez,  Source
syntaxin 428711.0390.2143No
36PBX2NAPBX2
Entrez,  Source
pre-B-cell leukemia transcription factor 229211.0180.2164No
37MYL9NAMYL9
Entrez,  Source
myosin, light chain 9, regulatory30510.9740.2138No
38NRAPNANRAP
Entrez,  Source
nebulin-related anchoring protein32310.9320.2081No
39DHX16NADHX16
Entrez,  Source
DEAH (Asp-Glu-Ala-His) box polypeptide 1632860.9170.2095No
40TNFRSF11BNATNFRSF11B
Entrez,  Source
tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)33870.8840.2081No
41CADM2NA33950.8820.2119No
42NF1NANF1
Entrez,  Source
neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)34770.8640.2114No
43CLDN14NACLDN14
Entrez,  Source
claudin 1434830.8610.2152No
44MMP2NAMMP2
Entrez,  Source
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)36140.8400.2119No
45BAIAP2NABAIAP2
Entrez,  Source
BAI1-associated protein 236420.8360.2144No
46GAMTNAGAMT
Entrez,  Source
guanidinoacetate N-methyltransferase38270.8040.2079No
47DLG1NADLG1
Entrez,  Source
discs, large homolog 1 (Drosophila)39990.7620.2019No
48ARHGEF6NAARHGEF6
Entrez,  Source
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 641150.7360.1989No
49CX3CL1NACX3CL1
Entrez,  Source
chemokine (C-X3-C motif) ligand 141370.7320.2012No
50ALOX15BNAALOX15B
Entrez,  Source
arachidonate 15-lipoxygenase, type B41580.7270.2036No
51ZYXNAZYX
Entrez,  Source
zyxin41810.7230.2058No
52ADAMTS5NAADAMTS5
Entrez,  Source
ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2)42310.7140.2064No
53RRASNARRAS
Entrez,  Source
related RAS viral (r-ras) oncogene homolog42410.7130.2093No
54MPZL1NAMPZL1
Entrez,  Source
myelin protein zero-like 142580.7110.2118No
55EGFRNAEGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)42600.7100.2151No
56WASLNAWASL
Entrez,  Source
Wiskott-Aldrich syndrome-like44070.6770.2101No
57PIK3CBNAPIK3CB
Entrez,  Source
phosphoinositide-3-kinase, catalytic, beta polypeptide44500.6680.2109No
58CDH1NACDH1
Entrez,  Source
cadherin 1, type 1, E-cadherin (epithelial)46450.6300.2030No
59MAPK14NAMAPK14
Entrez,  Source
mitogen-activated protein kinase 1446640.6260.2050No
60IKBKGNAIKBKG
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma47730.6000.2018No
61TSC1NATSC1
Entrez,  Source
tuberous sclerosis 147850.5990.2040No
62LAYNNALAYN
Entrez,  Source
layilin48700.5810.2020No
63ACTG1NAACTG1
Entrez,  Source
actin, gamma 148900.5790.2037No
64RASA1NARASA1
Entrez,  Source
RAS p21 protein activator (GTPase activating protein) 150010.5580.2002No
65CLDN18NACLDN18
Entrez,  Source
claudin 1850370.5480.2008No
66CRB3NACRB3
Entrez,  Source
crumbs homolog 3 (Drosophila)50510.5450.2027No
67MYL12BNA51290.5300.2009No
68NLGN3NANLGN3
Entrez,  Source
neuroligin 353490.4920.1909No
69VCAM1NAVCAM1
Entrez,  Source
vascular cell adhesion molecule 157500.4370.1705No
70CDSNNACDSN
Entrez,  Source
corneodesmosin57600.4370.1721No
71COL9A1NACOL9A1
Entrez,  Source
collagen, type IX, alpha 159920.4180.1611No
72CADM3NA61430.4150.1546No
73KRT31NAKRT31
Entrez,  Source
keratin 3161870.4150.1542No
74SORBS3NASORBS3
Entrez,  Source
sorbin and SH3 domain containing 365960.3500.1329No
75DMP1NADMP1
Entrez,  Source
dentin matrix acidic phosphoprotein66020.3490.1343No
76ITGA10NAITGA10
Entrez,  Source
integrin, alpha 1066300.3440.1344No
77NRXN2NANRXN2
Entrez,  Source
neurexin 267370.3290.1300No
78SPEGNASPEG
Entrez,  Source
SPEG complex locus68510.3150.1252No
79LIMA1NALIMA1
Entrez,  Source
LIM domain and actin binding 169020.3060.1238No
80TRONATRO
Entrez,  Source
trophinin69270.3020.1239No
81CDH6NACDH6
Entrez,  Source
cadherin 6, type 2, K-cadherin (fetal kidney)69390.3000.1247No
82LAMC2NALAMC2
Entrez,  Source
laminin, gamma 270790.2770.1182No
83NRTNNANRTN
Entrez,  Source
neurturin70850.2760.1192No
84ACTC1NAACTC1
Entrez,  Source
actin, alpha, cardiac muscle 172130.2550.1133No
85CD274NACD274
Entrez,  Source
CD274 molecule72160.2550.1144No
86INPPL1NAINPPL1
Entrez,  Source
inositol polyphosphate phosphatase-like 173930.2270.1056No
87EXOC4NAEXOC4
Entrez,  Source
exocyst complex component 475130.2080.0999No
88SYKNASYK
Entrez,  Source
spleen tyrosine kinase75950.1990.0963No
89CLDN6NACLDN6
Entrez,  Source
claudin 676570.1910.0938No
90CLDN8NACLDN8
Entrez,  Source
claudin 879510.1510.0780No
91SKAP2NASKAP2
Entrez,  Source
src kinase associated phosphoprotein 280940.1340.0707No
92HRASNAHRAS
Entrez,  Source
v-Ha-ras Harvey rat sarcoma viral oncogene homolog81200.1310.0699No
93ACTN4NAACTN4
Entrez,  Source
actinin, alpha 481210.1310.0705No
94AKT2NAAKT2
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 281930.1200.0671No
95VAV2NAVAV2
Entrez,  Source
vav 2 oncogene82120.1180.0666No
96SYMPKNASYMPK
Entrez,  Source
symplekin82590.1110.0646No
97KCNH2NAKCNH2
Entrez,  Source
potassium voltage-gated channel, subfamily H (eag-related), member 282690.1110.0646No
98CNN2NACNN2
Entrez,  Source
calponin 283370.1020.0613No
99ICAM5NAICAM5
Entrez,  Source
intercellular adhesion molecule 5, telencephalin85410.0750.0502No
100MPP5NAMPP5
Entrez,  Source
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)85550.0730.0499No
101SDC3NASDC3
Entrez,  Source
syndecan 3 (N-syndecan)86380.0610.0455No
102PTENNAPTEN
Entrez,  Source
phosphatase and tensin homolog (mutated in multiple advanced cancers 1)87110.0510.0417No
103TUBG1NATUBG1
Entrez,  Source
tubulin, gamma 187960.0410.0372No
104MSNNAMSN
Entrez,  Source
moesin89170.0260.0306No
105CD209NACD209
Entrez,  Source
CD209 molecule91170.0090.0194No
106ACTA1NAACTA1
Entrez,  Source
actin, alpha 1, skeletal muscle9467-0.008-0.0002No
107CTNND1NACTNND1
Entrez,  Source
catenin (cadherin-associated protein), delta 19541-0.021-0.0042No
108NEXNNANEXN
Entrez,  Source
nexilin (F actin binding protein)9572-0.026-0.0057No
109ITGB1NAITGB1
Entrez,  Source
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)9602-0.030-0.0072No
110GTF2F1NAGTF2F1
Entrez,  Source
general transcription factor IIF, polypeptide 1, 74kDa9844-0.057-0.0205No
111NFASCNANFASC
Entrez,  Source
neurofascin homolog (chicken)10311-0.097-0.0462No
112SGCENASGCE
Entrez,  Source
sarcoglycan, epsilon10587-0.137-0.0611No
113PTPRCNAPTPRC
Entrez,  Source
protein tyrosine phosphatase, receptor type, C10626-0.143-0.0625No
114CDH8NACDH8
Entrez,  Source
cadherin 8, type 210629-0.144-0.0619No
115SRCNASRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10694-0.154-0.0648No
116TIAL1NATIAL1
Entrez,  Source
TIA1 cytotoxic granule-associated RNA binding protein-like 110715-0.156-0.0652No
117CD86NACD86
Entrez,  Source
CD86 molecule10856-0.177-0.0722No
118RSU1NARSU1
Entrez,  Source
Ras suppressor protein 110882-0.181-0.0728No
119TAOK2NATAOK2
Entrez,  Source
TAO kinase 210885-0.181-0.0720No
120ARPC2NAARPC2
Entrez,  Source
actin related protein 2/3 complex, subunit 2, 34kDa10950-0.190-0.0747No
121CLDN5NACLDN5
Entrez,  Source
claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)11081-0.209-0.0810No
122MADCAM1NAMADCAM1
Entrez,  Source
mucosal vascular addressin cell adhesion molecule 111084-0.209-0.0801No
123CRATNACRAT
Entrez,  Source
carnitine acetyltransferase11109-0.213-0.0805No
124CLDN19NACLDN19
Entrez,  Source
claudin 1911526-0.275-0.1026No
125MAPK13NAMAPK13
Entrez,  Source
mitogen-activated protein kinase 1311527-0.275-0.1013No
126ICAM2NAICAM2
Entrez,  Source
intercellular adhesion molecule 211697-0.295-0.1094No
127COL16A1NACOL16A1
Entrez,  Source
collagen, type XVI, alpha 111799-0.311-0.1136No
128TJP1NATJP1
Entrez,  Source
tight junction protein 1 (zona occludens 1)11834-0.319-0.1140No
129PKD1NAPKD1
Entrez,  Source
polycystic kidney disease 1 (autosomal dominant)11884-0.327-0.1152No
130NEGR1NANEGR1
Entrez,  Source
neuronal growth regulator 112059-0.347-0.1233No
131TSPAN4NATSPAN4
Entrez,  Source
tetraspanin 412113-0.356-0.1246No
132CAP1NACAP1
Entrez,  Source
CAP, adenylate cyclase-associated protein 1 (yeast)12373-0.394-0.1373No
133CDH15NACDH15
Entrez,  Source
cadherin 15, M-cadherin (myotubule)12444-0.408-0.1393No
134YWHAHNAYWHAH
Entrez,  Source
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide12614-0.418-0.1468No
135DSC3NADSC3
Entrez,  Source
desmocollin 312619-0.418-0.1450No
136PLCG1NAPLCG1
Entrez,  Source
phospholipase C, gamma 112635-0.421-0.1438No
137ACTN1NAACTN1
Entrez,  Source
actinin, alpha 112856-0.445-0.1541No
138PTK2NAPTK2
Entrez,  Source
PTK2 protein tyrosine kinase 212873-0.447-0.1529No
139CLDN11NACLDN11
Entrez,  Source
claudin 11 (oligodendrocyte transmembrane protein)12876-0.448-0.1509No
140THY1NATHY1
Entrez,  Source
Thy-1 cell surface antigen12981-0.453-0.1545No
141CDH3NACDH3
Entrez,  Source
cadherin 3, type 1, P-cadherin (placental)13000-0.456-0.1534No
142ACTBNAACTB
Entrez,  Source
actin, beta13165-0.481-0.1603No
143AMIGO1NAAMIGO1
Entrez,  Source
adhesion molecule with Ig-like domain 113255-0.498-0.1630No
144PDZD3NAPDZD3
Entrez,  Source
PDZ domain containing 313536-0.543-0.1761No
145CLDN15NACLDN15
Entrez,  Source
claudin 1513587-0.555-0.1763No
146NLGN2NANLGN2
Entrez,  Source
neuroligin 213589-0.555-0.1737No
147MYH9NAMYH9
Entrez,  Source
myosin, heavy chain 9, non-muscle13628-0.563-0.1732No
148VWFNAVWF
Entrez,  Source
von Willebrand factor13772-0.589-0.1784No
149PARVANAPARVA
Entrez,  Source
parvin, alpha13825-0.600-0.1785No
150AMHNAAMH
Entrez,  Source
anti-Mullerian hormone13868-0.608-0.1779No
151COL17A1NACOL17A1
Entrez,  Source
collagen, type XVII, alpha 114020-0.640-0.1834No
152RAC2NARAC2
Entrez,  Source
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)14098-0.658-0.1846No
153AKT3NAAKT3
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)14156-0.671-0.1846No
154CERCAMNA14266-0.693-0.1874No
155LAMB3NALAMB3
Entrez,  Source
laminin, beta 314379-0.719-0.1903No
156PFN1NAPFN1
Entrez,  Source
profilin 114577-0.772-0.1977No
157VCLNAVCL
Entrez,  Source
vinculin14667-0.793-0.1989No
158GNAI2NAGNAI2
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 214733-0.810-0.1987No
159HADHNAHADH
Entrez,  Source
hydroxyacyl-Coenzyme A dehydrogenase14938-0.852-0.2061No
160CD276NACD276
Entrez,  Source
CD276 molecule14979-0.862-0.2043No
161MAP4K2NAMAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 215154-0.903-0.2098No
162VASPNAVASP
Entrez,  Source
vasodilator-stimulated phosphoprotein15336-0.951-0.2154No
163ACTN2NAACTN2
Entrez,  Source
actinin, alpha 215457-0.986-0.2175No
164CALB2NACALB2
Entrez,  Source
calbindin 2, 29kDa (calretinin)15498-0.998-0.2150No
165PARD6GNAPARD6G
Entrez,  Source
par-6 partitioning defective 6 homolog gamma (C. elegans)15628-1.037-0.2173No
166CLDN7NACLDN7
Entrez,  Source
claudin 715646-1.041-0.2133No
167ADAM15NAADAM15
Entrez,  Source
ADAM metallopeptidase domain 15 (metargidin)15688-1.058-0.2106No
168CDK8NACDK8
Entrez,  Source
cyclin-dependent kinase 815733-1.072-0.2079No
169THBS3NATHBS3
Entrez,  Source
thrombospondin 316331-1.324-0.2352Yes
170DSC1NADSC1
Entrez,  Source
desmocollin 116375-1.348-0.2312Yes
171ACTN3NAACTN3
Entrez,  Source
actinin, alpha 316502-1.414-0.2316Yes
172SHC1NASHC1
Entrez,  Source
SHC (Src homology 2 domain containing) transforming protein 116678-1.516-0.2342Yes
173TMEM8BNA16685-1.521-0.2273Yes
174NF2NANF2
Entrez,  Source
neurofibromin 2 (bilateral acoustic neuroma)16827-1.628-0.2275Yes
175FSCN1NAFSCN1
Entrez,  Source
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)16978-1.750-0.2276Yes
176EPB41L2NAEPB41L2
Entrez,  Source
erythrocyte membrane protein band 4.1-like 217044-1.808-0.2226Yes
177INSIG1NAINSIG1
Entrez,  Source
insulin induced gene 117202-2.009-0.2219Yes
178CDH4NACDH4
Entrez,  Source
cadherin 4, type 1, R-cadherin (retinal)17227-2.049-0.2135Yes
179ITGA9NAITGA9
Entrez,  Source
integrin, alpha 917315-2.199-0.2079Yes
180MAPK11NAMAPK11
Entrez,  Source
mitogen-activated protein kinase 1117451-2.412-0.2040Yes
181RHOFNARHOF
Entrez,  Source
ras homolog gene family, member F (in filopodia)17539-2.589-0.1966Yes
182MVDNAMVD
Entrez,  Source
mevalonate (diphospho) decarboxylase17563-2.616-0.1854Yes
183JAM3NAJAM3
Entrez,  Source
junctional adhesion molecule 317589-2.733-0.1738Yes
184MPZL2NA17654-2.903-0.1636Yes
185MYH10NAMYH10
Entrez,  Source
myosin, heavy chain 10, non-muscle17657-2.912-0.1498Yes
186SLC30A3NASLC30A3
Entrez,  Source
solute carrier family 30 (zinc transporter), member 317697-3.087-0.1373Yes
187EVLNAEVL
Entrez,  Source
Enah/Vasp-like17719-3.177-0.1234Yes
188WNK4NAWNK4
Entrez,  Source
WNK lysine deficient protein kinase 417725-3.210-0.1084Yes
189TGFBINATGFBI
Entrez,  Source
transforming growth factor, beta-induced, 68kDa17833-3.753-0.0965Yes
190MMP9NAMMP9
Entrez,  Source
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)17854-3.963-0.0788Yes
191PPP2R2CNAPPP2R2C
Entrez,  Source
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform17881-4.130-0.0606Yes
192SIRPANASIRPA
Entrez,  Source
signal-regulatory protein alpha17906-4.375-0.0411Yes
193VCANNA17935-4.655-0.0205Yes
194ACTG2NAACTG2
Entrez,  Source
actin, gamma 2, smooth muscle, enteric17946-4.7600.0016Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_APICAL_JUNCTION   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_APICAL_JUNCTION: Random ES distribution   
Gene set null distribution of ES for HALLMARK_APICAL_JUNCTION