Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_ADIPOGENESIS
Enrichment Score (ES)-0.22452527
Normalized Enrichment Score (NES)-0.97188836
Nominal p-value0.56796116
FDR q-value0.66255355
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_ADIPOGENESIS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1GPX3NAGPX3
Entrez,  Source
glutathione peroxidase 3 (plasma)134.9440.0286No
2LPLNALPL
Entrez,  Source
lipoprotein lipase514.7170.0545No
3ENPP2NAENPP2
Entrez,  Source
ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)2693.8380.0650No
4LAMA4NALAMA4
Entrez,  Source
laminin, alpha 43523.5780.0816No
5ANGPTL4NAANGPTL4
Entrez,  Source
angiopoietin-like 44753.2720.0942No
6MCCC1NAMCCC1
Entrez,  Source
methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)6612.8080.1004No
7LIFRNALIFR
Entrez,  Source
leukemia inhibitory factor receptor alpha8352.4930.1055No
8PLIN2NA9262.3900.1146No
9BCL6NABCL6
Entrez,  Source
B-cell CLL/lymphoma 6 (zinc finger protein 51)10142.2760.1232No
10ACADLNAACADL
Entrez,  Source
acyl-Coenzyme A dehydrogenase, long chain11952.0430.1252No
11PEX14NAPEX14
Entrez,  Source
peroxisomal biogenesis factor 1412951.9370.1311No
12TOB1NATOB1
Entrez,  Source
transducer of ERBB2, 113311.9000.1404No
13APOENAAPOE
Entrez,  Source
apolipoprotein E14201.8270.1463No
14DNAJB9NADNAJB9
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily B, member 914761.7810.1538No
15COL15A1NACOL15A1
Entrez,  Source
collagen, type XV, alpha 115621.7140.1592No
16EPHX2NAEPHX2
Entrez,  Source
epoxide hydrolase 2, cytoplasmic15641.7130.1693No
17GPD2NAGPD2
Entrez,  Source
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)18301.5110.1633No
18MGST3NAMGST3
Entrez,  Source
microsomal glutathione S-transferase 319381.4520.1659No
19CCNG2NACCNG2
Entrez,  Source
cyclin G219551.4420.1736No
20IDH1NAIDH1
Entrez,  Source
isocitrate dehydrogenase 1 (NADP+), soluble19991.4210.1796No
21IDH3GNAIDH3G
Entrez,  Source
isocitrate dehydrogenase 3 (NAD+) gamma23031.2520.1700No
22APLP2NAAPLP2
Entrez,  Source
amyloid beta (A4) precursor-like protein 224181.2080.1707No
23PTGER3NAPTGER3
Entrez,  Source
prostaglandin E receptor 3 (subtype EP3)27681.0710.1575No
24G3BP2NAG3BP2
Entrez,  Source
-31500.9480.1417No
25HIBCHNAHIBCH
Entrez,  Source
3-hydroxyisobutyryl-Coenzyme A hydrolase32000.9400.1445No
26DHRS7NADHRS7
Entrez,  Source
dehydrogenase/reductase (SDR family) member 732390.9300.1479No
27UBCNAUBC
Entrez,  Source
ubiquitin C34050.8810.1438No
28ACOX1NAACOX1
Entrez,  Source
acyl-Coenzyme A oxidase 1, palmitoyl34480.8710.1466No
29PORNAPOR
Entrez,  Source
P450 (cytochrome) oxidoreductase35000.8560.1488No
30ALDH2NAALDH2
Entrez,  Source
aldehyde dehydrogenase 2 family (mitochondrial)36350.8390.1463No
31CD151NACD151
Entrez,  Source
CD151 molecule (Raph blood group)36960.8320.1478No
32UQCRQNAUQCRQ
Entrez,  Source
ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa37210.8260.1514No
33MAP4K3NAMAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 339090.7830.1455No
34REEP5NAREEP5
Entrez,  Source
receptor accessory protein 540360.7530.1429No
35PHYHNAPHYH
Entrez,  Source
phytanoyl-CoA 2-hydroxylase40890.7420.1444No
36COQ9NACOQ9
Entrez,  Source
coenzyme Q9 homolog (S. cerevisiae)42440.7130.1399No
37RAB34NARAB34
Entrez,  Source
RAB34, member RAS oncogene family43420.6910.1386No
38VEGFBNAVEGFB
Entrez,  Source
vascular endothelial growth factor B43460.6900.1425No
39ACADSNAACADS
Entrez,  Source
acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain45890.6400.1327No
40QDPRNAQDPR
Entrez,  Source
quinoid dihydropteridine reductase46860.6210.1310No
41ADIPOQNAADIPOQ
Entrez,  Source
adiponectin, C1Q and collagen domain containing47440.6080.1314No
42GPX4NAGPX4
Entrez,  Source
glutathione peroxidase 4 (phospholipid hydroperoxidase)48090.5920.1313No
43HSPB8NAHSPB8
Entrez,  Source
heat shock 22kDa protein 848200.5900.1342No
44PREBNAPREB
Entrez,  Source
prolactin regulatory element binding48440.5850.1364No
45ARL4ANAARL4A
Entrez,  Source
ADP-ribosylation factor-like 4A50450.5460.1284No
46ARAFNAARAF
Entrez,  Source
v-raf murine sarcoma 3611 viral oncogene homolog51030.5340.1284No
47SDHBNASDHB
Entrez,  Source
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)52990.5000.1204No
48AIFM1NA53300.4960.1216No
49ESRRANAESRRA
Entrez,  Source
estrogen-related receptor alpha53760.4910.1220No
50RTN3NARTN3
Entrez,  Source
reticulon 353950.4880.1239No
51CMBLNACMBL
Entrez,  Source
carboxymethylenebutenolidase homolog (Pseudomonas)54750.4820.1223No
52UCP2NAUCP2
Entrez,  Source
uncoupling protein 2 (mitochondrial, proton carrier)56350.4550.1161No
53ADIGNA58220.4280.1081No
54SLC19A1NASLC19A1
Entrez,  Source
solute carrier family 19 (folate transporter), member 159100.4280.1058No
55LEPNALEP
Entrez,  Source
leptin (obesity homolog, mouse)59180.4260.1079No
56ORM1NAORM1
Entrez,  Source
orosomucoid 161180.4150.0992No
57TANKNATANK
Entrez,  Source
TRAF family member-associated NFKB activator62850.4000.0922No
58IFNGR1NAIFNGR1
Entrez,  Source
interferon gamma receptor 163710.3860.0897No
59SULT1A1NASULT1A1
Entrez,  Source
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 164900.3680.0853No
60MDH2NAMDH2
Entrez,  Source
malate dehydrogenase 2, NAD (mitochondrial)66880.3360.0762No
61ABCB8NAABCB8
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 868600.3130.0684No
62RIOK3NARIOK3
Entrez,  Source
RIO kinase 3 (yeast)68690.3110.0698No
63CSNACS
Entrez,  Source
citrate synthase69140.3040.0692No
64ESYT1NA69950.2900.0664No
65CD302NACD302
Entrez,  Source
CD302 molecule70040.2890.0676No
66FAHNAFAH
Entrez,  Source
fumarylacetoacetate hydrolase (fumarylacetoacetase)70220.2860.0684No
67ITGA7NAITGA7
Entrez,  Source
integrin, alpha 771130.2720.0649No
68OMDNAOMD
Entrez,  Source
osteomodulin71570.2650.0641No
69PPM1BNAPPM1B
Entrez,  Source
protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform74320.2210.0500No
70SOD1NASOD1
Entrez,  Source
superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))74950.2110.0478No
71SLC1A5NASLC1A5
Entrez,  Source
solute carrier family 1 (neutral amino acid transporter), member 575050.2100.0485No
72ITIH5NAITIH5
Entrez,  Source
inter-alpha (globulin) inhibitor H578020.1710.0329No
73COX8ANACOX8A
Entrez,  Source
cytochrome c oxidase subunit 8A (ubiquitous)80310.1420.0209No
74ADCY6NAADCY6
Entrez,  Source
adenylate cyclase 681970.1200.0123No
75ATP1B3NAATP1B3
Entrez,  Source
ATPase, Na+/K+ transporting, beta 3 polypeptide82770.1100.0085No
76UCK1NAUCK1
Entrez,  Source
uridine-cytidine kinase 182820.1100.0090No
77ACO2NAACO2
Entrez,  Source
aconitase 2, mitochondrial82900.1090.0092No
78RREB1NARREB1
Entrez,  Source
ras responsive element binding protein 182920.1090.0098No
79SLC25A10NASLC25A10
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 1083530.1010.0070No
80NDUFB7NANDUFB7
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa87040.052-0.0123No
81YWHAGNAYWHAG
Entrez,  Source
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide87290.048-0.0134No
82ATP5ONAATP5O
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein)87530.044-0.0144No
83GBE1NAGBE1
Entrez,  Source
glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen disease, glycogen storage disease type IV)88760.033-0.0211No
84PFKFB3NAPFKFB3
Entrez,  Source
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 389010.028-0.0223No
85DDTNADDT
Entrez,  Source
D-dopachrome tautomerase89180.026-0.0230No
86PGM1NAPGM1
Entrez,  Source
phosphoglucomutase 189230.025-0.0231No
87MTCH2NAMTCH2
Entrez,  Source
mitochondrial carrier homolog 2 (C. elegans)91490.005-0.0357No
88CYP4B1NACYP4B1
Entrez,  Source
cytochrome P450, family 4, subfamily B, polypeptide 193840.000-0.0489No
89CD36NACD36
Entrez,  Source
CD36 molecule (thrombospondin receptor)9407-0.000-0.0501No
90SCP2NASCP2
Entrez,  Source
sterol carrier protein 29491-0.013-0.0547No
91ADIPOR2NAADIPOR2
Entrez,  Source
adiponectin receptor 29700-0.043-0.0662No
92UQCR10NA9800-0.052-0.0714No
93ME1NAME1
Entrez,  Source
malic enzyme 1, NADP(+)-dependent, cytosolic10031-0.072-0.0839No
94DBTNADBT
Entrez,  Source
dihydrolipoamide branched chain transacylase E210052-0.074-0.0846No
95DHRS7BNADHRS7B
Entrez,  Source
dehydrogenase/reductase (SDR family) member 7B10140-0.081-0.0890No
96BAZ2ANABAZ2A
Entrez,  Source
bromodomain adjacent to zinc finger domain, 2A10157-0.084-0.0894No
97PQLC3NAPQLC3
Entrez,  Source
PQ loop repeat containing 310340-0.101-0.0991No
98SPARCL1NASPARCL1
Entrez,  Source
SPARC-like 1 (mast9, hevin)10674-0.150-0.1169No
99ATL2NA10764-0.162-0.1209No
100GRPEL1NAGRPEL1
Entrez,  Source
GrpE-like 1, mitochondrial (E. coli)10804-0.170-0.1221No
101ECHS1NAECHS1
Entrez,  Source
enoyl Coenzyme A hydratase, short chain, 1, mitochondrial10958-0.192-0.1296No
102CRATNACRAT
Entrez,  Source
carnitine acetyltransferase11109-0.213-0.1367No
103TALDO1NATALDO1
Entrez,  Source
transaldolase 111110-0.213-0.1355No
104SAMM50NASAMM50
Entrez,  Source
sorting and assembly machinery component 50 homolog (S. cerevisiae)11141-0.218-0.1359No
105MRPL15NAMRPL15
Entrez,  Source
mitochondrial ribosomal protein L1511199-0.226-0.1377No
106ACAA2NAACAA2
Entrez,  Source
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)11255-0.232-0.1395No
107CPT2NACPT2
Entrez,  Source
carnitine palmitoyltransferase II11265-0.234-0.1386No
108ETFBNAETFB
Entrez,  Source
electron-transfer-flavoprotein, beta polypeptide11337-0.245-0.1411No
109PHLDB1NAPHLDB1
Entrez,  Source
pleckstrin homology-like domain, family B, member 111370-0.249-0.1414No
110UBQLN1NAUBQLN1
Entrez,  Source
ubiquilin 111534-0.276-0.1490No
111AGPAT3NAAGPAT3
Entrez,  Source
1-acylglycerol-3-phosphate O-acyltransferase 311560-0.280-0.1487No
112BCL2L13NABCL2L13
Entrez,  Source
BCL2-like 13 (apoptosis facilitator)11822-0.316-0.1615No
113CYC1NACYC1
Entrez,  Source
cytochrome c-111877-0.325-0.1626No
114COQ5NACOQ5
Entrez,  Source
coenzyme Q5 homolog, methyltransferase (S. cerevisiae)12036-0.343-0.1695No
115ACADMNAACADM
Entrez,  Source
acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain12066-0.348-0.1690No
116ANGPT1NAANGPT1
Entrez,  Source
angiopoietin 112162-0.363-0.1722No
117SCARB1NASCARB1
Entrez,  Source
scavenger receptor class B, member 112172-0.365-0.1706No
118ALDOANAALDOA
Entrez,  Source
aldolase A, fructose-bisphosphate12225-0.371-0.1713No
119ECH1NAECH1
Entrez,  Source
enoyl Coenzyme A hydratase 1, peroxisomal12276-0.380-0.1718No
120NMT1NANMT1
Entrez,  Source
N-myristoyltransferase 112344-0.391-0.1733No
121LTC4SNALTC4S
Entrez,  Source
leukotriene C4 synthase12498-0.411-0.1795No
122STAT5ANASTAT5A
Entrez,  Source
signal transducer and activator of transcription 5A12573-0.412-0.1812No
123RNF11NARNF11
Entrez,  Source
ring finger protein 1112659-0.426-0.1834No
124UQCR11NA12732-0.440-0.1849No
125CATNACAT
Entrez,  Source
catalase12749-0.444-0.1831No
126PFKLNAPFKL
Entrez,  Source
phosphofructokinase, liver13103-0.473-0.2002No
127COX7BNACOX7B
Entrez,  Source
cytochrome c oxidase subunit VIIb13205-0.490-0.2030No
128JAGN1NAJAGN1
Entrez,  Source
jagunal homolog 1 (Drosophila)13274-0.501-0.2038No
129MRAPNAMRAP
Entrez,  Source
melanocortin 2 receptor accessory protein13342-0.509-0.2046No
130SLC27A1NASLC27A1
Entrez,  Source
solute carrier family 27 (fatty acid transporter), member 113603-0.559-0.2159No
131RETSATNARETSAT
Entrez,  Source
retinol saturase (all-trans-retinol 13,14-reductase)13613-0.561-0.2130No
132PPP1R15BNAPPP1R15B
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 15B13640-0.566-0.2112No
133SDHCNASDHC
Entrez,  Source
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa13774-0.589-0.2151No
134NDUFS3NANDUFS3
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)13841-0.603-0.2153No
135GHITMNAGHITM
Entrez,  Source
growth hormone inducible transmembrane protein13957-0.625-0.2180No
136DLDNADLD
Entrez,  Source
dihydrolipoamide dehydrogenase13981-0.630-0.2156No
137PIM3NAPIM3
Entrez,  Source
pim-3 oncogene13987-0.632-0.2121No
138CHUKNACHUK
Entrez,  Source
conserved helix-loop-helix ubiquitous kinase14002-0.635-0.2091No
139PPARGNAPPARG
Entrez,  Source
peroxisome proliferative activated receptor, gamma14022-0.640-0.2064No
140MYLKNAMYLK
Entrez,  Source
myosin, light chain kinase14083-0.654-0.2059No
141AK2NAAK2
Entrez,  Source
adenylate kinase 214411-0.728-0.2200Yes
142DLATNADLAT
Entrez,  Source
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)14426-0.732-0.2164Yes
143NKIRAS1NANKIRAS1
Entrez,  Source
NFKB inhibitor interacting Ras-like 114511-0.757-0.2167Yes
144SLC5A6NASLC5A6
Entrez,  Source
solute carrier family 5 (sodium-dependent vitamin transporter), member 614652-0.788-0.2199Yes
145ELOVL6NAELOVL6
Entrez,  Source
ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)14663-0.792-0.2157Yes
146DRAM2NA14691-0.799-0.2125Yes
147NDUFA5NANDUFA5
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa14695-0.801-0.2079Yes
148CHCHD10NA14705-0.803-0.2037Yes
149NDUFAB1NANDUFAB1
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa14783-0.821-0.2031Yes
150DECR1NADECR1
Entrez,  Source
2,4-dienoyl CoA reductase 1, mitochondrial14805-0.828-0.1994Yes
151HADHNAHADH
Entrez,  Source
hydroxyacyl-Coenzyme A dehydrogenase14938-0.852-0.2018Yes
152DGAT1NADGAT1
Entrez,  Source
diacylglycerol O-acyltransferase homolog 1 (mouse)14985-0.863-0.1992Yes
153LIPENALIPE
Entrez,  Source
lipase, hormone-sensitive15029-0.875-0.1965Yes
154FZD4NAFZD4
Entrez,  Source
frizzled homolog 4 (Drosophila)15035-0.876-0.1915Yes
155CMPK1NA15059-0.883-0.1876Yes
156ITSN1NAITSN1
Entrez,  Source
intersectin 1 (SH3 domain protein)15343-0.954-0.1979Yes
157PRDX3NAPRDX3
Entrez,  Source
peroxiredoxin 315564-1.017-0.2042Yes
158CDKN2CNACDKN2C
Entrez,  Source
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)15593-1.025-0.1997Yes
159TSTNATST
Entrez,  Source
thiosulfate sulfurtransferase (rhodanese)15596-1.027-0.1937Yes
160COQ3NACOQ3
Entrez,  Source
coenzyme Q3 homolog, methyltransferase (S. cerevisiae)15673-1.054-0.1917Yes
161GADD45ANAGADD45A
Entrez,  Source
growth arrest and DNA-damage-inducible, alpha15708-1.064-0.1873Yes
162IDH3ANAIDH3A
Entrez,  Source
isocitrate dehydrogenase 3 (NAD+) alpha15719-1.066-0.1816Yes
163IMMTNAIMMT
Entrez,  Source
inner membrane protein, mitochondrial (mitofilin)15880-1.126-0.1839Yes
164COX6A1NACOX6A1
Entrez,  Source
cytochrome c oxidase subunit VIa polypeptide 115936-1.150-0.1802Yes
165ELMOD3NA15963-1.157-0.1748Yes
166LPCAT3NA16093-1.210-0.1748Yes
167REEP6NAREEP6
Entrez,  Source
receptor accessory protein 616141-1.235-0.1702Yes
168ACLYNAACLY
Entrez,  Source
ATP citrate lyase16197-1.256-0.1658Yes
169GPHNNAGPHN
Entrez,  Source
gephyrin16235-1.277-0.1603Yes
170STOMNASTOM
Entrez,  Source
stomatin16303-1.306-0.1563Yes
171TKTNATKT
Entrez,  Source
transketolase (Wernicke-Korsakoff syndrome)16311-1.310-0.1490Yes
172UQCRC1NAUQCRC1
Entrez,  Source
ubiquinol-cytochrome c reductase core protein I16381-1.353-0.1448Yes
173SLC25A1NASLC25A1
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 116517-1.424-0.1440Yes
174PTCD3NAPTCD3
Entrez,  Source
Pentatricopeptide repeat domain 316657-1.504-0.1428Yes
175SORBS1NASORBS1
Entrez,  Source
sorbin and SH3 domain containing 116755-1.566-0.1390Yes
176SSPNNASSPN
Entrez,  Source
sarcospan (Kras oncogene-associated gene)16888-1.673-0.1365Yes
177MGLLNAMGLL
Entrez,  Source
monoglyceride lipase16963-1.735-0.1304Yes
178COL4A1NACOL4A1
Entrez,  Source
collagen, type IV, alpha 117070-1.831-0.1255Yes
179BCKDHANABCKDHA
Entrez,  Source
branched chain keto acid dehydrogenase E1, alpha polypeptide17143-1.925-0.1181Yes
180DHCR7NADHCR7
Entrez,  Source
7-dehydrocholesterol reductase17178-1.978-0.1083Yes
181PEMTNAPEMT
Entrez,  Source
phosphatidylethanolamine N-methyltransferase17239-2.065-0.0994Yes
182DNAJC15NADNAJC15
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily C, member 1517313-2.197-0.0905Yes
183PDCD4NAPDCD4
Entrez,  Source
programmed cell death 4 (neoplastic transformation inhibitor)17485-2.462-0.0855Yes
184GPAMNAGPAM
Entrez,  Source
glycerol-3-phosphate acyltransferase, mitochondrial17542-2.600-0.0732Yes
185SUCLG1NASUCLG1
Entrez,  Source
succinate-CoA ligase, GDP-forming, alpha subunit17688-3.052-0.0633Yes
186C3NAC3
Entrez,  Source
complement component 317698-3.089-0.0455Yes
187SNCGNASNCG
Entrez,  Source
synuclein, gamma (breast cancer-specific protein 1)17702-3.101-0.0273Yes
188ABCA1NAABCA1
Entrez,  Source
ATP-binding cassette, sub-family A (ABC1), member 117737-3.297-0.0096Yes
189FABP4NAFABP4
Entrez,  Source
fatty acid binding protein 4, adipocyte17845-3.8600.0073Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_ADIPOGENESIS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_ADIPOGENESIS: Random ES distribution   
Gene set null distribution of ES for HALLMARK_ADIPOGENESIS