Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_TYPE_I_DIABETES_MELLITUS |
| Enrichment Score (ES) | 0.49272847 |
| Normalized Enrichment Score (NES) | 1.4345719 |
| Nominal p-value | 0.05050505 |
| FDR q-value | 0.21512416 |
| FWER p-Value | 0.979 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | HLA-DRA | NA | HLA-DRA Entrez, Source | major histocompatibility complex, class II, DR alpha | 83 | 4.582 | 0.0783 | Yes |
| 2 | HLA-DRB1 | NA | HLA-DRB1 Entrez, Source | major histocompatibility complex, class II, DR beta 1 | 235 | 3.969 | 0.1417 | Yes |
| 3 | HLA-DPA1 | NA | HLA-DPA1 Entrez, Source | major histocompatibility complex, class II, DP alpha 1 | 345 | 3.598 | 0.2007 | Yes |
| 4 | HLA-DMA | NA | HLA-DMA Entrez, Source | major histocompatibility complex, class II, DM alpha | 556 | 3.030 | 0.2439 | Yes |
| 5 | HLA-DRB5 | NA | HLA-DRB5 Entrez, Source | major histocompatibility complex, class II, DR beta 5 | 611 | 2.898 | 0.2933 | Yes |
| 6 | FAS | NA | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 733 | 2.679 | 0.3350 | Yes |
| 7 | HLA-DRB3 | NA | HLA-DRB3 Entrez, Source | major histocompatibility complex, class II, DR beta 3 | 916 | 2.438 | 0.3690 | Yes |
| 8 | HLA-DMB | NA | HLA-DMB Entrez, Source | major histocompatibility complex, class II, DM beta | 1107 | 2.215 | 0.3985 | Yes |
| 9 | HLA-DRB4 | NA | HLA-DRB4 Entrez, Source | major histocompatibility complex, class II, DR beta 4 | 1321 | 2.023 | 0.4232 | Yes |
| 10 | CPE | NA | CPE Entrez, Source | carboxypeptidase E | 1404 | 1.949 | 0.4539 | Yes |
| 11 | HLA-DOB | NA | HLA-DOB Entrez, Source | major histocompatibility complex, class II, DO beta | 1477 | 1.892 | 0.4842 | Yes |
| 12 | HSPD1 | NA | HSPD1 Entrez, Source | heat shock 60kDa protein 1 (chaperonin) | 2160 | 1.465 | 0.4727 | Yes |
| 13 | GAD1 | NA | GAD1 Entrez, Source | glutamate decarboxylase 1 (brain, 67kDa) | 2280 | 1.421 | 0.4918 | Yes |
| 14 | HLA-E | NA | HLA-E Entrez, Source | major histocompatibility complex, class I, E | 2705 | 1.243 | 0.4906 | Yes |
| 15 | PRF1 | NA | PRF1 Entrez, Source | perforin 1 (pore forming protein) | 3267 | 1.069 | 0.4787 | Yes |
| 16 | IL12A | NA | IL12A Entrez, Source | interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) | 3354 | 1.041 | 0.4927 | Yes |
| 17 | HLA-A | NA | HLA-A Entrez, Source | major histocompatibility complex, class I, A | 4503 | 0.747 | 0.4423 | No |
| 18 | FASLG | NA | FASLG Entrez, Source | Fas ligand (TNF superfamily, member 6) | 4608 | 0.723 | 0.4496 | No |
| 19 | HLA-C | NA | HLA-C Entrez, Source | major histocompatibility complex, class I, C | 4653 | 0.713 | 0.4600 | No |
| 20 | HLA-DPB1 | NA | HLA-DPB1 Entrez, Source | major histocompatibility complex, class II, DP beta 1 | 5159 | 0.612 | 0.4429 | No |
| 21 | IL12B | NA | IL12B Entrez, Source | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 5356 | 0.576 | 0.4424 | No |
| 22 | LTA | NA | LTA Entrez, Source | lymphotoxin alpha (TNF superfamily, member 1) | 5480 | 0.553 | 0.4456 | No |
| 23 | HLA-F | NA | HLA-F Entrez, Source | major histocompatibility complex, class I, F | 5915 | 0.484 | 0.4301 | No |
| 24 | CD80 | NA | CD80 Entrez, Source | CD80 molecule | 6065 | 0.457 | 0.4301 | No |
| 25 | GAD2 | NA | GAD2 Entrez, Source | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) | 6435 | 0.394 | 0.4167 | No |
| 26 | HLA-DQB1 | NA | HLA-DQB1 Entrez, Source | major histocompatibility complex, class II, DQ beta 1 | 7133 | 0.297 | 0.3832 | No |
| 27 | HLA-DQA1 | NA | HLA-DQA1 Entrez, Source | major histocompatibility complex, class II, DQ alpha 1 | 7724 | 0.232 | 0.3545 | No |
| 28 | PTPRN | NA | PTPRN Entrez, Source | protein tyrosine phosphatase, receptor type, N | 7945 | 0.210 | 0.3460 | No |
| 29 | IL2 | NA | IL2 Entrez, Source | interleukin 2 | 8119 | 0.187 | 0.3398 | No |
| 30 | HLA-DOA | NA | HLA-DOA Entrez, Source | major histocompatibility complex, class II, DO alpha | 8378 | 0.164 | 0.3283 | No |
| 31 | ICA1 | NA | ICA1 Entrez, Source | islet cell autoantigen 1, 69kDa | 10405 | -0.024 | 0.2158 | No |
| 32 | HLA-DQA2 | NA | HLA-DQA2 Entrez, Source | major histocompatibility complex, class II, DQ alpha 2 | 10636 | -0.045 | 0.2038 | No |
| 33 | CD86 | NA | CD86 Entrez, Source | CD86 molecule | 11217 | -0.106 | 0.1734 | No |
| 34 | IFNG | NA | IFNG Entrez, Source | interferon, gamma | 11661 | -0.150 | 0.1514 | No |
| 35 | PTPRN2 | NA | PTPRN2 Entrez, Source | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 12400 | -0.238 | 0.1146 | No |
| 36 | TNF | NA | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 12645 | -0.269 | 0.1059 | No |
| 37 | HLA-B | NA | HLA-B Entrez, Source | major histocompatibility complex, class I, B | 14110 | -0.511 | 0.0335 | No |
| 38 | HLA-G | NA | HLA-G Entrez, Source | HLA-G histocompatibility antigen, class I, G | 14436 | -0.581 | 0.0259 | No |
| 39 | CD28 | NA | CD28 Entrez, Source | CD28 molecule | 16374 | -1.233 | -0.0598 | No |
| 40 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 17833 | -3.984 | -0.0689 | No |
| 41 | IL1A | NA | IL1A Entrez, Source | interleukin 1, alpha | 17880 | -4.259 | 0.0056 | No |
