Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_TYPE_II_DIABETES_MELLITUS |
| Enrichment Score (ES) | -0.3483205 |
| Normalized Enrichment Score (NES) | -1.1711403 |
| Nominal p-value | 0.19188192 |
| FDR q-value | 0.5572451 |
| FWER p-Value | 1.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | PIK3CA | NA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 749 | 2.649 | 0.0213 | No |
| 2 | IRS1 | NA | IRS1 Entrez, Source | insulin receptor substrate 1 | 843 | 2.527 | 0.0763 | No |
| 3 | MTOR | NA | 1024 | 2.302 | 0.1211 | No | ||
| 4 | IKBKB | NA | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 1288 | 2.052 | 0.1553 | No |
| 5 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 1410 | 1.946 | 0.1948 | No |
| 6 | PIK3R1 | NA | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 2108 | 1.493 | 0.1915 | No |
| 7 | INSR | NA | INSR Entrez, Source | insulin receptor | 2836 | 1.203 | 0.1796 | No |
| 8 | MAFA | NA | MAFA Entrez, Source | v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) | 3432 | 1.019 | 0.1707 | No |
| 9 | ADIPOQ | NA | ADIPOQ Entrez, Source | adiponectin, C1Q and collagen domain containing | 4626 | 0.718 | 0.1213 | No |
| 10 | SOCS4 | NA | SOCS4 Entrez, Source | suppressor of cytokine signaling 4 | 5092 | 0.625 | 0.1103 | No |
| 11 | SOCS3 | NA | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 5999 | 0.467 | 0.0709 | No |
| 12 | HK1 | NA | HK1 Entrez, Source | hexokinase 1 | 6036 | 0.461 | 0.0799 | No |
| 13 | MAPK9 | NA | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 6268 | 0.418 | 0.0769 | No |
| 14 | CACNA1C | NA | CACNA1C Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1C subunit | 6836 | 0.338 | 0.0534 | No |
| 15 | HK3 | NA | HK3 Entrez, Source | hexokinase 3 (white cell) | 7393 | 0.263 | 0.0286 | No |
| 16 | PIK3CB | NA | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 7635 | 0.240 | 0.0209 | No |
| 17 | IRS4 | NA | IRS4 Entrez, Source | insulin receptor substrate 4 | 7692 | 0.235 | 0.0234 | No |
| 18 | IRS2 | NA | IRS2 Entrez, Source | insulin receptor substrate 2 | 7737 | 0.231 | 0.0264 | No |
| 19 | KCNJ11 | NA | KCNJ11 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 11 | 7739 | 0.230 | 0.0318 | No |
| 20 | ABCC8 | NA | ABCC8 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 | 8848 | 0.116 | -0.0272 | No |
| 21 | MAPK10 | NA | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 9003 | 0.098 | -0.0334 | No |
| 22 | CACNA1E | NA | CACNA1E Entrez, Source | calcium channel, voltage-dependent, alpha 1E subunit | 9095 | 0.090 | -0.0363 | No |
| 23 | PDX1 | NA | 9172 | 0.082 | -0.0386 | No | ||
| 24 | PKLR | NA | PKLR Entrez, Source | pyruvate kinase, liver and RBC | 9203 | 0.078 | -0.0384 | No |
| 25 | MAPK8 | NA | MAPK8 Entrez, Source | mitogen-activated protein kinase 8 | 9814 | 0.009 | -0.0722 | No |
| 26 | CACNA1D | NA | CACNA1D Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1D subunit | 9829 | 0.007 | -0.0729 | No |
| 27 | PIK3R5 | NA | PIK3R5 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 5, p101 | 9845 | 0.004 | -0.0736 | No |
| 28 | GCK | NA | GCK Entrez, Source | glucokinase (hexokinase 4, maturity onset diabetes of the young 2) | 9908 | 0.000 | -0.0770 | No |
| 29 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 12360 | -0.233 | -0.2082 | No |
| 30 | CACNA1G | NA | CACNA1G Entrez, Source | calcium channel, voltage-dependent, alpha 1G subunit | 12467 | -0.245 | -0.2082 | No |
| 31 | PIK3R2 | NA | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 12508 | -0.252 | -0.2044 | No |
| 32 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 12596 | -0.262 | -0.2031 | No |
| 33 | TNF | NA | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 12645 | -0.269 | -0.1993 | No |
| 34 | SOCS1 | NA | SOCS1 Entrez, Source | suppressor of cytokine signaling 1 | 12911 | -0.303 | -0.2069 | No |
| 35 | SLC2A2 | NA | SLC2A2 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 2 | 13679 | -0.431 | -0.2394 | No |
| 36 | SLC2A4 | NA | SLC2A4 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 4 | 14071 | -0.505 | -0.2492 | No |
| 37 | PRKCE | NA | PRKCE Entrez, Source | protein kinase C, epsilon | 15221 | -0.779 | -0.2947 | No |
| 38 | CACNA1A | NA | CACNA1A Entrez, Source | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 15606 | -0.897 | -0.2947 | No |
| 39 | MAPK3 | NA | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 16431 | -1.263 | -0.3106 | Yes |
| 40 | HK2 | NA | HK2 Entrez, Source | hexokinase 2 | 17109 | -1.798 | -0.3055 | Yes |
| 41 | PRKCD | NA | PRKCD Entrez, Source | protein kinase C, delta | 17310 | -2.062 | -0.2676 | Yes |
| 42 | PRKCZ | NA | PRKCZ Entrez, Source | protein kinase C, zeta | 17333 | -2.098 | -0.2188 | Yes |
| 43 | CACNA1B | NA | CACNA1B Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1B subunit | 17537 | -2.524 | -0.1700 | Yes |
| 44 | SOCS2 | NA | SOCS2 Entrez, Source | suppressor of cytokine signaling 2 | 17732 | -3.288 | -0.1026 | Yes |
| 45 | PIK3CG | NA | PIK3CG Entrez, Source | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 17957 | -4.885 | 0.0013 | Yes |
