Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_TRYPTOPHAN_METABOLISM |
| Enrichment Score (ES) | 0.5088496 |
| Normalized Enrichment Score (NES) | 1.4851145 |
| Nominal p-value | 0.02124646 |
| FDR q-value | 0.19845365 |
| FWER p-Value | 0.918 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CYP1B1 | NA | CYP1B1 Entrez, Source | cytochrome P450, family 1, subfamily B, polypeptide 1 | 13 | 4.923 | 0.1078 | Yes |
| 2 | CYP1A1 | NA | CYP1A1 Entrez, Source | cytochrome P450, family 1, subfamily A, polypeptide 1 | 57 | 4.715 | 0.2094 | Yes |
| 3 | MAOB | NA | MAOB Entrez, Source | monoamine oxidase B | 175 | 4.197 | 0.2955 | Yes |
| 4 | KYNU | NA | KYNU Entrez, Source | kynureninase (L-kynurenine hydrolase) | 348 | 3.594 | 0.3651 | Yes |
| 5 | OGDHL | NA | OGDHL Entrez, Source | oxoglutarate dehydrogenase-like | 681 | 2.795 | 0.4082 | Yes |
| 6 | TDO2 | NA | TDO2 Entrez, Source | tryptophan 2,3-dioxygenase | 922 | 2.431 | 0.4485 | Yes |
| 7 | EHHADH | NA | EHHADH Entrez, Source | enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | 1329 | 2.016 | 0.4703 | Yes |
| 8 | ALDH3A2 | NA | ALDH3A2 Entrez, Source | aldehyde dehydrogenase 3 family, member A2 | 1409 | 1.948 | 0.5088 | Yes |
| 9 | ALDH2 | NA | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 2317 | 1.406 | 0.4893 | No |
| 10 | OGDH | NA | OGDH Entrez, Source | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 2907 | 1.180 | 0.4825 | No |
| 11 | ALDH7A1 | NA | ALDH7A1 Entrez, Source | aldehyde dehydrogenase 7 family, member A1 | 2956 | 1.162 | 0.5054 | No |
| 12 | IDO1 | NA | 3624 | 0.961 | 0.4895 | No | ||
| 13 | WARS | NA | WARS Entrez, Source | tryptophanyl-tRNA synthetase | 4277 | 0.798 | 0.4707 | No |
| 14 | INMT | NA | INMT Entrez, Source | indolethylamine N-methyltransferase | 4499 | 0.748 | 0.4749 | No |
| 15 | KMO | NA | KMO Entrez, Source | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | 5332 | 0.579 | 0.4413 | No |
| 16 | CYP1A2 | NA | CYP1A2 Entrez, Source | cytochrome P450, family 1, subfamily A, polypeptide 2 | 5521 | 0.546 | 0.4429 | No |
| 17 | ASMT | NA | ASMT Entrez, Source | acetylserotonin O-methyltransferase | 6450 | 0.392 | 0.3998 | No |
| 18 | TPH1 | NA | TPH1 Entrez, Source | tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) | 6775 | 0.345 | 0.3893 | No |
| 19 | TPH2 | NA | TPH2 Entrez, Source | tryptophan hydroxylase 2 | 6863 | 0.334 | 0.3918 | No |
| 20 | IDO2 | NA | 7284 | 0.276 | 0.3745 | No | ||
| 21 | CAT | NA | CAT Entrez, Source | catalase | 7933 | 0.211 | 0.3431 | No |
| 22 | DDC | NA | DDC Entrez, Source | dopa decarboxylase (aromatic L-amino acid decarboxylase) | 8364 | 0.164 | 0.3227 | No |
| 23 | ECHS1 | NA | ECHS1 Entrez, Source | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | 8574 | 0.146 | 0.3143 | No |
| 24 | ACAT1 | NA | ACAT1 Entrez, Source | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | 9186 | 0.080 | 0.2820 | No |
| 25 | MAOA | NA | MAOA Entrez, Source | monoamine oxidase A | 9633 | 0.034 | 0.2579 | No |
| 26 | AFMID | NA | AFMID Entrez, Source | arylformamidase | 9653 | 0.032 | 0.2575 | No |
| 27 | HADHA | NA | HADHA Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit | 10585 | -0.040 | 0.2065 | No |
| 28 | HADH | NA | HADH Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase | 12939 | -0.309 | 0.0822 | No |
| 29 | WARS2 | NA | WARS2 Entrez, Source | tryptophanyl tRNA synthetase 2 (mitochondrial) | 13156 | -0.342 | 0.0777 | No |
| 30 | ALDH9A1 | NA | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 13537 | -0.405 | 0.0654 | No |
| 31 | ACMSD | NA | ACMSD Entrez, Source | aminocarboxymuconate semialdehyde decarboxylase | 13873 | -0.468 | 0.0571 | No |
| 32 | ALDH1B1 | NA | ALDH1B1 Entrez, Source | aldehyde dehydrogenase 1 family, member B1 | 14350 | -0.563 | 0.0430 | No |
| 33 | GCDH | NA | GCDH Entrez, Source | glutaryl-Coenzyme A dehydrogenase | 14363 | -0.566 | 0.0548 | No |
| 34 | AANAT | NA | AANAT Entrez, Source | arylalkylamine N-acetyltransferase | 15693 | -0.927 | 0.0011 | No |
| 35 | AADAT | NA | AADAT Entrez, Source | aminoadipate aminotransferase | 15943 | -1.025 | 0.0099 | No |
| 36 | HAAO | NA | HAAO Entrez, Source | 3-hydroxyanthranilate 3,4-dioxygenase | 15952 | -1.028 | 0.0321 | No |
| 37 | AOX1 | NA | AOX1 Entrez, Source | aldehyde oxidase 1 | 16069 | -1.073 | 0.0493 | No |
| 38 | IL4I1 | NA | IL4I1 Entrez, Source | interleukin 4 induced 1 | 16271 | -1.180 | 0.0641 | No |
| 39 | ACAT2 | NA | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 16675 | -1.410 | 0.0727 | No |
