Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_THYROID_CANCER |
| Enrichment Score (ES) | -0.3829873 |
| Normalized Enrichment Score (NES) | -1.1837343 |
| Nominal p-value | 0.2172524 |
| FDR q-value | 0.5916397 |
| FWER p-Value | 1.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | TCF7 | NA | TCF7 Entrez, Source | transcription factor 7 (T-cell specific, HMG-box) | 189 | 4.141 | 0.1641 | No |
| 2 | RXRB | NA | RXRB Entrez, Source | retinoid X receptor, beta | 3804 | 0.915 | 0.0014 | No |
| 3 | MAP2K2 | NA | MAP2K2 Entrez, Source | mitogen-activated protein kinase kinase 2 | 3949 | 0.881 | 0.0305 | No |
| 4 | RXRA | NA | RXRA Entrez, Source | retinoid X receptor, alpha | 4154 | 0.829 | 0.0541 | No |
| 5 | HRAS | NA | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 4840 | 0.674 | 0.0444 | No |
| 6 | CDH1 | NA | CDH1 Entrez, Source | cadherin 1, type 1, E-cadherin (epithelial) | 4940 | 0.653 | 0.0664 | No |
| 7 | CCND1 | NA | CCND1 Entrez, Source | cyclin D1 | 5252 | 0.595 | 0.0741 | No |
| 8 | PAX8 | NA | PAX8 Entrez, Source | paired box gene 8 | 6146 | 0.439 | 0.0429 | No |
| 9 | KRAS | NA | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 7514 | 0.251 | -0.0227 | No |
| 10 | RXRG | NA | RXRG Entrez, Source | retinoid X receptor, gamma | 9140 | 0.085 | -0.1096 | No |
| 11 | TFG | NA | TFG Entrez, Source | TRK-fused gene | 9598 | 0.040 | -0.1334 | No |
| 12 | CCDC6 | NA | CCDC6 Entrez, Source | coiled-coil domain containing 6 | 9629 | 0.035 | -0.1336 | No |
| 13 | PPARG | NA | PPARG Entrez, Source | peroxisome proliferative activated receptor, gamma | 9858 | 0.002 | -0.1462 | No |
| 14 | RET | NA | RET Entrez, Source | ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) | 10972 | -0.077 | -0.2049 | No |
| 15 | NCOA4 | NA | NCOA4 Entrez, Source | nuclear receptor coactivator 4 | 11057 | -0.087 | -0.2059 | No |
| 16 | NRAS | NA | NRAS Entrez, Source | neuroblastoma RAS viral (v-ras) oncogene homolog | 12151 | -0.207 | -0.2581 | No |
| 17 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 12360 | -0.233 | -0.2599 | No |
| 18 | TCF7L2 | NA | TCF7L2 Entrez, Source | transcription factor 7-like 2 (T-cell specific, HMG-box) | 13312 | -0.370 | -0.2973 | No |
| 19 | TPR | NA | TPR Entrez, Source | translocated promoter region (to activated MET oncogene) | 14852 | -0.684 | -0.3542 | Yes |
| 20 | CTNNB1 | NA | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 14895 | -0.694 | -0.3272 | Yes |
| 21 | TPM3 | NA | TPM3 Entrez, Source | tropomyosin 3 | 14939 | -0.705 | -0.2999 | Yes |
| 22 | BRAF | NA | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 15145 | -0.758 | -0.2793 | Yes |
| 23 | MYC | NA | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 15151 | -0.760 | -0.2476 | Yes |
| 24 | LEF1 | NA | LEF1 Entrez, Source | lymphoid enhancer-binding factor 1 | 16125 | -1.101 | -0.2554 | Yes |
| 25 | NTRK1 | NA | NTRK1 Entrez, Source | neurotrophic tyrosine kinase, receptor, type 1 | 16204 | -1.143 | -0.2115 | Yes |
| 26 | MAPK3 | NA | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 16431 | -1.263 | -0.1709 | Yes |
| 27 | MAP2K1 | NA | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 16504 | -1.300 | -0.1200 | Yes |
| 28 | TP53 | NA | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 17352 | -2.136 | -0.0772 | Yes |
| 29 | TCF7L1 | NA | TCF7L1 Entrez, Source | transcription factor 7-like 1 (T-cell specific, HMG-box) | 17581 | -2.658 | 0.0222 | Yes |
